Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue最新文献

{"title":"[The research of establishing discriminant function for patients with angina pectoris by stepwise analysis based on serum inflammatory factors].","authors":"Zhi-bin Chen, Yan-bing Liang, Hao Tang, Zhong-hua Wang, Lijin Zeng, Jing-guo Wu, Zhen-yu Li, Zhong-Fu Ma","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.004","url":null,"abstract":"OBJECTIVE\u0000To improve cost-efficiency, discriminant functions in stepwise method was founded for the differential diagnosis of angina pectoris by detecting the serum level of high-sensitivity C-reactive protein (hs-CRP), macrophage migration inhibitory factor (MIF), interleukin-4 (IL-4) and interleukin-10 (IL-10) in patients with stable angina pectoris (SAP) and unstable angina pectoris (UAP).\u0000\u0000\u0000METHODS\u0000Thirty-nine SAP patients and 47 UAP patients were enrolled into the study, while 39 healthy volunteers were enrolled into the controlled group forming the entire set of training samples. The serum levels of hs-CRP, MIF, IL-4 and IL-10 were measured by enzyme linked immunosorbent assay (ELISA). Data was analyzed by software to define discriminant functions in the ways of \"entering\" and \"stepwise\". Both functions were evaluated by the results of validation.\u0000\u0000\u0000RESULTS\u0000By the way of \"enter independent together\", the following discriminant functions were defined based on the data of training samples' age, hs-CRP, MIF, IL-4, IL-10: healthy control group =-129.858 + 2.869×age -2.451×hs-CRP + 1.393×MIF + 6.001×IL-4 + 4.848×IL-10; SAP group=-161.037 + 2.896×age-2.022×hs-CRP + 1.662×MIF + 6.703×IL-4 + 6.287×IL-10; UAP group=-199.087 + 2.468×age-1.440×hs-CRP + 3.404×MIF-13.875×IL-4 + 7.752×IL-10. Retrospective validation showed 4.8% of total miss-grouping, while cross-validation showed 5.6% of total miss-grouping. By the way of \"stepwise\", the above data was screened by software and training samples' age, MIF and IL-10 were suggested to define the following functions: healthy control group = - 125.218 + 2.659 × age + 0.599×MIF + 5.040 × IL-10; SAP group=-157.864 + 2.721×age + 1.008×MIF + 6.468×IL-10; UAP group=- 197.327 + 2.360×age + 2.932×MIF + 7.640×IL-10. Both retrospective and cross validation showed 6.4% of total miss-grouping. Both sets of discriminant functions had the same efficiency (100%) for differential diagnosis of SAP and UAP.\u0000\u0000\u0000CONCLUSION\u0000The discriminant functions based on samples' age, MIF and IL-10, which were screened and suggested by stepwise method, may contribute to the differential diagnosis of atypical SAP and UAP, and therefore demonstrate better cost-efficiency.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"1 1","pages":"713-6"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79086077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Feasibility of focused transthoracic echocardiography in intensive care unit performed by intensivists].","authors":"Li-na Zhang, Y. Ai, Zhi-yong Liu, Chunmei Tian, Ji-xiang Zhu","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.012","url":null,"abstract":"OBJECTIVE\u0000To assess the clinical applicability of focused transthoracic echocardiography (TTE) in intensive care unit (ICU) performed by intensivists and its impacts on clinical managements.\u0000\u0000\u0000METHODS\u0000After 12-hour tutorials and initial cardiac clinical assessments, intensivists performed a focused TTE (2-4 views of 2D, without Doppler or M mode) examination in 88 patients to assess left ventricular function and left ventricular volume status, and rule out local ventricular wall motion abnormalities and significant pericardial effusions. Each investigation was immediately reviewed by an echocardiograph to determine the technical quality of the TTE and the accuracy of the intensivist's interpretation.\u0000\u0000\u0000RESULTS\u0000Intensivists successfully performed a diagnostic focused TTE in 86 patients (97.7%) and interpreted correctly in 75 patients (85.2%). Management including fluid treatment, inotropic agent and vasoactive agent in 22.7% of patients were changed directly based on the focused TTE, 45.5% of patients were provided with valuable information, while 31.8% of them with non-valuable information. The mean focused TTE acquisition time of the intensivist was (11.2±5.2) minutes.