Zentralblatt fur Veterinarmedizin. Reihe A最新文献

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[The metabolism of foreign substances in the horse with reference to other animal species]. [马体内外来物质的代谢,参照其他动物]。
A Schmid, H Schmid
{"title":"[The metabolism of foreign substances in the horse with reference to other animal species].","authors":"A Schmid,&nbsp;H Schmid","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper, the metabolism of xenobiotics in the horse, including differences to other species, is discussed. The most important metabolic reactions of phase I (oxidation, reduction and hydrolysis of substrates), as well as of phase II (conjugation of substrates with glucuronic acid, sulphuric acid, acetic acid, alkyl groups, amino acids, amino acid derivatives, glutathione etc.), are discussed and enzymes involved in the metabolic reactions are considered.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 7","pages":"493-508"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19967368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of combolen on the erythrocyte distribution in the dog]. 复方玉米粉对犬红细胞分布的影响。
R Langer, K Hempel, R Steigerwald, K Trenkel, H A Henrich
{"title":"[The effect of combolen on the erythrocyte distribution in the dog].","authors":"R Langer,&nbsp;K Hempel,&nbsp;R Steigerwald,&nbsp;K Trenkel,&nbsp;H A Henrich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of Combolen (3.9 mg/kg bw s.c.) on the distribution of erythrocytes in dogs was investigated. After application of Combolen, the hematocrit of the animals decreased exponentially within 1 h by 21%. The reversal of the reduction began from 2 h after the time of application, amounting to 4% within the first day and finishing by the fourth day. After injection of 51Cr-labelled erythrocytes, radioactivity in the circulation of Combolen-treated dogs decreased exponentially within 2 h by at least 30%. It was concluded that the dog's spleen, under physiological conditions, contains about 10% of the animal's blood. The time-courses of the decrease of hematocrit and radioactivity in the circulation were found to be very similar. In accordance with this observation, a high correlation (r = 0.97) between the level of radioactivity after injection of radio-labelled erythrocytes and the corresponding hematocrit values after application of Combolen was found. After application of erythrocytes, labelled with 99mTc, an extensive distribution from the circulation into the spleen was observed by scintigraphy. This process can be understood by using a closed-compartment model. An equation, based on this model, describes the observed time course of the hematocrit values, as well as the number of 51Cr-labelled erythrocytes, in Combolen-treated dog. Presumably, the observed effect of Combolen is the result of the relaxation of the smooth muscle cells in the trabeculae of the spleen, caused by central-nervous depression of sympathetic tone. Combolen seems to be a suitable tool in pre-clinical testing of a novel blood preserve with dog as a test animal. Its potent ability to eliminate erythrocytes from circulation is distinguishable from the sequestration of damaged red cells. Furthermore, its ability to prevent the spleen from uncontrolled hematocrit modulating actions in addition to its sedative effects is considered to be an invaluable advantage.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 7","pages":"509-22"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19967369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Methodological aspects for the determination of the coagulative activity of coagulation factors II, V, VII and X from dog plasma]. [犬血浆中凝血因子II、V、VII、X凝血活性测定的方法学方面]。
R Mischke
{"title":"[Methodological aspects for the determination of the coagulative activity of coagulation factors II, V, VII and X from dog plasma].","authors":"R Mischke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For optimization of single factor II, V, VII and X activity measurements in dogs, dilution series of dog pool plasma were prepared using different commercially available calcium thromboplastins and deficient plasmas. Measured by use of a canine reference curve, the single factor activity in humans was 89% (factor II), 13% (factor V), 27% (factor VII) and 84% (factor X). Because the factor V and VII activity in dogs is much higher than in humans, in measurements using human-deficient plasma, a high sample predilution of at least 1:40 seems to be of advantage. Otherwise extreme variations of the factor V and VII activity may also influence the results of the other single factors. For determination of factor II, V and X activity, therefore, a non-standardized human placenta thromboplastin was especially suitable. With this reagent, the results were also reproducible at high sample dilutions (1:80, factor II and X; 1:160, factor V). Because of the low sensitivity of non-standardized human placenta thromboplastin to factor VII, measurements of this factor at a sample dilution of 1:40 required a standardized human placenta, or rabbit brain thromboplastin had to be used. For factor II measurements, the selection of a suitable deficient plasma is particularly important. Here, the reference curve showed a clear dependence on the commercial preparation chosen.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 6","pages":"431-42"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18861400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic and pathophysiological aspects of the determination of kidney function in animals]. [动物肾脏功能测定的诊断和病理生理方面]。
