Arabian Journal of Chemistry最新文献

{"title":"The application of magnetic nanoparticles based β-cyclodextrin as recoverable catalyst in various organic transformations: An overview","authors":"Sara Payamifar ,&nbsp;Majid Abdouss ,&nbsp;Ahmad Poursattar Marjani","doi":"10.1016/j.arabjc.2024.106080","DOIUrl":"10.1016/j.arabjc.2024.106080","url":null,"abstract":"<div><div>Magnetite nanoparticles (MNPs), owing to their vast surface area, low toxicity, and biocompatibility, present a lot of chemical and biotechnological uses. Over the past decade, extensive attention has been expended on applying Fe₃O₄ nanoparticles as magnetically reusable solid support for various transition metals. The benefits of magnetic nanocatalytics are their simple separation by an external magnet, extreme reactivity, and a vast surface area of the catalysts. Also, the magnetic features of these catalysts induce their dispersion to be reversibly controlled via the magnetic field. Therefore, MNPs can be dispersed well in the reaction media. β-Cyclodextrin (β-CD), as a cyclic oligomer, has been extensively employed as an economical and eco-friendly alternative catalyst in diverse organic conversions that improved reaction efficiency. The modified β-CD with Fe₃O₄ led to mainly advantageous catalysts because of their helpful catalytic properties, eco-friendliness, easy separation, and ability to isolate from the reaction medium. In this report, our goal is to present an overview of magnetically reusable nanoparticles-based β-CD. This review’s major focus is the application of magnetic nanomaterials as catalysts in different organic transformations.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106080"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in metabolites content and bioactivity to regulate biomarkers of benign prostatic hyperplasia according to the growth stages of Sida rhombifolia","authors":"Min Gyu Park ,&nbsp;Yun Na Kim ,&nbsp;Jae sun Lee ,&nbsp;Yu Jung Kim ,&nbsp;Soo-Yong Kim ,&nbsp;Sangho Choi ,&nbsp;Min Hye Yang ,&nbsp;Bong-Oh Kwon ,&nbsp;Jung-Rae Rho ,&nbsp;Eun Ju Jeong","doi":"10.1016/j.arabjc.2024.106071","DOIUrl":"10.1016/j.arabjc.2024.106071","url":null,"abstract":"<div><div>It has been reported that the secondary metabolites produced by plants are influenced by genetic diversity and growth conditions, resulting in significant variations in chemical content even within the same species. In the previous study searching for bioactive materials from plants to improve benign prostatic hyperplasia (BPH), it was found that the methanolic extract of <em>Sida rhombifolia</em> in the family of Malvaceae exhibited the excellent inhibition on the expressions of 5-alpha reductase type 2 (5αR2) and androgen receptor (AR) in human prostate cells. In this study, we aimed to evaluate the change in the contents of major components of <em>S. rhombifolia</em> and the activity of improving BPH according to the growth stages of <em>S. rhombifolia</em>. Plant growth characteristics including plant height, stem diameter, leaf length, leaf width, and number of leaves were examined at intervals of approximately 15 days for 51 days. The contents of 20-Hydroxyecdysone and α-Ecdysone, the main constituents contained in <em>S. rhombifolia</em> on each day after transplantation (DAT) were analyzed using LC-ESI-MS/MS. The inhibitory activities of <em>S. rhombifolia</em> stems or leaves at each DAT on the expressions of AR, 5αR2, proliferating cell nuclear antigen (PCNA) and prostate specific antigen (PSA), were evaluated in human originated prostate cells, RWPE-1 and LNCaP cells activated by Testosterone propionate (TP). Considering the yield of the raw materials, the contents of metabolites, and the bioactivities, it was suggested that the appropriate collection period for <em>S. rhombifolia</em> as a bioactive material to improve BPH might be after 90 DAT.