World journal of Pharmacy and pharmaceutical sciences最新文献

{"title":"Stability indicating validated method development for the simultaneous estimation of tezacaftor, ivacaftor & elexacaftor in API and pharmaceutical dosage form","authors":"Mr. Ch. Prasad, Asst. Professor Rao, Chaohui Rao, R. Chandralekha","doi":"10.54037/wjps.2021.91202","DOIUrl":"https://doi.org/10.54037/wjps.2021.91202","url":null,"abstract":"A Simple accurate, precise method was developed for the simultaneous estimation of the Tezacaftor, Ivacaftor and Elexacaftor in bulk and tablet dosage form. Chromatogram was run through Kromasil C18 150×4.6 mm, 5µ. Mobile phase containing 0.1% OPA and acetonitrile in the ratio of 60: 40 v/v was pumped through column at a flow rate of 1ml / min. Temperature was maintained at 30º c. Optimized wavelength for Tezacaftor, Ivacaftor and Elexacaftor was 260.0 nm. Retention time of Tezacaftor, Ivacaftor and Elexacaftor were found to be 3.468 min, 2.322 min and 2.855 min. % RSD of system precision for Tezacaftor, Ivacaftor and Elexacaftor were found to be 1.0, 0.6 and 1.4 respectively. % RSD of method precision for Tezacaftor, Ivacaftor and Elexacaftor were found to be 1.0, 0.4 and 1.2 respectively. % Recovery was obtained as 99.44%, 100.03% and 100.15% for Tezacaftor, Ivacaftor and Elexacaftor respectively. LOD, LOQ values obtained from regression equations of Tezacaftor, Ivacaftor and Elexacaftor were 0.07 ppm and 0.21ppm, 0.29 ppm and 0.88 ppm ,0.40 ppm and 1.20 ppm respectively. Regression equation of Tezacaftor was y=10491x + 863.8, Ivacaftor was y= 18876x + 7683 and Elexacaftor was y= 33896x + 19526. Retention times are decreased, so; the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87987307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intravenous odansetron in hospitalized patients on measured QTC interval","authors":"David H. Kruchko, E. Ehrenpreis, Charles Broy","doi":"10.20959/WJPPS20205-15983","DOIUrl":"https://doi.org/10.20959/WJPPS20205-15983","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82271976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE STUDY OF THE PHENOLIC COMPOUNDS OF FOUR VARIETIES OF SORGHUM (SORGHUM BICOLOR (L) MOENCH) CULTIVATED IN BURKINA FASO","authors":"P. Raymond, Crépin I. Dibala, K. Konaté, M. Dicko","doi":"10.20959/WJPPS20203-15575","DOIUrl":"https://doi.org/10.20959/WJPPS20203-15575","url":null,"abstract":"Sorghum bicolor (Poaceae) is the oldest cultivated plant in the world. It grows in dry, sodden or high salinity soil and is a heat-tolerant plant considered to hold the most important rate of phenolic components. The bioactive composites of the stem, the leaf, the grains, the seeds and the glumes for four Sorghum bicolor species such as Framida, Sariaso 19, Sariaso 14 and Gnossiconi were extracted by ethanolic hydrochloric acid maceration and then assayed using spectrophotometric methods. The DPPH and ABTS methods were used to assess the antioxidant properties of these studied species. All organs (stems, leaves, girdles, grains and husks) presented some contents in compounds variable polyphénolics of a variety to the other. The contents in total phenolics were of 14,53 ± 0,25 mg GAE/100 mg of dry matter in the stems of Sariaso 14, of 27,43 ± 0.21mg GAE/100 mg of dry matter in the leaves of Gnossiconi, of 42,72 ± 4,03 mg GAE/100 mg of dry matter in the girdles of Framida, of 17, 17 ± 1,02 mg EAG/100 mg of dry matter in the grains of Sariaso 19 and 14,48 ± 0,26 mg GAE/100 mg of dry matter in the husks of Sariaso 14. For the contents in total flavonoid, the girdles of Framida (8,87 ± 4,03 mg QE/100 mg) would contain some in strong content, followed of the Stems of Framida (6,64 ± 0,38 mg QE/100 mg) and of the leaves of Sariaso 19 (4,54 ± 0,73 mg QE/100 mg). An interesting antioxidant activity was found for the different organs of all the four species using both DPPH and ABTS methods. Indeed, the ABTS method showed the contents of 8.26 ± 0.35 mg EAA / g and 10.57 ± 0.20 mg EAA / g for the stems and leaves of Framida respectively. Around 98.49 % of Framida’s leaves, 89.06 % of Gnossiconi’s stems and its grains presented the best WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 7.632 Volume 9, Issue 3, 5-17 Research Article ISSN 2278 – 4357 