S Reder, H Hartmann
{"title":"[Diagnostic and pathophysiological aspects of the determination of kidney function in animals].","authors":"S Reder,&nbsp;H Hartmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Early diagnosis of loss in renal function (< 60-70%) is not possible either by resorting to the parameters of plasma urea and creatinine concentrations (responsive to functional loss by > 75% or by reference to urine concentration capacity (urine density: sensitive to concentrations > 60%). However, clearance techniques for determination of the glomerular filtration rate (GFR) have proved suitable for quantitative assessment of renal function. Endogenous creatinine clearance is one of the most common clinical approaches in GFR determination. Criticism of results obtainable from endogenous creatinine clearance appears to be justified by pharmacokinetic aspects of creatinine as an indicator, as well as by some of its analytical peculiarities. The tediousness of the procedure is another counterproductive aspect pertaining to large-scale use of endogenous creatinine clearance in veterinary medicine. Total blood-plasma clearance of exogenous creatinine (T-Clexo.Creatinine) would provide vets with an accurate (diagnostic validity) and practical method for carrying out clinical kidney-function diagnostics. However, more research on a number of related issues will be required before the general introduction of the procedure.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 4","pages":"253-67"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The influence of rumen metabolism on cyclic N compounds in the blood plasma of ruminants]. [瘤胃代谢对反刍动物血浆中环氮化合物的影响]。
S Arui, M Stangassinger, D Giesecke
{"title":"[The influence of rumen metabolism on cyclic N compounds in the blood plasma of ruminants].","authors":"S Arui,&nbsp;M Stangassinger,&nbsp;D Giesecke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this paper was to study the effect of rumen metabolism on the concentration of certain cyclic N-compounds in blood plasma. The plasma from two groups of lambs in the phase of rumen development during early and late weaning was used. As a second model, samples from steers fed at maintenance and after emptying of the rumen via cannula were used. Plasma samples were obtained from the jugular vein in regular intervals. The HPLC-technique was employed as analytical method. The plasma levels of allantoin and of hippuric acid increased about 2.2-3.7 fold and 2.4-6.4 fold in lambs during rumen development. They decreased to about 43% and 13% after emptying the rumen of steers. These metabolites appear to reflect rumen protein synthesis and fibre breakdown and are considered useful estimators of rumen function. Cytidine, uridine, uric acid and hypoxanthine were only influenced in part by rumen metabolism. Plasma pseudouridine was decreased and creatinine was increased in lambs in relation to body mass and remained unaffected in steers.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 4","pages":"298-306"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of hypoxic conditions in calves using the erythrocyte density test (EDT)]. [用红细胞密度试验(EDT)评价犊牛缺氧状况]。
T Flegel, H Hartmann
{"title":"[Evaluation of hypoxic conditions in calves using the erythrocyte density test (EDT)].","authors":"T Flegel,&nbsp;H Hartmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The erythrocyte density separation test (EDT) divides the red blood cells into two groups: younger (less dense) and older (more dense) erythrocytes. Using this test enables veterinarians to assess the erythropoiesis in calves on the basis of the percentage of less dense (younger) red blood cells. Anemic calves, as well as those with pneumonic infections show higher proportions of less dense red blood cells in the EDT than healthy ones. This testing procedure makes it possible to estimate the effects of an oxygen deficiency condition, such as hypoxemia, anemia, shock etc. on the peripheral tissues. So the EDT represents a valuable complement to existing hematological laboratory methods. Carrying out the EDT is very simple and suitable in routine clinical testing.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"41 3","pages":"215-28"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18941310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pulsed Doppler echocardiography measurement in healthy warmblood horses]. [健康温血马的脉冲多普勒超声心动图测量]。
P Stadler, T Weinberger, E Deegen
{"title":"[Pulsed Doppler echocardiography measurement in healthy warmblood horses].","authors":"P Stadler,&nbsp;T Weinberger,&nbsp;E Deegen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty adult warm blooded horses (body weight 585 +/- 59 kg) were evaluated with pulsed doppler echocardiography. Locations for the transducer and the sample volume were determined to get typical blood flow tracings of the equine heart. Angle of doppler beam was between 37 degrees and 40 degrees in right heart atrioventricular flow tract and between 44 degrees and 47 degrees in left heart atrioventricular flow tract. Peak blood flow velocity (angle corrected) was 0.71 +/- 0.17 m/s in tricuspid valve and 0.92 +/- 0.22 in mitral valve. In right and left atrioventricular flow tracts in all sample volume positions typical double peaked spectral tracings of blood flow were seen. In supravalvular, valvular and subvalvular sample volume locations of the ventriculoatrial flow tracts angles were between 28 degrees and 33 degrees in right heart and between 34 degrees and 37 degrees in left heart. Peak flow velocity (angle corrected) was 0.98 +/- 0.13 m/s in pulmonary valve and 0.92 +/- 0.09 m/s in aortic valve. Paradoxical systolic and diastolic flows were seen. The flow velocity tracings were similar to those found in man. Flow velocity values of clinically normal horses have a wide range like in healthy human beings. Nevertheless flow tracings of healthy horses have a characteristical profile and may be helpful in detecting abnormal blood flow in heart diseased horses.