Zeitschrift fur Geburtshilfe und Neonatologie最新文献

{"title":"Collodion baby.","authors":"Javier Arredondo Montero, Alba Fernández García","doi":"10.1055/a-2872-8914","DOIUrl":"https://doi.org/10.1055/a-2872-8914","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resuscitation of newborn infants and postnatal support of transition - An overview of the European Resuscitation Council guideline 2025.","authors":"Lukas Peter Mileder, Michael Wagner","doi":"10.1055/a-2847-3068","DOIUrl":"10.1055/a-2847-3068","url":null,"abstract":"<p><strong>Abstract: </strong>In October 2025, the European Resuscitation Council published its latest practice guideline about \"Newborn Resuscitation and Support of Transition of Infants at Birth\". In this focused review, we summarize the most relevant elements of this guideline in a structured manner. For this purpose, we first outline the main aspects that remained unchanged from the 2021 guideline before focusing on the implemented modifications and changes.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"179-184"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bloody stool and bilious vomiting - Volvulus in non-rotation].","authors":"Glenn Malin Claire Fröschle, Anna Daniels, Julian Jürgens, Christian Tomuschat, Irwin Reiss, Mario Lange","doi":"10.1055/a-2777-2643","DOIUrl":"10.1055/a-2777-2643","url":null,"abstract":"<p><strong>Abstract: </strong>A volvulus in cases of non-rotation in newborns is a neonatal surgical emergency that is associated with high mortality if there is a delay in diagnosis and therapy. In addition to clinical signs such as bilious vomiting, bloody stools, a tender abdomen, and a lethargic patient, the diagnosis can be quickly made by sonographic evidence showing the \"whirlpool sign,\" allowing for the initiation of surgical therapy. We report on a full-term male newborn who was unremarkable at the routine U2 examination except for a weight loss of just under 10%. On the third day of life, the newborn began bilious vomiting and passed bloody stools. A suspected diagnosis of volvulus was made via sonography and was treated with immediate, intestine-preserving surgery.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"251-254"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145918525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Phenotype of X-linked Myotubular Myopathy: Hydrops Fetalis and Refractory Congenital Chylothorax with Fatal Outcome.","authors":"Chousein Amet, Umut Altunoglu, Süleyman Bayraktar, Bilge Bayraktar Tanyeri","doi":"10.1055/a-2825-7263","DOIUrl":"10.1055/a-2825-7263","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"258-260"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"For a better understanding of thermoregulation in premature infants≤28 weeks of gestation: infrared thermography (IRT) and photoplethysmography imaging (PPGI) in a hybrid camera model as non-contact measuring methods.","authors":"Milian Brasche, Markus Lüken, Steffen Leonhardt, Thorsten Orlikowsky, Konrad Heimann","doi":"10.1055/a-2840-5109","DOIUrl":"10.1055/a-2840-5109","url":null,"abstract":"<p><strong>Background: </strong>Infrared thermography (IRT) reveals significant temperature differences between central and peripheral body regions in preterm infants, despite stable core temperature. This suggests active thermoregulation. Photoplethysmography imaging (PPGI) enables contactless, spatially resolved perfusion measurement.</p><p><strong>Methods: </strong>Ten preterm infants [GA at birth: 26 weeks (24-28); postnatal age: 35 days (12-62); weight: 960 g (670-1290)] were examined in prone (PR) and supine (SU) positions in the incubator. PPGI (amplitude) and IRT were recorded from arm, head, and thorax every 10 s for 5 min per position, with a 10 min washout. Heart rate (ECG) was monitored. Lin's concordance correlation coefficient was calculated.</p><p><strong>Results: </strong>Central regions were ~1°C warmer than peripheral regions (p<0.05), independent of position. PPGI amplitude remained constant (< 1.0; p>0.05) in all regions, with no correlation between IRT and PPGI (p>0.05).</p><p><strong>Conclusion: </strong>In preterm infants, local perfusion remains stable despite regional temperature differences, suggesting that skin temperature is influenced more by passive heat diffusion than by perfusion changes.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"222-227"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[From Food Product to Substance of Human Origin - Regulation (EC) 2024/1938 and its Impact on the Handling of Human Milk].","authors":"Daniel Klotz, Janina Hahnloser, Dagmar Schilling-Leiß, Manfred Doll, Monika Berns","doi":"10.1055/a-2816-5471","DOIUrl":"10.1055/a-2816-5471","url":null,"abstract":"","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"185-191"},"PeriodicalIF":0.