World Journal of Pediatric Surgery最新文献

A diagnosis and treatment algorithm for adnexal masses in female children and adolescents. 一种女性儿童及青少年附件肿块的诊断与治疗方法。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-05-04 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001162

Liying Sun, Jiayu Shen, Symphorosa S C Chan, Karen Ng, Ani Amelia Zainuddin, Zoran Stankovic, Yasmin Jayasinghe, Sonia Grover, Hafizur Rahman, Huihui Gao

引用次数: 0

Congenital anomalies of the kidney and urinary tract in children treated at a tertiary hospital in Northern Tanzania: assessment of coexisting congenital anomalies. 在坦桑尼亚北部一家三级医院治疗的儿童肾脏和尿道先天性异常：对共存先天性异常的评估。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001108

Magdalena Benitho Mahenge, Zerra Israel Cheyo, Jasper Said Mbwambo, Frank B Bright, Orgeness Jasper Mbwambo

{"title":"Congenital anomalies of the kidney and urinary tract in children treated at a tertiary hospital in Northern Tanzania: assessment of coexisting congenital anomalies.","authors":"Magdalena Benitho Mahenge, Zerra Israel Cheyo, Jasper Said Mbwambo, Frank B Bright, Orgeness Jasper Mbwambo","doi":"10.1136/wjps-2025-001108","DOIUrl":"https://doi.org/10.1136/wjps-2025-001108","url":null,"abstract":"Background: A high burden of complications, including death, among children with congenital anomalies of the kidney and urinary tract (CAKUT) has been reported in African settings. We aimed to determine the pattern, age at diagnosis, and presence of coexisting anomalies in CAKUT in children at a tertiary referral hospital in northern Tanzania.Methods: A hospital-based retrospective study was conducted that retrieved data for children aged below 18 years who attended the urology clinic between January 2018 and December 2024. Variables from their clinical history, laboratory, and imaging investigations, including voiding cystourethrogram, transabdominal ultrasound, and CT, were extracted.Results: Of the 2214 children reviewed, 493 (22%) were diagnosed with CAKUT. The median age at presentation was 3 years (IQR 1-6). Of these, 60% had anomalies of the urethra, especially hypospadias and posterior urethral valves. This was followed by anomalies of the kidney (in 26% of 493), in which either a single kidney or ectopic kidneys were frequently diagnosed. The majority of children diagnosed with CAKUT had coexisting anomalies (67%). Most coexisting anomalies were genital malformations (24%).Conclusion: A high proportion of CAKUT is seen among children referred to the urology clinic of a tertiary referral hospital in northern Tanzania. The majority of children with CAKUT present late. Most are diagnosed with anomalies of the urethra and kidneys. Common coexisting anomalies are of the genitalia.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 3","pages":"e001108"},"PeriodicalIF":1.3,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global expert profiles, research hotspots, and journal networks in pediatric surgery: an AI-assisted bibliometric analysis. 全球专家简介、研究热点和儿科外科期刊网络：人工智能辅助文献计量分析。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-31 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001160

Rongqi Zhang, Xumeng Liu, Qi Qi, Yicheng Xie, Xinglong Wu, Qiang Shu

引用次数: 0

Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis. 手术坏死性小肠结肠炎早产儿坏死和死亡率与靶向免疫反应基因表达谱相关

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-24 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2026-001172

Parvesh Mohan Garg, Robin Riddick, Pengbo Zhang, Jeffrey Shenberger, Neha Varshney, David Sawaya, Padma Garg

{"title":"Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.","authors":"Parvesh Mohan Garg, Robin Riddick, Pengbo Zhang, Jeffrey Shenberger, Neha Varshney, David Sawaya, Padma Garg","doi":"10.1136/wjps-2026-001172","DOIUrl":"10.1136/wjps-2026-001172","url":null,"abstract":"Background: We sought to determine changes in the expression of immune response-related genes occurring in surgical necrotizing enterocolitis (NEC) tissues from infants with necrosis severity and survival status.Methods: Targeted RNA sequencing of a select panel of 395 immune response genes was performed on RNA isolated from formalin-fixed, paraffin-embedded intestinal tissue samples (n=36). DESeq2 was used to analyze differential expressions between infants with mild to moderate and severe necrosis and with respect to survival status after correcting for RNA integrity.Results: Thirty-five genes were differentially expressed (FDR-adjusted p<0.1) between mild-moderate necrosis and severe necrosis. Principal component analysis identified alternations in genes involved in host defense, natural killer (NK) cell signaling and development, and apoptosis which were overexpressed in severe necrosis (IGJ, GZMA, TNFSF10, KLRB1, and CD160). Expression of leukocyte antigens (ITGAM, ITGAX) and cytokine and chemokine receptors (such as IL1A, IL1B, CCL2, CCL3) was increased in patients with mild necrosis. Six genes were significantly differentially expressed (FDR-adjusted p<0.1) between survivors and the non-survivors. Genes related to chemokine neutrophil attractants (CXCL1, GBP, PTGS2, CXCL11, CXCL9, and CXCL10) were upregulated in non-survivors.Conclusion: Severe necrosis and non-survival in NEC infants were associated with differential gene expression related to host defense, NK cell signaling and development, and apoptosis. Understanding the role of these pathways in severe NEC may guide the development of prognostic and treatment pathways.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 2","pages":"e001172"},"PeriodicalIF":1.3,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13034352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface to topic collection: biliary atresia. 主题集前言：胆道闭锁。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-23 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001159