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"40 9-10","pages":"757-78"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19127428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experimental studies of the pathogenesis of rumen acidosis in sheep]. 绵羊瘤胃酸中毒发病机制的实验研究。
M Ganter, K Bickhardt, M Winicker, B Schwert
{"title":"[Experimental studies of the pathogenesis of rumen acidosis in sheep].","authors":"M Ganter,&nbsp;K Bickhardt,&nbsp;M Winicker,&nbsp;B Schwert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rumen acidosis was provoked in 13 cross-bred sheep by feeding oat (32 g/kg body weight) or wheat of different grinding levels (26 g/kg). Development of the diet-related disease was studied in 8 fistulated sheep fitted with a permanent rumen cannula and with implanted jugular vein catheter by analysing blood and rumen fluid sampled up to 48 hours after feed intake. Ingesta of the different segments of the digestive tract were collected from 5 sheep, necropsied 8 and 12 hours after feeding respectively. Concentrations of glucose, L- and D-lactate were measured in blood and digesta by enzymatic methods. Concentrations of amylopolyglucans and pH values were analysed in the digesta. Whereas the plasma concentration of glucose and L-lactate rose with a maximum at 8 to 12 hours after feeding, that of D-lactate was maximally increased after 24 hours. High concentrations of amylopolyglucans, glucose, L- and D-Lactate were found in the whole digestive tract 8 and 12 hours after feed intake. It is concluded from the results obtained that sheep show characteristics of monogastric intestinal digestion with the release of considerable amounts of glucose and of both lactate isomers after feeding fine distributed starch.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"40 9-10","pages":"731-40"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19127431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The postnatal development of porcine purine catabolism and the effect of the environmental temperature on turnover]. [猪嘌呤分解代谢的产后发育及环境温度对代谢的影响]。
D Giesecke, G Heiss, A Pospischil
{"title":"[The postnatal development of porcine purine catabolism and the effect of the environmental temperature on turnover].","authors":"D Giesecke,&nbsp;G Heiss,&nbsp;A Pospischil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experiments in piglets indicate that the catabolic metabolism of purines is only developed during the first 4 weeks of life. During this time the catalytic activity of uricase in liver homogenates is increased about 5.5 fold (p < 0.01). The counts of uricase-carrying peroxisomes and cores are increased to a similar degree (p < 0.01). In the same time the catalytic activity of cytosolic xanthine oxidase is elevated about 4.6 fold (p < 0.01), mainly in the second and third week. In blood plasma uric acid is decreased from 19 to 12 molar % during weeks 1 to 4, hypoxanthine, xanthine and allantoin remain relatively constant. In urine xanthine and uric acid are decreased, hypoxanthine and allantoin are increased. At the age of 2-3 days a decrease of ambient temperature from 32 to 20 degrees C caused an increase of the plasma pool (p < 0.01) and turnover (p < 0.05) of uric acid. Pool size and turnover of hypoxanthine are only slightly elevated. The results are discussed in view of the slow development of hepatic enzymes, the increase of uric acid pool at lowered ambient temperature and causal events leading to urate nephropathia.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"40 6","pages":"401-11"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19226140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Physiologic hypothermia of newborn kittens up to 6 weeks old]. [6周以下新生小猫的生理性低温]。
M Mähler, H Riedesel, K Gärtner, R Mörstedt, F Iglauer
{"title":"[Physiologic hypothermia of newborn kittens up to 6 weeks old].","authors":"M Mähler,&nbsp;H Riedesel,&nbsp;K Gärtner,&nbsp;R Mörstedt,&nbsp;F Iglauer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kittens showed a physiological hypothermia until they were 6 weeks of age. In the first 3 weeks of age rectal temperature was constantly low (37.6 +/- 0.3 degrees C). A linear increase of rectal temperature followed from the fourth to the sixth week of age inclusively and from the seventh week on rectal temperature reached the final temperature level (38.4 +/- 0.3 degrees C). This finding has to be considered in clinical assessment of kittens' body temperature.</p>","PeriodicalId":23904,"journal":{"name":"Zentralblatt fur Veterinarmedizin. Reihe A","volume":"40 5","pages":"393-6"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19203155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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