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13253024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of the Syndromic Meningitis/Encephalitis Molecular Panel in Neonates with Suspected Sepsis.","authors":"Ferhan Demirtas, İpeksu Yazır, Yasemin Ezgi Kostekci, Duygu Öcal, Emel Okulu, Halil Özdemir, Ömer Erdeve, Ergin Çiftçi, Zeynep Ceren Karahan, Begum Atasay, Saadet Arsan","doi":"10.1055/a-2874-4490","DOIUrl":"https://doi.org/10.1055/a-2874-4490","url":null,"abstract":"<p><strong>Background: </strong>Newborns are highly vulnerable to meningitis due to an immature blood-brain barrier. In cases of suspected clinical sepsis, empirical antibiotics are typically initiated after obtaining appropriate cultures when clinically indicated. This study aimed to evaluate the clinical utility of syndromic meningitis/encephalitis (sME) molecular panel testing in neonates with suspected sepsis, with a focus on its impact on clinical management and outcomes under selective versus routine testing strategies.</p><p><strong>Methods: </strong>Data of 58 neonates hospitalized between January 2019 and August 2023 who underwent sME panel testing on cerebrospinal fluid (CSF) samples were retrospectively analyzed. The test was performed selectively in Period 1 (January 2019-October 2022) and routinely in Period 2 (October 2022-August 2023). Patient findings were compared between periods in terms of diagnostic stewardship principles.</p><p><strong>Results: </strong>The mean gestational age and birth weight were 36±4 weeks and 2,334±941 g, respectively. In Period 1, herpes simplex virus (HSV) was detected in two (7.4%) patients, and antiviral therapy was started. In Period 2, one case each of human herpesvirus 6 (HHV-6) and enterovirus was identified. The length of antibiotic treatment and hospital stay was similar between sME panel-positive (n=4) and -negative (n=54) patients during the study period (p=0.241 and p=0.890, respectively). No positive CSF cultures were found in any of the 58 neonates.</p><p><strong>Conclusions: </strong>In neonates with suspected sepsis, sME panels may assist early identification of high-risk viral agents like HSV. However, given their cost and limited treatment impact without clear clinical indications, selective use based on clinical suspicion may offer a more appropriate and cost-effective approach.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148144741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Maternal Zonulin Levels in Fetal Growth Disorders.","authors":"Samettin Çelik, Sebati Sinan Urkmez, Yeşim Civil Ürkmez","doi":"10.1055/a-2764-1615","DOIUrl":"10.1055/a-2764-1615","url":null,"abstract":"<p><strong>Background: </strong>Zonulin, a biomarker linked to intestinal barrier dysfunction, may contribute to fetal growth disorders such as intrauterine growth restriction (IUGR) and small-for-gestational-age (SGA) pregnancies. This study evaluated maternal serum zonulin levels as a diagnostic tool for distinguishing IUGR from SGA and investigated their associations with perinatal outcomes.</p><p><strong>Methods: </strong>This cross-sectional study included singleton pregnancies between 32 and 37 weeks. Maternal blood samples collected at 16-18 weeks of gestation were analyzed for serum zonulin levels using ELISA, with measurements performed after group classification based on the final diagnosis (IUGR, SGA, and appropriate-for-gestational-age [AGA]). Demographic, obstetric, and neonatal data were analyzed. Diagnostic performance was assessed via receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Maternal serum zonulin levels were highest in the IUGR group, followed by SGA and AGA (p<0.001). The optimal cutoff for diagnosing IUGR was 15.70 ng/mL, with a sensitivity of 86.7% and specificity of 62.5% (AUC: 0.779). For distinguishing IUGR from SGA, the cutoff was 20.28 ng/mL (sensitivity: 71.7%, specificity: 73.3%, AUC: 0.748). Zonulin levels negatively correlated with birth weight, gestational age, and Apgar scores (p< 0.05).</p><p><strong>Conclusion: </strong>Maternal serum zonulin shows significant diagnostic potential for identifying IUGR and distinguishing it from SGA pregnancies. These findings suggest that zonulin could serve as a biomarker for pathological fetal growth restriction, warranting further studies to confirm its clinical utility.