Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue最新文献

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[Changes in cardiac specific microRNA-208a level in peripheral blood in ST segment elevation acute myocardial infarction patients]. ST段抬高急性心肌梗死患者外周血心脏特异性microRNA-208a水平的变化[j]。
Yi Yao, Xian Zhou, Xiao-bin Wang, Xiao-xia Duan, Chun-xiang Zhang, Xiao-ling Shi, Zhuang Chen, Zhong-cai Fan
{"title":"[Changes in cardiac specific microRNA-208a level in peripheral blood in ST segment elevation acute myocardial infarction patients].","authors":"Yi Yao,&nbsp;Xian Zhou,&nbsp;Xiao-bin Wang,&nbsp;Xiao-xia Duan,&nbsp;Chun-xiang Zhang,&nbsp;Xiao-ling Shi,&nbsp;Zhuang Chen,&nbsp;Zhong-cai Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To observe serum cardiac specific microRNA-208a (miR-208a) levels in ST segment elevation acute myocardial infarction (STEAMI) patients, and to explore the role of serum miR-208a levels in the diagnosis of STEAMI.</p><p><strong>Methods: </strong>The serum miR-208a concentrations were assessed within 12 hours after STEAMI, while 30 healthy individuals as control. Serum miR-208a concentrations were measured with real-time quantity reverse transcription-polymerase chain reaction (qRT-PCR), and serum cardiac troponin I (cTnI) or MB isoenzyme of creatine kinase (CK-MB) concentrations were measured with enzyme linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>The contents of serum cTnI or CK-MB in STEAMI patients were significantly higher than those in healthy individuals (cTnI: 17.72±8.43 μg/L vs. 0.05±0.01 μg/L, CK-MB: 250.83±177.26 μg/L vs. 71.20±20.50 μg/L, both P<0.01). Serum miR-208a concentrations were detected in all individuals with STEAMI within 60 PCR cycle (0-6 hours: 44.95±4.77, 6-12 hours: 43.98±4.68), but were beyond detection for all individuals in the healthy control group. The serum miR-208a relative levels in STEAMI patients were at least more than 215 fold than that in healthy persons, compared with qRT-PCR (Ct=60) of miR-208a in healthy control persons (P<0.01).</p><p><strong>Conclusion: </strong>Serum miR-208a may be a new biomarker the early diagnosis of STEAMI patients.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"717-20"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31064331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical characteristics of coronary artery disease patients with reduced left ventricular ejection fraction and their prognostic analysis]. 冠心病患者左室射血分数降低的临床特点及预后分析
Quan Li, Yue-chun Gao, Ji-qiang He, Teng-yong Jiang, Xue-jun Ren, Fang Chen
{"title":"[Clinical characteristics of coronary artery disease patients with reduced left ventricular ejection fraction and their prognostic analysis].","authors":"Quan Li,&nbsp;Yue-chun Gao,&nbsp;Ji-qiang He,&nbsp;Teng-yong Jiang,&nbsp;Xue-jun Ren,&nbsp;Fang Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the relationship between reduced left ventricular ejection fraction (LVEF) and characteristics of coronary artery disease (CAD) and investigate the association between reduced LVEF and cardiovascular prognosis.</p><p><strong>Methods: </strong>A total of 677 hospitalized patients with angiographic CAD were enrolled. All patients' clinical data were recorded. LVEF were measured, high sensitive C-reactive protein (hs-CRP), white blood cell (WBC) and classic cardiovascular risk factors were recorded after admission. All patients were followed up from admission. The primary end point was combination occurrence of major adverse cardiovascular and cerebral events (MACCE), including death, targeted vascular revascularization, non-fatal myocardial infarction and rehospitalization due to unstable angina or heart failure, transient ischemic attack or stroke.