【前庭神经炎患者自发性眼球震颤及受累半规管频率特征分析】。

H L Wang, L L Si, Y N Yan, H X Sun, Z D Li, X Y Li
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引用次数: 0

摘要

目的:探讨前庭神经炎(VN)患者自发性眼球震颤(SN)及受损伤半规管的频率特征。方法:这是一个横断面研究。山西省白求恩医院神经内科2020年6月至2021年10月收治的VN患者61例,男39例,女22例,平均年龄(46±13)岁,男女比例为1.77∶1。根据眼球震颤特征将61例患者分为非眼球震颤组(nSN)、水平型眼球震颤组(hSN)和水平扭转型眼球震颤组(htSN)。收集临床资料,以SN、单侧虚弱(UW)、定向优势(DP)、视频头脉冲测试(vHIT)增益作为观察指标。采用SPSS23.0软件进行统计分析。正态分布的定量资料(年龄、半规管增益、SN强度)用x¯±s表示,非正态分布的定量资料(病程、UW、DP)用M(Q1、Q3)表示,定性资料用率和构成比表示,差异分析采用单因素方差分析、秩和检验、卡方检验或Fisher精确概率法,P值考虑。(1) nSN、hSN、htSN病程分别为7.0(4.0、12.5)、6.0(3.5、11.5)、3.0(2.0、6.5)d,差异有统计学意义(χ2=7.31,P=0.026)。(2)htSN水平眼震强度为(16.8±8.6)°/s,显著高于hSN水平眼震强度(9.8±4.7)°/s (t=3.71, PP=0.690),三组间DP阳性率差异有统计学意义(χ2=12.23, P=0.002)。htSN患者水平眼震强度与垂直眼震强度呈正相关(r=0.59, P=0.001)。(3)三组患者受影响的水平眼震增益有统计学差异(F=8.28, P=0.001), hSN和htSN患者水平眼震增益显著低于nSN患者(t=2.74, P=0.008;t=4.05, PF=5.32, P=0.008)。nSN和hSN的前管增益均显著高于htSN (t=3.09, P=0.003;t = 2.15, P = 0.036)。htSN水平管增益与前管增益呈正相关(r=0.74, PP=0.015)。结论:VN患者SN的发生与病程、高低频率、受累半规管病情严重程度等因素有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Analysis of spontaneous nystagmus and the frequency characteristics of affected semicircular canals in patients with vestibular neuritis].

Objective: To investigate the spontaneous nystagmus (SN) and the frequency characteristics of affected semicircular canals in patients with vestibular neuritis (VN). Methods: This is a cross-sectional study. A total of 61 patients with VN admitted to the Department of Neurology of Shanxi Bethune Hospital from June 2020 to October 2021, 39 were male and 22 were female, with a mean age of (46±13) years old and male to female ratio of 1.77∶1. According to SN characteristics, 61 patients were divided into non-nystagmus group(nSN), horizontal nystagmus group(hSN) and horizontal-torsional nystagmus group (htSN). Clinical data were collected, and SN, unilateral weakness (UW), directional preponderance (DP), and video head impulse test (vHIT) gain were used as observation indicators. Statistical analysis by SPSS23.0 software. Normal distributed quantitative data (age, semicircular canal gain, SN intensity) were expressed by x¯±s, non-normal distributed quantitative data (disease course, UW, DP) were expressed by M(Q1,Q3), qualitative data were expressed by rate and composition ratio, difference analysis by one-way ANOVA, rank sum test, Chi-square test or Fisher's exact probability method, considered by P value<0.05. Results: (1)The disease course of nSN, hSN and htSN was 7.0 (4.0, 12.5), 6.0 (3.5, 11.5), and 3.0 (2.0, 6.5) days respectively, and there were statistical differences (χ2=7.31,P=0.026).(2)The horizontal nystagmus intensity of htSN was (16.8±8.6)°/s, which was significantly higher than that of (9.8±4.7)°/s in hSN (t=3.71, P<0.001). There was no significant difference in the positive rate of UW between the three groups (P=0.690), and there was a significant difference in the positive rate of DP in the three groups (χ2=12.23, P=0.002). The horizontal nystagmor intensity in the htSN was positively correlated with the vertical nystagmus intensity (r=0.59, P=0.001).(3)The gain of the affected horizontal canal of the three groups was statistically different (F=8.28, P=0.001), and the gain of the horizontal canal of hSN and htSN was significantly lower than that of nSN (t=2.74, P=0.008; t=4.05, P<0.001); The gain of the affected anterior canal in the three groups was statistically different (F=5.32, P=0.008). The gain of the anterior canal in both nSN and hSN was significantly higher than that in htSN (t=3.09, P=0.003; t=2.15, P=0.036). The horizontal canal gain of htSN is positively correlated with the anterior canal gain (r=0.74, P<0.001).(4)The affected semicircular canals in the two groups with no-vertical-component nystagmus (nSN and hSN) and the htSN were counted. The composition ratio of the affected semicircular canals in the two groups was different (χ2=8.34, P=0.015). Conclusion: The occurrence of SN in patients with VN is related to many factors, such as the disease course, low and high frequencies, and the severity of the condition in the affected semicircular canal.

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