Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova最新文献_第6页

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro2023123021144

M P Topuzova, I K Ternovykh, T A Shustova, A Yu Mikheeva, A O Chistyakova, T A Pavlova, N E Dudnikova, M L Pospelova, T M Alekseeva

{"title":"[Multiple system atrophy].","authors":"M P Topuzova, I K Ternovykh, T A Shustova, A Yu Mikheeva, A O Chistyakova, T A Pavlova, N E Dudnikova, M L Pospelova, T M Alekseeva","doi":"10.17116/jnevro2023123021144","DOIUrl":"https://doi.org/10.17116/jnevro2023123021144","url":null,"abstract":"The article presents a progressive neurodegenerative disease - multisystem atrophy, characterized by a combination of autonomic failure and various motor disorders, including parkinsonism and/or cerebellar ataxia; etiopathogenetic factors and variants of the clinical picture are described. We describe own clinical observation of a 59-old patient with cerebellar and bulbar syndromes, parkinsonism, pyramidal insufficiency, cognitive deficits, and autonomic dysfunction. The differential diagnosis included a whole range of neurodegenerative and hereditary diseases: Parkinson's disease, vascular parkinsonism, progressive supranuclear palsy, spinocerebellar ataxia, FXTAS, mitochondrial encephalopathies. The moderate severity of parkinsonism and the significant predominance of cerebellar symptoms and autonomic dysfunction make this clinical case difficult to diagnose. However, based on the life and disease history, clinical picture and research methods, a diagnosis of multiple system atrophy, cerebellar type (cerebellar, autonomic, bulbar syndrome, parkinsonism, pyramidal insufficiency and moderate cognitive impairment) was established. Differential search in such patients is a difficult task and includes a whole range of neurodegenerative and hereditary diseases due to the similarity of individual clinical and neuroimaging features and, unfortunately, the limited availability of molecular genetic diagnostic methods. However, earlier diagnosis is necessary to focus in time on the development of a personalized approach to the management of each such patient, taking into account the rate of symptoms development and steady progression, in order to ensure the longest possible survival time with an acceptable level of quality of life.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 2","pages":"144-150"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10788665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The role of the phenosanic acid in the combined treatment of patients with epilepsy]. 【酚酸在癫痫患者联合治疗中的作用】。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro2023123021151

K V Voronkova, A M Alieva, I G Nikitin, G M Musina, E V Surskaya, O S Zaitseva, N G Mashkevich, L V Gomonova, A S Petrukhin

{"title":"[The role of the phenosanic acid in the combined treatment of patients with epilepsy].","authors":"K V Voronkova, A M Alieva, I G Nikitin, G M Musina, E V Surskaya, O S Zaitseva, N G Mashkevich, L V Gomonova, A S Petrukhin","doi":"10.17116/jnevro2023123021151","DOIUrl":"https://doi.org/10.17116/jnevro2023123021151","url":null,"abstract":"Epilepsy is one of the most studied chronic neurological disorders in the world. Despite significant progress in epilepsy research, some patients continue to experience recurrent seizures. It has been proven that oxidative stress plays an important role in epilepsy. Targeting oxidative stress may provide a novel therapeutic intervention to attenuate epileptogenesis as well as cognitive and psychiatric impairment in patients with epilepsy. One of the promising directions in the search for new strategies for the treatment of epilepsy is the combined use of antiepileptic drugs with antioxidants that affect the pathogenetic links of this disease. The new Russian antiepileptic drug fenosanoic acid (Dibufelon) has an anticonvulsant effect due to the inhibition of lipid peroxidation of brain cells and the reconstruction of cell membranes. This mechanism of action also paves the way for an increase in the effectiveness of co-administered drugs with phenosanoic acid. The effect of the drug on the cognitive and mental functions of patients, the regression of asthenia phenomena is also observed. The clinical efficacy and safety of the combination of this drug with other antiepileptic drugs in epilepsy has been demonstrated in experimental and clinical studies.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 2","pages":"151-157"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10788666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Features of the reward-based decision-making in patients with alcohol use disorders]. [酒精使用障碍患者基于奖励的决策特征]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro202312302137

S A Galkin, N A Bokhan

{"title":"[Features of the reward-based decision-making in patients with alcohol use disorders].","authors":"S A Galkin, N A Bokhan","doi":"10.17116/jnevro202312302137","DOIUrl":"https://doi.org/10.17116/jnevro202312302137","url":null,"abstract":"Foreign studies increasingly emphasize the role of reward-based cognitive decision-making and its contribution to alcohol and drug abuse. Unfortunately, such studies are extremely few in Russia. Given the importance of the insufficiency of cognitive functions, primarily the decision-making process based on reward, among the risk factors of addictive pathology, increasing the severity of alcoholism, reducing the effectiveness of its therapy and rehabilitation, research in this direction is extremely relevant. This review summarizes and systematizes current data on the features of the cognitive decision-making process based on reward in patients with alcohol dependence. An analysis of the literature has shown that reward-based decision making is an important component of addictive behavior. Patients with alcohol dependence, as well as people, who abuse alcohol, demonstrate clear impairment of this cognitive function. Thus, the relative value of diagnosing disorders in decision-making in modern psychiatry is beyond doubt. It is recommended to include the above tests in the diagnostic complex of a psychiatrist, along with standard psychometric tools.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 2","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10798350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Virtual reality technology as a promising direction in neurorehabilitation]. [虚拟现实技术作为神经康复的一个有前途的方向]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro2023123011131

N S Bofanova, A Yu Tychkov, Ya A Khanfar, R V Zolotarev

引用次数: 0

[FIRES Syndrome in a Preschool Child]. [学龄前儿童的火灾综合症]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro2023123021132

