Journal of Korean Sleep Research Society最新文献

{"title":"Reduced Cerebral Perfusion of Putamen and Insular Cortex in Patients with Idiopathic Restless Leg Syndrome","authors":"E. Joo, Jung Sik Kim, Dae Iim Koo, Daeyoung Kim, K. J. Hwang, Jiyoung Kim, S. Hong","doi":"10.13078/JKSRS.12003","DOIUrl":"https://doi.org/10.13078/JKSRS.12003","url":null,"abstract":"Address for correspondence Seung Bong Hong, MD, PhD Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea Tel: +82-2-3410-3592 Fax: +82-2-3410-0052 E-mail: sbhong@skku.edu Objectives: To evaluate the cerebral perfusion pattern of idiopathic restless leg syndrome (RLS). Methods: We performed Tc-ethyl cysteinate dimer brain single-photon emission computed tomography (SPECT) in 36 drug-naive patients with RLS patients and 30 age-and gender matched normal cotrols during wakefulness. Their SPECT images underwent statistical parametric mapping analysis. Results: Mean age of patients and normal controls was 48.3 years and 80% of them were women. Most patients reported the sleep onset and maintenance insomnia due to RLS symtoms. Average duration of RLS was 10.5 years. Mean score of international RLS was 26.6, suggesting moderate to severe severity. They did not report daytime sleepiness (mean Epworth sleepiness scale, 7.0). All subjects underwent polysomnography, showing no definite obstructive sleep apnea syndrome. Seventeen of them (56.6%) had periodic leg movement during sleep (PLMS). Sleep quality was more deteriorated in patients than that in normal controls (increased sleep latency and arousal index, which resulted in reduced sleep efficiency). In RLS pateints, cerebral blood flow was decreased in the right putamen and insular cortex compared to normal controls (uncorrected p<0.005). There was no brain region showing increased cerebral perfusion in patients. Regional cerebral perfusion was not correlated to any sleep parameter including PLMS index or movement arousal index. Conclusions: Reduced cerebral perfusion in putamen and insular cortex in RLS suggested functional abnormalities in motor circuit and sensori-motor modulation, which may be related to pathophysiology of idiopathic RLS. J Korean Sleep Res Soc 2012;9:10-14","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122884095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Vertex Wave during Light Sleep according to Age","authors":"Sung Min Kim, G. Lee, S. Han, Ki-Young Jung","doi":"10.13078/JKSRS.12002","DOIUrl":"https://doi.org/10.13078/JKSRS.12002","url":null,"abstract":"Address for correspondence Ki-Young Jung, MD Department of Neurology, Korea University Medical Center, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, Korea Tel: +82-2-920-6649 Fax: +82-2-925-2472 E-mail: jungky@korea.ac.kr Objectives: Vertex wave during sleep is a hallmark of light sleep and related to brain development. We examined voltage characteristics of vertex wave according to age. Methods: Electroencephalographys were selected from routine waking and sleep EEG database. The inclusion criteria were that the age of subjects was more than 4 years old; EEG showed at least 5 typical vertex waves with no abnormal findings; the neurologic examination and neuroimaging findings were normal. EEGs were classified into 7 groups according to their age. Five to 20 epochs which included the time 320 ms before and after the maximum negativity of a vertex wave from each EEG record were selected. Voltage characteristics including amplitude and topographic distribution were evaluated. Intracerebral source location of vertex wave from each age group was identified using low resolution electromagnetic tomography (LORETA). Results: Amplitude of vertex wave was highest in the youngest age group, decreased with age thereafter. Voltage topography showed maximum negativity over central vertex area bilaterally in all age group, which did not show any significant difference among age group. Normalized amplitude of vertex waves showed significant main effect of location (df=1.356, F= 115.843, p<0.001). Interaction between age and location was