Zhonghua yi xue za zhi最新文献

{"title":"[Prone positioning during venovenous extracorporeal membrane oxygenation: challenges and value].","authors":"R Wang, L N Si, B Sun, G F Gan","doi":"10.3760/cma.j.cn112137-20250331-00771","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250331-00771","url":null,"abstract":"<p><p>The routine use of prone positioning during venovenous extracorporeal membrane oxygenation (VV-ECMO) remains controversial. While observational studies suggest a potential survival benefit in patients with acute respiratory distress syndrome (ARDS) supported by VV-ECMO, the recent negative findings from the PRONECMO trial have prompted renewed scrutiny of its clinical value. This article summarizes current evidence, examines the challenges and potential benefits of prone positioning during VV-ECMO, interpretates the negative results from the PRONECMO trial, and emphasizes the need for future studies to refine implementation strategies and evaluate its efficacy in different patient subgroups, with the goal of guiding more precise clinical decision-making.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2814-2819"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics analysis of patients with IgD type systemic light chain amyloidosis].","authors":"G X Duan, L Wen, N Peng, Y Liu, X L Dou, X L Sun, J Lu","doi":"10.3760/cma.j.cn112137-20250218-00384","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250218-00384","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the clinical characteristics of patients with IgD type systemic light chain (AL) amyloidosis. <b>Methods:</b> The patients diagnosed with IgD-type AL amyloidosis at Peking University People's Hospital and the First Affiliated Hospital of Dalian Medical University from June 2013 to April 2023 (IgD group) were retrospectively included. These patients were matched with non-IgD type AL amyloidosis patients using a 1∶4 propensity score (non-IgD group). The general clinical data of the patients (age, gender, the type of light chain, results of relevant examinations and so on), treatment planss, and efficacy were collected (the corresponding sample size was reduced due to the fact that some patients did not undergo relevant examinations or lost testing data). Follow-up was conducted until August 2024 to compare the clinical characteristics of the both groups of patients. <b>Results:</b> A total of 45 patients were included in the study. The IgD group was comprised of 9 patients, with 6 males and 3 females, and an average age of (58±12) years. The non-IgD group consisted of 36 patients, including 24 males and 12 females, with an average age of (58±10) years. The overall median follow-up time [<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)]was 58 (31, 84) months. In the IgD group, one patient had Kappa type while the remaining were Lambda type; seven cases involved kidney, and 6 cases involved heart. Two patients in IgD group had p53 deletion, but there was no p53 deletion in non-IgD group. The rate of soft tissue involvement [55.6% (5/9) vs 13.9% (5/36), <i>P</i>=0.025] and the level of free light chain difference (dFLC) (2 424 vs 140 mg/L, <i>P</i>=0.002) in the IgD group were higher than those in the non IgD group. Hemoglobin levels were lower in the IgD group [(102.3±24.0) vs (128.4±22.1) g/L, <i>P</i>=0.003], as well as lactate dehydrogenase [(190.1±26.0) vs (236.1±62.8) U/L, <i>P</i>=0.002]. A total of 8 patients in the IgD group received first-line treatment, among which 7 achieved hematological remission. Three patients in the IgD group and 5 patients in the non-IgD group died. <b>Conclusions:</b> The incidence rate for soft tissue involvement and dFLC level of the patients with IgD-type AL amyloidosis are higher in the IgD group. Conversely, hemoglobin levels and lactate dehydrogenase are lower.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2852-2858"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features of acute B lymphoblastic leukemia with TAF15::ZNF384 fusion gene].","authors":"Z Wang, X L Ma, F Wang, Y Zhang, L L Yuan, P X Cao, Y C Tan, X Chen, J Q Chen, J C Fang, H X Liu","doi":"10.3760/cma.j.cn112137-20250220-00407","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250220-00407","url":null,"abstract":"<p><p>A retrospective analysis was conducted on the clinical data of acute B lymphoblastic leukemia (B-ALL) patients with TAF15::ZNF384 fusion gene positive at Hebei Yanda Ludaopei Hospital from December 2018 to February 2022. The patients were followed up until December 2024 to analyze their clinical characteristics and outcomes. A total of 6 patients were included, including 4 males and 2 females, aged 16 to 47 years. The follow-up period ranged from 10 days to 65 months. All 6 patients sought medical attention due to incomplete remission (CR) after treatment at an external hospital or short-term recurrence after CR. Five of the 6 patients presented with chromosomal abnormalities at initial diagnosis, including 4 with t(12;17) (p13;q12) chromosomal translocation. Immunophenotyping showed the B lymphatic system markers CD19, CD22, and cytoplasmic CD79a were positive in all cases, accompanied by positive myeloid markers such as CD33 or CD31. Four patients showd positive expression of the lymphoid maker CD10. Among the 6 patients, 4 patients achieved CR after receiving chimeric antigen receptor T-cell (CAR-T) therapy, and maintained CR after bridging allogeneic hematopoietic stem cell transplantation (allo-HSCT). B-ALL patients harboring the TAF15::ZNF384 fusion gene often present with complex chromosomal abnormalities at the initial diagnosis and the immunophenotype is often characterized by B lymphatic system with positive myeloid markers. CAR-T immunotherapy followed by allo-HSCT may offer a promising approach to improving their prognosis.