\u0000\u0000\u0000CONCLUSIONS\u0000After a brief standard training in using echocardiographic system, intensivists can successfully performed and correctly interpreted a focused TTE for critically ill patients. Our study demonstrates that new information can be provided by focused TTE, which can alter management in a significant number of patients. The present study supports incorporating bedside goal-directed, focused TTE into intensivists' training programs in China.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"65 1","pages":"739-41"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81096503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The protective effect of propofol pretreatment on glutamate injury of neonatal rat brain slices].","authors":"Xiao-feng Zhou,&nbsp;Ding-ding Huang,&nbsp;Di-fen Wang,&nbsp;Jiang-quan Fu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study the protective effect of propofol precondition against glutamate (Glu) neurotoxicity to neonatal rat cerebrocortical slices.</p><p><strong>Methods: </strong>Brain slices of Sprague-Dawley (SD) rats were cultured in vitro and observed the morphologic changes. Brain slices were randomly divided into three groups: blank control group, Glu injury group (1 mmol/L Glu for 0.5 hour), propofol precondition group (20 mg/L propofol for 24 hours), each n=12. Changes in pathological and ultra-structure of cells were observed using microscope. Lactate dehydrogenase (LDH) leakage rate was measured. Meanwhile, the expression of glial fibrillary acidic protein (GFAP) was detected by immunohistochemical technology, then the positive cell were counted.</p><p><strong>Results: </strong>Cultured brain slices of cell were intact and survived well. Hematoxylin-eosin (HE) staining, electron microscopy and LDH test results showed that cerebral film neuron severely damage, gliosis, edema, LDH leakage rate in Glu injury group were significantly more severe compared with blank control group [(68.5±2.0)% vs. (16.0±2.5)%, P<0.01]. Reduce the brain slice of the propofol pretreatment group of neuronal cell jury, cell shape recovery significantly reduced LDH leakage rate compared with the Glu injury group [(38.5±2.4)% vs. (68.5±2.0)%, P<0.05]. Immunohistochemical detection of GFAP expression of Glu injury group glial cell body swelling, producing increase in the number of GFAP positive reaction strong, the number of positive cells compared with blank control group was significantly increased (50±5 cells/HP vs. 10±3 cells/HP, P<0.01). The recovery of propofol pretreatment group glial cell morphology, cell processes slender GFAP positive reaction decreased the number of positive cells compared with the Glu injury group was significantly decreased (30±4 cells/HP vs. 50±5 cells/HP, P<0.05).</p><p><strong>Conclusion: </strong>Propofol pretreatment has protective effect against Glu injured rat cerebrocortical slices.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"750-3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Protective effect of melatonin on myocardial injury in severely- burned rats].","authors":"Xiao-hua Han, Luo Xu","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.014","url":null,"abstract":"OBJECTIVE\u0000To investigate the protective effect of melatonin (MLT) on myocardial injury in severely-burned rats and its mechanism.\u0000\u0000\u0000METHODS\u0000A total of 30 Sprague-Dawley (SD) rats were randomly assigned to three groups: sham group, burn group and MLT group, each n=10. The dorsal skin of animal was immersed into boiling water for 15 seconds to induce 30% total body surface area (TBSA) full-thickness burn, or immersed into 37 centigrade water for sham operation. Immediately after burn, the animals in burn group and MLT group were given intraperitoneally vehicle (1% alcohol in normal saline) or MLT (10 mg/kg) respectively. Six hours postburn, the blood from tail vessel was collected for serum preparation. After sacrificed, the myocardial tissues of rats were collected for the determination of malondialdehyde (MDA) and reduced glutathione (GSH) as well as glutathione peroxidase (GSH-Px) and myeloperoxidase (MPO) activities. Serum levels of creatine kinase (CK) and lactate dehydrogenase (LDH) were also estimated.