also significant (df=4.088, F=3.327, p=0.016). However, age did not show any main effect on amplitude of vertex wave. Post-hoc analysis showed amplitude of group 1 (5 to 9 years), compared with other age groups, was significantly lowered only in Fz electrode. LORETA image showed maximum current density in the mid to posterior cingulate gyri, which was similar across all age groups. Conclusions: Our study suggests that vertex waves might be related to arousal response during sleep, although exact mechanism is still unclear. J Korean Sleep Res Soc 2012;9:5-9","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"518 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116249647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disturbances in the Elderly","authors":"Kwang Ki Kim, Il-Young Jung","doi":"10.13078/JKSRS.11008","DOIUrl":"https://doi.org/10.13078/JKSRS.11008","url":null,"abstract":"","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133783593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Propriospinal Myoclonus at Sleep Onset","authors":"Bomi Kim, Gha-Hyun Lee, Min Ju Kim, Ho-Sung Ryu, Sang-Ahm Lee","doi":"10.13078/JKSRS.11012","DOIUrl":"https://doi.org/10.13078/JKSRS.11012","url":null,"abstract":"Received June 30, 2011 Revised October 11, 2011 Accepted October 11, 2011 Address for correspondence Sang-Ahm Lee, MD Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea Tel: +82-2-3010-3440 Fax: +82-2-474-4691 E-mail: salee@amc.seoul.kr Propriospinal myoclnus is uncommon disorder characterized by arrhythmic jerk arising in muscles corresponding to a myelomere and spreading rostrally and caudally. Propriospinal myoclnus occurring only in the relaxation period preceding sleep was first described in 1997, and is extremely rare. Myoclonus showed a striking relationship with vigilance level. We report a case of propriospinal myoclnus at sleep onset with a polysomnographic and electromyographic studies, who is the first case in Korea to the best of our knowledge. J Korean Sleep Res Soc 2011;8:48-51","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124012264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Cases of Catathrenia (Nocturnal Groaning)","authors":"Min Ju Kim, Gha-Hyun Lee, Chun-sik Kim, Sang-Ahm Lee","doi":"10.13078/JKSRS.11010","DOIUrl":"https://doi.org/10.13078/JKSRS.11010","url":null,"abstract":"Received August 18, 2011 Revised November 4, 2011 Accepted November 16, 2011 Address for correspondence Sang-Ahm Lee, MD, PhD Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea Tel: +82-2-3010-3445 Fax: +82-2-474-4691 E-mail: salee@amc.seoul.kr Catathrenia(nocturnal groaning) is a rare disorder recently classified as a parasomnia. We presented three cases of catathrenia which of them performed continuous positive airway pressure (CPAP) titration. All patients had same patterns of breathing during catathrenia sound which recorded in polysomnography as central sleep apnea starting with deep inspiration. Catathrenia predominantly occurred in the last REM sleep period in case 1 but in all stages in case 2. Case 3 had all catathrenia in NREM sleep. Case 2 and 3 had combined obstructive sleep apnea (Apnea-hypopnea Index=21.7/hr and 20.5/hr). Case 1 and 2 performed CPAP titration. With or without combined obstructive sleep apnea, catathrenia events were remarkably decreased. J Korean Sleep Res Soc 2011;8:40-44","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129788081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Cerebral Perfusion of Motor Cortex in Patients with Periodic Limb Movement Disorder","authors":"E. Joo, Jung Sik Kim, S. Hong","doi":"10.13078/JKSRS.11009","DOIUrl":"https://doi.org/10.13078/JKSRS.11009","url":null,"abstract":"Address for correspondence Seung Bong Hong, MD, PhD Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea Tel: +82-2-3410-3592 Fax: +82-2-3410-0052 E-mail: ejoo@skku.edu eyuns@paran.com Objectives: The pathophysiology of sleep-related motor diseases and sleep dysfunction in movement disorders is widely unknown as yet. Functional brain imaging, in