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2883-2886"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A diagnostic model establishment of adult gastroesophageal reflux disease based on high-resolution manometry parameters of the esophagus].","authors":"S W Hu, W J Xiong, T Yu, Y Jiang, Y R Tang","doi":"10.3760/cma.j.cn112137-20250310-00578","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250310-00578","url":null,"abstract":"<p><p><b>Objective:</b> To establish a diagnostic model for adult gastroesophageal reflux disease (GERD) based on the high-resolution manometry (HRM) parameters of the esophagus. <b>Methods:</b> The clinical data of patients who underwent HRM and 24-hour esophageal pH+impedance examination due to suspected GERD at Jiangsu Province Hospital from January 2021 to October 2024 were retrospectively collected. According to the diagnostic criteria and examination results of GERD, the patients were divided into the GERD group [acid exposure time percentage (AET)>4.2% or total reflux times>80 times] and the non-GERD group, and the HRM parameters of the two groups were compared. Patients were randomly divided into the training set and the validation set in a ratio of 7∶3 using R 4.4. The Youden index maximization method was used to determine the optimal diagnostic cut-off value of a single HRM parameter for diagnosing GERD. The multivariate logistic regression model was used to analyze and screen the influencing factors for diagnosing GERD, and the nomogram of the GERD diagnostic model was drawn. The diagnostic ability and accuracy of the model were evaluated respectively by the area under the receiver operating characteristic curve (AUC) and the calibration curve. Finally, the clinical applicability of the model was determined by the decision curve analysis (DCA). <b>Results:</b> A total of 326 patients were included, among which 77 were in the GERD group, including 48 males and 29 females, with an age of [<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)] 57 (42, 64) years. There were 249 cases in the non-GERD group, including 90 males and 159 females, with an age of 53 (42, 59) years. The age, proportion of males, body mass index (BMI), proportion of cases classified by gastroesophageal junction (EGJ), proportion of cases with ineffective esophageal motility (IEM), and proportion of ineffective swallowing times in the GERD group were all higher than those in the non-GERD group. The gastroesophageal junction contraction index (EGJ-CI), the resting pressure of the lower esophageal sphincter (LESP), and the distal contraction score (DCI) were all lower than those in the non-GERD group (all <i>P<</i>0.05).The HHRM related parameters for diagnosing GERD were EGJ-CI, LESP, DCI, the proportion of ineffective swallowing times and failed peristalsis times. The corresponding optimal cut-off values (sensitivity and specificity) were 23 mmHg·cm (1 mmHg=0.133 kPa) (48%, 86%), 13.4 mmHg (81%, 59%), 1 130 mmHg·s·cm (66%, 60%), 0.15 (53%, 66%), 0.35 (24%, 89%), respectively. The results of the multivariate logistic regression model analysis showed that gender (<i>OR=</i>3.82, 95<i>%CI</i>: 1.69-8.61), BMI (<i>OR=</i>1.28, 95<i>%CI</i>: 1.12-1.46), and EGJ-CI (<i>OR=</i>0.95, 95<i>%CI</i>: 0.92-0.97), EGJ classification type Ⅲ EGJ (<i>OR=</i>6.66, 95<i>%CI</i>: 1.51-29.40), and IEM (<i>OR=</i>6.69, 95<i>%CI</i>: 1.27-35.27) were the influencing factors for the diagn","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2866-2873"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research on risk prediction of acute respiratory distress syndrome complicated with acute kidney injury: progress and challenges].","authors":"Z K Deng, S C Liu, Y M Li, L Sang","doi":"10.3760/cma.j.cn112137-20250424-01024","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250424-01024","url":null,"abstract":"<p><p>The risk of acute respiratory distress syndrome (ARDS) combined with acute kidney injury (AKI) is high and the prognosis is poor. Therefore, there is an urgent need for efficient and accurate methods to improve clinical doctors' early diagnosis and prognosis judgment of this comorbidity state. This article will review the research progress on risk prediction methods for ARDS combined with AKI, providing reference for clinical treatment and scientific research design. The clinical scoring system based on statistical methods can identify key predictive factors and is easy to implement, but it generally relies on single time point data, cannot capture dynamic changes, and lacks adaptability in complex clinical scenarios. The development of key biomarkers provides effective tools for clinical practice, but most of them are still in the validation stage, and standardization and cost-effectiveness issues need to be addressed. In recent years, artificial intelligence has shown outstanding performance in assisting clinical doctors in risk warning for critically ill patients. It can integrate multimodal data and has higher predictive efficiency than traditional methods. It has begun to be deployed and implemented in clinical practice, but multiple issues such as data standardization and model generalization still need to be addressed.