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"192-200"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Neonates Receiving Antihypertensive Treatment.","authors":"Zehra Aydin, Elvis Kraja, Samet Benli, Emine Ozlem Cam Delebe, Nevin Ozdemiroğlu, Munevver Tugba Temel","doi":"10.1055/a-2814-4099","DOIUrl":"10.1055/a-2814-4099","url":null,"abstract":"<p><strong>Objectives: </strong>Neonatal hypertension is uncommon but clinically significant due to its systemic complications. Data on the clinical course, etiologies, and outcomes of neonates receiving antihypertensive therapy in the neonatal intensive care unit are limited. This study aimed to describe the clinical characteristics, underlying etiologies, management strategies, and outcomes of neonates receiving antihypertensive therapy in a tertiary level 4 NICU.</p><p><strong>Methods: </strong>We conducted a retrospective review of medical records of neonates admitted to the NICU between January 2024 and June 2025 who received antihypertensive treatment. Etiologies were classified as renal, vascular, or miscellaneous. Follow-up data were analyzed to identify persistence of hypertension after discharge.</p><p><strong>Results: </strong>Of 17 neonates, 9 (52%) were preterm and 8 (47%) were term. Renal etiologies predominated (47%), including acute kidney injury, congenital anomalies of the kidney and urinary tract, and polycystic kidney disease. Vascular causes accounted for 5.8%, and miscellaneous etiologies, such as intracranial lesions and sepsis, for 47%. Monotherapy with amlodipine, enalapril, or captopril was used in most cases, while combination therapy was required in two neonates with renal etiologies. Four neonates (23.5%) were discharged on ongoing antihypertensive therapy, all with structural or genetic renal or vascular abnormalities.</p><p><strong>Conclusions: </strong>Neonatal hypertension is heterogeneous, with renal disorders being the most frequent cause. Persistent hypertension occurs mainly in neonates with structural renal or vascular abnormalities, while those with other causes often discontinue therapy before discharge. These findings highlight the importance of identifying neonates at risk for long-term complications.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"232-236"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Cerebral and Splanchnic Tissue Oxygenation During Enteral Feeding in Premature Infants with Duct-Dependent Congenital Heart Disease.","authors":"Dilek Yavuzcan Ozturk, Demet Oguz, Senay Coban, Erkut Ozturk","doi":"10.1055/a-2764-6472","DOIUrl":"10.1055/a-2764-6472","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to compare cerebral and splanchnic regional oxygen saturation(rSO2) in premature infants with duct-dependent congenital heart disease (CHD) using near-infrared spectroscopy (NIRS) with that of case-control premature infants without CHD.</p><p><strong>Materials and methods: </strong>Premature infants with duct-dependent CHD requiring prostaglandin E1 (PGE1) for more than 10 days and control preterm infants (without CHD) were monitored for 36 hours using NIRS to assess cerebral and splanchnic rSO2. Both groups received gavage enteral feeding. Multiple measurements were taken around feeding at three different times (30 minutes before, during, and 30 minutes after feeding).</p><p><strong>Results: </strong>A total of 16 cases were included in the study (8 CHD and 8 controls). The CHD infants had the following diagnoses: four with aortic coarctation, two with interrupted aortic arch, one with hypoplastic left heart syndrome, and one with D-transposition of the great arteries. The median gestational age (35 weeks in duct-dependent CHD vs. 34 weeks in controls) and birth weight (1850 g vs. 1800 g, respectively) were similar between the two groups (p>0.05). The median cerebral NIRS measurements in the controls were 12 points higher than in the cases (P=0.03), and the splanchnic NIRS measurements were 20 points higher (P=0.01). The median cerebral NIRS measurements in the cases were 60%, 64%, and 62% at baseline, during feeding, and post-feeding, respectively, while the controls had values of 72%, 74%, and 71% at the same times. The median splanchnic NIRS measurements in the cases were 30%, 35%, and 38% at baseline, during feeding, and post-feeding, respectively, while the controls had values of 50%, 52%, and 54%. Similar changes in cerebral and splanchnic NIRS values were observed during feeding in both the cases and controls (p>0.05).</p><p><strong>Conclusion: </strong>Premature neonates with duct-dependent CHD have a reduction in both cerebral and splanchnic rSO2 values when compared to age-matched controls. NIRS monitoring demonstrated lower regional oxygen saturation levels in duct-dependent CHD infants compared with controls, suggesting reduced tissue oxygenation during feeding. Further studies with larger sample sizes are needed in this area.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":" ","pages":"228-231"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145946504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}