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Genetic markers of pharmacokinetic features in patients with a severe outcome of schizophrenia, resistant to antipsychotic therapy 精神分裂症严重结局患者抗精神病治疗药代动力学特征的遗传标记
Science and Innovations Pub Date : 2023-08-08 DOI: 10.29235/1818-9857-2023-07-78-83
V. Obiedkov, I. Goloenko, O. Bokut, T. Dokukina, T. Golubeva, L. Tishkevich, A. Khodzhaev
{"title":"Genetic markers of pharmacokinetic features in patients with a severe outcome of schizophrenia, resistant to antipsychotic therapy","authors":"V. Obiedkov, I. Goloenko, O. Bokut, T. Dokukina, T. Golubeva, L. Tishkevich, A. Khodzhaev","doi":"10.29235/1818-9857-2023-07-78-83","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-07-78-83","url":null,"abstract":"The article analysed the relationships between genetic factors and resistance of patients with a severe outcome of schizophrenia to ongoing drug treatment, which is necessary to understand the reasons for the formation of such an endophenotype.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127700564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of innovation activity and digital transformation of industrial enterprises in Russia and Belarus 激活俄罗斯和白俄罗斯工业企业的创新活动和数字化转型
Science and Innovations Pub Date : 2023-08-08 DOI: 10.29235/1818-9857-2023-07-31-37
E. Moskvitina, Yu. Pronuso
{"title":"Activation of innovation activity and digital transformation of industrial enterprises in Russia and Belarus","authors":"E. Moskvitina, Yu. Pronuso","doi":"10.29235/1818-9857-2023-07-31-37","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-07-31-37","url":null,"abstract":"The authors outlined the strategic guidelines for the innovative development of the Russian Federation and the Republic of Belarus, and showed the need to expand the Industry 4.0 technologies implementation at industrial enterprises.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116090670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoration of tendons and ligaments of large joints using a Belarusian-made anchor fixator 使用白俄罗斯制造的锚固定器修复大关节的肌腱和韧带
Science and Innovations Pub Date : 2023-07-15 DOI: 10.29235/1818-9857-2023-06-78-83
A. Murzich, R. Sirotkin, P. Amelchenya
{"title":"Restoration of tendons and ligaments of large joints using a Belarusian-made anchor fixator","authors":"A. Murzich, R. Sirotkin, P. Amelchenya","doi":"10.29235/1818-9857-2023-06-78-83","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-06-78-83","url":null,"abstract":"This publication presents an analytical review of the literature and analyzes the own results of surgical treatment of patients with large joints tendons and ligaments damages using a Belarusian-made anchor fixator. The implant is made of titanium alloy, has a working part length from 5 to 16 mm, a thread diameter from 3 to 6,5 mm. The original design provides for the introduction of several threads into the anchor hole, ensures its strong fixation in the bone, including during arthroscopic operations. The method proposed by the authors is low-traumatic, safe and effective both for restoring damaged structures and economically, due to a reduction in the duration of hospitalization and subsequent recovery and a reduction in treatment costs due to the lower cost of the Belarusian construction compared to imported analogues.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128455484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allocative value of design and technological know-how 设计和技术诀窍的配置价值
Science and Innovations Pub Date : 2023-06-06 DOI: 10.29235/1818-9857-2023-05-33-37
B. Gusakov, V. Loiko
{"title":"Allocative value of design and technological know-how","authors":"B. Gusakov, V. Loiko","doi":"10.29235/1818-9857-2023-05-33-37","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-05-33-37","url":null,"abstract":"Industrial transformations in the production and business sectors provide a significant increase in the added value created by society through the use of innovative technologies and the release of innovative products. Additional added value is provided by the use of a combination in production processes: design and technological know-how, progressive means and objects of labor, highly qualified personnel, the attractiveness of a product or service for the customer. Allocative (distributive) cost of design and technological know-how implies the formation of a mechanism for optimizing the use of limited resources of society in \"Industry 4.0\". The optimization mechanism includes economic tools and levers. The economic tool forms a differentiated distribution of the additional added value of an innovative product between the design organization, the manufacturer and consumers of products and services, depending on the technical level of new products. The lever ensures the Pareto efficiency of these subjects and a high probability of implementing innovative developments. Economic levers are the dependence of the amount of encouragement of the subjects of innovation activity on two factors: the scale of production of the created innovative products and its priority for Belarus.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"489 2-3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116822424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resource-utility approach to ensuring the technological security of the Republic of Belarus 确保白俄罗斯共和国技术安全的资源利用办法
Science and Innovations Pub Date : 2023-06-06 DOI: 10.29235/1818-9857-2023-05-27-32
V. Baynev, S. Makarevich
{"title":"Resource-utility approach to ensuring the technological security of the Republic of Belarus","authors":"V. Baynev, S. Makarevich","doi":"10.29235/1818-9857-2023-05-27-32","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-05-27-32","url":null,"abstract":"The article is devoted to the development of the utility-based resource allocation approach to the analysis and management of socio-economic systems by extending it to the research, scientific, technical, and innovation spheres. One of the reasons for the inconsistency of scientific and technological progress is demonstrated to be the cost method for evaluating its effectiveness, which identifies costs with results and ignores the usefulness of scientific and technological progress achievements. Appropriate utility criteria and indicators for assessing and managing this area are proposed in terms of implementation of the technology recovery strategy for Belarus and its allied Russia. Based on the analysis of the dynamics of scientific, technical and technological development of a number of Western European countries, a significant positive impact on the scientific and technological progress resulted from using proposed utility assessing criteria oriented towards a more efficient use of limited resources has been proved. With this in mind, recommendations are given on the development and implementation of a technological recovery strategy as a tool not only to strengthen the technological security of the state, but also to overcome the global contradictions generated by scientific and technological progress.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"279 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116309646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaceutical market of the Republic of Belarus and intellectual property 白俄罗斯共和国药品市场和知识产权
