{"title":"The problem of specificity and selectivity of alkylating cytostatics; studies on N-2-chloroethylamido-oxazaphosphorines","authors":"N. Brock, H. Hohorst","doi":"10.1007/BF00284124","DOIUrl":"https://doi.org/10.1007/BF00284124","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"24 1","pages":"185-215"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85164912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oncocyten in einem Mammamischtumor der Hündin Eine elektronenmikroskopische Studie","authors":"D. Bomhard","doi":"10.1007/BF00282983","DOIUrl":"https://doi.org/10.1007/BF00282983","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"35 1","pages":"163-172"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90051259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Elektronenmikroskopische Untersuchungen an soliden Mammacarcinomen der Hündin","authors":"D. V. Bombard, R. Raddatz","doi":"10.1007/BF00282980","DOIUrl":"https://doi.org/10.1007/BF00282980","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"1 1","pages":"129-143"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90684398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutische Erfolge mit zentralwirksamen Pharmaka an Autochthonen 3-Methylcholanthren-Tumoren bei Ratten","authors":"Dr. A. v. Metzler","doi":"10.1007/BF00283973","DOIUrl":"https://doi.org/10.1007/BF00283973","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"34 1","pages":"300-307"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87138357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In memoriam Herwig Hamperl 12. September 1899—22.April 1976","authors":"","doi":"10.1007/BF00284118","DOIUrl":"https://doi.org/10.1007/BF00284118","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"62 1","pages":"103-119"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76806560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aufgeforderte Diskussionsbemerkung","authors":"K. Lennert","doi":"10.1007/BF00285259","DOIUrl":"https://doi.org/10.1007/BF00285259","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"26 1","pages":"137-139"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90826631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infrarot-Wärmekabine als milde Ganzkörper-Hyperthermie","authors":"W. Richter1, W. Schmidt2, Kurt Schmidt3","doi":"10.1055/s-2000-11214","DOIUrl":"https://doi.org/10.1055/s-2000-11214","url":null,"abstract":"","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"18 1","pages":"96 - 103"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79305362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Primary Endometrioid Adenocarcinoma of the Fallopian Tube","authors":"M. Terzić1, B. Štimec2","doi":"10.1055/s-2000-11216","DOIUrl":"https://doi.org/10.1055/s-2000-11216","url":null,"abstract":"is a rare malignant disease of the female genital tract. Carcinomas other than adenocarcinomas are extremely rare in the fallopian tube. We report a case of a malignant neoplasm of the fallopian tube with histological features of endometrioid adenocarcinoma that arose from the tubal epithelium. A 60-year-old woman with watery, intermittent vaginal discharge was found to have a right adnexal tumor. This case was diagnosed as primary carcinoma of the fallopian tube, FIGO Stage IIa. She underwent a total abdominal hysterectomy, a bilateral salpingo-oophorectomy, a pelvic and periaortic lymph nodes exploration, and an omentectomy, followed by radiotherapy. Histologically, the tumor presented as a primary endometrioid adenocarcinoma of the right fallopian tube","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"103 1","pages":"114 - 117"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76103534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutische Tumorvakzination","authors":"K. Schumacher","doi":"10.1055/s-2000-11215","DOIUrl":"https://doi.org/10.1055/s-2000-11215","url":null,"abstract":"Die Vorstellung, einen Impfstoff gegen Tumoren des Menschen zu entwickeln, ist so alt wie die Immunologie. Erste Versuche begannen vor 200 Jahren. Bis in die späten 30er Jahre des vorigen Jahrhunderts, als man weder Antibiotika noch Zytostatika hatte, setzte man ganz auf die körpereigenen Abwehrkräfte und suchte nach Wegen, diese zu verstärken. Frühzeitig wurde erkannt, dass Bakterien und ihre Produkte in der Lage waren, die Abwehrkräfte zu stimulieren. Gleichzeitig war man schon früh davon überzeugt, dass es auch beim Menschen eine spezifische Immunabwehr gegen Tumoren gibt, obwohl das erst in jüngster Zeit wirklich nachgewiesen wurde. Leider blieben die über viele Jahre immer wieder durchgeführten Studien zur Immunstimulation mit unspezifischen Agentien, inklusive der neuesten Entwicklungen wie Zytokine und LAKZellen, in ihren klinischen Ergebnissen sehr unbefriedigend. Nach Versuchen, durch Vakzination mit autologen oder allogenen Tumorzellen eine spezifische Immunantwort aufzubauen, die teilweise von Erfolg gekrönt waren, hat sich mit zunehmendem methodischen Fortschritt und besserer Charakterisierung von Tumorantigenen die Möglichkeit einer Vakzinierung mit tumortypischen Antigenen entwickelt. Diese Form einer aktiven spezifischen Immuntherapie, kombiniert mit Maßnahmen zur Verstärkung der Immunreaktion und mit gentherapeutischen Ansätzen, könnte im Anschluss an tumordestruktive Maßnahmen zu einem deutlichen Fortschritt, das heißt besseren Heilungsraten menschlicher Tumoren führen.","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"1 1","pages":"104 - 113"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83059539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delivery of N-(Phosphonacetyl)-L-aspartic acid encapsulated in thermosensitive sterically stabilized liposomes into cultured KB cells via folate receptor","authors":"Mohamed Gaber 1, D. Papahadjopoulos2","doi":"10.1055/s-2000-11213","DOIUrl":"https://doi.org/10.1055/s-2000-11213","url":null,"abstract":"in vitro","PeriodicalId":23887,"journal":{"name":"Zeitschrift für Krebsforschung und Klinische Onkologie","volume":"309 5 1","pages":"89 - 95"},"PeriodicalIF":0.0,"publicationDate":"2000-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72959374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}