Article Received on 23 Dec. 2019, Revised on 13 Jan. 2020, Accepted on 03 Feb. 2020 DOI: 10.20959/wjpps20203-15575 *Corresponding Author Dr. Crépin I. Dibala Laboratory of Food Biochemistry, Enzymology,","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"54 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82395129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIOXIDANTS EFFECTS IN CANCER SURVIVORS: A SHORT PERSPECTIVE.","authors":"A Thyagarajan,&nbsp;R P Sahu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There have been intense debates on the use of antioxidants as neoadjuvant therapy or in combination with anti-cancer agents in the treatment of human malignancies. While the safety and effectiveness of commonly used dietary antioxidants have been thoroughly assessed during chemotherapy and radiation therapy in cancer patients, more detailed analysis of their effects are needed to define its potential use in cancer survivors. Here, we summarize the findings of few comprehensive studies that investigated the potential implications of antioxidants in cancer survivors.</p>","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645267/pdf/nihms-1753801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39698519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESPOFEED AS THE REPLACEMENT OF ANTIBIOTIC IN THE TREATMENT OF COMPLICATED CHRONIC RESPIRATORY DISEASE (CCRD).","authors":"Arvind Sharma","doi":"10.20959/wjpps20179-10128","DOIUrl":"https://doi.org/10.20959/wjpps20179-10128","url":null,"abstract":"Many Drugs have been used as controlling measures for chronic respiratory diseases recently in the poultry farms. Drugs are not accepted due to the high cost, residual effects on human and not covering all pathogenic species. One of the ways that has been very much accepted nowadays is to use natural compounds and their active ingredients to treat the chronic respiratory diseases. In this research, we investigated the effect of tylosin and Respofeed (unique combination of essential oils and natural active ingredients). Samples were collected 21st, 27th and 35th day after the treatments and four various growth parameters (clinical scores, Air sac lesions, mortality and body weight) were assessed. All growth parameters were best with the group 4 which was treated with Respofeed. The present study was akin to the findings of [20, 21, 22, 23], who reported that volatile oils helps to treat CRD, improve body weight gain and reduces lesion scores.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"2 1","pages":"1718-1726"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74761375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IN-VITRO METHODS OF SCREENING OF ANTI-CANCER AGENT","authors":"S. Siddiqui","doi":"10.20959/wjpps20179-9940","DOIUrl":"https://doi.org/10.20959/wjpps20179-9940","url":null,"abstract":"Global cancer population is more than 6.75 billion, and today cancer is the leading cause of mortality. Medical therapy in cancer treatment is an area of investigation for which efforts are being made to come up with novel chemical entities for better treatment of cancer. Discovery of new anti-cancer drugs is based on a mechanistic approach and has reliance on empiric cell-based screening of new drugs for its anticancer effects. To summarize the data related to current in-vitro methods for screening of anticancer agents. Reviewed here are some selected In-vitro cell based methods for screening of anti-cancer drugs. These are the combinations of systematic methods based on existing theories and models. New anti-cancer drug is necessary with novel profile of anti-tumor activity. This review will summarize most popular in-vitro cell based screening methods, which are economically good enough to establish the anti-cancer activity of newly evolved anti-cancer drugs.