Zhonghua nei ke za zhi最新文献

{"title":"[Management of hypertension in non-dialysis and dialysis patients with chronic kidney disease: Chinese expert consensus].","authors":"","doi":"10.3760/cma.j.cn112138-20220909-00670","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220909-00670","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a global public health problem that is usually progressive. Hypertension is a risk factor for the progression of CKD, and cardiovascular disease is the most common cause of death in patients with CKD. In Chinese patients with CKD, there is a high prevalence of hypertension and a poor rate of control. Several studies have demonstrated that effective blood pressure control can delay the progression of kidney disease and reduce the risk of cardiovascular events and all-cause mortality. Based on previously published high-quality evidence, guidelines and consensus reports, the Zhongguancun Nephropathy and Blood Purification Innovation Alliance formulated a new consensus. This consensus includes blood pressure measurement; the blood pressure management of non-dialysis patients, dialysis patients and kidney transplantation patients, and the interaction between commonly used drugs and antihypertensive drugs. The consensus aims to further strengthen the standardization and safety of blood pressure management in CKD patients, delay disease progression, reduce disease burden, and comprehensively improve the quality-of-life and prognosis of patients with CKD.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"748-774"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9779033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Autoimmune hemolysis as the initial manifestation in simultaneous pancreatic cancer and diffuse large B-cell lymphoma with hemophagocyticlymphohistocytosis:a case report].","authors":"C W Qi, Q Li, W Xiao, Z Y Luan","doi":"10.3760/cma.j.cn112138-20220624-00477","DOIUrl":"10.3760/cma.j.cn112138-20220624-00477","url":null,"abstract":"自身免疫性溶血性贫血和噬血细胞综合征常继发于病毒感染、血液系统恶性肿瘤及自身免疫病，特别是与B-淋巴瘤相关性噬血细胞综合征相比，T/NK-淋巴瘤相关性噬血细胞综合征发病率高、EB病毒颗粒检出率高，实体肿瘤合并自身免疫性溶血性贫血和噬血细胞综合征的报道也罕见。本文报道一例老年男性，入院时表现为自身免疫性溶血性贫血，给予糖皮质激素治疗，病情仍迅速进展，经病理证实同时患有小B淋巴细胞白血病和胰体部腺癌，并因反复黑便行肠镜及免疫组织化学（IHC）检查确诊为横结肠脾区EB病毒阳性弥漫大B细胞淋巴瘤，最终因消化道出血抢救无效。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"855-859"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protective effect of intervention with cannabinoid type-2 receptor agonist JWH133 on pulmonary fibrosis in mice].","authors":"X Wu,&nbsp;W T Yang,&nbsp;Y J Cheng,&nbsp;L Pan,&nbsp;Y Q Zhang,&nbsp;H L Zhu,&nbsp;M L Zhang","doi":"10.3760/cma.j.cn112138-20220907-00663","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220907-00663","url":null,"abstract":"<p><p><b>Objective:</b> JWH133, a cannabinoid type 2 receptor agonist, was tested for its ability to protect mice from bleomycin-induced pulmonary fibrosis. <b>Methods:</b> By using a random number generator, 24 C57BL/6J male mice were randomly divided into the control group, model group, JWH133 intervention group, and JWH133+a cannabinoid type-2 receptor antagonist (AM630) inhibitor group, with 6 mice in each group. A mouse pulmonary fibrosis model was established by tracheal instillation of bleomycin (5 mg/kg). Starting from the first day after modeling, the control group mice were intraperitoneally injected with 0.1 ml of 0.9% sodium chloride solution, and