World Journal of Pediatric Surgery最新文献

{"title":"Intra-arterial chemotherapy for retinoblastoma: a structured narrative review.","authors":"Yan Hong Ren, Daohuan Kang, Caiping Shi, Wen Sun","doi":"10.1136/wjps-2026-001213","DOIUrl":"10.1136/wjps-2026-001213","url":null,"abstract":"<p><p>Retinoblastoma (Rb) is the most common primary intraocular malignancy in children. Intra-arterial chemotherapy (IAC), often termed ophthalmic artery chemosurgery, has emerged as an important globe-preserving treatment modality for advanced intraocular Rb. We focused on technical delivery, clinical indications, regimen selection, oncological safety, globe salvage, functional preservation and complications. Current evidence indicates that, in appropriately selected patients and experienced centers, IAC can improve local tumor control and globe salvage while reducing systemic toxicity when compared with intravenous chemotherapy. While melphalan remains the backbone chemotherapeutic agent, escalation to topotecan and/or carboplatin should be guided by tumor burden, vitreous or subretinal seeding, prior treatment response, evidence strength and expected functional potential. Functional preservation should be defined as more than anatomical globe retention; it should include age-appropriate visual acuity or fixation, electroretinography, macular and foveal integrity, avoidance of retinal or choroidal ischemia, amblyopia management, binocular visual development and quality-of-life outcomes. IAC remains associated with ocular and vascular risks, including retinal or choroidal ischemia, cataract formation and ophthalmic artery stenosis or occlusion. Future multicenter prospective studies should use standardized outcome measures, scenario-specific recommendations and molecular monitoring, including aqueous humor cell-free DNA analysis, to refine patient selection and support function-preserving care.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001213"},"PeriodicalIF":2.1,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative hyperinflammation and recovery challenges in necrotizingenterocolitis.","authors":"Christopher John Luschen, Catherine J Hunter","doi":"10.1136/wjps-2025-001164","DOIUrl":"10.1136/wjps-2025-001164","url":null,"abstract":"<p><p>Necrotizing enterocolitis (NEC) remains one of the most devastating gastrointestinal emergencies in neonates, particularly affecting premature infants with immature intestinal, immune and microvascular systems. While surgical intervention is often lifesaving in severe NEC, the postoperative period introduces distinct challenges that critically influence survival and long-term outcomes. This review examines postoperative hyperinflammation as a central driver of morbidity following surgical NEC. Despite resection of necrotic bowel, many infants experience persistent systemic inflammation characterized by dysregulated innate immune activation, excessive cytokine release and sustained gut barrier dysfunction. Key mediators including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β and IL-8 contribute to endothelial injury, capillary leak, hemodynamic instability and multiorgan dysfunction. Ongoing intestinal permeability and microbial translocation perpetuate inflammatory signaling, delaying mucosal healing and predisposing infants to recurrent NEC, sepsis and short bowel syndrome. Clinically, postoperative hyperinflammation manifests as systemic inflammatory response syndrome, coagulopathy, feeding intolerance, impaired wound healing and neurodevelopmental injury. Recovery is frequently prolonged by nutritional compromise, dependence on parenteral nutrition and recurrent infections, which further amplify inflammatory stress. Current management remains largely supportive, focusing on optimization of nutrition, infection prevention and multidisciplinary care. Emerging immunomodulatory and microbiome-based therapies remain investigational. Postoperative hyperinflammation remains a difficult and complex sequelae of NEC and future investigation is needed to improve long-term outcomes.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001164"},"PeriodicalIF":2.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13384141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148608015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental impairment in infants with necrotizing enterocolitis: a comprehensive review of mechanisms, outcomes, and emerging strategies.","authors":"Michele Bosisio, Miguel A Garcia, Augusto Zani","doi":"10.1136/wjps-2026-001199","DOIUrl":"10.1136/wjps-2026-001199","url":null,"abstract":"<p><p>Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition predominantly affecting preterm infants and is characterized by intestinal inflammation, ischemia, and, in advanced cases, bowel necrosis. Although advances in neonatal care have improved survival, infants with NEC remain at substantially increased risk of long-term neurodevelopmental impairment (NDI), including cognitive, motor, sensory, and behavioral deficits. Clinical