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2820-2826"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and risk factors for mortality in perioperative cardiac arrest patients].","authors":"Y Song, J H Wang, H Zhang, C Xu, Y C Xu, Q B Ma","doi":"10.3760/cma.j.cn112137-20250103-00027","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250103-00027","url":null,"abstract":"<p><p><b>Objective:</b> To summarize the clinical characteristics and explore the risk factors for in-hospital mortality in patients experiencing perioperative cardiac arrest (PCA). <b>Methods:</b> This study retrospectively analyzed the clinical data of patients who experienced PCA at Peking University Third Hospital from January 1, 2012, to June 30, 2022. Patients were classified into survival and non-survival groups based on their discharge outcome. Demographic characteristics, surgical information, anesthesia methods, and postoperative complications were compared between the two groups. Furthermore, a multivariable logistic regression model was employed to identify independent predictors for in-hospital mortality in PCA patients. <b>Results:</b> This study included a total of 225 PCA patient (152 males and 73 females), with a mean age of (60.0±17.0) years. Among them, 190 patients (84.4%) died in-hospital and 35 (15.6%) patients survived to discharge. Patients in the survivor group were significantly younger than those in the non-survivor group[(53.5±16.4) vs (61.2±16.9) years, <i>P</i>=0.015], and had a lower incidence of postoperative major adverse cardiovascular events (MACE) [11.4%(4/35) vs 56.8%(108/190), <i>P</i><0.001], acute kidney injury [0 vs 16.0%(30/190), <i>P</i>=0.006], acute liver injury [0 vs 12.6%(24/190),<i>P</i>=0.031]. Even after adjusting for key clinical variables including age, sex, diabetes mellitus, duration of cardiopulmonary resuscitation, and the use of norepinephrine and dopamine for resuscitation, multivariable logistic regression analysis indicated that postoperative MACE remained an risk factor for in-hospital mortality in PCA patients (<i>OR</i>=12.18, 95%<i>CI</i>: 2.62-56.64, <i>P</i>=0.001). <b>Conclusions:</b> This study demonstrates a high in-hospital mortality rate among patients experiencing perioperative cardiac arrest, survivors are typically younger and experienced a lower incidence of postoperative complications. Postoperative MACE is identified as an independent predictor of in-hospital mortality in PCA patients.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2859-2865"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and prognosis of immune checkpoint inhibitor-associated myasthenia gravis].","authors":"Q Meng, M F Zhu, Z Huang, X D Hao, Z Y Sun, L L Tan, P H Li, Y K Zhang, J W Zhang, Y Huang","doi":"10.3760/cma.j.cn112137-20250124-00205","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250124-00205","url":null,"abstract":"<p><p>The clinical data and follow-up outcomes of 9 patients diagnosed with immune checkpoint inhibitor (ICI)-associated myasthenia gravis (MG) admitted to Henan Provincial People's Hospital from January 2021 to October 2024 were collected retrospectively to analyze their clinical characteristics and prognosis. Nine patients were enrolled, including 4 males and 5 females, aged [<i>M</i> (<i>Q</i>₁, <i>Q</i>₃)] 69 (55, 77) years. All patients had tumors and had received ICI treatment. The time from the start of ICI treatment to the occurrence of MG symptoms or aggravation of the condition was 26 (20, 39) d. Seven patients were classified Myasthenia Gravis Foundation of America Clinical Classification (MGFA) Ⅲ-Ⅴ. All 9 patients had increased creatine kinase and transaminase. Troponin was measured in 5 patients, and all showed elevated levels. ICI therapy was discontinued in all patients at the onset or exacerbation of MG symptoms, and they subsequently received immunomodulatory therapy with pyridostigmine combined with glucocorticoids and/or intravenous immunoglobulin. Symptoms improved in 7 patients and 2 patients showed poor therapeutic effect. The follow-up time was 12.0 (4.5, 16.5) months, and 2 patients died due to the progression of MG superimposed on underlying diseases at the end of the follow-up. ICI-related MG mostly occurs in the early stage of ICI treatment, and is characterized by severe symptoms, rapid progression, and easy complications with myositis/myocarditis. Active initiation of acetylcholinesterase inhibitors combined with immunotherapy can significantly improve outcomes.