Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії最新文献

{"title":"IDENTIFYING RISK FACTORS FOR TREATMENT FAILURE IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS RECEIVING BENDAMUSTINE±RITUXIMAB THERAPY","authors":"I. Drabovska, G. Maslova","doi":"10.31718/2077-1096.24.2.18","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.18","url":null,"abstract":"Introduction. The initial assessment of prognosis is of particular importance in determining the management of patients with B-cell chronic lymphocytic leukemia and the choice of specific therapy. \u0000The aim is to analyze the risk factors for failure to achieve a complete response to the bendamustine±rituximab treatment regimen in patients with B-cell chronic lymphocytic leukemia. \u0000Materials and methods. Twenty-two patients undergoing treatment for B-cell chronic lymphocytic leukemia (B-CLL) progression were included in the study. Response to treatment was assessed on the 56th day, categorized as complete, partial, or no response. Patients were divided into three groups based on their response: group I (n=6) included patients who showed a complete response after receiving bendamustine±rituximab; group II (n=11) included patients who achieved a partial response; and group III (n=5) consisted of patients with no response. Risk factors for chemotherapy resistance, as well as general and biochemical blood counts, were evaluated and subjected to statistical analysis. \u0000Results: Stage III (C) and IV (C) according to the Rai, Binet classification were recorded in 33.2% of patients with a complete response to chemotherapy, in 36.4% of patients with a partial response to chemotherapy, and in 60% of patients with no response to specific treatment. A decrease in hemoglobin level below 100 g/L was recorded only in patients with a partial response and no response, namely in 4 (36%) patients of group II and 1 (20%) patient of group III. On day 56, in patients of group II who received a partial response, there was a direct correlation between the level of leukocytes in the hemogram and the activity of aspartate aminotransferase (r=0.71; p=0.01) and the content of total bilirubin (r=0.63; p=0.03) in the biochemical blood test. After 2 courses of chemotherapy in patients of group III, a direct correlation of high strength between the level of leukocytes in the hemogram and the activity of aspartate aminotransferase (r=0.93; p=0.02) and alanine aminotransferase (r=0.93; p=0.02) in the biochemical blood test was found. The bendamustine±rituximab chemotherapy regimen has a high safety profile.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLEEP QUALITY AND AVOIDANCE BEHAVIOR IN COMBATANTS WITH POST-TRAUMATIC STRESS DISORDER","authors":"D.I. Boiko, O.V. Mats, O. I. Shkidchenko","doi":"10.31718/2077-1096.24.2.4","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.4","url":null,"abstract":"Introduction. Post-traumatic stress disorder (PTSD) is often characterized by various symptoms that result in behavioral changes in patients, among which sleep disturbances and avoidant behavior are commonly observed. However, despite evidence indicating a complex bilateral relationship between emotions and sleep, only few studies have explored the associations between sleep disturbances and avoidant behavior in the context of PTSD. \u0000The aim of the study is to assess the severity of avoidant behaviour and insomnia in combatants with posttraumatic stress disorder. \u0000Materials and methods. We conducted a clinical study of 45 combatants who were divided into 2 groups: group 1 (n=24) included combatants with PTSD; group 2 (n=21) consisted of combatants without PTSD. The Pittsburgh Sleep Quality Questionnaire was used to analyse sleep quality, namely subjective sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbances, sleep medication use, and daily dysfunction. Avoidance behavior was measured using a multidimensional experience avoidance questionnaire. \u0000Results. We found that group 1 demonstrated worse subjective sleep quality (p=0.002), longer sleep latency (p<0.001), lower sleep efficiency (p=0.019) and more severe sleep disturbances (p<0.001). There were no statistically significant differences between the groups in terms of sleep duration, severity of sleeping pills use, and daily dysfunction. The overall severity of sleep quality disorders was higher in group 1 compared to group 2 (p<0.001). Avoidance behavior (p=0.007) and repression and denial (p<0.001) were more pronounced in group 1 compared to group 2. At the same time, group 1 had lower stress endurance (p<0.001). The overall level of experiental avoidance in group 1 was higher than in group 2 (p<0.001). Numerous associations between sleep quality characteristics and experiental avoidance were found as well. \u0000Conclusions. The study has revealed that combatants with PTSD have more pronounced manifestations of behavioural avoidance, repression and denial, as well as a lower level of stress endurance. At the same time, combatants with PTSD demonstrate a deterioration in the subjective quality of sleep, a decrease in its effectiveness and an increase in the severity of its disturbances. It has been found that avoidance behavior in combatants has numerous connections with the characteristics of sleep quality that may be suggested as a potential factor for improving psychotherapeutic interventions.