\u0000\u0000\u0000RESULTS\u0000Compared with the sham control, burn injury increased MDA by 66.7% (1.55±0.17 nmol/mg vs. 0.93±0.05 nmol/mg) and decreased GSH by 27.8% (13.58±0.33 nmol/mg vs. 18.82±0.55 nmol/mg, both P<0.01) in myocardial tissues, GSH-Px activity was also slightly inhibited (74.04±3.42 nmol×min(-1)×mg(-1) vs. 93.79±3.76 nmol×min(-1)×mg(-1), P<0.05), but MPO level was found to increase to 2.8 folds (9.43±1.15 U/g vs. 3.41±0.27 U/g, P<0.01). These changes indicated the occurrence of oxidative stress in myocardial tissues after severe burn. MLT treatment relieved most of the abnormality with significant statistical significances (MDA: 0.89±0.08 nmol/mg vs. 1.55±0.17 nmol/mg, GSH: 17.23±0.54 nmol/mg vs. 13.58±0.33 nmol/mg, MPO: 6.91±0.51 U/g vs. 9.43±1.15 U/g, P<0.05 or P<0.01). In addition, the serum levels of CK and LDH in burn group increased to 37.8 folds and 7.4 folds respectively (both P<0.01). MLT treatment reduced CK by 32.9% and reduced LDH by 21.2% (P<0.05 and P<0.01).\u0000\u0000\u0000CONCLUSION\u0000MLT treatment exerts the protective effect on myocardial injury in severely-burned rats, which is attributed predominantly to its inhibition on burn-induced oxidative stress injury.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"50 1","pages":"747-9"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78784149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation between osteoprotegerin gene 209G/A, 245T/G and 1181G/C polymorphism and acute coronary syndromes in Han people of Fujian area].","authors":"Zhu-ron Luo, Qin-jing Xie","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.009","url":null,"abstract":"OBJECTIVE\u0000To explore the association of osteoprotegerin (OPG) gene polymorphisms 209G/A, 245T/G and 1181G/C in the Han population of Fujian province with acute coronary syndrome (ACS) and its severity.\u0000\u0000\u0000METHODS\u0000A prospective study was conducted. Two hundred and fifty-two cases without sibship of Fujian Han people was enrolled from July 2010 to September 2011, in which 68 healthy subjects as controls. One hundred and eighty-four patients with ACS were divided into three groups, 60 had one-vessel, 68 had two-vessel, and 54 had three-vessel lesion, 2 had not been found stenosis. DNA was extracted from venous blood, different groups of OPG gene polymorphism was identified by Sanger Method. OPG 209G/A, 245T/G and 1181G/C genotype frequencies and allelic frequencies were analyzed between ACS subjects and normal subjects and among the three groups of ACS, and the relationship between gene polymorphisms and ACS severity.\u0000\u0000\u0000RESULTS\u0000No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G between the ACS and control groups. Significant differences were observed in the genotype and allelic frequencies of OPG gene 1181G/C between the ACS and control groups [1181G/C GG: 92 (50.0%) vs. 43 (63.2%), CC: 26 (14.1%) vs. 0, GC: 66 (35.9%) vs. 25 (36.8%), χ(2)=11.240, P=0.004; allelic gene G: 250 (67.9%) vs. 111 (81.6%), allelic gene C: 118 (32.1%) vs. 25 (18.4%), χ(2)=9.148, P=0.002]. No significant differences were observed in the genotype and allelic frequencies of OPG gene 209G/A, 245T/G and 1181G/C between those groups.\u0000\u0000\u0000CONCLUSIONS\u0000There were no significant difference in frequencies OPG genotype and allele in polymorphisms 209G/A, 245T/C between patients with ACS and control group in Han population of Fujian province. There were difference in frequencies OPG genotype and allele in polymorphisms 1181G/C between patients with ACS and control group, but it was not differently distributed among patients with single-, double-, or triple-vessel lesion.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"94 1","pages":"730-3"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82285360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Observation and multifactor analysis of refractory medium-severe heart failure by micro-inflammation modification in uremic patients].","authors":"Yan-bin Wang,&nbsp;Wei Meng,&nbsp;Hui Zhang,&nbsp;Qing-hua Zhai,&nbsp;Hua Xiang,&nbsp;Ya-ping Zhao,&nbsp;Jing Rong,&nbsp;Shuai Chang,&nbsp;Hai-yan Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic strategies and prognostic factors of refractory medium-severe heart failure in uremic patients.