the model group mice were intraperitoneally injected with 0.1 ml of 0.9% sodium chloride solution. The JWH133 intervention group mice were intraperitoneally injected with 0.1 ml of JWH133 (2.5 mg/kg, dissolved in physiological saline), and the JWH133+AM630 antagonistic group mice were intraperitoneally injected with 0.1 ml of JWH133 (2.5 mg/kg) and AM630 (2.5 mg/kg). After 28 days, all mice were killed; the lung tissue was obtained, pathological changes were observed, and alveolar inflammation scores and Ashcroft scores were calculated. The content of type Ⅰ collagen in the lung tissue of the four groups of mice was measured using immunohistochemistry. The levels of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in the serum of the four groups of mice were measured using enzyme-linked immunosorbent assay (ELISA), and the content of hydroxyproline (HYP) in the lung tissue of the four groups of mice was measured. Western blotting was used to measure the protein expression levels of type Ⅲ collagen, α-smooth muscle actin (α-SMA), extracellular signal regulated kinase (ERK1/2), phosphorylated P-ERK1/2 (P-ERK1/2), and phosphorylated ribosome S6 kinase type 1 (P-p90RSK) in the lung tissue of mice in the four groups. Real-time quantitative polymerase chain reaction was used to measure the expression levels of collagen Ⅰ, collagen Ⅲ, and α-SMA mRNA in the lung tissue of the four groups of mice. <b>Results:</b> Compared with the control group, the pathological changes in the lung tissue of the model group mice worsened, with an increase in alveolar inflammation score (3.833±0.408 vs. 0.833±0.408, <i>P</i><0.05), an increase in Ashcroft score (7.333±0.516 vs. 2.000±0.633, <i>P</i><0.05), an increase in type Ⅰ collagen absorbance value (0.065±0.008 vs. 0.018±0.006, <i>P</i><0.05), an increase in inflammatory cell infiltration, and an increase in hydroxyproline levels [(1.551±0.051) μg/mg vs. (0.974±0.060) μg/mg, <i>P</i><0.05]. Compared with the model group, the JWH133 intervention group showed reduced pathological changes in lung tissue, decreased alveolar inflammation score (1.833±0.408, <i>P</i><0.05), decreased Ashcroft score (4.167±0.753, <i>P</i><0.05), decreased type Ⅰ collagen absorbance value (0.032±0.004, <i>P</i><0.05), reduced inflammatory cell infiltration, and decreased hydroxyp","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"841-849"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Recommendations for diagnosis and treatment of systemic lupus erythematosus].","authors":"N Shen,&nbsp;Y Zhao,&nbsp;L H Duan,&nbsp;L J Song,&nbsp;X F Zeng,&nbsp;Y Liu,&nbsp;Y Zhao","doi":"10.3760/cma.j.cn112138-20221027-00793","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221027-00793","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with complicated pathogenesis and diverse clinical manifestations. The current recommendations of the Chinese Rheumatology Association are based on a comprehensive investigation of evidence based medicine, domestic and international guidelines for SLE, and experts' proposals, and aim to provide a more scientific and authoritative reference for the diagnosis and management of SLE. The recommendations focus on four aspects; clinical manifestations, laboratory evaluation, diagnosis and disease assessment, and disease treatment and monitoring. The goal of the recommendations is to standardize the diagnosis and treatment of SLE in China so as to improve the prognosis of SLE patients.