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106071"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of water on liquid ammonia-based sustainable dyeing of ramie fiber","authors":"Shaochen Li ,&nbsp;Qingyong Zhao ,&nbsp;Jianhua Xiong ,&nbsp;Nahid Pervez ,&nbsp;Lina Lin ,&nbsp;Yingjie Cai ,&nbsp;Vincenzo Naddeo","doi":"10.1016/j.arabjc.2024.106043","DOIUrl":"10.1016/j.arabjc.2024.106043","url":null,"abstract":"<div><div>Liquid ammonia dyeing emerges as an environmentally benign and sustainable option for the textile industry, characterized by a minimal ecological impact. However, its adoption is hampered by certain limitations, such as suboptimal dye exhaustion and issues with color uniformity, which present significant hurdles to its widespread industrial application. Building on the premise that the addition of water to an ethanol solvent can enhance reactive dye exhaustion in cotton fiber dyeing, this study delves into the dyeing behavior of ramie fiber using a water-liquid ammonia mixture with Reactive Red 195. The incorporation of water into the liquid ammonia solution was observed to marginally decrease the color strength (K/S value) of the dyed ramie fiber, compared to the dyeing with anhydrous liquid ammonia. This reduction is likely due to the diminished expansion of the amorphous regions within the fiber. However, the color levelness of the dyed ramie fiber was enhanced by the addition of water to the liquid ammonia. To decipher the influences on the dyeing process, the Taguchi method, utilizing an orthogonal array (L16), was applied. The analysis revealed that the dye mass factor was the predominant influencer (79.08 %), followed by the liquor ratio factor (18.53 %), with both factors demonstrating statistically significant effects (p &lt; 0.05). A multifaceted analysis of the samples was conducted using advanced techniques such as XRD (X-ray diffraction), FTIR (Fourier transform infrared), TGA (thermogravimetric analysis), and SEM (scanning electron microscopy). These analyses confirmed that the water-liquid ammonia treatment induced changes in the samples’ properties. The treated samples exhibited lower barium activity numbers and breaking force values, indicating structural alterations. Furthermore, the molecular structure of Reactive Red 195 remained intact throughout the dyeing process in the water-liquid ammonia mixture, thereby affirming its viability for practical applications in the textile industry.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106043"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing sponge-like activated carbon from Manihot esculenta tubers for high-performance supercapacitors","authors":"Markus Diantoro ,&nbsp;Nuviya Illa Muthi Aturroifah ,&nbsp;Joko Utomo ,&nbsp;Ishmah Luthfiyah ,&nbsp;Ida Hamidah ,&nbsp;Brian Yuliarto ,&nbsp;Andrivo Rusydi ,&nbsp;Worawat Meevesana ,&nbsp;Santi Maensiri ,&nbsp;Pramod K. Singh","doi":"10.1016/j.arabjc.2024.106068","DOIUrl":"10.1016/j.arabjc.2024.106068","url":null,"abstract":"<div><div>Activated carbon plays a crucial role in enhancing supercapacitor performance by optimizing parameters such as surface area, pore structure, and morphology. This study investigates activated carbon derived from <em>Manihot esculenta</em> tubers, which offers a promising, sponge-like porous morphology suitable for supercapacitor electrodes. Activated carbon derived from <em>Manihot esculenta</em> tubers was synthesized utilizing chemical activation with varying concentrations of potassium hydroxide (KOH) as the activator 0 M (C-S0), 1 M (AC-S1M), 2 M (AC-S2M), and 4 M (AC-S4M). The AC-S4M sample variant achieved the highest surface area (471.645 m²g⁻¹) and total volume (0.253 cm³g⁻¹). Electrochemical characterization using symmetric coin cell supercapacitors demonstrated excellent specific capacitance of 146.570 Fg⁻¹ at 0.1 Ag⁻¹ in a 6 M KOH aqueous electrolyte. Notably, the highest energy density of 15.525 Whkg⁻¹ at a power density of 174.660 Wkg⁻¹ was achieved. These results underscore the potential of <em>Manihot esculenta</em> tubers-derived activated carbon as a sustainable, high-performance electrode material, advancing environmentally friendly energy storage technologies, which remain interesting for further studies.