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"43 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE MYOCARDIAL INFARCTION DURING VRD CHEMOTHERAPY IN A PATIENT WITH MULTIPLE MYELOMA: A CLINICAL CASE","authors":"V. Ostrovskyi","doi":"10.31718/2077-1096.24.2.213","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.213","url":null,"abstract":"Acute myocardial infarction is a critical condition associated with significant morbidity and mortality rates. Myocardial infarction-related acute myocardial injury is characterized by a rapid elevation and subsequent decline in cardiac troponin concentration. According to the relevant data patients with multiple myeloma are in a high-risk category for venous and arterial thrombosis. Therefore, the incidence of cardiovascular complications, which include myocardial infarction, in these patients is higher than in the general population. \u0000The development of metaplastic anemia further compounds this risk by diminishing myocardial oxygen supply. Moreover, chemotherapy for oncohematological diseases carries the potential for cardiotoxic cardiovascular complications. Immunomodulator drugs like Thalidomide and Lenalidomide, frequently utilized in multiple myeloma treatment, have been associated with Lenalidomide-induced myocardial infarction—a prevalent adverse effect. The use of proteasome inhibitors such as Bortezomib and Carfilzomib poses an increased risk for myocardial infarction development. \u0000This clinical case presents an instance of acute myocardial infarction in a multiple myeloma patient during low cumulative chemotherapy dosage, comprising Lenalidomide and Bortezomib. It underscores the necessity for enhanced clinical, instrumental, and laboratory monitoring before each specific chemotherapy course in high-risk multiple myeloma patients. Such monitoring facilitates the early detection of chemotherapy-induced cardiotoxic effects, allowing for timely intervention and management.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN CIRCADIAN CHARACTERISTICS OF PATIENTS WITH PARKINSON DISEASE AFTER CORRECTION OF POOR SLEEP QUALITY USING MELATONIN: AN OPEN-LABEL CONTROLLED RANDOMISED TRIAL","authors":"A. Shkodina","doi":"10.31718/2077-1096.24.2.69","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.69","url":null,"abstract":"Introduction. Recent studies are increasing the amount of evidence suggesting that the circadian system is disrupted in Parkinson's disease that can lead to poor sleep. Currently, international guidelines for managing non-motor symptoms of Parkinson's disease do not have recommendations with proven efficacy, but only methods with potential benefit. Two of the most widely available methods for correcting poor sleep quality in patients with Parkinson's disease in Ukraine are sleep hygiene training, also known as somnoeducation, and melatonin administration. \u0000The aim of the study is to compare the state of circadian characteristics before and after the correction of poor sleep quality in patients with Parkinson's disease in the context of sleep hygiene and an integrated approach with the implementation of chronotherapy using melatonin. \u0000Materials and methods. We conducted a clinical trial at the Centre for Patients with Parkinson's Disease and Other Neurodegenerative Diseases, which included 34 patients with poor sleep quality who were randomised into 2 groups: group 1a (n = 17) consisted of patients with Parkinson's disease who followed sleep hygiene rules and received chronotherapy; group 1b (n = 17) involved patients with Parkinson's disease who followed sleep hygiene rules but did not take any medications to improve sleep. Circadian characteristics were analysed using the Munich Chronotype Questionnaire. \u0000Results. Our study has found that the correction of poor sleep quality by introducing sleep hygiene into the treatment process of patients with Parkinson's disease demonstrates a shift in the time of sleep onset and mid-sleep to earlier, accompanied by a shift in chronotypes towards earlier, as well as an increase in sleep duration against a decrease in the time spent in bed, which led to an increase in the average actual sleep efficiency. At the same time, melatonin supplementation helps to reduce sleep latency in Parkinson's disease. \u0000Conclusions. Adherence to sleep hygiene recommendations contributes to changes in circadian characteristics and improves sleep efficiency in patients with Parkinson's disease, regardless of melatonin administration. Additional use of melatonin to correct the quality of sleep for 1 month is accompanied by a reduction in the sleep latency period.