</p>","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"775-784"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress of arginine vasopressin V2 receptor antagonist tolvaptan in the treatment of cirrhotic ascites].","authors":"Y Y Hu,&nbsp;X Zhang,&nbsp;Y D Wang,&nbsp;C Y Zhao","doi":"10.3760/cma.j.cn112138-20220630-00488","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20220630-00488","url":null,"abstract":"腹水是肝硬化常见且增加死亡风险的重要并发症之一。精氨酸加压素（AVP）V2受体拮抗剂托伐普坦（TLV）作为肝硬化腹水治疗的新型药物选择，尤其适合合并低钠血症患者，其作用疗效及安全性评价在多项研究中确立。但也有最新证据显示肝硬化合并难治性腹水患者使用TLV获益有限。本文将对TLV治疗肝硬化合并腹水的作用机制、疗效与安全性及应用策略进行综述，以期规范其在肝硬化合并腹水患者中的合理应用。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"881-884"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Two cases of EB virus-positive diffuse large B-cell lymphoma with HAVCR2 mutation].","authors":"X Q Nie,&nbsp;C F Huang,&nbsp;Z Yin,&nbsp;Y Yang,&nbsp;X Zhou,&nbsp;D Fang,&nbsp;R Cao,&nbsp;Q F Liu,&nbsp;R Lin,&nbsp;Y J Deng,&nbsp;G P Yu","doi":"10.3760/cma.j.cn112138-20221018-00764","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20221018-00764","url":null,"abstract":"报道2例EB病毒（EBV）阳性弥漫性大B细胞淋巴瘤（DLBCL）伴HAVCR2突变患者。2例患者均无免疫缺陷病史，发病后均出现机会性感染，外周血T细胞绝对计数明显减少，T细胞和肿瘤组织高表达T细胞免疫球蛋白和黏蛋白结构域-3（TIM-3）；二代测序检出甲型肝炎病毒细胞受体2（HAVCR2）基因突变。1例患者接受了R-COP方案（利妥昔单抗、环磷酰胺、长春新碱、泼尼松）治疗效果欠佳，T细胞计数和功能未恢复，EBV未清除，总生存仅为7个月；另一例患者接受程序性死亡受体1（PD-1）抑制剂联合CHOP样方案（环磷酰胺、表柔比星、长春新碱、地塞米松）治疗获得完全缓解持续时间超过6个月，T细胞计数和功能恢复正常，EBV被清除。结合文献复习提示HAVCR2突变导致TIM-3过表达继发T细胞耗竭，获得性免疫缺陷导致EBV再激活可能与EBV阳性DLBCL的发生、发展密切相关；提示尽早使用免疫检查点抑制剂恢复免疫功能可能改善疗效。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"863-866"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of spontaneous nystagmus and the frequency characteristics of affected semicircular canals in patients with vestibular neuritis].","authors":"H L Wang,&nbsp;L L Si,&nbsp;Y N Yan,&nbsp;H X Sun,&nbsp;Z D Li,&nbsp;X Y Li","doi":"10.3760/cma.j.cn112138-20230130-00041","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20230130-00041","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the spontaneous nystagmus (SN) and the frequency characteristics of affected semicircular canals in patients with vestibular neuritis (VN). <b>Methods:</b> This is a cross-sectional study. A total of 61 patients with VN admitted to the Department of Neurology of Shanxi Bethune Hospital from June 2020 to October 2021, 39 were male and 22 were female, with a mean age of (46±13) years old and male to female ratio of 1.77∶1. According to SN characteristics, 61 patients were divided into non-nystagmus group(nSN), horizontal nystagmus group(hSN) and horizontal-torsional nystagmus group (htSN). Clinical data were collected, and SN, unilateral weakness (UW), directional preponderance (DP), and video head impulse test (vHIT) gain were used as observation indicators. Statistical analysis by SPSS23.0 software. Normal distributed quantitative data (age, semicircular canal gain, SN intensity) were expressed by x¯±s, non-normal distributed quantitative data (disease course, UW, DP) were expressed by <i>M</i>(<i>Q</i>₁,<i>Q</i>₃), qualitative data were expressed by rate and composition ratio, difference analysis by one-way ANOVA, rank sum test, Chi-square test or Fisher's exact probability method, considered by <i>P</i> value<0.05. <b>Results:</b> (1)The disease course of nSN, hSN and htSN was 7.0 (4.0, 12.5), 6.0 (3.5, 11.5), and 3.0 (2.0, 6.5) days respectively, and there were statistical differences (χ2=7.31,<i>P</i>=0.026).