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106068"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of baicalein and fangchinoline on abemaciclib metabolism in vivo and in vitro and molecular docking analysis","authors":"Xiaohai Chen ,&nbsp;Fengsheng Hong ,&nbsp;Hualu Wu,&nbsp;Yuxin Shen,&nbsp;Hailun Xia,&nbsp;Ren-ai Xu,&nbsp;Lu Shi","doi":"10.1016/j.arabjc.2024.106073","DOIUrl":"10.1016/j.arabjc.2024.106073","url":null,"abstract":"<div><div>The primary objective of this study was to investigate the effects of baicalein and fangchinoline on the metabolism of abemaciclib. We hypothesized that these two natural compounds could significantly affect the metabolism of abemaciclib by inhibiting the activity of the CYP3A4 enzyme, thus potentially increasing its concentration in the body. <em>In vitro</em>, rat liver microsomes (RLM) and human liver microsomes (HLM) were employed to explore the inhibitory effects and mechanisms of baicalein and fangchinoline on abemaciclib. <em>In vivo</em>, twelve healthy male Sprague-Dawley (SD) rats were randomly assigned to three groups: Group A (control group), Group B (baicalein), and Group C (fangchinoline). The concentrations of abemaciclib and its metabolite N-desethylabemaciclib (M2) were evaluated using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Finally, molecular docking method was employed to understand the interaction between abemaciclib and baicalein. It was indicated by the <em>in vitro</em> findings that both baicalein and fangchinoline inhibited abemaciclib metabolism in RLM through a mixed mechanism of competitive and non-competitive inhibition pathway. In HLM, baicalein inhibited abemaciclib metabolism by employing a hybrid mechanism of uncompetitive and non-competitive inhibition, while fangchinoline exhibited its inhibition in a competitive manner. <em>In vivo</em>, pharmacokinetic experiments revealed significant increases for AUC_(0-t) and AUC_(0-∞) of abemaciclib in Group B and Group C when compared to Group A, while the plasma clearance (CLz/F) of abemaciclib exhibited significant reductions. Moreover, molecular docking studies showed that both abemaciclib and baicalein docked to the active pocket of CYP3A4. This study demonstrated that the co-administration of baicalein or fangchinoline significantly affected the metabolism of abemaciclib, providing valuable insights for its clinical application.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106073"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-fine carbon decorated TiO2/C/g-C3N4 hybrid for strong physical adsorption and efficient photodegradation of pollutants","authors":"Azim Khan ,&nbsp;Ruhumuriza Jonathan ,&nbsp;Shafiq Ur Rehman ,&nbsp;Muhammad Shoaib ,&nbsp;Feng Cao ,&nbsp;Sajjad Ali ,&nbsp;Mohamed Bououdina ,&nbsp;Pir Muhammad Ismail ,&nbsp;Junwei Wang ,&nbsp;Hazem Abu-Farsakh ,&nbsp;Yifan Liu ,&nbsp;Xian Jian","doi":"10.1016/j.arabjc.2024.106034","DOIUrl":"10.1016/j.arabjc.2024.106034","url":null,"abstract":"<div><div>Enhancement in the visible light absorption and efficient interfacial charge transfer is crucial for optimizing photocatalytic efficiency in the degradation of pollutants such as methyl orange (MO) and formaldehyde. This study focuses on the properties of a TiO₂/C/g-C₃N₄ hybrid efficient photocatalyst, which is developed using an air calcination method to deposit graphitic nitride (g-C₃N₄) onto a carbon-modified TiO₂ surface. The characterization techniques, including high-resolution transmission electron Microscopy (HRTEM), X-ray diffraction (XRD), Raman spectroscopy, thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS), were used to provide a comprehensive understanding of the material’s structural, morphological, thermal, and chemical properties. This hybrid catalyst is specifically engineered for the efficient decomposition of methyl orange (MO) and formaldehyde, demonstrating a significant increase in photocatalytic activity. The TiO₂/C/g-C₃N₄ photocatalyst also exhibits an enhanced specific surface area of 181.2 m²/g, which facilitates increased physical adsorption and photo-catalytic active sites. Experimental results confirm that this catalyst effectively adsorbs MO physically even in the dark without degradation. Combining physical and photo-catalytic functions, this catalyst degrades 94 % of MO within 180 min with the initial concentration 0.2 mol/L of MO, and achieves almost 100 % decolorization of MO under visible light irradiation. Notably, the catalyst retains its high activity after 4 cycles of MO degradation, underscoring its durability and consistent performance. Additionally, the hybrid catalyst features a staggered type-II energy level configuration, which effectively enhances charge separation and boosts photocatalytic efficacy. The incorporation of an ultrafine carbon layer further augments electron mobility towards the surface, crucial for effective catalytic reactions. This study paves the way for future development of highly efficient photocatalytic materials for environmental purification.