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"8 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF REGULATORY AND LEGAL SUPPORT FOR THE PREVENTION OF DIABETES MELLITUS IN CHILDREN","authors":"K. V. Pocheniuk, I.A. Holovanova","doi":"10.31718/2077-1096.24.2.182","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.182","url":null,"abstract":"Diabetes mellitus has become one of the most prevalent chronic diseases in childhood today. International forecasts suggest that the incidence of diabetes will continue to rise in the coming decades, leading to a lifelong burden for millions of children worldwide. Therefore, prediction, prevention, and optimal treatment of diabetes, as well as early prevention of serious long-term complications, remain essential. Providing highly qualified medical care to diabetic patients is a crucial step in preventing the development of complications. \u0000The purpose of this article is to review existing research on diabetes prevention strategies for children, considering the different levels of medical care support available. \u0000Materials and Methods. This study investigates the organization of preventive care for children with diabetes in Ukraine. Researchers employed three key methods: bibliosemantic analysis, content analysis focused on analyzing Ukraine relevant regulations and legal frameworks, and the method of systemic approach and analysis to gain a comprehensive understanding of how preventive care is currently organized for children with diabetes in Ukraine. \u0000Results. In Ukraine, preventive measures and the provision of medical care to pediatric patients with diabetes in the past years and today are regulated by a number of documents and orders of the Ministry of Health. As part of the Comprehensive Program “Diabetes Mellitus” (1999) and in accordance with the Order of the Ministry of Health of Ukraine “On Improving the Organization of Providing Endocrinological Care to the Population of Ukraine” (2006), the State Register of Patients with Diabetes Mellitus (SYNADIAB) was created. The next step was the approval of the State Target Program “Diabetes Mellitus”. Subsequently, the Project of the national program “Health 2020: Ukrainian Dimension” became an effective tool, which outlined the main principles of the program implementation in the “Endocrinology” section for 2013-2020. It defined measures at all stages of diabetes prevention, such as primary prevention, which consists of maintaining and strengthening the general state of health and preventing or delaying the development of diabetes; secondary prevention should improve early detection of diabetes mellitus; tertiary prevention, which ensures the effectiveness and safety of treatment of children with diabetes to prevent the development of long-term complications. Today, the guidelines for the management of children with diabetes mellitus have been continued in such documents as “Diabetes Mellitus in Children”, Evidence-Based Clinical Guidelines (2023) and Standards of Care (2023). \u0000Conclusion. Diabetes mellitus is a chronic disease that ranks third in prevalence after cardiovascular and cancerous diseases and second in the structure of endocrine diseases after thyroid gland pathology. Today, the prevalence of diabetes mellitus among children is constantly increasing and, therefore, solving the issue","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"20 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVEMENT OF CAPILLAROSCOPY METHOD FOR STUDYING HUMAN MICROCIRCULATION","authors":"O.M. Petrovskyi, V.V. Soloviov, N. V. Soloviova, A.V. Mishchenko, O. E. Zakolodna, T.Yu. Kuznetsova","doi":"10.31718/2077-1096.24.2.257","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.257","url":null,"abstract":"The human circulatory system has historically captivated researchers in the field of medicine. Modern medicine, however, has moved beyond identifying a single crucial element, such as the heart or venous system, for maintaining blood flow. Instead, it emphasizes a more analytical approach, focusing on the interconnected functioning of all components within the system. The aim of this work is to analyze the existing methods of studying blood microcirculation and to improve the technology of capillaroscopy, technical means of raster microphotography to determine the physiological state and disorders of capillary circulation. \u0000To achieve this objective, we address the following tasks: analyzing existing non-invasive methods for studying the human vascular system; enhancing the optical capillaroscopy method through the utilization of modern high-resolution digital cameras, computer, and multimedia equipment, along with appropriate software for analyzing electronic images; developing a technological scheme and equipment design for digital microphotography of capillaries in the periungual region of the upper extremities; providing software solutions for registering and analyzing digital microphotographic images obtained through capillaroscopy; conducting experimental studies to explore the structure and properties of capillaries utilizing the developed technologies and equipment. \u0000Magnetic resonance imaging (MRI) enables the comprehensive evaluation of both anatomical and functional aspects of blood flow. Magnetic resonance angiography (MRA) capitalizes on the distinction between the signal emitted by moving tissue (blood) and that of surrounding stationary tissue, facilitating the acquisition of vascular images without the need for radiopaque contrast agents. Ultrasonography integrates Doppler and conventional ultrasound techniques, providing physicians with insights into blood vessel structure and blood flow dynamics. Traditional ultrasound employs sound waves that are imperceptible to the human ear and bounce off blood vessels, while Doppler ultrasound measures the velocity of sound wave reflection from moving elements. Ophthalmoscopy constitutes a fundamental component of standard ophthalmological examinations, serving as a pivotal tool for diagnosing