Ji-Young Jung, Ho-Won Lee, I. Jang, K. Suk, Maan-Gee Lee
{"title":"Caffeine Maintains Arousal Level and Prevents Change of Electroencephalogram Spectral Powers with Time at Rest","authors":"Ji-Young Jung, Ho-Won Lee, I. Jang, K. Suk, Maan-Gee Lee","doi":"10.13078/JKSRS.14002","DOIUrl":"https://doi.org/10.13078/JKSRS.14002","url":null,"abstract":"Caffeine is one of the most commonly used central stimulants. It is frequently used for its mood and performance enhancing effects. The daily caffeine intake of Korean university students and North American adults are approximately 120 mg and 200 mg, respectively. Caffeine increases vigilance and diminishes sleepiness, and administration of these doses stimulates attention and restores performance degraded by factors such as fatigue and boredom. Central stimulating effects of caffeine have been evaluated by quantitative electroencephalography (qEEG) analysis. Although many studies have used qEEG analysis, inconsistencies still remain regarding the effects of caffeine on electroencephalography (EEG) spectral powers. These inconsistencies could be attributed to experimental differences between studies. Many studies have been conducted to clarify the effects of various parameters, such as, dose-dependency, eyes open or closed, and vigilance control. However, recording duration for qEEG analysis has not been well considered. According to multiple sleep latency test (MSLT) studies, sleep latency in normal adults during the day is around 15 min. Considering that the duration of the EEG recordings are generally 10–30 min, sleep can occur during recording and thus EEG rhythms can change. Accordingly, the selection of a part from a recording for qEEG analysis can affect the outcome of studies on the effects of caffeine on EEG spectral powers. In contrast to subjective questionnaires or neuropsychological tests, qEEG analysis has the advantage of being able to provide objective descriptions of temporal changes. Therefore, we examined the effect of caffeine effect on temporal change by qEEG by dividing the recording period into two segments and by comparing the qEEG parameters of","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128382660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep Disorders in Neurodegenerative Disorders","authors":"Jong-Geun Seo, S. P. Park, Ho-Won Lee","doi":"10.13078/JKSRS.14001","DOIUrl":"https://doi.org/10.13078/JKSRS.14001","url":null,"abstract":"Neurodegenerative diseases result from deterioration of neurons which may eventually lead to central nervous system-related dysfunction including sleep disorders. The pathogenesis of these disturbances may be secondary to direct structural alterations of the sleep-wake generating cells and networks or be the consequence of several indirect mechanisms. The most frequent sleep disturbances in patients with neurodegen erative diseases are insomnia, hypersomnia, parasomnias, excessive nocturnal motor activity, circadian sleep-wake rhythm disturbances, and respiratory dysrhythmias. Here, we classify the neurodegenerative diseases, taking into consideration the type of molecular neurodegeneration as synucleinopathies and tauopathies and reviewed sleep disorders observed in each degeneration type. The aim of this review is to provide data on sleep disturbances in two categories of neurodegenerative disorders.","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131067325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three Cases of Rapid Eye Movement Sleep Behavior Disorder after Encephalitis","authors":"Joo Yea Jin, Bomi Kim, Sang Ahm Lee","doi":"10.13078/JKSRS.14007","DOIUrl":"https://doi.org/10.13078/JKSRS.14007","url":null,"abstract":"Received December 13, 2013 Revised May 5, 2014 Accepted May 15, 2014 Address for correspondence Sang Ahm Lee, MD, PhD Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea Tel: +82-2-3010-3445 Fax: +82-2-474-4691 E-mail: salee@amc.seoul.kr Most secondary form of rapid eye movement (REM) sleep behavior disorder (RBD) is associated with neurodegenerative diseases or narcolepsy. However, RBD may also occur in acute or subacute conditions