Science and Innovations Pub Date : 2023-05-15 DOI: 10.29235/1818-9857-2023-04-52-56
Y. Nechepurenko
{"title":"Pharmaceutical market of the Republic of Belarus and intellectual property","authors":"Y. Nechepurenko","doi":"10.29235/1818-9857-2023-04-52-56","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-04-52-56","url":null,"abstract":"The article considers the trends in the development of the drug market in the Republic of Belarus. It shows the role of the holding «Belpharmprom» enterprises in the production of medicines. The analysis of the patent-licensing situation in the pharmaceutical industry is carried out. A relationship has been established between the number of created original medicines and the number of patents for inventions received on them. Based on the analysis of state policy in pharmaceutical activities, a conclusion was made about the reorientation of enterprises to the production of generics. It was revealed that foreign drug manufacturers use two patent strategies in Belarus: they provide legal protection for their products and block the Belarusian pharmaceutical market mainly using the Eurasian Patent Convention.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133706752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A utility approach to evaluating innovation 评估创新的实用方法
Science and Innovations Pub Date : 2023-05-15 DOI: 10.29235/1818-9857-2023-04-28-32
N. Zenchuk
{"title":"A utility approach to evaluating innovation","authors":"N. Zenchuk","doi":"10.29235/1818-9857-2023-04-28-32","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-04-28-32","url":null,"abstract":"Evaluation and comparison of the potentials of various possible alternatives for innovative development are necessary for making informed management decisions. The article presents a method for quantifying the effect and effectiveness of innovations in the field of equipment and technology and of consumer goods, based on a utility approach, that is, based on their impact on economic growth. It is necessary to take into account the fundamental difference in identifying the utility effect and efficiency of introducing innovations into production and consumer goods. In the first case, an approach is proposed, the foundations of which were created by V.Ya. Elmeev, in the second - the methodology developed by the author. Comparison of the projected effects of innovations in these areas on the scale of the national economy makes it possible to foresee the possibility of a slowdown in economic growth in advance and develop adequate measures to regulate it.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125068266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles in the treatment of malignant neoplasms 纳米粒子在恶性肿瘤治疗中的应用
Science and Innovations Pub Date : 2023-05-15 DOI: 10.29235/1818-9857-2023-04-77-83
A. Stanovaya, V. Zhogla, I. Galets-Buy, S. Loznikova, D. Shcherbin
{"title":"Nanoparticles in the treatment of malignant neoplasms","authors":"A. Stanovaya, V. Zhogla, I. Galets-Buy, S. Loznikova, D. Shcherbin","doi":"10.29235/1818-9857-2023-04-77-83","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-04-77-83","url":null,"abstract":"The penetration of new technologies into chemistry, biology and medicine has led to the creation of new disciplines - nanotechnology and nanomedicine, branches of science in which the size of the object of study becomes critical. At the same time, the widespread application of nanoparticles in biology and medicine requires an understanding of the fundamental mechanisms of their interaction with biological systems. This is especially important for the development of new methods of treatment and diagnosis with their help. The presented review is devoted to the use of nanoparticles in the treatment of malignant neoplasms and the creation of gene therapy systems based on them. The review considers various types of nanoparticles and features of their effect on malignant neoplasms, methods and techniques for using nanoparticles for the diagnosis and treatment of cancer, as well as related problems and limitations. The characteristics of clinical preparations based on nanoparticles are presented.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117197993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Border in Belovezha forest: what will happen to biodiversity and natural ecosystems? Belovezha森林边界:生物多样性和自然生态系统将发生什么?
Science and Innovations Pub Date : 2023-05-15 DOI: 10.29235/1818-9857-2023-04-62-69
D. Grumo, R. Tsvirko, P. Heshtaut, M. Rahouski
{"title":"Border in Belovezha forest: what will happen to biodiversity and natural ecosystems?","authors":"D. Grumo, R. Tsvirko, P. Heshtaut, M. Rahouski","doi":"10.29235/1818-9857-2023-04-62-69","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-04-62-69","url":null,"abstract":"The authors assessed the impact of the barrier structure on the border of Poland and Belarus on the biodiversity of the UNESCO World Heritage Site \"Belovezhskaya Pushcha\", predicted the degree of impact on the natural complex by species and sources, compiled a potential system for long-term monitoring of the state of natural ecosystems, and drawn up a plan of urgent measures to minimize the negative impact.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"400 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123546826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives of the China-Belarus’ «Great Stone» industrial park development as an eco-industrial park 中白“大石”产业园作为生态产业园的发展展望
Science and Innovations Pub Date : 2023-04-10 DOI: 10.29235/1818-9857-2023-03-36-42
A. Ausiuk
{"title":"Perspectives of the China-Belarus’ «Great Stone» industrial park development as an eco-industrial park","authors":"A. Ausiuk","doi":"10.29235/1818-9857-2023-03-36-42","DOIUrl":"https://doi.org/10.29235/1818-9857-2023-03-36-42","url":null,"abstract":"Proposals have been developed for the transition of the Chinese-Belarusian industrial park “Great Stone” to the model of an eco-industrial park. A review of the Chinese experience in the formation of eco-in-dustrial parks was carried out. Based on the results of a sociological survey of residents of the Chinese-Belarusian industrial park “Great Stone”, the conditions and directions for strengthening its environmental orientation were determined. The expediency of creating an ecological center in the park management structure is substantiated and the directions of its activity are proposed.","PeriodicalId":250051,"journal":{"name":"Science and Innovations","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126327155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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