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Mid-Term Results and Risk Factors For 10 Years of Functional Single Ventricle Associated With Total Anomalous Pulmonary Venous Connection. 全肺静脉连接异常的功能性单心室10年中期结果和危险因素。
The heart surgery forum Pub Date : 2022-03-08 DOI: 10.1532/hsf.4343
Bin Li, Aijun Liu, Ming Yang, Junwu Su, Xiangming Fan
{"title":"Mid-Term Results and Risk Factors For 10 Years of Functional Single Ventricle Associated With Total Anomalous Pulmonary Venous Connection.","authors":"Bin Li, Aijun Liu, Ming Yang, Junwu Su, Xiangming Fan","doi":"10.1532/hsf.4343","DOIUrl":"https://doi.org/10.1532/hsf.4343","url":null,"abstract":"BACKGROUND\u0000There are few surgical treatment results in elderly patients with functional single ventricle (FSV) and total anomalous pulmonary venous connection (TAPVC). We retrospectively analyzed 10 years of mid-term surgical treatment results and risk factors of these age-specific people.\u0000\u0000\u0000METHODS\u0000Between March 2008 and December 2018, 43 consecutive patients with FSV and TAPVC received initial surgical palliation in our center. There were 20 cases of supracardiac TAPVC, 21 of cardiac type, and two cases of mixed type. Initial surgical palliation procedures involved pulmonary artery banding (PAB) for patients, modified Blalock-Taussing shunt (mBTs) for five patients, and bidirectional Glenn (BDG) for 34 patients. TAPVC repair was performed in 12 patients during BDG.\u0000\u0000\u0000RESULTS\u0000The 1-year and 5-year overall survival rates were 69.7% and 62.8%, respectively. In TAPVC repair group and non-TAPVC repair group, the 1-year overall survival rates after initial surgical palliation were 41.7 and 80.5%, respectively, and the 3-year ones were 25% and 77%, respectively. There were significant differences in the type of TAPVC (P < 0.001), preoperative pulmonary venous obstruction (P = 0.001), and overall mortality (P = 0.001) between these two groups. Cox univariate and multivariable analysis indicated concomitant TAPVC repair was the only risk factor for mortality.\u0000\u0000\u0000CONCLUSIONS\u0000The mid-term results of surgical treatment of FSV and TAPVC, especially for patients who underwent concomitant TAPVC repair, remain poor. TAPVC repair may be a priority over single-ventricular palliative surgery for patients with FSV and TAPVC.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116365769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Follow up after Transfemoral Transcatheter Aortic Valve Implantation in Lower Risk Patients Using the Balloon-Expandable Bioprosthesis: Gender-Dependent Outcomes. 低危患者经股导管主动脉瓣植入术后的长期随访:使用可膨胀生物假体:性别依赖的结果。
The heart surgery forum Pub Date : 2022-03-08 DOI: 10.1532/hsf.4451
D. Useini, M. Schlömicher, A. Aweimer, P. Haldenwang, J. Strauch, P. Patsalis
{"title":"Long-term Follow up after Transfemoral Transcatheter Aortic Valve Implantation in Lower Risk Patients Using the Balloon-Expandable Bioprosthesis: Gender-Dependent Outcomes.","authors":"D. Useini, M. Schlömicher, A. Aweimer, P. Haldenwang, J. Strauch, P. Patsalis","doi":"10.1532/hsf.4451","DOIUrl":"https://doi.org/10.1532/hsf.4451","url":null,"abstract":"INTRODUCTION\u0000Long-term data on gender-related outcomes after transfemoral transcatheter aortic valve implantation (TF-TAVI) using newer generations heart valves in lower-risk patients are sparse. We aimed to evaluate gender-dependent long-term outcomes after TF-TAVI in lower-risk patients using the third-generation balloon expandable bioprosthesis.\u0000\u0000\u0000METHODS\u0000Data of 103 patients undergoing TF-TAVI using the third-generation balloon expandable bioprosthesis were analyzed. We conducted up to six years follow up and performed comparison on gender basis: men (45 patients; 82 ± 4.7 years; STS Score 3.7 ± 1.6%) vs. women (58 patients; 83.2 ± 4.5 years; STS Score 3.6 ± 1.8%). The mean follow-up time was 30 months.