Mark Davenport

引用次数: 0

Follow-up of jaundice-free biliary atresia survivors using M2BPGi and APRI in a local hospital. 应用M2BPGi和APRI对某医院无黄疸胆道闭锁患者的随访。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001156

Takeshi Shirai, Sotaro Okuya

{"title":"Follow-up of jaundice-free biliary atresia survivors using M2BPGi and APRI in a local hospital.","authors":"Takeshi Shirai, Sotaro Okuya","doi":"10.1136/wjps-2025-001156","DOIUrl":"10.1136/wjps-2025-001156","url":null,"abstract":"In local hospitals with resource-limited regions lacking access to liver transplantation (LT) centers, it is important to detect early warning signs of liver damage and portal hypertension in jaundice-free biliary atresia (BA) survivors with native livers. Twenty-three blood samples and scorings from six BA survivors (Child-Pugh score 5 points) were evaluated using serum Mac-2 binding protein glycosylation isomer (M2BPGi) and aspartate aminotransferase to platelet ratio index (APRI) at a local hospital. The levels of M2BPGi and APRI were positively correlated (r=0.93, p<0.001), and these also correlated with liver biochemistry. In cases with signs of portal hypertension, such as varices and a dilatation of vein associated with portal vein, the levels of M2BPGi and APRI were significantly higher than in cases without these signs (p<0.001). High levels of M2BPGi and APRI suggest progressive liver damage and portal hypertension. In local hospitals with limited medical resources, evaluation using M2BPGi and APRI may be useful for the follow-up of jaundice-free BA survivors.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 2","pages":"e001156"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategy to identify biliary atresia efficiently: A perspective from a Texas center. 一种有效识别胆道闭锁的策略：来自德克萨斯州中心的观点。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001142

Sanjiv Harpavat, Tebyan A Rabbani, Ashley M Upton, Sridevi Devaraj, Jose A Hernandez, Benjamin L Shneider

引用次数: 0

Anesthesia for thoracic surgery in infants with congenital lung malformations. 婴儿先天性肺畸形胸外科手术的麻醉。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-16 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001091

Ruofan Wang, Yi He, Yuyi Zhao, Yunxia Zuo, Bin Du, Miao Yuan, Zhen Luo

{"title":"Anesthesia for thoracic surgery in infants with congenital lung malformations.","authors":"Ruofan Wang, Yi He, Yuyi Zhao, Yunxia Zuo, Bin Du, Miao Yuan, Zhen Luo","doi":"10.1136/wjps-2025-001091","DOIUrl":"10.1136/wjps-2025-001091","url":null,"abstract":"Congenital lung malformations (CLMs) are disorders arising from defective embryonic development of the airways, lung parenchyma, and pulmonary vasculature, often presenting as heterogeneous lesions like congenital pulmonary airway malformation (CPAM), pulmonary sequestration (PS), and congenital lobar overinflation (CLO). CLMs in infants present unique anesthetic challenges -particularly the risk of progressive distention in cystic areas and the anatomical difficulty of achieving stable lung isolation- but institutional rarity limits clinical experience and consensus-driven practices. This review examines recent clinical anesthesia practices for infants with CLMs undergoing thoracic surgery, offering comprehensive guidance on perioperative anesthesia management, with an emphasis on ventilation management. Crucially, we evaluate the selection and precise positioning of lung isolation devices, such as left endobronchial intubation and bronchial blockers. Furthermore, it provides a structured management strategy for intraoperative hypoxemia and outlines lung-protective ventilation frameworks-incorporating low tidal volumes and personalized PEEP-to consolidate contemporary evidence and optimize the perioperative anesthetic approach for this vulnerable population.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 2","pages":"e001091"},"PeriodicalIF":1.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pretransplant mortality in children awaiting living donor liver transplantation: a prospective center-based study. 等待活体肝移植的儿童移植前死亡率：一项前瞻性中心研究。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-09 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001138