severity, surgical NEC, and comorbidities, including intraventricular hemorrhage and metabolic instability, further exacerbate neurodevelopmental risk. Neuroimaging and electrophysiological studies have consistently revealed structural and microstructural brain abnormalities that provide early prognostic markers. While prematurity contributes to baseline vulnerability, growing evidence indicates that NEC-specific factors, such as systemic inflammation, disruption of the gut-brain axis, and immune-mediated injury, play a central role in the pathogenesis of brain injury. Preclinical research targeting inflammation, oxidative stress, microbiome modulation, and high-mobility group box 1-Toll-like receptor 4 (HMGB1-TLR4) signaling has demonstrated promising neuroprotective effects, underscoring the need for translational strategies. This review comprehensively examines the literature on NDI in infants with NEC to compare the clinical outcomes of this population of babies with those of their preterm peers, evaluate the underlying mechanisms of brain injury associated with NEC, and discuss emerging preventative and therapeutic strategies to address this morbidity.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001199"},"PeriodicalIF":2.1,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation enhances stromal cell survival for safe neonatal therapy: a pilot study.","authors":"Jasmine Lee, Kelly Henige, Fikir Mesfin, Sharon Joseph, Krishna Manohar, Chris Shelley, Jianyun Liu, Minglin Ma, Minseok Lee, Troy Markel","doi":"10.1136/wjps-2026-001197","DOIUrl":"10.1136/wjps-2026-001197","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stromal cells (MSCs) have demonstrated therapeutic benefit in preclinical models of necrotizing enterocolitis (NEC), yet clinical translation remains limited by concerns about immune clearance and tumorigenic risk. Encapsulation strategies offer a potential solution by limiting systemic exposure while preserving efficacy. We hypothesized that encapsulation of MSCs would improve cell survival and maintain cell identity in this proof-of-concept study.</p><p><strong>Methods: </strong>Luciferase-expressing MSCs were generated via lentiviral transduction and validated for luminescence. Mice received MSCs either intraperitoneally (<i>n</i>=4) or encapsulated in the surgically implanted thread-reinforced encapsulation device (THRED) (<i>n</i>=4). Bioluminescence imaging tracked viability over 8 days. Viability and identity of extracted cells were assessed by flow cytometry and stromal cell marker analysis.</p><p><strong>Results: </strong>The bioluminescent signal declined in both groups, but MSCs delivered in the THRED retained significantly greater viability on day 4 (<i>p</i>=0.0286) and day 8 (<i>p</i>=0.0286). Cells extracted from the device remained viable (<i>p</i>=0.0286) and maintained stromal cell marker expression matching non-implanted controls (<i>n</i>=4). Flow cytometry demonstrated the viability of explanted cells, as well as preserved identity based on cell surface markers.</p><p><strong>Conclusion: </strong>Encapsulation within the THRED preserves MSC viability and identity <i>in vivo</i>. This approach provides a clinically practical method to deliver MSC therapy during initial NEC surgery or drain placement with retrieval at a later procedure. This serves as a proof-of-concept and offers a feasible solution to current barriers in neonatal MSC therapy.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001197"},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based tools to address current gaps in transition to adult care for youth with chronic surgical conditions: a perspective piece.","authors":"Siena O'Neill, Elena Guadagno, Esli Osmanlliu","doi":"10.1136/wjps-2025-001099","DOIUrl":"10.1136/wjps-2025-001099","url":null,"abstract":"","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001099"},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.","authors":"Yitong Zhao, Jielin Yang, Bo Li, Dorothy Lee, Yi Xiong, Agostino Pierro, Qian Jiang","doi":"10.1136/wjps-2026-001222","DOIUrl":"10.1136/wjps-2026-001222","url":null,"abstract":"<p><strong>Background: </strong>Hirschsprung disease (HSCR) is characterized by distal aganglionosis. Persistent postoperative dysmotility and enterocolitis suggest that intrinsic epithelial vulnerabilities may remain within the ganglionic bowel. We here aimed to define both the state of the epithelium and its metabolism in HSCR.</p><p><strong>Methods: </strong>Distal colonic tissues from patients with HSCR and non-HSCR controls (HSCR allied disorders) were examined by single-cell RNA sequencing. Particular attention was given to nicotinamide adenine dinucleotide (NAD⁺) metabolism and oxidative phosphorylation across epithelial subsets. Immunofluorescence and immunohistochemistry for γH2A.X, PARP1, TOM20, KRT20, and poly(ADP-ribose) (PAR) validated transcriptional signatures of cellular stress, metabolic remodeling, and impaired epithelial maturation.