A Case of Atypical Kleine-Levin Syndrome

Abstract

Received December 8, 2013 Revised December 9, 2013 Accepted December 9, 2013 Address for correspondence Ho-Won Lee, MD, PhD Department of Neurology, School of Medicine, Brain Science & Engineering Institute, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Korea Tel: +82-53-200-3271 Fax: +82-53-200-3299 E-mail: neuromd@knu.ac.kr Kleine-Levin syndrome is characterized by recurrent episodes of hypersomnia and associated cognitive and behavioral impairments. We present a 47-year-old female patient with recurrent hypersomnia and disorder of appetite. During each episode, patient slept more than 24 hours with hyperphagia or anorexia. Physical examinations, laboratory tests, and brain MRI showed no significant abnormality in the patient. Nocturnal polysomnographic study showed high sleep efficiency, reduced sleep latency and rapid eye movement (REM) sleep latency, and increased sleep stage 1 & 2. The multiple sleep latency tests showed one episode of sleep-onset REM periods. This is the first atypical case report of Kleine-Levin syndrome in Korea which showed short duration of episodes and hypersomnia combined with anorexia. J Korean Sleep Res Soc 2013;10:56-58