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Zeitschrift fur Immunitatsforschung. Immunobiology最新文献

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[X. Meeting of the Society for Immunology; 1-4 October 1978 in Freiburg i. Br]. [X。免疫学学会会议;1978年10月1日至4日，弗莱堡[j]。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-10-01
J S Ahmed, S H Kaufmann, H Hahn
{"title":"[X. Meeting of the Society for Immunology; 1-4 October 1978 in Freiburg i. Br].","authors":"J S Ahmed, S H Kaufmann, H Hahn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"155 1","pages":"1-76"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11252920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the serum protein inhibitor of the V.D.R.L. test. vdrl试验血清蛋白抑制剂的研究。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
G H Butler, L J Brenner
{"title":"Characterization of the serum protein inhibitor of the V.D.R.L. test.","authors":"G H Butler,&nbsp;L J Brenner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The V.D.R.L. test for syphilis was used to evaluate the ability of various serum protein fractions to inhibit cardiolipin flocculation tests for syphilis. Serum protein fractions obtained by modifications of the method of Ecker et al. (1) were chromatographed by DEAE or gel filtration and characterized by immunodiffusion and electrophoresis. These experiments indicated that the V.D.R.L. inhibitor substance was in the IgM fraction of serum, although it has not yet been determined whether the inhibitor is an IgM antibody or another component which cofractionates with IgM.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"442-50"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11927155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of peanut agglutinin with human lymphocytes. Binding properties and topology of the receptor site. 花生凝集素与人淋巴细胞的相互作用。受体位点的结合特性和拓扑结构。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
R A Newman, G Uhlenbruck, K Schumacher, A V Mil, D Karduck
{"title":"Interaction of peanut agglutinin with human lymphocytes. Binding properties and topology of the receptor site.","authors":"R A Newman,&nbsp;G Uhlenbruck,&nbsp;K Schumacher,&nbsp;A V Mil,&nbsp;D Karduck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between the mitogenic lectin PNA and other mitogenic and non-mitogenic lectins was investigated. PNA labelled with 125I was found to bind equally well to T and B lymphocytes, after neuraminidase treatment, with 3.88 times 10(6) and 3.73 times 10(6) binding sites respectively. Only the T cell fraction was stimulated, however, and only after neuraminidase treatment. Preincubation of neuraminidase-treated cells with non-mitogenic lectins and antiserum which appeared to bind to the same receptor as PNA, enhanced the latter's stimulatory properties. Capping and co-capping techniques were used to examine the topology of lectin receptors on the lymphocyte surface. The receptor glycoprotein for the mitogenic PNA lectin was found to be distinct from that possessing the Con A and PHA receptors, as well as that possessing the receptor for the non-mitogenic lectin from Helix pomatia.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"451-62"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11927156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of a primary DNA-synthesis response by trinitrobenzosulfonate (TNBS)-activated suppressor cells; characterization of the inhibitory cells. 三硝基苯磺酸盐(TNBS)激活的抑制细胞对dna合成反应的抑制作用抑制细胞的表征。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
W Suessmuth, W Droege
{"title":"Inhibition of a primary DNA-synthesis response by trinitrobenzosulfonate (TNBS)-activated suppressor cells; characterization of the inhibitory cells.","authors":"W Suessmuth,&nbsp;W Droege","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Repeated intravenous injections of high doses of trinitrobenzosulfonate (TNBS) or dinitrobenzosulfonate (DNBS) activate suppressor cells which inhibit the in vivo activation of a primary DNA synthesis response against trinitrochlorobenzene (TNCB) and dinitrochlorobenzene (DNCB), respectively, almost completely and the delayed type hypersensitivity (DH) response only partially. When tested on the DNA-synthesis response, the suppressor cells show excellent specificity with little cross reactivity of TNBS (or DNBS) induced suppressor cells for DNCB- (or TNCB-) specific responses. TNBS- and DNBS-specific suppressor activity is found in spleen cells, mesenteric lymph nodes and peripheral lymph nodes. The activation of suppressor cells is resistant to the early effects of adult thymectomy (ATx), but sensitive to pretreatment with cyclophosphamide (CyP). The suppressor cells are not simply haptenated cells. They need several days for their activation and are inactivated by incubation for 30 minutes at 56 degrees C or by 2,000 R irradiation. Attempts to obtain soluble suppressor factors by in vitro incubation or extraction of these suppressor cells failed.