involving the central nervous system, for example structural lesions, encephalitis, Guillain-Barre syndrome, drug and alcohol withdrawal. Three patients developed RBD after acute inflammatory encephalitis, which lasted for 3 months to 1 year. They talked, moved and walked nightly while asleep. During night polysomnography, there were REM sleep without atonia and abnormally increased REM sleep as 37–87% of total sleep. The RBD improved with clonazepam and there was no recurrence at 1 year follow-up. The global encephalitis could be responsible for the RBD and destruction of sleep architecture. J Korean Sleep Res Soc 2014;11(1):38-43","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134437744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Kwon, M. Sung, Han-A Cho, E. Chang, Kwangae Park, Jangwoon Park, Eun-Jin Jeon, Eunha Kim, Seunghoon Lee, H. You, Taeil Ha, W. Shin
{"title":"Effects of an Indigo Blanket on Insomnia Symptoms:Double Blind, Placebo-Controlled, Randomized Pilot Study","authors":"Y. Kwon, M. Sung, Han-A Cho, E. Chang, Kwangae Park, Jangwoon Park, Eun-Jin Jeon, Eunha Kim, Seunghoon Lee, H. You, Taeil Ha, W. Shin","doi":"10.13078/JKSRS.14006","DOIUrl":"https://doi.org/10.13078/JKSRS.14006","url":null,"abstract":"Thirty subjects were recruited in this study and were randomly divided into two groups, indigo blanket and placebo asked to complete the sleep questionnaires [Insomnia Severity Index, Pittsburgh Sleep Quality Index, World Health Organization (WHO)-5 Well-Being Index] and to record the sleep diary before and after they use the blanket. The effects of each blanket was evaluated by sleep quality improvement and sleep satisfaction during their use of blanket, based on the sleep diary and sleep questionnaires.","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131010319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Minjik Kim, Jin-Young Song, Sung Min Kim, Y. Moon, Y. Koo, Ki-Young Jung
{"title":"Effect of Pramipexole on Cognitive Functions in Restless Legs Syndrome","authors":"Minjik Kim, Jin-Young Song, Sung Min Kim, Y. Moon, Y. Koo, Ki-Young Jung","doi":"10.13078/JKSRS.14004","DOIUrl":"https://doi.org/10.13078/JKSRS.14004","url":null,"abstract":"Address for correspondence Ki-Young Jung, MD, PhD Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea Tel: +82-2-2072-4988 Fax: +82-2-2072-7424 E-mail: jungky10@gmail.com Objectives: Neuropsychological evaluations have revealed cognitive dysfunction in restless legs syndrome (RLS) patients, especially frontal lobe functions. Although dopamine agonists improve RLS sensory symptoms and periodic leg movements during sleep, there was no study regarding the effects of dopamine agonist on cognition in patients with RLS. Methods: Sixteen drug-naive RLS patients were enrolled. They underwent sleep questionnaires, Beck Depression Inventory, and neuropsychological evaluation, consisting of Rey Complex Figure Test and recognition trial (RCFT), Korean-California Verbal Learning Test, Controlled Oral Word Association Test (COWAT) before and after treatment with pramipexole (PMP). PMP was administered over a period of 12 weeks every night 1 h before bedtime. Paired Student’s t-test and Spearman’s correlation analysis were used for analyses. Results: After treatment with PMP, the International RLS Severity Scale score was significantly decreased. Sleep quality and depression also significantly improved after the treatment. RCFT immediate recall, COWAT phoneme word frequency, and digit symbol coding scores significantly improved compared to those before the treatment (17.72±7.84 vs. 20.13±7.33, p=0.05; 36.50±12.62 vs. 41.50±12.58, p=0.03; 68.19±21.11 vs. 73.81±21.11, p=0.02, respectively). There were no significant correlations between changes in clinical variables and in cognitive functions before and after the treatment. Conclusions: This study suggests that treatment with PMP in RLS patients improves not only RLS sensory symptoms, but also cognitive functions. J Korean Sleep Res Soc 2014;11(1):16-20","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128667543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jong-Geun Seo, Ho-Won Lee, Sung-Pa Park, Kyunghun Kang