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"109 1","pages":"409-424"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75909458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IN VITRO INVESTIGATION OF ANTIBACTERIAL AND ANTILEISHMANIAL ACTIVITIES OF GUM-RESIN OF BOSWELLIA SERRATA USING (0.5%) DMSO SOLUTION AS AN ALTERNATIVE SOLVENT FOR EXTRACTION","authors":"N. Al-Ogaili","doi":"10.20959/WJPPS20179-10086","DOIUrl":"https://doi.org/10.20959/WJPPS20179-10086","url":null,"abstract":"Boswellia serrata belongs to the family Burseraceae, is a plant that produces frankincense. The plant is native to India and extends to Pakistan. The tree yields oleo-gumresin which has been used for a variety of therapeutic purposes such as cancer, inflammation, arthritis, asthma, psoriasis, colitis, Crohn’s Disease, and hyperlipedimia, antibacterial and antifungal activities. The current study investigated the antibacterial (S. aureus and E. coli) and antileishmanial (L.tropica and L. donovani) activities of B. serrata aqueous crude extract using (0.5%) DMSO solvent for extraction. The phytochemical analysis of crude extract was positive for saponin only. The extract failed to inhibit bacterial growth on MullerHinton agar plate. Lower concentrations (5%, 2.5% and 1.25%) of extract showed antileishmanial activity against two species of Leishmania. The (10%) concentration lacked antileishmanial activity. The study concludes that B. serrate gumresin has a potential antileishmanial activity against two species of Leishmania using a safe concentration of (0.5%) DMSO as an alternative aqueous solvent for methanol extracting gumresins.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"29 1","pages":"190-199"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80293275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANTIMICROBIAL ACTIVITY OF SHODHITA AND MARITA SHILAJATU","authors":"A. Kumari","doi":"10.20959/wjpps20179-10114","DOIUrl":"https://doi.org/10.20959/wjpps20179-10114","url":null,"abstract":"Shilajata is a herbomineral compound with many beneficial therapeutic properties. It is stated in charka that, there is no such Sadhya roga by which with the effect of Shilajatu cannot be treated. Shilajatu is benefiticial in all medicinal uses with all scientific manner when consumed eradicates whichever be the disease and strengthens the bala of the person. Shilajata is more effective than several currently available clinically efficacious immunomudulators. Benefits of Shilajatu are mainly antiaging, good aphrodisiac, Anti inflammatory, antiallergic and good antimicrobial agent. In the rashashastra texts, it is one among maharasa and exists in two types as 1-Gomutra Gandhi and 2karapoora Gandhi Shilajatu. Among both of them gomutra Gandhi Shilajatu is consider superior and used for the preparation of medicine. The Samhita have classified into four (charaka) and six (susruta), Depending on the presence of metal ore found in the mountains from which the Shilajatu is collected. In ancient texts numbers of krimighna and kusthghna dravyas are explained. The word krimi is campared to various types of micro organismin contemporary science, which include bacteria and fungi etc. In ayurveda many herbal, mineral and herbomineral drugs are mentioned that are having antimicrobial WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 6.647 Volume 6, Issue 9, 1664-1668 Research Article ISSN 2278 – 4357 Article Received on 10 July 2017, Revised on 01 August 2017, Accepted on 22 August 2017, DOI: 10.20959/wjpps20179-10114 *Corresponding Author Dr. Anita Kumari Lecturer Dept. of Rasashastra and Bhaishajya Kalpana, M. L. R. Ayurvedic Medical College Charkhi Dadri Bhiwani.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"139 1","pages":"1664-1668"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80532135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTI INFLAMMATORY AND ANALGESIC ACTIVITIES OF CORDIA MONOICA ROXB STEM","authors":"M. Trivedi","doi":"10.20959/WJPPS20179-10080","DOIUrl":"https://doi.org/10.20959/WJPPS20179-10080","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"15 1","pages":"1530-1536"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84891833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREPARATION AND IN VITRO EVALUATION OF CHITOSAN-CARRAGEENAN CROSSLINKED BLEND MICROSPHERES FOR CONTROLLED RELEASE OF NATEGLINIDE","authors":"P. Ramakrishna","doi":"10.20959/WJPPS20179-10125","DOIUrl":"https://doi.org/10.20959/WJPPS20179-10125","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"8 1","pages":"1704-1717"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84117921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}