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"416-32"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11524208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of peripheral B and T lymphocytes in piglets. 仔猪外周血B和T淋巴细胞的发育。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
C Reyero, J G Thalhammer, G Reszler, W Stöckl
{"title":"Development of peripheral B and T lymphocytes in piglets.","authors":"C Reyero,&nbsp;J G Thalhammer,&nbsp;G Reszler,&nbsp;W Stöckl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The percentage of B and T lymphocytes in the peripheral blood of piglets during their first 35 days of life was estimated by means of the immunofluorescence-labelled anti-L chains sera and the spontaneous E-rosette techniques. The mean values obtained for adult pigs PBL were 23.8 +/- 10.2% of B and 38.0 +/- 8.4% of T lymphocytes. The piglets showed a linear increase for the B lymphocytes starting from a mean value of 4% observed for the newborns. The trend of the T lymphocytes was represented by a bimodal curve. It starts for newborns at 3% and shows a change in shape by the 10th day. It is suggested that the piglets have adult levels of B and T lymphocytes by the time of weaning.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"409-15"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11524207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-mediated immunity in response to HBs antigen. 对HBs抗原的细胞介导免疫反应。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
A Szkaradkiewicz, W Kiczka
{"title":"Cell-mediated immunity in response to HBs antigen.","authors":"A Szkaradkiewicz,&nbsp;W Kiczka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The response of peripheral blood leukocytes to purified HBsAg was studied in vitro by means of the leukocyte migration test in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis carrying GBsAg, and in asymptomatic carriers of HBs antigen. In the acute period of the disease no leukocyte migration inhibition could be observed. Patients with chronic aggressive hepatitis also frequently failed to develop cell-mediated immunity to HBsAg. Results obtained for HBs antigen carriers did not differ from those of normal blood donors. The observations may indicate participation of cell-mediated immunity in the development of liver damage.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"463-70"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11927040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood-group A and G specific structures in toad (Bufo) spawn. Comparative studies on three species (Bufo bufo, Bufo viridis, Bufo calamita). 蟾蜍(Bufo)卵中A、G血型的特异性结构。三种Bufo Bufo的比较研究(Bufo, viridis, Bufo calamita)。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
M Wrann, H Schenkel-Brunner, H Kothbauer
{"title":"Blood-group A and G specific structures in toad (Bufo) spawn. Comparative studies on three species (Bufo bufo, Bufo viridis, Bufo calamita).","authors":"M Wrann,&nbsp;H Schenkel-Brunner,&nbsp;H Kothbauer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Permethylation analyses of the spawn material of three toad (Bufo) species allow the conclusion that the serologically determinant group in Bufo bufo spawn is identical with that found in human and hog blood-group A substances (i.e. GalNAc(alpha1,3) [Fuc(alpha1,2)] Gal -), and the serologically determinant group in Bufo viridis and Bufo calamita spawn is identical with that found in blood-group H substances (i.e. Fuc(alpha1,2) Gal -).</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"471-3"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11772390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promotion of L1210 tumour growth by macrophages. 巨噬细胞促进L1210肿瘤生长。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-09-01
R P Huget, H D Flad, H G Opitz