particular radioisotope techniques, is considered to be powerful tool to investigate pathomechanisms of periodic limb movement disorder (PLMD). Methods: We performed Tc-ethyl cysteinate dimer brain single-photon emission computed tomography in 25 drug-naive patients with PLMD and 23 age-and gender matched normal cotrols during wakefulness. For statistical parametric mapping analysis, single-photon emission computed tomography images were spatially normalized to the standard template and then smoothed using a 14-mm full width at half maximum Gaussian kernel. Results: Mean age of patients and normal controls was 48.6 years and over half of them were male. Most patients reported the sleep onset and maintenance insomnia due to repetitive leg jerks. Average duration of insomnia was 7.5 years. They denied the history of restless leg syndrome and there was no sleep disorders such as obstructive sleep apnea syndrome which was confirmed by polysomnography. Mean PLM during sleep index and movement arousal index were markedly increased to 45.3/hr and 7.5/hr, respectively. Their sleep quality was poorer than that of normal patients. In PLMD patients, cerebral blood flow was significantly increased in the bilateral precentral gyri as compared to normal controls. There was no brain region showing decreased perfusion in patients. Regional cerebral perfusion was not correlated to any polysomnography parameter including PLMS index or movement arousal index. Conclusions: Different perfusion pattern in bilateral primary motor cortices may provide the evidences of motor cortical impairment in patients with PLMD. J Korean Sleep Res Soc 2011;8:35-39","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130283967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Melatonergic Agents","authors":"Hyung Ki Kim","doi":"10.13078/JKSRS.11007","DOIUrl":"https://doi.org/10.13078/JKSRS.11007","url":null,"abstract":"Melatonini sam ajorc hronobiologicalr egulatora ndh asb eenu sedf ort het reatmento fs leepp roblemsi n- cludingi nsomnia,�p arasomnia,�a ndc ircadianr hythms leepd isorders.�Be causeo fm elatonin'�s horth alf-life,� itss uitabilitya sad rugi sl imited.�Th us,�t hed evelopmento fp rolonged-releasem elatonina ndo therm elatoner- gicr eceptora gonistsw ithal ongerd urationo fa ctionw eren eeded.�R amelteon,�n on-indolicm elatonergica go- nisti st hefi rstd ruga pprovedi nt heU SAf ort het reatmento fi nsomnia.�I ts howedh ighlys electivem elatonin� MT1/MT2�r eceptora ffinitiesw hicha reb elievedt om ediatet hec ircadianr hythmw hereas,�n egligiblea ffinity � fort heM T3�r eceptora ndo therr eceptorsi nb rain.�Th iss electiver eceptora ffinitym aye xplaint hel acko fs ig- nificanta dversee ffecta ndl acko fd ependencyo rd ruga busep otential.�A nothern on-indolicm elatonergica go- nisti sa gomelatinei nitiallye valuatedf ori tsc hronobiotice ffect. �A fteri tss erotonergice ffectw asd iscovered,�i t� wasi nvestigateda sa na ntidepressant.�Th erea res tudiesi ndicatingu sefulnessi nc ontrollinga nxietyd isorder� andi ns easonala ffectived isorder.�S omes tudiess howeda gomelatineh asap otentialu sefulnessi ni mproving� sleepa rchitecture.�T asimelteoni sa lsoa nn on-indolicm elatonergica gonistw hichh ash igha ffinityf orb othM T1/ MT2�r eceptorsi nh umansa nds howedas imilara ffinityt om elatonin.�T IK-301,�a ni ndolicm elatonina nalogue� alsod isplaysah igha ffinityt owardsm elatoninM T1/MT2�r eceptors.�R ecently,�T IK-301�h asb eens hownt hati t� alsoa ctsa sa na ntagonisto ft hes erotoninr eceptors ubtype�5 -HT2Ba nd�5 -HT2c,�m orep otentt hana gomelatine.� Toe lucidatee fficacya nds afetyo fn ewlyd evelopedm elatonergicd rugs,�l ongert ermm ulticenterc linicalt ri- alsa ren eeded.