The Australasian journal of dermatology最新文献

{"title":"Relevance of sun safety in patients commencing crizotinib for non-small cell lung cancer.","authors":"Sarah Heynemann, Paul Mitchell","doi":"10.1111/ajd.13503","DOIUrl":"https://doi.org/10.1111/ajd.13503","url":null,"abstract":"tributed. Diffuse dermal angiomatosis commonly affects patients with severe peripheral vascular disease, for which this patient had risk factors, including obesity, hypertension and dyslipidaemia. Management is focused on treatment of any condition that may be inducing hypoxia. Based on their antiangiogenic properties, corticosteroids have been used successfully. Smoking cessation, local revascularisation and isotretinoin have been effective in cases of diffuse dermal angiomatosis. Spontaneous resolution is also possible. Cutaneous reactive angiomatoses present rarely and heterogeneously and may be mistaken for more common conditions including cellulitis. This diagnosis should be considered in patients with systemic conditions or potential vascular disease, who present with cutaneous lesions not responding to conventional treatment.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e332-e333"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38720017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare case of linear IgA bullous dermatosis showing IgA, IgG and IgM reactivity.","authors":"Gim Hui Lim, Sophie Carrie Shan Cai, Joyce Siong See Lee, Qiping Chen","doi":"10.1111/ajd.13558","DOIUrl":"https://doi.org/10.1111/ajd.13558","url":null,"abstract":"1. Mistry BD, Alavi A, Ali S et al. A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. Int. J. Dermatol. 2017; 56(12): 1319–27. 2. Yahya H. Necrobiosis lipoidica in a Nigerian woman Report of a case. Niger. J. Clin. Pract. 2019; 22(11): 1626–8. 3. Conde-Montero E, Avil es-Izquierdo JA, Mendoza-Cembranos MD et al. Dermoscopy of necrobiosis lipoidica. Actas Dermosifiliogr 2013; 104(6): 534–7. 4. Pasquali P, Gonzalez S, Fortu~ no A et al. In-vivo assessment of a case of cutaneous sarcoidosis using reflectance confocal microscopy. An. Bras. Dermatol. 2019; 94(1): 93–5. 5. Sibbald C, Reid S, Alavi A. Necrobiosis Lipoidica. Dermatol. Clin. 2015; 33(3): 343–60.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e361-e362"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13558","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitiligo-like depigmentation associated with Xuesaitong capsule treatment.","authors":"Jialing Chen, Xintao Cen, Jianqiang Shi","doi":"10.1111/ajd.13507","DOIUrl":"https://doi.org/10.1111/ajd.13507","url":null,"abstract":"Xuesaitong capsule, which is a Chinese herbal monomer preparation consisting of Panax notoginseng saponins, has been mainly used to treat microcirculatory disturbance-associated diseases. Dermatological adverse events include skin rash and pruritus, but pigmentary changes not yet been reported. A 21-year-old Chinese man presented with depigmented lesions on the hands and waist. For the previous six months he had self-medicated with Xuesaitong (300 mg/ day) for glomerular disease. After 6 days of treatment depigmenting lesions appeared on his face. Two weeks later, the lesions had progressed and involved the chest, back, waist, forearms and hands. He denied any previous skin lesions at these sites. Xuesaitong was immediately discontinued by the patient himself. The lesions slightly repigmented one week after drug withdrawal. Spontaneous repigmentation on most of the depigmented lesions was noted over the following two months. There was no personal or family history of vitiligo, other depigmenting disorders or autoimmune diseases. The patient did not receive any treatment for vitiligo. Clinical examination revealed depigmented macules (Fig. 1a-c). Routine investigations of blood, urine, renal","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e338-e339"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38726453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porokeratoma in the nipple: A case report.","authors":"Wenjun Qian, Siying Xiong, Xin Tian","doi":"10.1111/ajd.13490","DOIUrl":"https://doi.org/10.1111/ajd.13490","url":null,"abstract":"challenging. Organ transplantation accompanied with immunosuppressive treatments is an important risk factor for alternariosis T incidence rate. Post-transplantation patients often have difficulty withstanding systemic antifungal therapy; amphotericin B potentially causes renal toxicity, and itraconazole can interact pharmacologically with immunosuppressive treatments. Torres-Rodr ıguez et al. reported a case of subcutaneous alternariosis treated with persistent thermotherapy without antifungal treatment. Suda et al. reported a case of cutaneous alternariosis initially treated with itraconazole (200 mg/day p.o.), which was later switched to voriconazole (400 mg/day p.o.). Skin lesions regressed following combination therapy with thermotherapy; however, the patient suffered from rotary vertigo and liver damage due to antifungal therapy use. Here, we present a case of cutaneous alternariosis successfully treated using thermotherapy combined with terbinafine hydrochloride 1% cream in a renal transplant patient. Following kidney transplantation for diabetic nephropathy, a 54-year-old woman received tacrolimus (0.1 mg/kg/ day), mycophenolate mofetil (1 g/day) and methylprednisolone (60 mg/day). One year after transplantation, she observed a red papule on her right forearm without previous trauma and subjective symptoms, which grew to form a protruding, irregular, 5 9 7 cm large, reddish plaque over a period of 