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106034"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Cu-doped Ni-B amorphous alloy catalyst and its catalytic performance for BH4- oxidation","authors":"Ying Zhang ,&nbsp;Xiao Tian ,&nbsp;Jiale Han ,&nbsp;Xiaojie Zhang ,&nbsp;Yuanyuan Gao ,&nbsp;Gerile Naren ,&nbsp;Yanchun Yang","doi":"10.1016/j.arabjc.2024.106059","DOIUrl":"10.1016/j.arabjc.2024.106059","url":null,"abstract":"<div><div>Searching for non-precious metal anode catalysts with high catalytic activity and low cost is essential for direct borohydride fuel cells (DBFC). The Ni-B alloys with crystalline states prepared by physical methods commonly exhibit high B content (NiB₄, NiB₆, etc.). This work first prepared four kinds of amorphous Ni-B alloy with low boron content by the chemical reduction method. The composition of Ni-B alloy is critical to its performance. Cu is doped in the Ni-B alloy in a suitable proportion to improve the catalytic activity further. The crystal structure, microstructure, and composition information of Ni-B and Ni-B-Cu alloys were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), selective area electronic diffraction (SAED), X-ray photoelectron spectroscopy (XPS), and inductively coupled plasma-optical emission spectrometer (ICP-OES) tests. The results show that the Ni-B and Ni-B-Cu alloys are amorphous nanoparticles with particle sizes of about 70 and 50 nm, respectively. The electrocatalytic oxidation BH₄⁻ performance of Ni-B and Ni-B-Cu was studied by cyclic voltammetry (CV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS). It was shown that Ni-B and Ni-B-Cu alloy catalysts have good catalytic activity for BH₄⁻ oxidation reaction, and Cu doping improves the catalytic activity of the Ni-B alloy for borohydride oxidation reaction (BOR). In addition, it is found that the maximum power density (79.124 mW·cm⁻²) of the direct borohydride fuel cell using Ni-B-Cu/NF (NF: nickel foam) as an anode electrode is significantly higher than that of the Ni-B/NF electrode (21.063 mW·cm⁻²). The Ni-B and Ni-B-Cu alloys with low boron content can be used as potential anode catalyst materials for DBFC.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106059"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of natural product-based quorum sensing inhibitors in plant pathogen control: A review","authors":"Ai-Qun Chen ,&nbsp;Zhou-Qing Long ,&nbsp;Ya Xiao,&nbsp;Yu-Mei Feng,&nbsp;Ya Zhou,&nbsp;Shan Yang,&nbsp;Yan-Mei Liao,&nbsp;Xiang Zhou,&nbsp;Li-Wei Liu,&nbsp;Zhi-Bing Wu,&nbsp;Song Yang","doi":"10.1016/j.arabjc.2024.106050","DOIUrl":"10.1016/j.arabjc.2024.106050","url":null,"abstract":"<div><div>Quorum sensing (QS), an intercellular communication process, depends on the generation, release, and detection of extracellular signaling molecules (autoinducers). Upon binding to their corresponding receptors, these autoinducers activate target genes, regulating various bacterial activities including bioluminescence, swimming and swarming motility, symbiosis, protein secretion, plasmid exchange, secondary metabolite production, and biofilm development. Many interactions between plants and microorganisms depend on bacterial QS systems, making them a powerful tool for regulating plant growth and controlling plant pathogens. As QS research deepens, more QS inhibitors (QSIs) emerge, exhibiting diversification. According to its structure, QSIs can be divided into furanone, lactone, substituted Homoserine Lactone (HSL), and Autoinducing Peptide (AIP), further divided into natural products and synthetic products. Natural QSIs primarily originate from animal, plant, and microbial sources. Thereby, QSIs play an important role in plant pathogen control. In order to systematically summarize and extend the application potential of natural product as vital antibacterial active constituent, the mechanisms and applications of natural product-based QSIs in plant pathogen control were discussed and highlighted. We hope this review will provide the comprehensive understanding of the function and underlying action mechanism of natural product-based antimicrobial molecule, and inspire the development of new bactericides targeting QS mechanisms.