Marco Colasurdo, Adel M Malek, Carl B Heilman, Peter Kan
{"title":"Endovascular CSF Diversion with the eShunt: Bridging Adult Trials to Pediatrics.","authors":"Marco Colasurdo, Adel M Malek, Carl B Heilman, Peter Kan","doi":"10.1016/j.wneu.2025.124181","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124181","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124181"},"PeriodicalIF":1.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiancheng Jin, Huimin Shen, Guotao Peng, Jiankuai Zhou, Dan Xu, Yili Chen, Jun Mo
{"title":"The Role of Comprehensive Structural Preservation Strategy in Skull Base Reconstruction Following Endoscopic Endonasal Surgery for Pituitary Neuroendocrine Tumors: A Retrospective Single-Center Study.","authors":"Jiancheng Jin, Huimin Shen, Guotao Peng, Jiankuai Zhou, Dan Xu, Yili Chen, Jun Mo","doi":"10.1016/j.wneu.2025.124171","DOIUrl":"https://doi.org/10.1016/j.wneu.2025.124171","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate and compare the surgical outcomes of endoscopic endonasal surgery (EES) for pituitary neuroendocrine tumors (PitNETs) using two surgical approaches: the comprehensive structural preservation strategy based on transseptal approach (CSP-TSA) and the traditional transnasal approach (TNA).</p><p><strong>Methods: </strong>We retrospectively analyzed 62 patients who underwent EES for PitNETs at our center between March 2021 and September 2024. Patients were categorized into CSP-TSA (n = 32) and TNA (n = 30) groups based on the surgical approach. Outcomes assessed included tumor resection extent, biochemical remission rate of functional PitNETs, visual function improvement rate, and postoperative cerebrospinal fluid (CSF) leakage rate between the two groups. Statistical comparisons were performed to evaluate differences between the two groups.</p><p><strong>Results: </strong>A total of 62 patients were included in the study, with 30 undergoing TNA and 32 undergoing CSP-TSA. The two groups were well-matched in terms of baseline demographic and clinical characteristics. Both approaches achieved comparable rates of gross total resection (GTR), hormonal remission, and visual function improvement. However, significant differences were observed in postoperative CSF leakage rates (0% in CSP-TSA vs. 13.3% in TNA; p = 0.049).</p><p><strong>Conclusions: </strong>The CSP-TSA demonstrated equivalent efficacy in tumor resection and functional outcomes compared to TNA, while significantly reducing postoperative CSF leakage and overall complication rates. The protective reconfiguration of the anterior wall of the sphenoid sinus (AWSS), in-situ bone flap (ISBF) of the sellar floor, and sphenoid mucosal flap (SMF) may enhance skull base reconstruction in CSP-TSA, highlighting its potential as a superior strategy for structural preservation in EES for PitNETs.</p>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":" ","pages":"124171"},"PeriodicalIF":1.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Randomized Clinical Trials in Cerebrovascular Neurosurgery: Analysis of Discontinuation and Nonpublication Prevalence and Trends","authors":"Molly Butler , Lydia Kaoutzani , Scott Rahimi","doi":"10.1016/j.wneu.2025.124159","DOIUrl":"10.1016/j.wneu.2025.124159","url":null,"abstract":"<div><h3>Objective</h3><div>Premature randomized clinical trial (RCT) discontinuation and nonpublication have been shown to frequently compromise advancements in medicine. However, the extent to which these problems exist in RCTs of cerebrovascular disease is not well understood. This study aims to investigate the prevalence of discontinuation and nonpublication among cerebrovascular clinical trials and explore characteristics associated with each.</div></div><div><h3>Methods</h3><div>We searched <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> using selected keywords to identify relevant RCTs. Trials generated in our search were screened to exclude unrelated trials, active trials, and trials completed within the previous three years. We analyzed included RCTs to identify the publication status or reason for discontinuation.