1 year (Fig. 1a). Serum b-d-glucan levels were within the normal range. Histopathological analysis showed the presence of numerous spherical bodies and infiltration of inflammatory cells, mainly lymphocytes and histiocytes, in the dermis (Fig. 1b and c). Grocott staining revealed several spores and hyphae in the dermis (Fig. 1d and e). Fungal cultures of the biopsy specimen produced colonies with the morphology of Alternaria species, that is brown-olivaceous colonies and conidia with transverse and longitudinal or oblique septa (Fig. 1f and g). Considering the side effects of systemic antifungal therapy in immunosuppressed individuals and the progressive enlargement and depth of alternariosis, we applied thermotherapy combined with terbinafine hydrochloride 1% cream. Disposable adhesive heat pads at 50–55°C were applied for 12 h/day every day, and terbinafine cream once a day. After 6 months of this combination therapy, the plaque had completely resolved (Fig. 1h). Histopathological analysis revealed no fungal structures and cultures of biopsy samples exhibited no fungal growth. No relapse was detected over an 8-month follow-up. Granted the mechanism of this combination therapy remains unclear, it could nevertheless accelerate the treatment period compared to thermotherapy alone; the combination therapy took 6 months and the thermotherapy alone took 1 year. Note that metastatic/disseminated infection should be excluded especially in heavily immunocompromised patients prior to use of local therapy. This combination therapy could be a safe and eff","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e325-e326"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13490","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38527680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug reaction with eosinophilia and systemic symptoms due to agomelatine.","authors":"Ashod Kherlopian, Gayle Fischer, Gloria Fong","doi":"10.1111/ajd.13506","DOIUrl":"https://doi.org/10.1111/ajd.13506","url":null,"abstract":"1. Uehara M, Hatano Y, Kato A et al. Two cases of congenital aplasia cutis with dermal melanocytosis. J. Dermatol. 2012; 39: 501– 3. 2. Cho A, Lee S, Lee Y et al. Aplasia cutis congenita with hair collar sign and dermal melanocytosis. Int. J. Dermatol. 2012; 51: 745–7. 3. Takayama E, Harada A, Ikura Y et al. Two cases of aplasia cutis congenita with hair collar signs and macrophage hyperplasia. J. Dermatol. 2019; 46: 734–8. 4. dos Videira IFS, Moura DFL, Magina S. Mechanisms regulating melanogenesis. An. Bras. Dermatol. 2013; 88: 76–83. 5. Rakowska A, Maj M, Zadurska M et al. Trichoscopy of focal alopecia in children-new trichoscopic findings: hair bulbs arranged radially along hair-bearing margins in aplasia cutis congenita. Skin Appendage Disord. 2016; 2: 1–6.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e336-e337"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38623774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective treatment of folliculitis decalvans with cyclosporin: A case series.","authors":"Rebekka Jerjen, Nekma Meah, Lara Trindade de Carvalho, Dmitri Wall, Shyamalar Gunatheesan, Rodney Sinclair","doi":"10.1111/ajd.13532","DOIUrl":"https://doi.org/10.1111/ajd.13532","url":null,"abstract":"Folliculitis decalvans is a neutrophilic cicatricial alopecia that preferentially affects the scalp vertex and occiput. Therapy aims to arrest inflammation and prevent hair loss. Response to antibiotic and anti-inflammatory treatments is unpredictable, resulting in a sometimes chronic, recalcitrant course. We report three patients with refractory folliculitis decalvans responding to cyclosporin. In the absence of a validated outcome measure for folliculitis decalvans, we considered photographic and symptomatic improvement; maintenance of the same therapeutic dose; and ability to taper therapy in assessing treatment response.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e345-e347"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13532","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38788267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute cutaneous lupus erythematosus induced by PD-1 Inhibitor therapy: two case reports and literature review.","authors":"Adrian Diago, Luis Hueso, Mariano Ara-Martín, Isabel Abadías-Granado","doi":"10.1111/ajd.13538","DOIUrl":"https://doi.org/10.1111/ajd.13538","url":null,"abstract":"has not yet been systematically evaluated. The patients in this series responded to doses lower than the standard dosing used in other skin and systemic disorders (3.5-5 mg/kg/ day). Initial treatment response by our first patient at a low dose prompted treatment initiation at lower doses for subsequent patients in this series. Other immunosuppressive treatment approaches could also be considered for patients with refractory folliculitis decalvans, as demonstrated by our recent case series using tofacitinib. Our study is limited by small sample size and use of concomitant medication. Further studies are required to further evaluate the safety and effectiveness of cyclosporin in folliculitis decalvans as well as standardise a therapeutic dose. Our findings suggest cyclosporin may be a treatment option for folliculitis decalvans, particularly when activity persists despite antibacterial treatment or conventional immunosuppression.