IMPACT OF QUERCETIN ON PATHOMORPHOLOGICAL CHARACTERISTICS OF MANDIBULAR BONE IN RATS FOLLOWING ITS FRACTURE UNDER CHRONIC ALCOHOL INTOXICATION

Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії Pub Date : 2024-05-20 DOI:10.31718/2077-1096.24.2.120

K.I. Nestulia, I.I. Starchenko, V.O. Kostenko

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Abstract

This study aims at investigating the impact of water-soluble form of quercetin on the pathomorphological characteristics of the mandibular bone in rats following its incomplete fracture under chronic alcohol intoxication was investigated. Fourteen white male Wistar rats weighing 190-240 g were randomly divided into two groups: Group 1 comprised rats with incomplete mandibular fractures under chronic alcohol intoxication; animals in Group 2 received daily intraperitoneal injections of water-soluble quercetin (corvitin) in a dose of 10 mg/kg of quercetin for 14 days following the injury induction. It has been shown that chronic alcohol intoxication hinders reparative regeneration of bone tissue after an incomplete mandibular fracture, and is accompanied by a decrease in the relative amount of reticulofibrous bone tissue and fibroblastic cellular elements at the injury site, especially mature fibroblasts, as well as by delayed maturation of granulation tissue. Under experimental conditions, quercetin administration significantly contributed to normalizing the regenerative process by the 14th day of the posttraumatic period. This normalization was evidenced by increased relative amounts of reticulofibrous bone tissue, prevalence of fibroblastic cells in granulation tissue, and accelerated formation of the regenerate blood microcirculatory channel.

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槲皮素对慢性酒精中毒大鼠下颌骨骨折后病理形态特征的影响

本研究旨在探讨水溶性槲皮素对慢性酒精中毒大鼠下颌骨不完全骨折后病理形态特征的影响。将 14 只体重为 190-240 克的白色雄性 Wistar 大鼠随机分为两组：第 1 组为慢性酒精中毒下颌骨不完全骨折的大鼠；第 2 组动物在诱导损伤后 14 天内每天腹腔注射水溶性槲皮素（山茱萸素），剂量为 10 毫克/千克槲皮素。研究表明，慢性酒精中毒会阻碍下颌骨不完全骨折后骨组织的修复性再生，并伴随着损伤部位网状纤维骨组织和成纤维细胞元素（尤其是成熟的成纤维细胞）相对数量的减少，以及肉芽组织成熟的延迟。在实验条件下，到创伤后第 14 天，服用槲皮素可显著促进再生过程的正常化。这种正常化表现在网状纤维骨组织相对数量的增加、肉芽组织中成纤维细胞的普遍存在以及再生血液微循环通道的加速形成。

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Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії

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