</p><p><strong>Results: </strong>All patients were tracked for (15±12) months, and patients were divided into normal LVEF group (LVEF≥0.50, n=585) and reduced LVEF group (LVEF<0.50, n=92) according to LVEF level. Compared with normal LVEF group, reduced LVEF group had more severe coronary stenosis (Gensini score: 62.85±41.45 vs. 47.68±33.26, P<0.05), a higher level of WBC and hs-CRP (WBC: 7.60±2.71 ×10(9)/L vs. 7.09±2.13 ×10(9)/L, hs-CRP: 5.68±3.97 mg/L vs. 3.97±3.75 mg/L, both P<0.05). A total of 146 MACCE occurred during follow-up periods. Compared with no-MACCE group, LVEF levels were significantly lower in MACCE group (0.576±0.113 vs. 0.603±0.101) and there were a higher level of hs-CRP and Gensini score in MACCE group (hs-CRP: 5.26±3.99 mg/L vs. 3.91±3.72 mg/L, Gensini score: 53.72±35.50 vs. 48.63±34.59, all P<0.05). Moreover, both of univariate and multivariate Cox regression analysis indicated LVEF be an independent predictor of MACCE in patients with CAD [univariate: relative risk (RR)=0.974, 95% confidence interval (95%CI) 0.960 to 0.988, P=0.000; multivariate: RR=0.979, 95%CI 0.961 to 0.998, P=0.033]. Kaplan-Meier analysis suggested that patients with reduced LVEF had an increased MACCE occurrence (χ(2)=14.56, P<0.05).</p><p><strong>Conclusion: </strong>LVEF level may be associated with coronary artery severity, and could be independently predict the prognosis of CAD.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"734-8"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of ulinastatin on Toll like receptor 4 expression in endotoxin induced myocardial injury rats]. [乌司他丁对内毒素致心肌损伤大鼠Toll样受体4表达的影响]。
Xin Chen, Li-Hua Zhou, Zhi-Min Huang, Chong-Yang Dong, Jing Lin, Li-Peng Zhang, De-Ping Li
{"title":"[Effects of ulinastatin on Toll like receptor 4 expression in endotoxin induced myocardial injury rats].","authors":"Xin Chen,&nbsp;Li-Hua Zhou,&nbsp;Zhi-Min Huang,&nbsp;Chong-Yang Dong,&nbsp;Jing Lin,&nbsp;Li-Peng Zhang,&nbsp;De-Ping Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"763-5"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31061969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Feasibility of focused transthoracic echocardiography in intensive care unit performed by intensivists]. [重症监护病房经胸超声心动图集中检查的可行性]。
Li-na Zhang, Yu-hang Ai, Zhi-yong Liu, Chun-hui Tian, Ji-xiang Zhu
{"title":"[Feasibility of focused transthoracic echocardiography in intensive care unit performed by intensivists].","authors":"Li-na Zhang,&nbsp;Yu-hang Ai,&nbsp;Zhi-yong Liu,&nbsp;Chun-hui Tian,&nbsp;Ji-xiang Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical applicability of focused transthoracic echocardiography (TTE) in intensive care unit (ICU) performed by intensivists and its impacts on clinical managements.</p><p><strong>Methods: </strong>After 12-hour tutorials and initial cardiac clinical assessments, intensivists performed a focused TTE (2-4 views of 2D, without Doppler or M mode) examination in 88 patients to assess left ventricular function and left ventricular volume status, and rule out local ventricular wall motion abnormalities and significant pericardial effusions. Each investigation was immediately reviewed by an echocardiograph to determine the technical quality of the TTE and the accuracy of the intensivist's interpretation.</p><p><strong>Results: </strong>Intensivists successfully performed a diagnostic focused TTE in 86 patients (97.7%) and interpreted correctly in 75 patients (85.2%). Management including fluid treatment, inotropic agent and vasoactive agent in 22.7% of patients were changed directly based on the focused TTE, 45.5% of patients were provided with valuable information, while 31.8% of them with non-valuable information. The mean focused TTE acquisition time of the intensivist was (11.2±5.2) minutes.</p><p><strong>Conclusions: </strong>After a brief standard training in using echocardiographic system, intensivists can successfully performed and correctly interpreted a focused TTE for critically ill patients. Our study demonstrates that new information can be provided by focused TTE, which can alter management in a significant number of patients. The present study supports incorporating bedside goal-directed, focused TTE into intensivists' training programs in China.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"739-41"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The protective effect of propofol pretreatment on glutamate injury of neonatal rat brain slices]. [异丙酚预处理对新生大鼠脑片谷氨酸损伤的保护作用]。