� J Korean Sleep Res Soc 2011;8:25-30","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125510213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Exploding Head Syndrome: Focus on Polysomnographic Finding","authors":"Junghwan Yoon, K. Hwang, T. Roh, W. Shin","doi":"10.13078/JKSRS.11011","DOIUrl":"https://doi.org/10.13078/JKSRS.11011","url":null,"abstract":"Received December 14, 2011 Revised December 24, 2011 Accepted December 26, 2011 Address for correspondence Won Chul Shin, MD Department of Neurology, College of Medicine, Kyung Hee University, 892 Dongnam-ro, Gangdong-gu, Seoul 134-727, Korea Tel: +82-2-440-6166 Fax: +82-2-440-7243 E-mail: shinwc@khu.ac.kr Exploding head syndrome is a rare nocturnal disorder that the patient experiences a loud sound. The events occur usually during a period of drowsiness preceding sleep. The polysomnography studies in exploding head syndrome are very rare. We report a case of exploding head syndrome that a total of 8 typical episodes were recorded in polysomnography. A 51 years old female was admitted due to nocturnal loud sound from 2 month ago. There was no headache and no history of sleep problems. During the polysomnography, the events recorded 8 times, 6 of the events occurred during waking time prior to sleep onset, 2 developed in N1 sleep. In our case, the events appear to arise from early drowsiness with predominant alpha rhythm, with interspersed theta activity. J Korean Sleep Res Soc 2011;8:45-47","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121871826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysomnographic Study of Sleep Bruxism in Adults: Preliminary Study","authors":"H. Kim, H. Han","doi":"10.13078/JKSRS.11003","DOIUrl":"https://doi.org/10.13078/JKSRS.11003","url":null,"abstract":"Received May 23, 2011 Revised June 10, 2011 Accepted June 17, 2011 Address for correspondence Hyun Jeong Han, MD, PhD Department of Neurology, Myongji Hospital, Kwandong University College of Medicine, 697-24 Hwajeong-dong, Deogyang-gu, Goyang 412-270, Korea Tel: +82-31-810-5403 Fax: +82-31-969-0500 E-mail: neurohan@kd.ac.kr Objectives: Sleep bruxism is the grinding of teeth during sleep. Sleep bruxism may also be associated with various sleep disorders. However, little is known about sleep structures and disturbances of sleep bruxism. This study was aim at study of sleep architectures using overnight polysomnography in patients with sleep bruxism. Methods: We retrospectively analyzed sleep parameters and architectures in 10 healthy subjects and 13 patients with sleep bruxism. Overnight polysomnography (PSG) and sleep questionnaires including Epworth sleepiness scale (ESS), Beck Depression Inventory (BDI) were performed. The sleep variables included proportions of rapid eye movement (REM) sleep, non-REM sleep such as N1, N2 and N3, total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), Periodic limbs movement during sleep (PLMS) index, respiratory disturbance index (RDI), latency to sleep onset were analyzed between control and sleep bruxism groups. Results: TST, the proportion of non-REM and REM sleep, sleep efficiency, PLMS index and Epworth questionnaire showed not differences between SB and control. Arousal index and BDI in SB were significantly higher than controls (both, p<0.05). Conclusions: In contrast to previous studies, we suggest that patients with sleep bruxism are not good sleeper based on polysomnography study. Further studies will be required to assess the sleep quality of sleep bruxer. J Korean Sleep Res Soc 2011;8:9-13","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134270980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Idiopathic REM Sleep Behaviour Disorder Suspected Presymptomatic Stage of Neurodegenerative Disorders","authors":"Jin-Won Bae, J. Cho, D. Kim, C. Lyoo, Jae-Hyeok Lee","doi":"10.13078/JKSRS.11004","DOIUrl":"https://doi.org/10.13078/JKSRS.11004","url":null,"abstract":"A Case of Idiopathic REM Sleep Behaviour Disorder Suspected Presymptomatic Stage of Neurodegenerative Disorders Jin-Won Bae, Jae-Wook Cho, Dae-Jin Kim, Chul Hyoung Lyoo and Jae-Hyeok Lee Department of Neurology, Pusan National University Hospital, Busan, Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Department of Neurology, Yonsei University College of Medicine, Seoul, Korea","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121376436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}