Cardiology & Vascular Research最新文献

{"title":"Idiopathic Aortic Thrombosis and Thromboembolism in Young Women","authors":"Suyue M. Zhang, G. Joshi, R. Khoury, B. Parker, Andrii Labchuk, Chad E. Jacobs, John V. White, L. Schwartz","doi":"10.33425/2639-8486.1138","DOIUrl":"https://doi.org/10.33425/2639-8486.1138","url":null,"abstract":"Introduction: Spontaneous aortic thrombosis causing distal embolization and acute limb ischemia is an ominous medical condition with a poor prognosis. Herein are reported the clinical courses of two women who presented with severe lower extremity ischemia caused by distal embolization of spontaneous aortic thrombus without obvious antecedent arterial disease. This unusual diagnosis should be expected in patients presenting with persistent lower extremity pain and numbness even in the absence of overt physical findings. Case 1: A 42 year-old woman with mild hyperlipidemia complained of left leg numbness and weakness. She was treated with analgesia but her symptoms worsened. Lower extremity ultrasound revealed a significant infra-inguinal perfusion defect; computed tomography revealed mural thrombus in a normal aorta along with extensive thrombotic occlusion of the left popliteal and tibial arteries. Attempts at endovascular recanalization were unsuccessful; the patient underwent successful left popliteal-to-plantar artery bypass with autologous vein. Case 2: A 57 year-old woman without medical history presented to a local Emergency Room with a five-day history of numbness in the right lower extremity. Computed tomographic angiography revealed complete infrarenal aortic occlusion in a 3 cm diameter area of mild aortic ectasia along with iliac and distal right infrainguinal thromboembolism. The patient was treated with aortobifemoral bypass grafting with right leg fasciotomy, which restored perfusion and function. Conclusion: Spontaneous aortic thrombosis causing distal embolization and acute limb ischemia is an ominous medical condition with a poor prognosis. Episodes of embolization may be intermittent and asymptomatic such that, when symptoms finally occur, the distal thrombus is often chronic and inaccessible. The diagnosis should be suspected in patients with unexplained lower extremity symptoms and pulse deficits; it can be readily established with computed tomography.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130363045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Deep T-Wave Inversions and QT Prolongation with Azithromycin Treatment","authors":"Melissa Wasilewski, S. Kwiatkowski, Kunal Kapoor, Sumon Roy","doi":"10.33425/2639-8486.1135","DOIUrl":"https://doi.org/10.33425/2639-8486.1135","url":null,"abstract":"The tendency of macrolide antibiotics to prolong the QT interval in certain patient populations is well documented. In contrast, limited reports exist of medication-induced deep T-wave inversions. We recently encountered a case of azithromycin-induced QT prolongation with concurrent deep TWI, an association that is rarely observed in clinical practice. As similar ECG changes can be seen with life-threatening conditions such as coronary ischemia and cerebral hemorrhage, comprehensive workup to rule out acute pathologies is critical when this pattern is recognized.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126067739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De Winter’s Pattern - A Rare Electrocardiographic Sign of the Proximal Left Anterior Descending Artery Occlusion","authors":"Ashmita KC, V. Yadav, Ratna Mani Gajurel, C. Poudel, R. Khanal, S. Shakya, R. Ghimire, Sutap Yadav","doi":"10.33425/2639-8486.1136","DOIUrl":"https://doi.org/10.33425/2639-8486.1136","url":null,"abstract":"De Winter’s pattern is a rare anterior wall ST segment elevation myocardial infarction (STEMI) equivalent electrocardiogram (ECG) pattern that signifies 2% of proximal left anterior descending (LAD) coronary artery occlusion. We present a case of 48 years old male who presented in emergency room with a typical ischemic type of chest pain for 2 hours duration whose 12 lead ECG showed the typical De Winter’s pattern. The patient underwent immediate coronary angiography (CAG) which revealed 95-99% thrombotic occlusion of the proximal to mid left anterior descending artery. He underwent primary percutaneous coronary intervention (PPCI) with an Everolimus eluting stent that eventually resulted in a favorable outcome. Through this case report, we aim to highlight the importance of timely recognition of the rare ECG pattern and the role of PPCI as an optimal therapeutic option for such patients.