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Pub Date : 2012-12-01 DOI: 10.3760/CMA.J.ISSN.1003-0603.2012.12.015
Xiao-feng Zhou, Ding-ding Huang, Di-fen Wang, Jiang-quan Fu
{"title":"[The protective effect of propofol pretreatment on glutamate injury of neonatal rat brain slices].","authors":"Xiao-feng Zhou, Ding-ding Huang, Di-fen Wang, Jiang-quan Fu","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.015","url":null,"abstract":"OBJECTIVE\u0000To study the protective effect of propofol precondition against glutamate (Glu) neurotoxicity to neonatal rat cerebrocortical slices.\u0000\u0000\u0000METHODS\u0000Brain slices of Sprague-Dawley (SD) rats were cultured in vitro and observed the morphologic changes. Brain slices were randomly divided into three groups: blank control group, Glu injury group (1 mmol/L Glu for 0.5 hour), propofol precondition group (20 mg/L propofol for 24 hours), each n=12. Changes in pathological and ultra-structure of cells were observed using microscope. Lactate dehydrogenase (LDH) leakage rate was measured. Meanwhile, the expression of glial fibrillary acidic protein (GFAP) was detected by immunohistochemical technology, then the positive cell were counted.\u0000\u0000\u0000RESULTS\u0000Cultured brain slices of cell were intact and survived well. Hematoxylin-eosin (HE) staining, electron microscopy and LDH test results showed that cerebral film neuron severely damage, gliosis, edema, LDH leakage rate in Glu injury group were significantly more severe compared with blank control group [(68.5±2.0)% vs. (16.0±2.5)%, P<0.01]. Reduce the brain slice of the propofol pretreatment group of neuronal cell jury, cell shape recovery significantly reduced LDH leakage rate compared with the Glu injury group [(38.5±2.4)% vs. (68.5±2.0)%, P<0.05]. Immunohistochemical detection of GFAP expression of Glu injury group glial cell body swelling, producing increase in the number of GFAP positive reaction strong, the number of positive cells compared with blank control group was significantly increased (50±5 cells/HP vs. 10±3 cells/HP, P<0.01). The recovery of propofol pretreatment group glial cell morphology, cell processes slender GFAP positive reaction decreased the number of positive cells compared with the Glu injury group was significantly decreased (30±4 cells/HP vs. 50±5 cells/HP, P<0.05).\u0000\u0000\u0000CONCLUSION\u0000Propofol pretreatment has protective effect against Glu injured rat cerebrocortical slices.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"22 1","pages":"750-3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90782039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Hemodynamic effects of midazolam and fentanyl combination in multiple trauma patients]. 咪达唑仑与芬太尼联用对多发创伤患者血流动力学的影响。
Wen-jie Wang, Hou-qing Lu, Ren-de Shao, Yang Wang
{"title":"[Hemodynamic effects of midazolam and fentanyl combination in multiple trauma patients].","authors":"Wen-jie Wang,&nbsp;Hou-qing Lu,&nbsp;Ren-de Shao,&nbsp;Yang Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 11","pages":"687-8"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31030194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Treatment of acute chlorine poisoning with chemical-induced lung injury using high-dose dexamethasone combined with anisodamine: a report of 526 patients]. [大剂量地塞米松联合山莨菪碱治疗急性氯中毒合并化学致肺损伤526例报告]。
Xi-yi Xia, Qi-han Zheng, Mao-xing Yue
{"title":"[Treatment of acute chlorine poisoning with chemical-induced lung injury using high-dose dexamethasone combined with anisodamine: a report of 526 patients].","authors":"Xi-yi Xia,&nbsp;Qi-han Zheng,&nbsp;Mao-xing Yue","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 11","pages":"689"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31030195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The correlation analysis between glucose level and its variability and prognosis in traumatic patients]. [创伤患者血糖水平及其变异性与预后的相关性分析]。
Zhao-hui Liu, Lei Su, Jin-chun Wu, Jian-hao Tan, Yin-guang Liao, Zhi-feng Liu