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 33","pages":"2874-2877"},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of suture ligation combined with pingyangmycin injection on pharyngolaryngeal cavernous hemangioma].","authors":"J K Ma, Z H Lyu, J J Tian, W Xu","doi":"10.3760/cma.j.cn112137-20250325-00726","DOIUrl":"https://doi.org/10.3760/cma.j.cn112137-20250325-00726","url":null,"abstract":"<p><p>This study investigated the efficacy of suture ligation combined with pingyangmycin injection in treating pharyngolaryngeal cavernous hemangioma. The clinical data of patients diagnosed with pharyngolaryngeal cavernous hemangioma in the Department of Otorhinolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital from January 2006 to June 2017 were retrospectively collected. A total of 45 patients (23 males and 22 females) aged 15-79 (47.7±6.4) years were included. All patients underwent suture ligation and injection of pingyangmycin under laryngoscopic guidance. Open surgical intervention was performed for tumors that extended into the neck. Among the 45 patients, complete regression was observed after a single treatment in 31 cases, while the remaining patients achieved full regression following two to three treatments. All patients were followed up for a minimum of 12 months after treatment, with a median follow-up duration of 18 (13-48) months. Notably, there were no reported functional disorders related to voice or swallowing. The current study indicates that combination of suture ligation and pingyangmycin injection not only enhances efficacy but also preserves the structural integrity and function of critical organsin patients with pharyngolaryngeal cavernous hemangioma.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 32","pages":"2776-2779"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current status and future prospects of antibacterial treatment for Carbapenem-resistant gram-negative bacterial infections in solid organ transplant recipients].","authors":"C R Ju, X Xu, X Xu, W J Xue","doi":"10.3760/cma.j.cn112137-20250218-00381","DOIUrl":"10.3760/cma.j.cn112137-20250218-00381","url":null,"abstract":"<p><p>In recent years, infections caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) and other multidrug-resistant (MDR) pathogens have posed significant challenges in solid organ transplantation (SOT). SOT recipients who develop CR-GNB infections face risks such as graft loss, respiratory failure, leading to a mortality rate exceeding 40%. This review examines the current resistance landscape and the characteristics of MDR infections in SOT recipients, discussing the epidemiological features of CR-GNB infections in SOT patients, the resistance profiles and mechanisms of common CR-GNB (e.g., Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa), and evidence-based principles and strategies for antimicrobial therapy. The article provides an in-depth analysis of the efficacy, pharmacokinetic/pharmacodynamic (PK/PD) properties, and adverse effects of both commonly used antibiotics (such as tigecycline, polymyxins, and ceftazidime/avibactam) and the novel agents (including eravacycline and sulbactam/durlobactam), emphasizing the importance of combination therapy and personalized treatment approaches. Additionally, it explores the clinical potential of emerging rapid diagnostic technologies (e.g., CRISPR/Cas systems, mass spectrometry) and innovative treatments such as phage therapy and immunomodulation. Looking ahead, the review envisions a future where, guided by rapid and precise diagnostics, multidisciplinary management can optimize antimicrobial regimens for MDR infections in transplant recipients. The goal is to achieve individualized, effective treatment strategies, thereby improving outcomes in severe infections and advancing the management of CR-GNB infections in SOT patients in China.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 32","pages":"2701-2708"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Expert consensus on the establishment and management of sleep clinics in medical institutions (2025 edition)].","authors":"","doi":"10.3760/cma.j.cn112137-20250427-01052","DOIUrl":"10.3760/cma.j.cn112137-20250427-01052","url":null,"abstract":"<p><p>Sleep health is a core element of public health. Sleep disorders are strongly linked to various chronic diseases, posing a serious threat to public health. Given the large number of individuals with sleep disorders in China, establishing professional and standardized sleep medicine centers is an essential requirement for advancing comprehensive sleep health management. The sleep clinic serves as the central hub of a sleep medicine center, undertaking critical functions such as initial patient screening, triage, and interdisciplinary coordination. This expert consensus writing group, incorporating opinions from specialists across relevant sleep medicine societies and associations, systematically proposes a framework and management requirements for the standardized development of sleep clinics. This expert consensus includes defining the scope of clinical services, establishing construction standards, and outlining personnel training and qualification certification. And it aims to establish a full life-cycle sleep health management network by standardizing development criteria, quality control processes, and resource allocation.</p>","PeriodicalId":24023,"journal":{"name":"Zhonghua yi xue za zhi","volume":"105 ","pages":"2709-2717"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}