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"354 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113998048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sagacity to Decode Cardiogenesis Mystries: Etiological Perspective of Cardiovascular Malformations","authors":"A. Alabdulgader, Ali S Alhazmi, Lamees A Alabdulgader","doi":"10.33425/2639-8486.1130","DOIUrl":"https://doi.org/10.33425/2639-8486.1130","url":null,"abstract":"The Birth of etiological studies in the current era: Quarter-Century of our life has been passed while we are still diving in the science of human cardiogenesis and Cardiovascular Malformations. The far away, great dream in the horizon is establishment of cardiogenesis knowledge capable of leading us to intervene and abort the developmental derangement leading to congenital cardiovascular malformation in human species. Knowledge of the epidemiology of congenital heart disease is the basis on which investigative efforts will emerge to identify the causes of cardiac dysmorphogenesis and afford opportunities to prevent them. Anatomical and pathophysiological classification of congenital heart disease was found to be useful in clinical practice but useless or even misleading for investigating etiological factors of congenital heart diseases. We adopted an etiological perspective of congenital heart diseases which in many directions pose no relation to the current anatomical and pathophysiological classification. For example, bicuspid aortic valve which prove to be very common in all races with incidence of 3-5% of world populations, carries no clinical significance until hemodynamically significant gradient developed with aging to yield left ventricular outflow tract obstruction at valvular origin. On the other hand, in our new etiological perspective bicuspid aortic valve is strong developmental land mark for spectrum of congenital malformations of the heart ranging from simple aortic valve disease to the extreme Shones complex with sever hypoplasia of the left ventricle, mitral valve, aortic valve and the aortic arch and branches hypoplasia. Presence of simple spectrum of Shones disease in one family member may point to sever diseases in other family members with mutations in the gene encoding myosin and other shared mutations. On the other hand, clinical diseases with exactly same pharmaceutical treatment plans like muscular ventricular septal defect and supracristal ventricular septal defect, carries two different developmental pathways in our new etiological perspective. We in the current era need to base our approach to investigate cardiogenesis secrets, on embryologic terms but not the pathophysiological grouping which was established for clinical and therapeutic puposes. Viewing cardiac defects from mechanistic rather than strictly anatomical perspective is the true call for wisdom if we are targeting prevention of cardiac dysmorphogenesis in human.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133416942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences: Potential Impact in Vascular Physiopathology or Ischemic Heart Disease","authors":"J. Kingma Jr","doi":"10.33425/2639-8486.1134","DOIUrl":"https://doi.org/10.33425/2639-8486.1134","url":null,"abstract":"Pathophysiological mechanisms for development and progression of ischemic heart disease, which is essentially an age-related condition, may differ between men and women. Age-related changes in cardiac and vascular anatomy and physiopathology combined with traditional risk factors affect the likelihood of developing heart disease. Sex specific features of cardiac and vascular remodeling with age are associated with a higher prevalence of ischemic heart disease in women post-menopause. Cardiac symptoms such as chest pain/discomfort are often less in women, which generally results in less aggressive clinical treatment compared to men. Incidentally, treatment guidelines for acute myocardial infarction have for the most part, been established from studies with a large male cohort. Sex differences relating to effects of ischemia on overall cardiovascular function could contribute to worse clinical outcomes for females. Treatment options for women also arise because they generally present with multiple co-morbidities. The present review focuses on recent findings for sex differences in pathogenesis of ischemic heart disease, vascular function as well as potential use of cardio protection strategies.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126526672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-coated Balloon Angioplasty Versus Drug-eluting Stenting for Femoropopliteal Arterial Disease: A Review of the Current Status","authors":"D. Sim, M. Jeong, Youngkeun Ahn, Carlos Mena Hurtado, John F. Martin, A. Mathur","doi":"10.33425/2639-8486.1132","DOIUrl":"https://doi.org/10.33425/2639-8486.1132","url":null,"abstract":"Endovascular procedures are frequently performed for symptomatic femoropopliteal disease. Drug-eluting stents (DES) and drug-coated balloons (DCB) were introduced to improve long-term outcomes and demonstrated superior outcomes to percutaneous transluminal angioplasty in randomised clinical trials. Femoropopliteal disease, however, can be challenging to treat using an endovascular approach as this segment suffers increased biomechanical stress during extremity movements, which may lead to chronic vascular injury or even stent fracture. The advantages of DCB include the direct and homogeneous delivery of an antiproliferative agent to the arterial wall, and the ability to reach tortuous and longer lesions without a vascular implant; however, the lack of scaffold makes the intervention prone to significant recoil. Even though the use of DCB, a leave-nothing-behind strategy, may appear desirable, the need for bailout stenting will increase as lesions become more complex. This review summarises and compares the currently available evidence regarding the use of DCB and DES in the treatment of femoropopliteal disease.