eye conditions and evaluating the condition of blood vessels. Additionally, ophthalmoscopy aids in diagnosing autoimmune disorders. Capillaroscopy enables comprehensive assessments of both systemic and regional microcirculation disorders, facilitating the characterization of tissue metabolism. Dysfunction in capillary function contributes to circulatory impairments, leading to blood stasis, metabolic irregularities, and compromised immunity, thereby exacerbating existing conditions and predisposing individuals to new diseases. Optical computerized capillaroscopy offers a non-invasive means of visualizing, examining, and archiving capillary images, enabling clinicians to make informed assessments regar","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"38 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF QUERCETIN ON PATHOMORPHOLOGICAL CHARACTERISTICS OF MANDIBULAR BONE IN RATS FOLLOWING ITS FRACTURE UNDER CHRONIC ALCOHOL INTOXICATION","authors":"K.I. Nestulia, I.I. Starchenko, V.O. Kostenko","doi":"10.31718/2077-1096.24.2.120","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.120","url":null,"abstract":"This study aims at investigating the impact of water-soluble form of quercetin on the pathomorphological characteristics of the mandibular bone in rats following its incomplete fracture under chronic alcohol intoxication was investigated. Fourteen white male Wistar rats weighing 190-240 g were randomly divided into two groups: Group 1 comprised rats with incomplete mandibular fractures under chronic alcohol intoxication; animals in Group 2 received daily intraperitoneal injections of water-soluble quercetin (corvitin) in a dose of 10 mg/kg of quercetin for 14 days following the injury induction. It has been shown that chronic alcohol intoxication hinders reparative regeneration of bone tissue after an incomplete mandibular fracture, and is accompanied by a decrease in the relative amount of reticulofibrous bone tissue and fibroblastic cellular elements at the injury site, especially mature fibroblasts, as well as by delayed maturation of granulation tissue. Under experimental conditions, quercetin administration significantly contributed to normalizing the regenerative process by the 14th day of the posttraumatic period. This normalization was evidenced by increased relative amounts of reticulofibrous bone tissue, prevalence of fibroblastic cells in granulation tissue, and accelerated formation of the regenerate blood microcirculatory channel.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"19 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SOURCES OF SUPEROXIDE ANION RADICAL IN SMALL INTESTINE TISSUES IN RATS SUBJECTED TO SURGICAL TRAUMA SIMULATED UNDER EXPERIMENTAL MODEL OF POSTTRAUMATIC STRESS DISORDER","authors":"R.M. Riabushko, V.O. Kostenko","doi":"10.31718/2077-1096.24.2.137","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.137","url":null,"abstract":"The sources of superoxide anion radical (.О ) in the tissues of the small intestine in rats subjected to surgical trauma simulated under an experimental model of posttraumatic stress disorder (PTSD) were investigated. The study involved 42 white Wistar rats weighing 210-230 g, divided into 6 groups: group 1 comprised intact animals, group 2 included animals with the PTSD induced through single-prolonged stress (SPS), group 3 consisted of rats subjected to a sham surgical operation, group 4 comprised animals undergoing laparotomy, group 5 involved rats undergoing a sham surgical operation following SPS, and group 6 included animals undergoing laparotomy under modeled SPS. The rate of .О generation in the small intestine homogenate was measured spectrophotometrically using the nitroblue tetrazolium test. The .О production by NADPH-dependent (microsomal and NO synthase) electron transport chains (ETC), NADH-dependent (mitochondrial) ETC and leukocyte NADPH oxidase was assessed. The findings obtained have demonstrated that experimental SPS modeling leads to an increase in oxidative stress in the small intestine tissues of rats. This is manifested by an increase in the rate of .О formation with the participation of microsomes, mitochondria and leukocyte NADPH oxidase. On the 7th day after laparotomy under the experimental PTSD model, the .О production in the tissues of the small intestine by different sources (microsomes, mitochondria and leukocyte NADPH oxidase) exceeds their values obtained after a single laparotomy or after performing a sham operation under single long-term stress.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"74 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141121264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDEX ASSESSMENT OF PERIODONTAL TISSUES AND DETERMINATION OF TREATMENT NEEDS IN PATIENTS WITH CHRONIC RHEUMATIC HEART DISEASE","authors":"O. Myhal, R. Z. Ogonovskyi, Z. Honta, K. Sichkoriz, K. A. Moroz, O. Y. Kordiyak","doi":"10.31718/2077-1096.24.2.80","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.80","url":null,"abstract":"This study addresses the pressing scientific and practical issue in modern dentistry: enhancing dental care effectiveness for patients with chronic rheumatic heart disease. \u0000The purpose of this research is to comprehensively assess the condition of tooth-supporting tissues and quantify inflammatory phenomena in periodontal