</div></div><div><h3>Results</h3><div>Of the 421 included RCTs, 245 (58.2%) were completed and 176 (41.8%) were discontinued. Trials investigating medical devices and government-funded trials had the lowest rates of discontinuation. Participant accrual difficulty was the most common reason for discontinuation identified (12.5%), though 52.8% of the discontinued trials did not provide a reason for discontinuation. There were 226 published trials (53.7%) and 195 unpublished trials (46.3%). Unpublished trials included 135 of the 176 discontinued trials (76.7%) and 60 of 245 completed trials (24.5%). Trial discontinuation was significantly associated with nonpublication. Trials funded by the National Institutes of Health were less likely to be unpublished.</div></div><div><h3>Conclusions</h3><div>Premature discontinuation was common among cerebrovascular trials in neurosurgery and frequently attributed to difficulties with patient enrollment. Nonpublication was especially common among discontinued trials. Our findings may highlight opportunities to improve research efficiency and potentially improve outcomes for patients with cerebrovascular diseases.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"199 ","pages":"Article 124159"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Reply to the Letter to the Editor Regarding “Burnout Among Neurosurgeons and Residents in Neurosurgery: A Systematic Review and Meta-Analysis of the Literature”","authors":"Ismail Zaed , Salvatore Chibbaro","doi":"10.1016/j.wneu.2025.124170","DOIUrl":"10.1016/j.wneu.2025.124170","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"200 ","pages":"Article 124170"},"PeriodicalIF":1.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor Regarding “Penetrating Brain Injury: Bridging Global Disparities in Care and Advancing Management Strategies”","authors":"Yalcin Golcuk","doi":"10.1016/j.wneu.2025.124165","DOIUrl":"10.1016/j.wneu.2025.124165","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"200 ","pages":"Article 124165"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor Regarding “Predictive Factors for Postoperative Cerebrospinal Fluid Drainage in Neurosurgical Management of Intracranial Aneurysms”","authors":"Yuliia Solodovnikova, Ksenia Yarova, Anatoliy Son","doi":"10.1016/j.wneu.2025.124160","DOIUrl":"10.1016/j.wneu.2025.124160","url":null,"abstract":"","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"200 ","pages":"Article 124160"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Byung-Jou Lee , Hae-Won Koo , Seonghoon Jeong , Kwang Hyeon Kim
{"title":"Correlation Between Calcification of Facet Joint Capsule and Dynamic Instability in Lumbar Degenerative Spondylolisthesis","authors":"Byung-Jou Lee , Hae-Won Koo , Seonghoon Jeong , Kwang Hyeon Kim","doi":"10.1016/j.wneu.2025.124163","DOIUrl":"10.1016/j.wneu.2025.124163","url":null,"abstract":"<div><h3>Background</h3><div>To evaluate the association between facet joint capsule calcification (FCC) on computed tomography and dynamic instability on weight-bearing flexion-extension lateral X-ray in patients with degenerative spondylolisthesis at L4-5.</div></div><div><h3>Methods</h3><div>Clinical and radiologic data from 388 patients with degenerative spondylolisthesis who underwent lumbar magnetic resonance imaging, computed tomography, and dynamic X-ray within a 1-month interval from January 2012 to December 2021 were reviewed in this study. Radiologic factors associated with dynamic instability were evaluated: FCC, facet degeneration grade, facet joint fluid, facet tropism, disc degeneration grade, traction spur, and vacuum phenomenon. We evaluated the association between FCC and dynamic instability and determined the best cutoff value of cross-sectional area (CSA) of FCC for predicting dynamic instability.</div></div><div><h3>Results</h3><div>The FCC, facet joint degeneration, disc degeneration grade, and traction spur were significantly correlated with dynamic instability. The optimal cutoff point of the average CSA of FCC was measured at 14.46 mm2 with 82.3% and 96.0% sensitivity and specificity, respectively, with an area under the curve of 0.950. In the distribution in CSA of FCC according to grade of facet joint degeneration, the best cutoff value of CSA of FCC related to dynamic instability, 14.46 mm<sup>2</sup>, is almost the same as the mean value of CSA of FCC for grade 2 of facet joint degeneration.</div></div><div><h3>Conclusions</h3><div>FCC is significantly correlated with dynamic instability in degenerative spondylolisthesis at L4-5. FCC is a radiologic finding that can be helpful in detecting dynamic instability together with dynamic X-ray.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"199 ","pages":"Article 124163"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng Qian, Tommi K. Korhonen, Mikael von und zu Fraunberg