Tri Hening Rahayatri, Ni Made Sarastri Widyani, Hanifah Oswari

{"title":"Pretransplant mortality in children awaiting living donor liver transplantation: a prospective center-based study.","authors":"Tri Hening Rahayatri, Ni Made Sarastri Widyani, Hanifah Oswari","doi":"10.1136/wjps-2025-001138","DOIUrl":"10.1136/wjps-2025-001138","url":null,"abstract":"Background: High mortality in children awaiting liver transplantation is a significant concern. At Cipto Mangunkusumo Hospital, the only active and established pediatric living-donor liver transplantation (LDLT) center in Indonesia, similar challenges persist. This study aims to determine the mortality rate, time to death or transplantation and causes of death in children listed for LDLT at our center.Methods: This prospective single-center cohort study was conducted from January 2023 to December 2024. Consecutive sampling included all eligible children age 0-18 listed for LDLT. Participants were monitored from listing until pretransplant death, transplantation, loss to follow-up or study completion. The primary outcome was all-cause mortality on the LDLT waiting list.Results: Sixty-two children were enrolled; 64.51% (n=40) were female with biliary atresia accounting for 72.58% of diagnoses. Malnutrition was identified in 70.97% (n=44) and 35.48% (n=22) had a history of cytomegalovirus (CMV) infection. Median duration from listing to death was 87.5 days. Median time to transplantation was 263.5 days. During follow-up, 22 children died with sepsis as the leading cause, 22 underwent LDLT, 13 were lost to follow-up and 5 remained on the waiting list. Donor scarcity contributed substantially to prolonged listing and loss to follow-up.Conclusions: Children listed for liver transplantation experience a high waiting list mortality at our center. This is primarily due to infection, malnutrition and socioeconomic factors. Sepsis persists as the principal cause of death. LDLT remains the only feasible option for children requiring liver transplantation in Indonesia.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 2","pages":"e001138"},"PeriodicalIF":1.3,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of mortality and short-term outcomes after emergency pediatric abdominal surgery in South-Western Uganda. 乌干达西南部儿科急诊腹部手术后死亡率和短期预后的预测因素。

IF 1.3 4区医学

World Journal of Pediatric Surgery Pub Date : 2026-03-06 eCollection Date: 2026-01-01 DOI: 10.1136/wjps-2025-001112

James Alfred Okello, Felix Oyania, Carlos Cabrera Dreque, David Mutiibwa, David Komakech

{"title":"Predictors of mortality and short-term outcomes after emergency pediatric abdominal surgery in South-Western Uganda.","authors":"James Alfred Okello, Felix Oyania, Carlos Cabrera Dreque, David Mutiibwa, David Komakech","doi":"10.1136/wjps-2025-001112","DOIUrl":"https://doi.org/10.1136/wjps-2025-001112","url":null,"abstract":"Background: Emergency abdominal surgeries (EASs) in children are often necessary to address life-threatening congenital and acquired conditions. This study aimed to determine short-term outcomes and predictors of in-hospital mortality after EAS in children at Mbarara Regional Referral Hospital (MRRH), South-Western Uganda.Methods: This prospective study was conducted from June to September 2024 and included children aged 0-17 years who underwent EAS at MRRH. Outcomes measured were 30-day in-hospital mortality, complications, and length of hospital stay. Overall survival after EAS was plotted using Kaplan-Meier curves. Cox regression analysis was used to determine predictors of in-hospital mortality after EAS.Results: The 30-day mortality rate for all pediatric abdominal surgery was 152 per 10 000 person-days of hospitalization. Among 96children who required EAS at MRRH, the risk of death was significantly increased in those who had hypoxemia (adjusted hazard ratio (aHR) 12.4, p=0.011) and hypokalemia (aHR 5.02, p=0.044). Forty-one patients (42.7%) developed postoperative complications, the most common being surgical site infection (14.58%) and pneumonia (5.2%).Conclusion: The 30-day mortality rate after pediatric EAS in our setting is high and children who present with hypokalemia and hypoxemia are at increased risk of mortality after EAS.","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 2","pages":"e001112"},"PeriodicalIF":1.3,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12970129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0