tissues among patients with chronic rheumatic heart disease, as well as to determine the necessary extent of periodontal care based on periodontal indices. \u0000Participants and methods. The periodontal tissues of 719 patients with chronic rheumatic heart disease from the Rheumatology Department of Lviv Regional Clinical Hospital, along with 290 clinically healthy individuals in the comparison group, were examined. To evaluate the clinical course of dystrophic-inflammatory periodontal diseases in patients with chronic rheumatic heart disease, we examined 267 individuals in the main group who had generalized periodontitis, categorized as follows: 42 patients with initial stage (I degree), 115 with moderate (II degree), and 110 with severe (III degree) periodontitis. The comparison group comprised 70 patients diagnosed with generalized periodontitis, among them, 21 had initial-stage disease, 29 had moderate-stage disease, and 20 had severe-stage disease. \u0000During the analysis, the oral hygiene was assessed by applying hygienic indices by J.C. Green and J.R. Vermillion (OHI-S, 1964) and Fedorov-Volodkina. The Muhlemann and Son index was used to objectively measure gingival papillary bleeding (RVI); the papillary-marginal-alveolar index (PMA) in the Parma modification, in combination with the Schiller-Pysarev test (1989), was employed to evaluate gingival inflammation. The periodontal index (PI) by A.L. Russel (1956) was used to assess the state of periodontal tissues, and pathological changes were recorded using the periodontal screening PSR test. Results were scored, and based on established criteria and scores, the need for treatment and its extent were determined. \u0000Results and discussion. According to the results of dental examinations in patients with chronic rheumatic heart disease, a high prevalence of periodontal diseases was found, reaching 92.49%. This was 13.18% higher compared to the prevalence in the control group. Dystrophic-inflammatory conditions with advanced severity levels were predominant, as evidenced by the index indicators. In chronic rheumatic heart disease patients, the average periodontal index was 6.11±0.10, compared to 4.14±0.19 in clinically healthy individuals (p < 0.05). Moreover, a higher lesion of periodontal tissues was observed in younger age groups. As the duration of rheumatic disease increased, the frequency of detecting generalized periodontitis also increased, with this condition being diagnosed in all subjects with a 10-year history of rheumatic disease. \u0000Conclusion. The Analysis of the research data on the condition of periodontal tissues, along with objective index assessments, reveals the foll","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"19 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOSTERING KEY VALUES OF ACADEMIC INTEGRITY THROUGH THE EDUCATIONAL PROCESS AT POLTAVA STATE MEDICAL UNIVERSITY","authors":"T.O. Petrushanko, O.M. Boychenko, T.D. Bublii","doi":"10.31718/2077-1096.24.2.241","DOIUrl":"https://doi.org/10.31718/2077-1096.24.2.241","url":null,"abstract":"Academic integrity serves as the cornerstone of an individual's moral character and their approach to scholarly endeavors. It reflects the moral values that students bring with them to higher education institutions, aiming to enhance and refine them throughout their academic journey and beyond. This article aims to explore the principles underlying the development of academic integrity among teachers, lecturers, and its implementation in the scholarly and educational activities of higher education institutions. Lecturers serve as the primary examples of academic integrity for students. Their commitment to ethical standards, honesty, and openness in discussing ethical issues can influence students and serve as a model for their behavior. At Poltava State Medical University (PSMU), a repository has been established as a platform for showcasing teachers' scientific achievements, publications, research, and other academic accomplishments. Additionally, a bioethics commission oversees adherence to data collection and processing rules, animal experimentation, and the use of new technologies, fostering a conducive atmosphere in line with the ethical standards of academic integrity at PSMU. The patent department at PSMU oversees research ethics, citation rules, and plagiarism prevention, providing educational support, consultation, and assistance in developing intellectual property standards. The university's website offers online resources that encourage teachers to take greater responsibility for their actions and achievements. By making achievements publicly accessible, PSMU promotes adherence to ethical and quality standards among faculty members. Thus, fostering a virtuous academic environment requires a comprehensive approach that includes proper regulatory and legal frameworks, as well as organizational and preventive-educational measures. Establishing an educational environment based on academic integrity for future professionals enables high-quality outcomes, thereby shaping competitive specialists in the global market of social services.","PeriodicalId":24028,"journal":{"name":"Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії","volume":"94 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141123100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}