{"title":"[The correlation analysis between glucose level and its variability and prognosis in traumatic patients].","authors":"Zhao-hui Liu,&nbsp;Lei Su,&nbsp;Jin-chun Wu,&nbsp;Jian-hao Tan,&nbsp;Yin-guang Liao,&nbsp;Zhi-feng Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of glucose level, variability on the prognosis of traumatic patients.</p><p><strong>Methods: </strong>A retrospective study involving 300 traumatic patients admitted to intensive care unit (ICU) was performed. The average glucose (GluAve), glucose standard deviation (GluSD) and glucose coefficient of variation (GluCV) during the first 72 hours were calculated. Patients were divided into survivor group (n=249) and non-survivor group (n=51) based on outcomes. The GluAve, GluSD and GluCV were compared between the two groups. Patients were allocated into five subgroups based on GluAve (3.9-5.5, 5.6-6.6, 6.7-7.7, 7.8-9.9, ≥10.0 mmol/L) as well as four subgroups on GluCV (<15%, 15%-30%, 30%-50%, >50%). The mortality in hospital was compared among the different subgroups and the different GluCV in the same level of GluAve subgroups, respectively. Multifactor logistic regression was used to determine the risk factor of hospital death.</p><p><strong>Results: </strong>The levels of GluAve, GIuSD, GluCV of non-survivor group were higher than those of survivor group [11.31±4.38 mmol/L vs. 8.50±3.40 mmol/L, 2.85±1.94 mmol/L vs. 1.87±1.67 mmol/L, (28.30±23.08)% vs. (20.90±13.70)%, all P<0.05]. With the gradual increment of GluAve and GluCV level, the mortality was raised accordingly (χ (2)(1)=26.332, P=0.000; χ (2)(2)=65.522, P=0.000). In the subgroup of GluAve 7.8-9.9 mmol/L, the mortality was 9.09% (3/33) with GluCV <15% versus 46.15% (6/13) with GluCV >50% (P<0.01) respectively, and in the subgroup of GluAve ≥10.0 mmol/L, the mortality corresponding rates were 21.05% (4/19) with GluCV < 15% and 61.54% (8/13) with GluCV > 50% (P<0.05). The multivariable logistic regression analysis demonstrated that GluAve and GluCV were risk factors of mortality[GluAve odds ratio (OR)=1.150, 95% confidence interval (95%CI) was 1.042 to 1.270, P=0.006; GluCV OR=1.022, 95%CI was 0.999 to 1.040, P=0.040], GluSD had no effect on mortality.</p><p><strong>Conclusions: </strong>The increase in GluAve and GluCV in traumatic patients are significantly correlated with mortality. Control the level and the variability of blood glucose might be an important aspect of the multiple trauma death reduction.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 11","pages":"643-6"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31031319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical observation of the role of Chenxia Sijunzi decoction in promoting the recovery of gastrointestinal function in critically ill patients]. [晨霞四君子汤促进危重患者胃肠功能恢复的临床观察]。
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Pub Date : 2012-11-01 DOI: 10.3760/CMA.J.ISSN.1003-0603.2012.11.011
Jian-hong Guo, Gai Chen, Sheng-quan Yang, M. Wei, Xiao Chen
{"title":"[Clinical observation of the role of Chenxia Sijunzi decoction in promoting the recovery of gastrointestinal function in critically ill patients].","authors":"Jian-hong Guo, Gai Chen, Sheng-quan Yang, M. Wei, Xiao Chen","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.11.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.11.011","url":null,"abstract":"OBJECTIVE\u0000To observe the clinical effects of Chenxia Sijunzi decoction on promoting gastrointestinal function recovery in severe patients.\u0000\u0000\u0000METHODS\u0000A prospective randomized controlled study was conducted. Eighty severe patients feeding with enteral nutrition from September 2011 to March 2012 were divided into three groups according to the method of random number table. The traditional Chinese medicine group and western medicine group were consisted of 35 cases respectively, and 10 cases were control group. Control group was routine symptomatically treated without any medicines for promoting gastrointestinal power function, helping the lower extremities to move and enhancing the turn over, letting the gastrointestinal function recover by its self. Chinese medicine group was tube fed with Chenxia Sijunzi decoction on the basis of control group, western medicine group was tube fed with the multienzyme tablets and mosapride dispersible tablets on the basis of control group. Then the differences in bowel sound recovery time and the time for passage of gas by anus and the bowel movement time and length of stay in hospitals within three groups were observed.