</p><p><strong>Methods: </strong>A single center, self control clinical research was conducted, and the data consisted of 30 uremic patients with refractory medium-severe heart failure undergoing maintenance hemodialysis (MHD), who received routine combined modality therapy and Xuebijing injection (to modify micro-inflammation). The systolic function of the left ventricle was compared before and after therapy. Multiple linear regression models were established to predict the improvements of systolic function of ventricle. Relationship between the accumulated dose of Xuebijing injection and changes of C-reactive protein (ΔCRP) was observed.</p><p><strong>Results: </strong>The values of left ventricle ejection fraction (LVEF), fractional shortening (FS), and stroke volume (SV) after therapy were improved compared with those before therapy [LVEF: 0.42±0.07 vs. 0.34±0.04, FS: (21.07±3.83)% vs. (16.33±2.43)%, SV: 66.83±7.00 ml vs. 52.20±7.62 ml, all P<0.01]. In terms of cardiac output (CO), there was no statistical difference before and after therapy (4.77±0.65 L/min vs. 4.49±0.68 L/min, P>0.05). In the multiple linear regression models of ΔLVEF, ΔFS and ΔSV, the independent variables that affect dependent variables included age, ΔCRP, changes of hemoglobin (ΔHb), accumulated dose of Xuebijing injection, changes of HCO(3)(-) (Δ HCO(3)(-)), changes of serum creatinine (ΔSCr), Hb and CRP after therapy, the factors and weights of which had slight variation on accordance with different dependent variables. There was significant positive correlation between accumulated dose of Xuebijing injection and ΔCRP (r=0.561, P=0.001).</p><p><strong>Conclusions: </strong>Xuebijing injection can improve heart function in uremic patients by modifying micro-inflammation, whose accumulated dose and therapeutic effect show positive correlation. In addition the improvement of heart failure has something to do with age, ΔHb, Hb after therapy, the correction of acidosis and dialysis sufficiency.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"754-8"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The predictive values of D-dimer for the early prognosis of the acute myocardial infarction (AMI): a review of 3134 AMI patients].","authors":"Jun Yang, Chun-Sheng Li","doi":"10.3760/CMA.J.ISSN.1003-0603.2012.12.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1003-0603.2012.12.007","url":null,"abstract":"OBJECTIVE\u0000To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction (AMI), then may be helpful in risk assessment in emergency department.\u0000\u0000\u0000METHODS\u0000Three thousand one hundred and thirty-four emergency AMI cases admitted to the hospital from January 1, 2009 to December 31, 2010 were retrospectively reviewed, and their age, gender, past medical history, D-dimer, MB isoenzyme of creatine kinase (CK-MB), cardiac troponin I (cTnI), the precursor of the N-terminal pro-brain natriuretic peptide (NT-proBNP), electrocardiogram (ECG) before treatment, and the CK-MB, cTnI and echocardiography left ventricular ejection fraction (LVEF) 2 hours after the treatment of percutaneous coronary intervention (PCI) or thrombolytic drugs, whether died and time from onset to death were recorded. According to the results of multivariate logistic regression analysis, draw the receiver operating characteristic curve (ROC curve) and fitting curve, and analyzed the relativity between the D-dimer before the treatment and prognosis of myocardial infarction.\u0000\u0000\u0000RESULTS\u0000Multivariate logistic regression analysis showed that age [odds ratio (OR)=1.109, 95% confidence interval (95%CI) 1.073 to 1.147, P=0.000], whether undergoing emergency PCI (OR=4.162, 95%CI 1.980 to 8.748, P=0.000), D-dimer before treatment (OR=1.001, 95%CI 1.000 to 1.002, P=0.001), the LVEF values (OR=0.946, 95%CI 0.928 to 0.964, P=0.000) and cTnI after 2 hours of treatment (OR=1.011, 95%CI 1.004 to 1.018, P=0.002) were correlated to 28-day death. The ROC curves showed that age [area under curve (AUC) 0.796, P=0.000], whether undergoing emergency PCI (AUC 0.704, P=0.000), D-dimer before treatment (AUC 0.797, P=0.000) were positively correlated with the 28-day death; the LVEF values (AUC 0.261, P=0.000) were negative correlated with the 28-day death. The fitting curve of D-dimer before treatment, the time from onset to death and the LVEF showed no linear correlation.