\u0000\u0000\u0000RESULTS\u0000Cardiovascular risk factors at baseline were similar, without significant differences between men and women. The 30-day mortality was 4.4% in men vs. 3.4% in women (P = 0.745). The 30-day stroke was 4.4% in men vs. 1.7% in women (P = 0.582). The major vascular injury rate and the pacemaker rate was 2.3% vs. 10.7% (P = 0.134) and 19.5% vs. 18.9% (P = 1) in men vs. women, respectively. There was a significant difference of mean long-term survival: men, 42.1 months [95%CI: 33.154-51.101] vs. women, 57.3 months [95%CI: 50.618-64.159], P = 0.015.\u0000\u0000\u0000CONCLUSION\u0000Although considerably more prone to procedural complications, women had a significantly long-term survival benefit after TF-TAVI in lower-risk patients despite similar baseline characteristics.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121227506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Giant Ascending Aortic Aneurysm Compressed the Left Main Bronchus and Esophagus: A Case Report. 巨大升主动脉瘤压迫左主支气管及食道1例。
The heart surgery forum Pub Date : 2022-03-08 DOI: 10.1532/hsf.4281
Shao-Yi Yang, Shen Zhang, Ge Liu, Yiyao Jiang, C. Shi
{"title":"A Giant Ascending Aortic Aneurysm Compressed the Left Main Bronchus and Esophagus: A Case Report.","authors":"Shao-Yi Yang, Shen Zhang, Ge Liu, Yiyao Jiang, C. Shi","doi":"10.1532/hsf.4281","DOIUrl":"https://doi.org/10.1532/hsf.4281","url":null,"abstract":"We report a 39-year-old Chinese man with a giant ascending aortic aneurysm that compressed the left main bronchus and esophagus. Cabrol procedure was successfully performed. The symptoms of dry cough, dysphagia, chest tightness, and asthma disappeared. Without any complications, the patient was discharged home.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126934618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Cardiovascular Surgery Requirements in Children and Adolescents Admitted With Chest Pain To A Pediatric Emergency Clinic. 在儿科急诊诊所因胸痛入院的儿童和青少年的心血管手术需求评估
The heart surgery forum Pub Date : 2022-02-28 DOI: 10.1532/hsf.4341
Cebbar Yildirimcakar, Oğuz Omay, B. Açar, Özgür Çakir, M. Deveci, Okan Tuğral, A. Babaoğlu
{"title":"Assessment of Cardiovascular Surgery Requirements in Children and Adolescents Admitted With Chest Pain To A Pediatric Emergency Clinic.","authors":"Cebbar Yildirimcakar, Oğuz Omay, B. Açar, Özgür Çakir, M. Deveci, Okan Tuğral, A. Babaoğlu","doi":"10.1532/hsf.4341","DOIUrl":"https://doi.org/10.1532/hsf.4341","url":null,"abstract":"INTRODUCTION\u0000Chest pain in children and adolescents is an important symptom in the pediatric emergency clinic. The aim of this study is to assess the characteristics of chest pain and cardiovascular surgery in the pediatric population.\u0000\u0000\u0000MATERIALS AND METHODS\u0000There were 352 children who presented with chest pain to the pediatric emergency department between December 2007 and February 2017. These children were included in this study, which is a retrospective observational study.\u0000\u0000\u0000RESULTS\u0000Among the 352 patients, six patients (1.7%) underwent cardiovascular surgery. Forty-eight patients (13.6%) were diagnosed with cardiac disease, and the most common cardiac causes were myocarditis and pericarditis.\u0000\u0000\u0000CONCLUSION\u0000Only six patients (1.7%) who were admitted to the emergency department with chest pain needed cardiovascular surgery. The chest pain in children required less surgery, and mortality and morbidity were lower compared with adult cardiac chest pain.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134505006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Is Modified Del Nido Cardioplegia as Effective as Del Nido Cardioplegia in Patients With Isolated Coronary Artery Bypass Surgery? 改良的德尔尼多心脏停搏器对孤立冠状动脉搭桥术患者是否与德尔尼多心脏停搏器一样有效?