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e347-e349"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38855540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of keratoacanthoma with perineural invasion: case reports and literature review.","authors":"Koji Nakajima, Ayumi Korekawa, Hajime Nakano, Daisuke Sawamura","doi":"10.1111/ajd.13550","DOIUrl":"https://doi.org/10.1111/ajd.13550","url":null,"abstract":"1. Yeh CP, Chiu YW, Chen CC et al. Extranodal natural killer/Tcell lymphoma, nasal type, presenting with acneiform eruptions: A previously undescribed variant. Dermatol. Sin. 2020; 38: 105–9. 2. de Mel S, Hue SS, Jeyasekharan AD et al. Molecular pathogenic pathways in extranodal NK/T cell lymphoma. J. Hematol. Oncol. 2019; 12(1): 33. 3. Jiang L, Li P, Quan Q et al. Cutaneous extranodal natural killer (NK) / T cell lymphoma: A comprehensive clinical features and outcomes analysis of 71 cases. Leuk. Res. 2020; 88: 106284. 4. Delgado-Jimenez Y, Perez-Gala S, Nam-Cha S et al. Extranodal NK/T-cell lymphoma nasal type mimicking pyoderma gangrenosum. Acta Derm. Venereol. 2007; 87: 176–7. 5. Au WY, Weisenburger DD, Intragumtornchai T et al. Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood 2009; 113: 3931–7. doi: 10.1111/ajd.13550","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e353-e354"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25510794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful thermotherapy combined with terbinafine hydrochloride 1% cream for cutaneous alternariosis in a post-transplantation patient.","authors":"Tomoka Harada, Takeshi Fukumoto, Korefumi Nakamura, Kenichiro Ohnuma, Chikako Nishigori","doi":"10.1111/ajd.13489","DOIUrl":"https://doi.org/10.1111/ajd.13489","url":null,"abstract":"granules in the tissue (Fig. 1g). Based on this formation, the lesion was diagnosed as a haemorrhagic schwannoma with haemosiderin deposition. Typically, a schwannoma is globoid-shaped, is encapsulated, tan in colour and is homogeneously firm. Melanotic schwannoma, characterised by the accumulation of melanin, was a differential diagnosis in the present case. To help with diagnosis, Masson-Fontana staining and Perl staining are useful for determining whether the deposition is melanin or haemosiderin. Clinically, schwannomas are difficult to diagnose because they have considerable diversity in terms of clinical findings and behaviour. Recently, dermoscopy has become a useful tool for dermatologists to aid in the diagnose cutaneous tumours; however, there has been only one report describing the dermoscopic findings of schwannoma. Described are arborising vessels, structureless areas and brown pigmentation. On comparing the dermoscopic features with the histopathological findings the homogeneous brown areas corresponded to the leakage of red blood cells and haemosiderin deposition in the sub-epidermal portion of a fibrous capsule. The blue colour of the tumour could be caused by the Tyndall effect of haemosiderin pigment in the dermis. In summary, we reported a case of haemorrhagic schwannoma and its dermoscopic features. Our case and a previous report suggest that ‘homogeneous brown areas’ and ‘blue colour’ could be dermoscopic indicators of haemorrhagic schwannoma.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e323-e325"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38500126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retained sewing machine needle remnants as a cause of foreign body granuloma in the nail unit mimicking squamous cell carcinoma.","authors":"Zeynep Altan Ferhatoğlu, Fatih Göktay, Emre Kaynak, Pembegül Güneş","doi":"10.1111/ajd.13510","DOIUrl":"https://doi.org/10.1111/ajd.13510","url":null,"abstract":"showed the absence of melanocytes in the epidermis and no other changes (Fig. 2a-b). Immunohistochemistry showed negativity for Melan-A (Fig. 2c). He was diagnosed, clinically and pathologically, with vitiligo-like depigmentation induced by Xuesaitong. Published reports of drug-induced vitiligo are rare, with most reports in patients with melanoma receiving immunotherapy. It has been proposed that melanocyte antigens released by the destruction of melanoma cells after immunotherapy could trigger breakdown of the immune tolerance to normal melanocytes. Xuesaitong, a Chinese herbal medicine, mainly consists of Panax notoginseng saponins. The fact that the patient developed depigmentation within two weeks of starting the capsules with rapid spontaneous repigmentation after withdrawal supports the diagnosis of vitiligo-like depigmentation induced by Xuesaitong. It is unclear at present why this extremely rare case occurred in a 21-year-old young man. Prior studies have shown that Panax notoginseng saponins have immunological adjuvant effects on specific antibody production and cellular responses against specific antigens. It also promotes the production of IFN-c and TNF-a. Therefore, we postulate that Panax notoginseng saponins may enhance immune responses to melanocyte antigens. Furthermore, Wei et al reported that Panax notoginseng saponins led to the inhibition of proliferation in regulatory T cells. It has been suggested that decreased regulatory T cells in peripheral blood and lesional skin of patients with vitiligo could lead to weakened immunosuppressive function and, therefore, a reduced threshold for developing autoimmune disorders. However, the depigmented areas in our patient were typical for vitiligo, so the Xuesaitong may have been coincidental and not responsible for this pigmentary loss.","PeriodicalId":243138,"journal":{"name":"The Australasian journal of dermatology","volume":" ","pages":"e339-e341"},"PeriodicalIF":2.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/ajd.13510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38622416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}