{"title":"Promotion of L1210 tumour growth by macrophages.","authors":"R P Huget,&nbsp;H D Flad,&nbsp;H G Opitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low numbers (10(4)) of peritoneal exudate L1210 mouse lymphoma cells were injected into DBA/2 mice subcutaneously and the development of tumours was followed. Tumour takes occurred in 100% of the animals within 9 days after tumour transplantation. The latent period of tumour development was prolonged by 6-10 days when tumour cells of the peritoneal exudate, depleted of adherent/phagocytic cells, were used in the inoculum or when tumour cells derived from continuous cell cultures were used. Addition of adherent cells in high numbers to in-vitro-derived L1210 cells accelerated tumour growth. This effect was found to be not specific for adherent/phagocytic cells, as liver cells had the same influence on tumour growth. It is concluded that, under certain experimental conditions, a cell population with the functional properties of macrophages is able to promote tumour development, most likely due to their non-specific effect on the micro-environment of the growing tumour.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 5","pages":"433-41"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11927154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-HBc titers in HBeAg and anti-HBe positive asymptomatic HBsAg carriers. HBeAg和抗hbe阳性无症状HBsAg携带者的抗hbc滴度。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-06-01
G Hess, J Wagner, W Arnold, R H Purcell, K H Meyer zum Büschenfelde
{"title":"Anti-HBc titers in HBeAg and anti-HBe positive asymptomatic HBsAg carriers.","authors":"G Hess,&nbsp;J Wagner,&nbsp;W Arnold,&nbsp;R H Purcell,&nbsp;K H Meyer zum Büschenfelde","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was undertaken to establish markers for HBV replication in relation to HBeAg and anti-HBe. HBsAg carriers with serum HBeAg had DNA polymerase activity in the serum and HBcAg in the liver nuclei. Anti-HBe positive and anti-HBe/HBeAg negative sera lacked these markers. For anti-HBc the following geometrical mean titers were calculated: 1: 12,000 for HBeAg positive, 1:9, 100 for anti-HBe and anti-HBc positive, and 1:2,800 for anti-HBc positive anti-HBe/HBeAg negative asymptomatic HBsAg carriers. Follow up studies revealed mostly unchanged anti-HBc titers in all three groups over an observation period of ten to twenty months. Our data argue for a prolonged HBV replication in all HBsAg carrier subgroups compared to individuals with an uncomplicated acute virus-B-hepatitis. This study gives no final answer whether HBeAg negative HBsAg carriers have a continous HBV replication.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 3","pages":"208-17"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure of immunoglobulin D: evidence for the absence of an extra disulfide bridge in the Fc fragment. 免疫球蛋白D的结构:Fc片段中缺乏额外二硫桥的证据。
Zeitschrift fur Immunitatsforschung. Immunobiology Pub Date : 1978-06-01
A Garcia-Pardo
{"title":"Structure of immunoglobulin D: evidence for the absence of an extra disulfide bridge in the Fc fragment.","authors":"A Garcia-Pardo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular weight determinations of immunoglobulin D suggest the presence of an extra region of the delta chain. In an attempt to locate this region, an IgDlambda myeloma protein (Gur), was digested with trypsin for 4 min at 56 degrees and the Fc fragment isolated by ion exchange chromatography. N-terminal analysis of this fragment showed a heterogeneity in the site of splitting by trypsin. The Fc was digested with pepsin and trypsin and the cysteine containing peptides isolated by a two dimensional paper high voltage electrophoresis (diagonal map) at pH 3.5. Further purification of these peptides was carried out by HVE at pH 6.5 and 2.1 and their amino acid composition and partial sequence were determined. Only five cysteic acid peptides were obtained, one corresponding to the inter heavy-heavy bridge and the other four, to intra chain bridges. This finding would exclude the possibility of an extra \"classical domain\" in this region. The position of these peptides in the delta chain has been arranged based on homology with the other classes of immunoglobulins.</p>","PeriodicalId":23935,"journal":{"name":"Zeitschrift fur Immunitatsforschung. Immunobiology","volume":"154 3","pages":"218-25"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11877599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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