The heart surgery forum Pub Date : 2022-02-28 DOI: 10.1532/hsf.4491
Kemal Karaarslan, I. Erdinc
{"title":"Is Modified Del Nido Cardioplegia as Effective as Del Nido Cardioplegia in Patients With Isolated Coronary Artery Bypass Surgery?","authors":"Kemal Karaarslan, I. Erdinc","doi":"10.1532/hsf.4491","DOIUrl":"https://doi.org/10.1532/hsf.4491","url":null,"abstract":"OBJECTIVE\u0000Is modified del Nido cardioplegia superior to del Nido cardioplegia in coronary artery bypass patients?\u0000\u0000\u0000MATERIAL AND METHODS\u0000All patients underwent cardiopulmonary bypass and retrospectively were analyzed. A total of 70 patients were included in the study. Thirty-four patients who were given cold (+ 4-8C ') modified del Nido cardioplegia antegrade were evaluated. Other patients received classical del Nido cardioplegia. Hot shot warm blood cardioplegia was given to all patients before the cross-clamp was removed. The results of both groups were compared.\u0000\u0000\u0000RESULTS\u0000There was no significant difference between cardiac arrest times in both groups. A statistically significant difference was found in the modified del Nido cardioplegia group in the working of the heart. Less fibrillation was observed in the modified del Nido cardioplegia group. No difference found between the groups, regarding myocardial preservation. No decrease in hemoglobin was observed in the modified del Nido group on the postoperative first day.\u0000\u0000\u0000CONCLUSIONS\u0000We know that return to spontaneous sinus rhythm and fibrillation reduces ischemia-reperfusion injury. At the same time, we can see that epicardial edema was less in the modified del Nido group. We think that less anemia is an advantage of modified del Nido cardioplegia.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122780113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Correction of Spontaneous Outflow Graft Twisting of HeartMate 3 LVAD via a Subcostal Approach. 经肋下入路心脏伴侣3号左心室辅助器自发性流出型移植物扭转的手术矫正。
The heart surgery forum Pub Date : 2022-02-28 DOI: 10.1532/hsf.4405
H. Nishida, V. Jeevanandam, S. Nathan, T. Ota
{"title":"Surgical Correction of Spontaneous Outflow Graft Twisting of HeartMate 3 LVAD via a Subcostal Approach.","authors":"H. Nishida, V. Jeevanandam, S. Nathan, T. Ota","doi":"10.1532/hsf.4405","DOIUrl":"https://doi.org/10.1532/hsf.4405","url":null,"abstract":"We present two cases of successful surgical correction of a HeartMate 3 left ventricular assist device (LVAD) outflow graft twisting through a subcostal approach. These twistings were diagnosed with computed tomography or pull-back pressure measurement. Technically, a subcostal approach allowed us to access directly the twisted outflow graft and the device connector in a less invasive fashion as compared with a re-sternotomy. Diagnostic modality and surgical tips that address graft twisting are presented within the discussion of these two case studies. The institutional review board of our institution approved this study and waived the requirement for informed consent.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"105 41","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120827147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Simple Technique of Sternal Closure Using An Absorbable Mesh Plate. 使用可吸收网板的简易胸骨闭合技术。
The heart surgery forum Pub Date : 2022-02-25 DOI: 10.1532/hsf.4443
Hirotaka Watanuki, Yasuhiro Futamura, M. Tochii, Kayo Sugiyama, Katsuhiko Matsuyama
{"title":"The Simple Technique of Sternal Closure Using An Absorbable Mesh Plate.","authors":"Hirotaka Watanuki, Yasuhiro Futamura, M. Tochii, Kayo Sugiyama, Katsuhiko Matsuyama","doi":"10.1532/hsf.4443","DOIUrl":"https://doi.org/10.1532/hsf.4443","url":null,"abstract":"BACKGROUND\u0000Several authors have investigated various sternal closure materials and technologies for sternal fixation; nonetheless, the optimal technique for primary sternal closure remains unclear. This study aimed to evaluate the sternal stability of a simple technique using a mesh-type plate (Super Fixorb MX40®; Takiron Co. Ltd., Osaka, Japan), as compared with wire cerclage.