(2)The horizontal nystagmus intensity of htSN was (16.8±8.6)°/s, which was significantly higher than that of (9.8±4.7)°/s in hSN (<i>t</i>=3.71, <i>P</i><0.001). There was no significant difference in the positive rate of UW between the three groups (<i>P</i>=0.690), and there was a significant difference in the positive rate of DP in the three groups (χ2=12.23, <i>P</i>=0.002). The horizontal nystagmor intensity in the htSN was positively correlated with the vertical nystagmus intensity (<i>r</i>=0.59, <i>P</i>=0.001).(3)The gain of the affected horizontal canal of the three groups was statistically different (<i>F</i>=8.28, <i>P</i>=0.001), and the gain of the horizontal canal of hSN and htSN was significantly lower than that of nSN (<i>t</i>=2.74, <i>P</i>=0.008; <i>t</i>=4.05, <i>P</i><0.001); The gain of the affected anterior canal in the three groups was statistically different (<i>F</i>=5.32, <i>P</i>=0.008). The gain of the anterior canal in both nSN and hSN was significantly higher than that in htSN (<i>t</i>=3.09, <i>P</i>=0.003; <i>t</i>=2.15, <i>P</i>=0.036). The horizontal canal gain of htSN is positively correlated with the anterior canal gain (<i>r</i>=0.74, <i>P</i><0.001).(4)The affected semicircular canals in the two groups with no-vertical-component nystagmus (nSN and hSN) and the htSN were counted. The composition ratio of the affected semicircular canals in the two groups was different (χ2=8.34, <i>P</i>=0.015). <b>Conclusion:</b> The occurrence of SN in pat","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"814-818"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9800295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The changes in definition and diagnosis of vestibular syndrome and related diseases].","authors":"X K Qi,&nbsp;Y X Zheng","doi":"10.3760/cma.j.cn112138-20230204-00056","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20230204-00056","url":null,"abstract":"以头晕和/或眩晕表现为主的前庭综合征及其相关疾病的概念及诊断标准近些年有较大更新，如良性阵发性位置性眩晕、前庭性偏头痛、脑小血管病、持续性姿势-知觉性头晕等。因此，在前庭综合征或前庭疾病临床实践中必须不断更新概念，掌握标准和诊断操作路径。基于此，本文进一步简述前庭综合征概念的变化，结合临床实践归纳成表格化式的前庭综合征病因分类，并对不同年龄阶段的前庭疾病诊断思路加以梳理，对发作性前庭综合征常见疾病给予推荐的诊断流程图，并且对常见前庭综合征相关疾病诊断当中容易困惑的临床症候和需要注意的鉴别诊断要点加以阐释，以便相关学科及各级医师掌握，更好地对以头晕和/或眩晕表现为主的前庭综合征相关疾病进行鉴别诊断。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"737-742"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical characteristics and management in different stages of vestibular neuritis].","authors":"J H Zhuang","doi":"10.3760/cma.j.cn112138-20230207-00063","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20230207-00063","url":null,"abstract":"前庭神经炎（VN）是一侧外周前庭功能急性损害后，患者临床主要表现为急性、严重、持续性眩晕和不稳的一种急性前庭综合征。症状持续超过24 h，无听力下降和无其他局灶神经症状，体格检查显示单向水平略扭转自发眼震，眼震快相指向健侧，床旁甩头试验向患侧快速甩头时见纠正性扫视，姿势不稳易向自发眼震慢相侧倾倒。临床可将VN分为3期，2周内为急性期，2周至3个月为亚急性期，3个月以上为慢性期，不同分期其临床特征和治疗各不相同，同时也代表不同的前庭代偿机制。急性期患者表现为前庭静态症状，VN诊断主要依据临床症状和体征，鉴别诊断重点排除小脑后下和小脑前下动脉梗死，治疗应使用激素，前庭代偿以适应为主。亚急性期患者表现为前庭动态症状，治疗以使用促进前庭代偿药物和前庭康复训练，前庭代偿以感觉替代和适应为主。一些患者在慢性期已完成前庭代偿，临床几乎无症状体征，部分患者由于代偿不全或形成新的多感觉整合，发展为持续性姿势感知性头晕，治疗包括解释、习服、认知-行为治疗和抗焦虑抑郁药。