\u0000\u0000\u0000CONCLUSIONS\u0000D-dimer was correlated with the early prognosis of patients with myocardial infarction, but was not correlated with the time from onset to death. The rise in D-dimer at the early stage of AMI may be helpful to indicate the critical condition of the AMI patients.","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"158 1","pages":"725-9"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74171382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of circulating microRNA-92a for endothelial damage induced by percutaneous coronary intervention].","authors":"Hong Wang,&nbsp;Lin Wang,&nbsp;Ling Liu,&nbsp;Ying-zhong Lin,&nbsp;You-qiong Li,&nbsp;Hong-mei Lu,&nbsp;Guo-ping Gong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To explore the role of microRNA-92a (miR-92a) in evaluating endothelium damage induced by percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>A case control study was prospectively conducted. Fifty-eight patients with ST-segment elevation acute myocardial infarction (STEAMI) received PCI were enrolled. MiR-92a expression in circulation was determined on the next day after PCI (reverse transcription-polymerase chain reaction). The correlation between miR-92a expression in circulation and PCI influence factors, such as inflation pressure, duration of balloon inflation and length of culprit atheromatous plaque were explored.</p><p><strong>Results: </strong>MiR-92a was lower in inflation pressure 11-19 atm (1 atm=101.325 kPa) group [n=43, mean -0.36, 95% confidence interval (95%CI) -0.60 to -0.12] than inflation pressure ≤10 atm group (n=11, mean 1.16, 95%CI 0.80 to 1.52, P<0.01) and ≥ 20 atm group (n=4, mean 0.26, 95%CI 0.26 to 0.26, P=0.1); and also lower in duration of balloon inflation 6-7 seconds group (n=24, mean -0.42, 95%CI -0.83 to -0.01) than in duration of balloon inflation ≤ 5 seconds group (n=9, mean 0.63, 95%CI 0.49 to 0.78, P=0.03) and ≥ 8 seconds group (n=25, mean 0.45, 95%CI 0.10 to 0.80, P<0.001); lower in implanted stent length ≤30 mm (n=31, mean -0.48, 95%CI -0.80 to -0.16) than those >30 mm (n=27, mean 0.16, 95%CI 0.01 to 0.32, P<0.01). A significantly negative correlation was found between inflation pressure and duration of balloon inflation. (r=-0.48, P<0.001).</p><p><strong>Conclusions: </strong>There is a relationship between circulating miR-92a, inflation pressure and duration of balloon inflation. Circulating miR-92a could be used to evaluate the endothelium injury induced by PCI, and be used as a new target of prevention and treatment of endothelial dysfunction following revascularization.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"721-4"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The predictive values of D-dimer for the early prognosis of the acute myocardial infarction (AMI): a review of 3134 AMI patients].","authors":"Jun Yang,&nbsp;Chun-sheng Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction (AMI), then may be helpful in risk assessment in emergency department.</p><p><strong>Methods: </strong>Three thousand one hundred and thirty-four emergency AMI cases admitted to the hospital from January 1, 2009 to December 31, 2010 were retrospectively reviewed, and their age, gender, past medical history, D-dimer, MB isoenzyme of creatine kinase (CK-MB), cardiac troponin I (cTnI), the precursor of the N-terminal pro-brain natriuretic peptide (NT-proBNP), electrocardiogram (ECG) before treatment, and the CK-MB, cTnI and echocardiography left ventricular ejection fraction (LVEF) 2 hours after the treatment of percutaneous coronary intervention (PCI) or thrombolytic drugs, whether died and time from onset to death were recorded. According to the results of multivariate logistic regression analysis, draw the receiver operating characteristic curve (ROC curve) and fitting curve, and analyzed the relativity between the D-dimer before the treatment and prognosis of myocardial infarction.