N V Skripchenko, E Y Gorelik, E S Egorova, A A Vilnits, E Y Skripchenko, V B Voitenkov, N V Marchenko, A I Konev

引用次数: 0

[Improving the effectiveness of pharmacotherapy in comorbid patients with chronic cerebral ischemia on an outpatient basis]. [在门诊基础上提高慢性脑缺血合并症患者药物治疗的有效性]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro202312303151

T L Vizilo, E G Arefieva

{"title":"[Improving the effectiveness of pharmacotherapy in comorbid patients with chronic cerebral ischemia on an outpatient basis].","authors":"T L Vizilo, E G Arefieva","doi":"10.17116/jnevro202312303151","DOIUrl":"https://doi.org/10.17116/jnevro202312303151","url":null,"abstract":"Objective: To study the efficacy and safety of sequential therapy with Mexidol (500 mg 1 time/day for 14 days intravenously) and Mexidol FORTE 250 (Mexidol FORTE 250 for 250 mg 3 times/day, 60 days) in patients with chronic cerebral ischemia (CCI) on an outpatient basis.Material and methods: The open comparative study included 56 patients aged 46-74 years, age - 60.5+7.9 years. In all patients, the diagnosis of CCI was confirmed by clinical and neuroimaging methods. Patients of group 1 (n=28) received basic therapy and Mexidol, group 2 (n=28) received only basic therapy.Results: Against the background of therapy in patients of group 1, there was a statistically significant improvement in the state of cognitive functions, a decrease in the severity of symptoms of depression and anxiety, manifestations of asthenia. The treatment was characterized by good tolerability, absence of adverse events and cases of drug interactions.Conclusion: Sequential therapy with Mexidol and Mexidol FORTE 250 drugs provides relief of the main clinical manifestations of CCI, is characterized by good tolerability and safety.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 3","pages":"51-55"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Modern principles of therapy for patients with spinal muscular atrophy]. 【脊髓性肌萎缩症的现代治疗原则】。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro202312303134

N S Bofanova, A R Eliseeva, V S Onchina

{"title":"[Modern principles of therapy for patients with spinal muscular atrophy].","authors":"N S Bofanova, A R Eliseeva, V S Onchina","doi":"10.17116/jnevro202312303134","DOIUrl":"https://doi.org/10.17116/jnevro202312303134","url":null,"abstract":"Spinal muscular atrophy (SMA) is a common cause of childhood mortality among hereditary diseases of the central nervous system, which are caused by the processes of degeneration and death of motor neurons of the anterior horns of the spinal cord. An urgent issue of modern neurology is pathogenetic therapy for this group of patients, the purpose of which is to increase the level of motoneuron survival protein. We performed a search on current methods of treating SMA in Web of Science, Scopus, PubMed, Embase by the keywords: spinal muscular atrophy, neuromuscular diseases, pathogenetic therapy. Significant progress has been made in the treatment of SMA over the past 7 years. A major advance is the introduction of disease-modifying therapies using SMN2 splicing modulation or gene replacement therapy. At the moment, there are 3 FDA-approved drugs for pathogenetic therapy: Nusinersen, Risdiplam, Zolgensma. The article compares the drugs, evaluates their safety and effectiveness according to the available literature. Modern drugs for the pathogenetic therapy of SMA are highly effective and reduce the mortality rate. The results of clinical trials predict the emergence of new modern drugs. This suggests a favorable prognosis for the treatment of patients with SMA.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 3","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A clinical case of multiple sclerosis with an episode of schizophrenia-like syndrome]. [多发性硬化症伴精神分裂症样综合征发作的临床病例]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro2023123041120

U Sh Kuzmina, A V Tukhvatullin, K Z Bakhtiyarova, M A Kutlubaev, O V Lyutov, T R Gizatullin

引用次数: 0

[A role of neurosteroids in the pathogenesis of psychiatric disorders]. [神经类固醇在精神疾病发病机制中的作用]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro202312304131

D S Petelin, S P Bairamova, R V Akhapkin, N V Kudryashov, O Yu Sorokina, S A Semin, B A Volel

{"title":"[A role of neurosteroids in the pathogenesis of psychiatric disorders].","authors":"D S Petelin, S P Bairamova, R V Akhapkin, N V Kudryashov, O Yu Sorokina, S A Semin, B A Volel","doi":"10.17116/jnevro202312304131","DOIUrl":"https://doi.org/10.17116/jnevro202312304131","url":null,"abstract":"Despite the proven importance of neurosteroids in many physiological processes, their role in the pathogenesis of the most of psychiatric disorders remains relatively understudied. This article reviews the current clinical evidence on the effects of neurosteroids on the formation and treatment of anxiety disorder, depression, bipolar disorder, and schizophrenia. In particular, the article points out the ambivalent nature of the effects of neurosteroids on GABAA- and other receptors. We are especially interested in the anxiolytic and anxiogenic effects of some neurosteroids, the antidepressant effect of allopregnanolone in treating postpartum and other forms of depression, and the nature of short- and long-term mechanisms of antidepressant effects of neurosteroids of different types. The currently unproven hypothesis about the effect of changes in the level of neurosteroids on the course of bipolar disorder is also discussed, with an analysis of the scientific evidence on the development of schizophrenic symptomatology in relation to changing neurosteroid levels in the context of positive and cognitive symptoms.","PeriodicalId":24030,"journal":{"name":"Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova","volume":"123 4","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9427363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Ethnic features of multipathology in elderly and senile patients of the Republic of Sakha suffering from chronic brain ischemia]. [萨哈共和国老年和老年慢性脑缺血患者的多病理民族特征]。

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova Pub Date : 2023-01-01 DOI: 10.17116/jnevro202312307150

P I Kudrina, A N Bogolepova, A L Ariev

引用次数: 0