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 7","pages":"743-747"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of small GTP-binding protein GDP dissociation stimulator on adipocyte hypertrophy and glucose metabolism disorder in mice].","authors":"T Xiong,&nbsp;T Wang,&nbsp;X W Chen,&nbsp;Y X Yang,&nbsp;Z W Ma,&nbsp;B Y Zuo,&nbsp;D X Wang","doi":"10.3760/cma.j.cn112138-20230209-00072","DOIUrl":"https://doi.org/10.3760/cma.j.cn112138-20230209-00072","url":null,"abstract":"<p><p><b>Objective:</b> To explore the effect and mechanism of small GTP-binding protein GDP dissociation stimulator (SmgGDS) on the development of obesity. <b>Methods:</b> (1) 8-week-old C57BL/6J mice were randomly assigned to normal diet and high fat diet group, with 6 mice in each group. They were fed regular feed and a high fat diet containing 60% fat for 4 months, respectively. The expression of SmgGDS in epididymal adipose tissue (eWAT), liver, and skeletal muscle were measured using Western-blot. (2) 6-week-old wild-type (WT) and SmgGDS knockdown (KD) mice were divided into four groups, each receiving high fat diet for 4 months (7 in each group) and 7 months (9 in each group). Glucose tolerance test (GTT) and insulin tolerance test (ITT) were conducted; The weight, adipose tissue, and liver weight of mice were recorded; HE staining examined adipose tissue structural changes; Western-blot determined extracellular signal-regulated kinase (ERK) 1/2 phosphorylation levels in eWAT; Real time fluorescence quantitative polymerase chain reaction (RT-qPCR) was used to detect mRNA levels of CCAAT/enhancer binding protein α (C/EBPα), C/EBPβ and peroxisome proliferator activated receptor γ (PPARγ) in eWAT. (3) Mouse embryonic fibroblasts (MEFs) extracted from WT and KD mice were induced for differentiation. Oil red O staining and Western-blot were used to detect lipid droplet and expression of SmgGDS and phospho-ERK; C/EBPα, C/EBPβ and PPARγ mRNA levels were measured using RT-qPCR. (4) 10-week-old C57BL/6J mice were randomly assigned into two groups, with 7 mice in each group. Mice were infected with SmgGDS overexpressing adeno-associated virus (AAV-SmgGDS) or empty vector intraperitoneally, then fed with high fat diet. After 4 weeks, performed GTT and ITT; Recorded the weight and adipose tissue weight of mice; HE staining was used to analyze structural changes of eWAT; Western-blot was used to detect the phosphorylation level of ERK in eWAT. <b>Results:</b> (1) The expression of SmgGDS was significantly upregulated in eWAT of high fat diet fed mice (normal diet group: 0.218±0.037, high fat diet group:0.439±0.072, <i>t</i>=2.74, <i>P</i>=0.034). (2) At 4 months of high fat diet intervention, the glucose tolerance (60 minutes after glucose injection, WT group: 528 mg/dl±21 mg/dl, KD group: 435 mg/dl±17 mg/dl, <i>t</i>=3.47, <i>P</i>=0.030; 90 minutes, WT group: 463 mg/dl±24 mg/dl, KD group: 366 mg/dl±18 mg/dl, <i>t</i>=3.23, <i>P</i>=0.047;120 minutes, WT group: 416 mg/dl±21 mg/dl, KD group: 297 mg/dl±16 mg/dl, <i>t</i>=4.49, <i>P</i>=0.005) and insulin sensitivity (15 minutes after insulin injection, WT group: 77.79%±3.45%, KD group: 54.30%±2.92%, <i>t</i>=3.49, <i>P</i>=0.005; 30 minutes, WT group: 62.27%±5.31%, KD group: 42.25%±1.85%, <i>t</i>=2.978, <i>P</i>=0.024; 90 minutes, WT group: 85.69%±6.63%, KD group: 64.71%±5.41%, <i>t</i>=3.120, <i>P</i>=0.016) of KD mice were significantly improved compared to the WT group, with an increase in eWAT weig","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 ","pages":"833-840"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9598942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}