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106050"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Sitosterol ameliorates the cognitive deficits and neuropathological hallmarks in an Alzheimer’s disease model","authors":"Mohd Sajad ,&nbsp;Rafat Ali ,&nbsp;Rajesh Kumar ,&nbsp;Nida Jamil khan ,&nbsp;Shadma Wahab ,&nbsp;Saad Ali Alshehri ,&nbsp;Sonu Chand Thakur","doi":"10.1016/j.arabjc.2024.106072","DOIUrl":"10.1016/j.arabjc.2024.106072","url":null,"abstract":"<div><div>Alzheimer’s disease is a neurodegenerative condition causing cognitive decline. Aluminum chloride (AlCl₃) is a neurotoxin linked to oxidative stress and neurodegenerative disorders. In light of inadequate current treatments, there is an urgent need for more approaches to treat Alzheimer’s disease. β-sitosterol, a phytosterol found in grape skin, fern, and red wine, has potential health benefits. This research aims to assess its preventive impact on AlCl₃-induced Alzheimer’s disease. The animals were divided into five groups: Group I (control), Group II (AlCl₃ 70 mg/kg), Group III (Rivastigmine 2.3 mg/kg), and Groups IV and V (β-sitosterol 50 and 100 mg/kg with AlCl₃). AlCl₃ was administered from days 5–25, treatments from 26–42 days, and behavioral parameters were measured on days 5, 16, 26, and 42, after which brain samples were collected for the estimation level of oxidative stress, cholinergic function, Glycogen synthase kinase-3β, Rho kinase, Lipoxygenase-5, TNF-α, COX-2, and Na⁺K⁺ATPase expression and activity. The β-sitosterol prevented cognitive impairment caused by AlCl₃ via the reduction of oxidative stress, the improvement of cholinergic function, and the suppression of Glycogen synthase kinase-3β, Rho kinase, Lipoxygenase-5, TNF-α, COX-2, and Na⁺K⁺ATPase expression and activity. <em>In<!--> <!-->silico</em> studies demonstrated the strong affinity of β-sitosterol towards Alzheimer’s disease biomarkers, confirming their function in preventing and regulating its pathogenesis. Consequently, the findings point out that β-sitosterol has an anti-Alzheimer’s ability<!--> <!-->by reducing the toxicity caused by AlCl₃.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106072"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143154462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reaction mechanism of p-hydroxystyryl-substituted BODIPY with ABTS•+ and Fe3+ in solutions and in liposomes","authors":"Qinhai Xu ,&nbsp;Kang Li ,&nbsp;Peng Wang","doi":"10.1016/j.arabjc.2024.106041","DOIUrl":"10.1016/j.arabjc.2024.106041","url":null,"abstract":"<div><div>The reaction mechanism of <em>p</em>-hydroxystyryl-substituted BODIPY (BOH) with two oxidative cations, namely ABTS^•+ and Fe³⁺, was investigated in a water–ethanol mixed solution and in liposome suspensions, respectively, using different spectroscopic methods. In solution, the oxidation of BOH (with orange fluorescence) by the two cations occurred at the ethylene group (C<img>C) locating between the dipyrrole and phenol groups and resulted in conjugation-truncated products exhibiting characteristic green fluorescence emission. In heterogeneous small unilamellar vesicles (SUV), water soluble ABTS^•+ was evidenced to oxidize BOH embedded in the lipid bilayers of SUV, while Fe³⁺ did not. The lack of reaction between Fe³⁺ and BOH was attributed to the complexation between Fe³⁺ and the phenolic hydroxyl group of BOH on the surface of the SUV. The reaction kinetics results indicated that, in homogeneous solution, the oxidation rate of Fe³⁺ was three orders of magnitude slower than that of ABTS^•+ for BOH. The location and orientation of BOH within the SUV were discussed based on the reaction phenomena. BOH could be as a good antioxidant fluorescent prober for ABTS^•+ detection with a detection limit of 1.5 * 10⁻⁷ M and a linear rang of 0–4.93 μM. What’s more, the amphiphilic BOH dispersed in the round GUV (BOH + GUV) could show the bright red fluorescence. This research suggests the significant potential of BOH as an antioxidant fluorescent probe for <em>in situ</em> bioimaging.</div></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"18 1","pages":"Article 106041"},"PeriodicalIF":5.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}