{"title":"A Novel, Straightforward and Affordable Suction-Irrigation Device for Microneurosurgery: A Technical Note","authors":"Cheng Qian, Tommi K. Korhonen, Mikael von und zu Fraunberg","doi":"10.1016/j.wneu.2025.124161","DOIUrl":"10.1016/j.wneu.2025.124161","url":null,"abstract":"<div><h3>Background</h3><div>Irrigation and suction devices are essential tools in microneurosurgery, allowing the maintenance of a clear operative field and meticulous dissection of critical neurovascular structures. Currently available suction-irrigation devices are in limited use due to their high price and difficulty of use in real-life situations. We present a novel suction-irrigation apparatus that is easy to utilize in every microneurosurgical operation and can be assembled with tools available in most neurosurgical centers.</div></div><div><h3>Methods</h3><div>The irrigation device of a Medtronic irrigating drill is attached to a Fukushima suction tip with a small silicone band. Suction power is controlled by the surgeon's fingertip using a malleable suction tip, and irrigation is controlled using the drill's foot pedal. Narrated videos exemplifying the assembly and use of the suction-irrigation device were recorded.</div></div><div><h3>Results</h3><div>We have used the suction-irrigation device in 107 surgeries to date since its first application and have found it to enhance the operative experience as it provides optimal surgical visibility with reduced effort compared to traditional means. Adjuvant drugs such as nimodipine may be added to the irrigation fluid. The use of the suction-irrigation apparatus reduces the requirement of bipolar coagulation and improves operating comfort compared to a traditional stand-alone suction device and an assistant irrigating.</div></div><div><h3>Conclusions</h3><div>We present the application of a cost-effective suction-irrigation technique that can be easily assembled from widely used traditional neurosurgical tools. The novel device enables minimally traumatic neurovascular microdissection even in the setting of subarachnoid hemorrhage and highly vascular tumors.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"200 ","pages":"Article 124161"},"PeriodicalIF":1.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yufei He , Hong Wang , He Liu , Chao Wu , Yuhan Guo , Fan Bai
{"title":"Global Research Trends in Anterior Cervical Fusion Surgery: A 25-Year Bibliometric Analysis","authors":"Yufei He , Hong Wang , He Liu , Chao Wu , Yuhan Guo , Fan Bai","doi":"10.1016/j.wneu.2025.124145","DOIUrl":"10.1016/j.wneu.2025.124145","url":null,"abstract":"<div><h3>Background</h3><div>Anterior cervical fusion surgery (ACFS) is a well-established surgical intervention for cervical degenerative disease. To delineate current research trends and forecast future directions and emerging hotspots, this study conducted a bibliometric analysis of ACFS over the past 25 years.</div></div><div><h3>Methods</h3><div>We conducted a search in the Web of Science Core Collection database to identify articles and reviews on ACFS from 2000 to 2024. Bibliometric analysis was performed using CiteSpace 6.3.R3 and Bibliometrix (R package).</div></div><div><h3>Results</h3><div>A total of 4002 articles and reviews were analyzed. This study revealed consistent growth in publications over time. China and the United States were the leading contributors in publications, authors, and institutional output, with Rush University ranking first among institutions (226 papers). <em>Spine</em> ranked first in both publication volume (n = 487) and total citations (n = 24,881), highlighting its pivotal role in the field. Among authors, Liu H published the most papers (n = 104), while Riew KD received the highest citations (n = 2399). The most frequently used keywords were “diskectomy” (948), “spine” (826), and “fusion” (733), with “interbody fusion” being the earliest (2000) and most impactful keyword (burst strength: 45.66).</div></div><div><h3>Conclusions</h3><div>This study provides a comprehensive overview of ACFS research over the past 25 years through bibliometric analysis. The findings enhance understanding of current research landscapes and aid in anticipating future developments in this field.</div></div>","PeriodicalId":23906,"journal":{"name":"World neurosurgery","volume":"199 ","pages":"Article 124145"},"PeriodicalIF":1.9,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}