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that age [odds ratio (OR)=1.109, 95% confidence interval (95%CI) 1.073 to 1.147, P=0.000], whether undergoing emergency PCI (OR=4.162, 95%CI 1.980 to 8.748, P=0.000), D-dimer before treatment (OR=1.001, 95%CI 1.000 to 1.002, P=0.001), the LVEF values (OR=0.946, 95%CI 0.928 to 0.964, P=0.000) and cTnI after 2 hours of treatment (OR=1.011, 95%CI 1.004 to 1.018, P=0.002) were correlated to 28-day death. The ROC curves showed that age [area under curve (AUC) 0.796, P=0.000], whether undergoing emergency PCI (AUC 0.704, P=0.000), D-dimer before treatment (AUC 0.797, P=0.000) were positively correlated with the 28-day death; the LVEF values (AUC 0.261, P=0.000) were negative correlated with the 28-day death. The fitting curve of D-dimer before treatment, the time from onset to death and the LVEF showed no linear correlation.</p><p><strong>Conclusions: </strong>D-dimer was correlated with the early prognosis of patients with myocardial infarction, but was not correlated with the time from onset to death. The rise in D-dimer at the early stage of AMI may be helpful to indicate the critical condition of the AMI patients.</p>","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"725-9"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of death characteristics and its potential mechanisms in rats with endotoxin- induced cardiomyopathy].","authors":"De-guang Feng,&nbsp;Chun-hua Jin,&nbsp;Xiang Xue,&nbsp;Jing Xiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To approach the changes in heart failure and dying regularity of rats with endotoxin-induced cardiomyopathy, and to offer some help for clinical diagnosing and further investigation.</p><p><strong>Methods: </strong>Injecting refined endotoxin (10 mg/kg) via vein of Wistar rats. The first experiment: antidromic observing the endotoxic rats from death to the beginning to discover the performance of clinic heart function which could forecast death. The second experiment: setting 6 rats per group, respectively killing the rats at 4, 8, 16, 24, 32, 40, 48 and 72 hours after endotoxin injection, and killing 6 normal rats as control group, getting the tissue of left ventricle for biochemistry test, routine pathological examination, transmission electron microscope examination, expression level of α(1)-actin gene with reverse transcription-polymerase chain reaction (RT-PCR), and serum creatine kinase (CK) was test within 24 hours.</p><p><strong>Results: </strong>The first experiment: heart rate (HR) and left ventricular end-systolic pressure (LVESP) of endotoxic rats began significant lower than normal at 4 hours before death (F(1)=22.032, P(1)=0.000; F(2)=29.420, P(2)=0.000), maximum rate of rise/drop of left ventricular pressure (±dp/dt max) began significant lower than normal at 8 hours before death (F(1)=17.272, P(1)=0.000; F(2)=19.685, P(2)=0.000), left ventricular end-diastolic pressure (LVEDP) showed no significant during the whole time (F=0.265, P=0.988). The heart function of all the rats showed no significant changes in the first 4 hours after injection. Mortality was 73.9% from injection to 24 hours later. Most of them died in 8-16 hours after injection. The one who had survived over 24 hours could have 2/3 probability to survive to 48 hours. The second experiment: CK in serum of different groups showed no significant difference (F=0.402, P=0.805), but showed obvious discreteness in each group except normal group. Electron microscopy and pathological examination showed obvious intracellular and intercellular damage since 8 hours later from injection. Pathology displayed that cells range disorder, mitochondria swelling, capillary hemorrhage, transverse striation disappearing, construction of myocardial cell loosing, and lateral dissociation phenomena. Electron microscopy discovered that the fiber direction and transverse striation became vague and disappeared, mitochondria got injury, the fiber became disordered, cell-cell junction were damaged seriously. Compared with the control group (0.637±0.160), the gene expression level of α(1)-actin decreased after endotoxin injection. The value dropped to the bottom at 8 hours (0.493±0.067) after injection and then rised slowly but dropped to the second wave trough again at 32 hours (0.875±0.128), but had no statistic significance; the expression of α(1)-actin gene eventually rised significantly at 40, 48, 72 hours after injection (2.231±0.545, 1.850±0.436, 2.0","PeriodicalId":23992,"journal":{"name":"Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue","volume":"24 12","pages":"742-6"},"PeriodicalIF":0.0,"publicationDate":"2012-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31063186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}