</p><p><strong>Results: </strong>Compared with control, HSCR epithelium showed marked transcriptional remodeling, with accumulation of stem and transit-amplifying cells, and depletion of differentiated epithelial lineages, indicating impaired epithelial maturation. These changes were most pronounced in the distal ganglionic colon with a reduced epithelial KRT20 signal, where oxidative phosphorylation, ATP synthesis, and lipid and steroid metabolic pathways were broadly suppressed. Key NAD⁺ biosynthetic enzymes were downregulated, while NAD⁺-consuming sirtuins and PAR polymerases (PARP) were upregulated, particularly in HSCR ganglionic colon crypt populations. Similarly, HSCR tissues exhibited increased crypt γH2A.X and nuclear PARP1, as well as elevated TOM20 and poly/mono-ADP-ribose staining, consistent with metabolic and genomic stress.</p><p><strong>Conclusion: </strong>HSCR epithelium displays metabolic fragility characterized by NAD⁺ biosynthetic insufficiency, increased NAD⁺ consumption, mitochondrial remodeling, DNA damage, and impaired epithelial maturation. These epithelial alterations complement enteric nervous system (ENS)-centered disease models and suggest that NAD⁺-related pathways may represent modifiable programs relevant to postoperative mucosal resilience and susceptibility to Hirschsprung disease-associated enterocolitis (HAEC).</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001222"},"PeriodicalIF":2.1,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-stage deep learning framework for neuroblastoma differentiation by integrating cell segmentation and multiscale modeling.","authors":"Jieni Xiong, Zhu Zhu, Weizhong Gu, Yawen Li, Manli Zhao, Jiabin Cai, Chensheng Sun, Jinhu Wang, Gang Yu","doi":"10.1136/wjps-2025-001149","DOIUrl":"10.1136/wjps-2025-001149","url":null,"abstract":"<p><strong>Background: </strong>As the most common extracranial solid tumor in children, accurate and consistent pathological diagnosis of neuroblastoma (NB) is critical for clinical decision-making. However, traditional methods relying on manual interpretation are constrained by tumor heterogeneity and inter-observer variability, necessitating the development of objective and quantitative intelligent auxiliary diagnostic technologies.</p><p><strong>Methods: </strong>This study introduces a two-stage deep learning framework with hybrid supervision, achieving precise classification of NB through collaborative optimization of cell-level segmentation and multiscale classification. In the first stage, the enhanced Medical Segment Anything Model (MedSAM) uses a cross-attention mechanism to achieve pixel-level tumor cell segmentation, attaining a Dice coefficient of 0.94. In the second stage, an optimized Swin Transformer (ST) is employed to construct the classification network, enabling full slice analysis via a confidence voting strategy.</p><p><strong>Results: </strong>On an independent dataset comprising 185 whole-slide images from 185 patients, the model attained an overall area under the receiver operating characteristic curve (AUC) of 0.864 (95% confidence interval (CI): 0.747 to 0.952), significantly outperforming existing methods (8.7% higher than the second-best model, ResNeXt). Among the three NB subtypes (undifferentiated, poorly differentiated, and differentiating), the recognition accuracy is the highest for the poorly differentiated subtype, which accounts for the largest proportion in clinical practice.</p><p><strong>Conclusion: </strong>This approach effectively addresses issues related to the tumor microenvironment interference and small-sample generalization through a cascaded feature extraction and decision-making mechanism, providing a robust intelligent auxiliary tool for NB pathological diagnosis.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 4","pages":"e001149"},"PeriodicalIF":2.1,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13343061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical spectrum, familial patterns, and surgical interventions in patients with cleft lip and/or palate: experience from a specialized cleft care center in Pakistan.","authors":"Areesha Rashid, Sidra Sajid, Muhammad Asghar Khan, Saima Naz, Tanveer Ahmad, Sajid Malik","doi":"10.1136/wjps-2025-001163","DOIUrl":"10.1136/wjps-2025-001163","url":null,"abstract":"<p><strong>Background: </strong>Cleft lip and/or palate (CL/P) is a common congenital anomaly with multifactorial etiology. Data describing the phenotypic spectrum of CL/P in Pakistan is limited. This study aimed to describe the demographic and clinical characteristics, familial pattern, surgical intervention profile, and maternal risk factors associated with CL/P in a Pakistani cohort.</p><p><strong>Methods: </strong>Patients with CL/P were recruited from a tertiary care hospital in Faisalabad, Pakistan, into a cross-sectional study design during September 2023 and March 2024. Descriptive statistics were collected, and bivariable and multivariable logistic regression analyses were performed.