{"title":"The Interrelations of Quality of Sleep, Depressive Symptoms, and Quality of Life in Idiopathic Parkinson’s Disease","authors":"Jong-Geun Seo, Ho-Won Lee, Sung-Pa Park, Kyunghun Kang","doi":"10.13078/JKSRS.14003","DOIUrl":"https://doi.org/10.13078/JKSRS.14003","url":null,"abstract":"Objectives: Sleep disorder is common in patients with neurodegenerative diseases. Several studies showed that sleep quality impacts on cognitive function, psychiatric symptoms, and quality of life. The purpose of this study is to evaluate the interrelations of quality of sleep, depressive symptoms, and quality of life in idiopathic Parkinson’s disease (IPD). Methods: We enrolled 69 patients with IPD who had visited our clinic. IPD was diagnosed by UK Parkinson’s Disease Society brain bank clinical diagnostic criteria. We assessed by Pittsburgh Sleep Quality Index (PSQI), Korean Mini-Mental State Examination, Clinical Dementia Rating, Geriatric Depression Scale (GDS), and 36-item Short-Form Health Survey (SF-36). Results: Poor sleep quality was defined by PSQI score 6 or above. Therefore, 36 patients (52.2%) of subjects had poor sleep quality. There were no significant differences in the demographics. The patients with poor sleep quali ty showed more cognitive dysfunction and depressive symptoms than those with good sleep quality. The PSQI scores significantly correlated with GDS and SF-36 scores. Also, quality of sleep exerted negative ef fect on quality of life and quality of life exerted negative effect on depressive symptoms. Conclusions: This study showed that there were significant interrelations among quality of sleep, depressive symptoms, and quality of life. Therefore, it is needed for evaluation and management of sleep disorders to improve quality of life in patients with IPD.","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115542325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seung Ju Kim, D. S. Park, Doh-Eui Kim, H. Oh, Dushin Jeong, Hyung-Kook Park, K. Yang
{"title":"Contralateral Periodic Limb Movement during Sleep after Ischemic Stroke in the Globus Pallidus","authors":"Seung Ju Kim, D. S. Park, Doh-Eui Kim, H. Oh, Dushin Jeong, Hyung-Kook Park, K. Yang","doi":"10.13078/JKSRS.13012","DOIUrl":"https://doi.org/10.13078/JKSRS.13012","url":null,"abstract":"as repetitive and regular involuntary movement. It occurs primarily in the legs during sleep and usually consists of foot dorsiflexion and less often flexion at the knee or the hip. PLMS occurs 10-20% of general population and most prevalently in restless legs syndrome (RLS), which accounts for 80-90% of cases, but these movements can co-occur with a variety of sleep, medical, and neurological disorders and even with stroke. Previously reported cases of PLMS following ischemic stroke exhibited different clinical manifestations depending on the lesion site. These were associated with motor weakness with or without RLS. Here we report a case of contralateral PLMS without RLS following ischemic stroke in the right globus pallidus.","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130235858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Ryu, Eun Mi Lee, Gha-Hyun Lee, Bomi Kim, Cheon-Sik Kim, Sang-Ahm Lee
{"title":"Characteristics of Sleep Apnea in Obstructive Sleep Apnea Patients with Mixed Breathing Patterns","authors":"H. Ryu, Eun Mi Lee, Gha-Hyun Lee, Bomi Kim, Cheon-Sik Kim, Sang-Ahm Lee","doi":"10.13078/JKSRS.13009","DOIUrl":"https://doi.org/10.13078/JKSRS.13009","url":null,"abstract":"Objectives: Varieties of mixed breathing patterns such as mixed or central sleep apnea in patients with obstructive sleep apnea (OSA) may observed during polysomnography. Our object is to compare the general feature and sleep apnea characteristics between OSA with and without mixed breathing pattern. Methods: Total 244 patients who were diagnosed as OSA [apnea-hypopnea index (AHI) ≥5 /h] were studied retrospectively. Mixed breathing pattern was defined as mixed apnea index plus central apnea index (MCAI) with ≥5 /h (Mix-OSA). OSA without mixed breathing pattern (Non-mix-OSA) was defined with MCAI with <5 /h. Central sleep apnea syndrome was excluded. We investigated differences of the distribution and shifting of apnea index across sleep stage, position and sleep time between Mix-OSA and Non-mix-OSA group. Results: The prevalence of Mix-OSA was 42 of 244 OSA patients (17.2%). There were no significant differences in demographics except higher AHI in Mix-OSA group. Mix-OSA showed a significant increment of MCAI and hypopnea index during non rapid eye movement sleep while Non-mix-OSA showed increased obstructive apnea index (OAI) in rapid eye movement sleep period. In both groups, supine body position was related to high OAI. There were no meaningful differences in sleep apnea according to the timing of sleep in both groups. Conclusions: OSA patients with mixed breathing pattern had more severe OSA than Non-mix-OSA. There were some significant differences in sleep apnea characteristics between OSA with and without mixed breathing pattern. However, their clinical significance still remains unclear. J Korean Sleep Res Soc 2013;10:45-50","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133943181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Atypical Kleine-Levin Syndrome","authors":"Jong-Geun Seo, S. Seo, Sung-Pa Park, Ho-Won Lee","doi":"10.13078/JKSRS.13011","DOIUrl":"https://doi.org/10.13078/JKSRS.13011","url":null,"abstract":"Received December 8, 2013 Revised December 9, 2013 Accepted December 9, 2013 Address for correspondence Ho-Won Lee, MD, PhD Department of Neurology, School of Medicine, Brain Science & Engineering Institute, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Korea Tel: +82-53-200-3271 Fax: +82-53-200-3299 E-mail: neuromd@knu.ac.kr Kleine-Levin syndrome is characterized by recurrent episodes of hypersomnia and associated cognitive and behavioral impairments. We present a 47-year-old female patient with recurrent hypersomnia and disorder of appetite. During each episode, patient slept more than 24 hours with hyperphagia or anorexia. Physical examinations, laboratory tests, and brain MRI showed no significant abnormality in the patient. Nocturnal polysomnographic study showed high sleep efficiency, reduced sleep latency and rapid eye movement (REM) sleep latency, and increased sleep stage 1 & 2. The multiple sleep latency tests showed one episode of sleep-onset REM periods. This is the first atypical case report of Kleine-Levin syndrome in Korea which showed short duration of episodes and hypersomnia combined with anorexia. J Korean Sleep Res Soc 2013;10:56-58","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129924293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphological Changes in Narcolepsy","authors":"E. Joo","doi":"10.13078/JKSRS.13007","DOIUrl":"https://doi.org/10.13078/JKSRS.13007","url":null,"abstract":"Received December 8, 2013 Revised December 9, 2013 Accepted December 9, 2013 Address for correspondence Eun Yeon Joo, MD, PhD Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea Tel: +82-2-3410-3597 Fax: +82-2-3410-0052 E-mail: ejoo@skku.edu Narcolepsy is a chronic neurological disorder with the abnormal regulation of the sleep-wake cycle, resulting in excessive daytime sleepiness, disturbed nocturnal sleep, and manifestations related to rapid eye movement sleep such as cataplexy, sleep paralysis, and hypnagogic hallucination. Over the past decade, numerous neuroimaging studies, have been performed to characterize the pathophysiology and various clinical features of narcolepsy. Here we review structural findings based on brain magnetic resonance imaging in narcolepsy with cataplexy, which include voxel-based morphometry, cortical thickness analyses, and hippocampal volumetry. The current state of research suggests that structural neuroimaging is a useful tool to investigate and understand the anatomical correlates and brain abnormalities of narcolepsy. J Korean Sleep Res Soc 2013;10:35-38","PeriodicalId":243131,"journal":{"name":"Journal of Korean Sleep Research Society","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114518673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}