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124284488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Physicians' Knowledge of the Management of Sudden Cardiac Arrest","authors":"D. M, Wane O, Gaye C, Manga Sj, Badredine A, Ralaizandry Us, Bindia D, Traoré Mm, M. A","doi":"10.33425/2639-8486.1133","DOIUrl":"https://doi.org/10.33425/2639-8486.1133","url":null,"abstract":"Introduction: Sudden cardiac arrest (SCA) is the abrupt loss of heart function and breathing. It is an absolute medical emergency. The management is based on the principle of the chain of survival. The main objective of this study was to assess the diagnostic and therapeutic abilities of physicians on the care of SCA. Material And Method: It was a multicentre, cross-sectional and descriptive analytical study covering the period from September 01st, 2018 to February 30, 2019. Included were all general practitioners, emergency physicians, cardiologists and anesthetists-resuscitators who agreed to complete the survey. The parameters studied were recognition of signs of SCA and the knowledge about the steps of the chain of survival. Results: We included 78 physicians with an average age of 35,16 years. There were 39 generalists and 39 specialists. The three SCA diagnostic criteria were known to 49 physicians (62.8%). More than half of physicians (n = 54, 69.2%) mastered the chronology of the steps of the chain of survival. The rhythm sequence of chest compressions and insufflations was controlled by 56.4% of physicians (n = 44). About the defibrillation, 70,51% (n=55) responded that it was not systematic in front of any SCA. Thirty-eight physicians were aware of the sequence of adrenaline administration. Only 24 doctors knew the time for amiodarone administration. A minority of 10 physicians has been able to fully define the acronym ABCDE. Conclusion: The level of physicans knowledge on the management of sudden cardiac arrest is relatively average. Every physician must be trained in basic cardiopulmonary resuscitation in order to save lives.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117194051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency Nursing of Patients with Acute Left Heart Failure","authors":"Lu Can, Liu Meng-meng, Yan Huai-feng, Q. Lin, Qi- xing, Qi Chun-mei","doi":"10.33425/2639-8486.1131","DOIUrl":"https://doi.org/10.33425/2639-8486.1131","url":null,"abstract":"Objective: We are aimed at exploring the emergency treatment and nursing measures for patients with acute left heart failure. Methods: We selected 48 patients with acute left heart failure in our department monitored by ecg immediately after admission. Open venous access;Sitting position, sagging legs, inhalation of alcohol humidified oxygen, heart strengthening, diuresis, sedation, asthma, vasodilation, shock patients were given vasopressor drugs or intra-aortic balloon counterpulsation;And psychological care. Results: 44 cases were improved after active rescue, with only 4 cases died, which the success rate of rescue was 91.67%. Conclusion: Timely, rapid and standardized nursing is very important to improve the success rate of acute left heart failure and prognosis of patients.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128780628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of COVID - 19 Induced Myocarditis - Symptomatology, Prognosis, and Clinical Findings","authors":"Vikas Jaiswal, S. Nagpal, Christine Angela E. Labitag, J. Tayo, Abhinav Patel, K. Lo, R. Vijayan, Wanessa F. Matos, Sadia Yaqoob, Priyanka Panday, Saloni Savani, Zeinab Alnahas, Arushee Bhatnagar, Y. Diaz, J. Dylewski","doi":"10.1101/2021.05.29.21258059","DOIUrl":"https://doi.org/10.1101/2021.05.29.21258059","url":null,"abstract":"Objective: With the advent of a novel coronavirus in December 2019, several case studies have reported its adversity on cardiac cells. We conducted a systematic review that describes the symptomatology, prognosis, and clinical findings of patients with COVID-19-related myocarditis. Methods: Search engines including PubMed, Google Scholar, Cochrane Central, and Web of Science were queried for SARS-CoV-2 or COVID 19 and myocarditis. PRISMA guidelines were employed, and peer-reviewed journals in English related to COVID-19 were included. Results: This systematic review included 22 studies and 37 patients. Eight patients (36%) were confirmed myocarditis, while the rest were possible myocarditis. Most patients had elevated cardiac biomarkers, including troponin, CRP, CK, CK-MB, and NT-pro BNP. Electrocardiogram results noted tachycardia (47%), left ventricular hypertrophy (50%), ST-segment alterations (41%), and T wave inversion (18%). Echocardiography presented reduced LVEF (77%), left ventricle abnormalities (34%), right ventricle aberrations (12%), and pericardial effusion (71%). Further, CMR showed reduced myocardial edema (75%), non-ischemic patterns (50%), and hypokinesis (26%). The mortality was significant at 25%. Conclusions: Mortality associated with COVID-19 myocarditis appears significant but underestimated. Further studies are warranted to evaluate and quantify patients actual prognosis and outcomes with COVID-19 myocarditis.","PeriodicalId":238598,"journal":{"name":"Cardiology & Vascular Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127244673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}