</p><p><strong>Results: </strong>A total of 503 independent patients with CL/P were enrolled (53% male). CL/P was categorized into cleft lip (CL, 26%), cleft palate (CP, 36%), and cleft lip with palate (CLP, 38%). Male sex was associated with higher odds of CL, while female sex was associated with higher odds of CP. Rural residence was a significant predictor for CLP (adjusted odds ratio (aOR)=1.80, <i>p</i><0.05), whereas age 1-5 years was strongly associated with CP (aOR=2.36, <i>p</i><0.001). Parental consanguinity was notably high (77%), and 18% had a positive family history of CL/P. Only 38% of mothers reported folic acid supplementation. Pesticide exposure was reported in 32% of mothers. Surgical correction had been performed in only 27% of patients.</p><p><strong>Conclusion: </strong>Cleft types demonstrate distinct demographic and maternal risk factor profiles. High rates of consanguinity, low folic acid uptake, and significant surgical gaps highlight critical areas for public health intervention in resource-limited settings.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 3","pages":"e001163"},"PeriodicalIF":2.1,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13311566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert consensus on surgical management of unilateral Wilms tumor (2025).","authors":"Dongsheng Wang, Xiaofeng Chang, Xin Liu, Hongting Lu, Lei Zhang, Jinhu Wang, Jinghao Yan, Hongquan Geng, Dawei He, Zhongrong Li, Kai Li, Yong Li, Zhibao Lv, Jian Shen, HongCheng Song, Daxing Tang, Jian Wang, Shan Wang, Yeming Wu, Jianguo Zhang, Shouhua Zhang, Weiping Zhang, Qiang Zhao, Dapeng Jiang, Yi Yang, Huanmin Wang","doi":"10.1136/wjps-2026-001204","DOIUrl":"10.1136/wjps-2026-001204","url":null,"abstract":"<p><p>Wilms tumor (WT) is the most common primary malignant renal tumor in children. Currently, there is no unified consensus regarding surgical management of WT. This is particularly so in complex cases where tumors are large, where there is invasion of adjacent organs, for nephron-sparing procedures, and for lymph node biopsy. Non-standardized surgical procedures can lead to tumor recurrence and progression; this is of increasing clinical concern. Standardizing the surgical approach and protocols for WT is therefore of great importance to improving treatment outcomes and patient prognosis. To better guide clinical practice, the Oncology Surgery Group and Urology Surgery Group of Pediatric Surgery Branch of the Chinese Medical Associationhave formulated this expert consensus. Based on previous clinical research findings and existing guidelines, the consensus provides specific recommendations for surgical approach and for decision-making.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 3","pages":"e001204"},"PeriodicalIF":2.1,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13289308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic retrograde appendiceal irrigation for children with recurrent abdominal pain and appendiceal fecaliths: a retrospective cohort study.","authors":"Fengge Wang, Zhenni Zhu, Chijun Hu, Qin Liu","doi":"10.1136/wjps-2025-001152","DOIUrl":"10.1136/wjps-2025-001152","url":null,"abstract":"<p><strong>Background: </strong>Recurrent abdominal pain (RAP) in children with appendiceal fecaliths and mesenteric lymphadenitis poses a diagnostic and therapeutic challenge, often mimicking appendicitis. The role of interventional endoscopy in this setting is undefined.</p><p><strong>Methods: </strong>We retrospectively analyzed children with RAP, sonographically confirmed appendiceal fecaliths, and ileocecal lymphadenitis who underwent ultrasound-guided endoscopic retrograde appendiceal irrigation (ERAI) from 2021 to 2023. Technical success, complications, immediate symptom resolution, and follow-up outcomes were assessed.</p><p><strong>Results: </strong>Totally, 73 patients (mean age 8.3 years) who underwent successful ERAI (100% technical success) were included in this study for safety analysis. Three were lost to follow-up, leaving 70 for efficacy analysis. Immediate pain resolution was reported in 98.6% (69/70) of patients with follow-up. Minor complications such as self-limiting bleeding and procedure-related discomfort occurred in 8.2% (6/73) and 9.6% (7/73) of patients, respectively. There were no perforations or major adverse events. During a median follow-up of 15.5 months, the abdominal pain recurrence rate was 18.6%. The sonographic prevalence of mesenteric lymphadenitis decreased significantly from 100% preoperatively to 21.9% postoperatively (<i>p</i><0.01).</p><p><strong>Conclusions: </strong>ERAI appears to be a feasible and safe super-minimally invasive procedure for selected children with RAP associated with appendiceal fecaliths and lymphadenitis, and was associated with rapid symptomatic relief and a significant reduction in lymphadenitis.</p>","PeriodicalId":23823,"journal":{"name":"World Journal of Pediatric Surgery","volume":"9 3","pages":"e001152"},"PeriodicalIF":2.1,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148228507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}