\u0000\u0000\u0000METHODS\u0000A total of 70 patients who underwent cardiovascular surgery through median sternotomy between July 2019 and May 2020 were included. Two pieces of mesh-type plates were placed under the sternum in combination with wiring. The technique for sternal closure was randomly applied, which was mainly based on the surgeon's preferences: mesh plate (mesh group: N = 33) or conventional wire cerclage (wire group: N = 37). Sternal displacement was measured using computed tomography at discharge.\u0000\u0000\u0000RESULTS\u0000Pain scale scores and analgesic use on postoperative day 7 were similar between the two groups. However, the displacement in both the anterior-posterior and lateral directions was significantly smaller in the mesh group.\u0000\u0000\u0000CONCLUSIONS\u0000The use of the mesh plate device for sternal closure is simple, safe, easy, and potentially reliable without anterior-posterior sternal displacement.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131764691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Establishment and Validation of a Predictive Model for Long-Term Severe Functional Tricuspid Regurgitation after Mitral Valve Replacement. 二尖瓣置换术后长期严重功能性三尖瓣反流预测模型的建立与验证。
The heart surgery forum Pub Date : 2022-02-24 DOI: 10.1532/hsf.4425
Qiqi Liu, Shuang Chen, Wen-Chi Shen, Xin Duan, Xingxing Ren, Zeya Sun, J. Tian, J. Xue, Guoqing Du
{"title":"Establishment and Validation of a Predictive Model for Long-Term Severe Functional Tricuspid Regurgitation after Mitral Valve Replacement.","authors":"Qiqi Liu, Shuang Chen, Wen-Chi Shen, Xin Duan, Xingxing Ren, Zeya Sun, J. Tian, J. Xue, Guoqing Du","doi":"10.1532/hsf.4425","DOIUrl":"https://doi.org/10.1532/hsf.4425","url":null,"abstract":"BACKGROUND\u0000The objective was to develop and validate an individualized nomogram to predict severe functional tricuspid regurgitation (S-FTR) after mitral valve replacement (MVR) via retrospective analysis of rheumatic heart disease (RHD) patients' pre-clinical characteristics.\u0000\u0000\u0000METHODS\u0000Between 2001-2015, 442 MVR patients of RHD were examined. Transthoracic echocardiography detected S-FTR, and logistic regression model analyzed its independent predictors. R software established a nomogram prediction model, and Bootstrap determined its theoretical probability, which subsequently was compared with the actual patient probability to calculate the area under the curve (AUC) and calibration plots. Decision curve analysis (DCA) identified its clinical utility.\u0000\u0000\u0000RESULTS\u0000Ninety-six patients developed S-FTR during the follow-up period. Both uni- and multivariate analyses found significant correlations between S-FTR occurrence with gender, age, atrial fibrillation (AF), pulmonary arterial hypertension (PH), left atrial diameter (LAD), and tricuspid regurgitation area (TRA). The individualized nomogram model had the AUC of 0.99 in internal verification. Calibration test indicated high agreement of predicted and actual S-FTR onset. DCA also showed that utilization of those six aforementioned factors was clinically useful.\u0000\u0000\u0000CONCLUSION\u0000The nomogram for the patient characteristics of age, gender, AF, PH, LAD, and TRA found that they were highly predictive for future S-FTR onset within 5 years. This predictive ability therefore allows clinicians to optimize postoperative patient care and avoid unnecessary tricuspid valve surgeries.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132525585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does an Early Implantation of Extracorporeal Membrane Oxygenator in High-Risk Emergency Open Heart Surgery Patients Improve the Outcome in Comparison with Elective Patients? A Prospective Cohort Comparative Study. 与择期患者相比,高危急诊心内直视手术患者早期植入体外膜氧合器是否能改善预后?前瞻性队列比较研究。
The heart surgery forum Pub Date : 2022-02-24 DOI: 10.1532/hsf.4431
Ahmed Abdeljawad, Y. Mubarak