\u0000\u0000\u0000RESULTS\u0000The time of bowel sound recovery (41.02±7.52 hours, 44.02±6.23 hours), gas passage time by anus (49.90±6.95 hours, 51.32±5.12 hours) and the bowel movement time (58.22±6.71 hours, 60.91±3.72 hours) in both traditional Chinese medicine and the western medicine group were significantly reduced compared with the control group (54.62±5.51 hours, 64.68±9.47 hours, 78.20±7.11 hours, all P<0.01), and the days in hospital (5.1±1.7 days, 5.0±1.5 days) were shortened significantly compared with the control group (8.9±1.4 days, both P<0.01). However, results did not demonstrate any significant differences in each testing index between traditional Chinese medicine and western medicine group (all P>0.05).\u0000\u0000\u0000CONCLUSION\u0000Chenxia Sijunzi decoction can promote severe patient's gastrointestinal function recovery and reduce hospitalization days.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"71 1","pages":"674-6"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80960008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
[Clinical study of value of transcranial Doppler ultrasonography in diagnosing brain death in severe craniocerebral injury]. [经颅多普勒超声诊断重型颅脑损伤脑死亡价值的临床研究]。
Li Wang, Mu Li, Yong-qiang Wang, Xue-quan Feng, Rui Liu, Wei Li, Zhen-guang Feng
{"title":"[Clinical study of value of transcranial Doppler ultrasonography in diagnosing brain death in severe craniocerebral injury].","authors":"Li Wang,&nbsp;Mu Li,&nbsp;Yong-qiang Wang,&nbsp;Xue-quan Feng,&nbsp;Rui Liu,&nbsp;Wei Li,&nbsp;Zhen-guang Feng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical value of transcranial Doppler(TCD) ultrasonography in diagnosing brain death in patients with severe craniocerebral injury.</p><p><strong>Methods: </strong>Forty patients of severe craniocerebral injury defined by a scene Glasgow coma scale(GCS)≤8, admitted to Department of Neurosurgery of First Central Clinical Hospital of Tianjin Medical University, were divided into two groups based upon the prognosis: the death group(n=15) and the survival group (n=25). All patients were examined dynamically by TCD, and the occurrence of retrograde diastolic flow (RDF) and mean velocity (Vm) of middle cerebral arteries (MCA) were measured as well as the pulse index (PI).</p><p><strong>Results: </strong>In the survival group, 3 showed partial RDF which was found within 24 hours after injury, and the duration was short lasting for no more than 12 hours, and the RDF wave disappeared very quickly after treatment of drug or operation. These patients were in persistent vegetative state with Glasgow outcome score (GOS) 2, having been followed up for 6 months. In the death group, 12 showed fully RDF, 2 showed very small systolic spike. The characteristic change of 14 patients' cerebral hemodynamics took place 6-40 hours before clinical brain death. Compared with survival group, Vm of MCA was significantly decreased (20.07±13.97 cm/s vs. 56.72±16.87 cm/s), the value of PI was significantly increased (3.95±3.51 vs. 1.25±1.06), and the occurrence of RDF was also elevated (93.3% vs. 12.0%) in the death group, the differences were statistically significant (P<0.05 or P<0.01).</p><p><strong>Conclusion: </strong>TCD with the advantages of easy and bedside operation, noninvasiveness, no disturbance from sedatives and repeatability in cerebral hemodynamic examination is of great clinic practical value in early diagnosing brain death in patients with severe cranial injury.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 11","pages":"670-3"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31030188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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