{"title":"Does an Early Implantation of Extracorporeal Membrane Oxygenator in High-Risk Emergency Open Heart Surgery Patients Improve the Outcome in Comparison with Elective Patients? A Prospective Cohort Comparative Study.","authors":"Ahmed Abdeljawad, Y. Mubarak","doi":"10.1532/hsf.4431","DOIUrl":"https://doi.org/10.1532/hsf.4431","url":null,"abstract":"BACKGROUND\u0000Extracorporeal membrane oxygenator (ECMO) has been implemented in refractory postcardiotomy cardiogenic shock (PCCS) patients to maintain excellent oxygenation and hemodynamic support. The aim of this study is to compare the results of early ECMO implantation to treat refractory PCCS in emergency versus elective patients who developed univentricular or biventricular pump failure.\u0000\u0000\u0000PATIENTS AND METHODS\u0000Between January 2019 and June 2021, 35 patients received ECMO after refractory PCCS. Patients have been categorized into two groups: Group A contains 18 patients who were urgently operated on and Group B, which includes 17 patients who were electively operated on. ECMO was implanted through central cannulation (right atrium and ascending aorta), or through peripheral cannulation (femoral vessels or through axillary artery).\u0000\u0000\u0000RESULTS\u0000There was no statistically significant difference between the two ECMO groups in the preoperative patient's characteristics, complication rate, duration of mechanical ventilation, post-ECMO weaning hospital stay, duration of ICU stay, in-hospital mortality, and number of patients discharged from the hospital or in 1-year survival on follow up.\u0000\u0000\u0000CONCLUSION\u0000Early use of ECMO in high-risk emergency cardiac surgery should be taken into consideration when possible, without hesitance. Emergency and elective patients benefit equally from ECMO implantation and show comparable complication rates.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116335082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Atorvastatin Exerts Protective Effect on Cardiopulmonary Bypass Induced Renal Injury in Rats via PPAR-γ. 阿托伐他汀通过PPAR-γ对体外循环大鼠肾损伤的保护作用。
The heart surgery forum Pub Date : 2022-02-16 DOI: 10.1532/hsf.4225
Tao Zhang, Jianjun Ge, Can Wei
{"title":"Atorvastatin Exerts Protective Effect on Cardiopulmonary Bypass Induced Renal Injury in Rats via PPAR-γ.","authors":"Tao Zhang, Jianjun Ge, Can Wei","doi":"10.1532/hsf.4225","DOIUrl":"https://doi.org/10.1532/hsf.4225","url":null,"abstract":"BACKGROUND\u0000To investigate the protective effect and possible mechanism of atorvastatin pretreatment on renal function after cardiopulmonary bypass (CPB) in rats.\u0000\u0000\u0000METHODS\u0000Twenty-four adult male Sprague-Dawley (SD) rats randomly were divided into three groups: Sham operation group, CPB group, and administration group (N = 8 in each group). The caudal artery and right jugular vein were used to establish the CPB circuit for the CPB and administration groups. Drugs were administered by oral gavage one week before the operation. All rats were executed for succeeding experiments 72h after the operation. Plasma levels of creatinine (Cre) and IL-8 at different time points and levels of TNF-α and MPO in renal tissue were detected by ELISA. Renal pathological changes were observed by HE staining. PPAR-γ expression was determined by immunohistochemistry and western blot.\u0000\u0000\u0000RESULTS\u0000All rats survived the whole process without incident. Renal function of rats undergoing CPB was impaired to varying degrees based on the plasma Cre concentration, and atorvastatin pretreatment alleviated this effect. The concentrations of six inflammatory cytokines (IL-1β, IL-6,IL-8, IFN-γ,TNF-α, and MPO) were significantly elevated after CPB procedure, while atorvastatin pretreatment ameliorated the inflammatory condition caused by CPB. Further analysis showed that in both HK-2 cells and renal tissues, atorvastatin promoted the expression of PPAR-γ.\u0000\u0000\u0000CONCLUSION\u0000Atorvastatin pretreatment exerted protective effect on CPB-associated kidney injury and inflammation in rats. The activation of PPAR-γ may contribute to the protective effect of Atorvastatin.","PeriodicalId":257138,"journal":{"name":"The heart surgery forum","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126911524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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