Zeitschrift fur Alternsforschung最新文献_第5页

[Submaximal stress test and lactate dynamics following acute myocardial infarct in elderly patients]. [老年患者急性心肌梗死后的亚极大负荷试验和乳酸动力学]。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

G Dahn, K Kothe, R Knie, H P Ludwig, H Dronski

引用次数: 0

[Perioperative risk of valve replacement surgery in the elderly]. 老年人瓣膜置换术围手术期风险分析。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

K Kothe, B Porstmann, R Aurisch, J Butzeck

{"title":"[Perioperative risk of valve replacement surgery in the elderly].","authors":"K Kothe, B Porstmann, R Aurisch, J Butzeck","doi":"","DOIUrl":"","url":null,"abstract":"The indication of surgical valva replacement also at older age (greater than 60 years) with chronically rheumatic valvular diseases requires both the assessment of the pre-operative constellation of findings and perioperative complications. From this combined point of view statements concerning the strategy of valve replacement at older age seem to be concludable. In the frame of a prospective study perioperative parameters were monitored in n = 90 patients with preoperative high-risk constellation out of a total of n = 300 patients for the quick recording of additional complications (such as perioperative myocardial damage, cardiac low output syndrome, and cases of death at the ICU). The average age of the whole group of patients was 52 years (25-68 years), that of the patients greater than 60 years was 63.6 years (61-68 years). In 72% of the older patients the preoperative high-risk constellation was confirmed by 50% deceased; 16% cLOS; 6% perioperative myocardial damage (PMD). On a total of 41% of the patients a combined operation was performed (valve replacement and bypass operation), there of 2/3 with aortic valve replacement and 1/3 with mitral valve replacement. The ejection fraction restricted heavily already before the operation (less than or equal to 30%) was the essential cause of perioperative complications (cases of death, cLOS) together with the combined operation. The immedicable pulmonary hypertension complicated the already preoperatively impaired left-ventricular function in a high percentage of patients with mitral valve replacement.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":23809,"journal":{"name":"Zeitschrift fur Alternsforschung","volume":"44 5","pages":"267-72"},"PeriodicalIF":0.0,"publicationDate":"1989-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13954814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Rehabilitative measures in elderly patients]. [老年患者康复措施]。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

W Geissler

引用次数: 0

[Physical conditioning following acute myocardial infarct in the elderly]. [老年人急性心肌梗死后的身体调节]。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

R Knie, K Kothe, G Dahn, H R Peikert, H P Ludwig

引用次数: 0

[An orienting stress test following acute myocardial infarct in the elderly]. [老年人急性心肌梗死后定向应激试验]。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

G Dahn, K Kothe, H Fiegler, H R Peikert, H Dronski

引用次数: 0

[Aortocoronary venous bypass operation in the elderly]. 老年冠状动脉旁路搭桥手术。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

V K Kothe, B Porstmann, R Aurisch, J Butzeck

{"title":"[Aortocoronary venous bypass operation in the elderly].","authors":"V K Kothe, B Porstmann, R Aurisch, J Butzeck","doi":"","DOIUrl":"","url":null,"abstract":"On the extended diagnosis for an aorto-coronary venous bypass operation, with a greater involvement of patients with instable angina pectoris symptomatik (inApS), left main artery disease (LAD), aneurysmal resection, and \"bad\" ventricle (ejection fraction global less than or equal to 30%), the preoperative risk was evaluated in n = 600 patients. In a total of n = 150 patients with preoperative high-risk constellation perioperative parameters were monitored to find complications (perioperative myocardial damage [PMD], cardiac low output syndrome [LOS]). Among them were n = 40 patients aged greater than 60 years (60-72), their average age being 62.9 years. In 30% of these older patients the preoperative high-risk constellation was confirmed: 15% PMD, 10% LOS, and 5% deceased. The further postoperative course (up to the 6th month) is objectified by the ejection fraction global (EFg) by multiple checks. As a whole, patients greater than 60 years with extended diagnosis for ACVB operation do not show any significant increase in hospital mortality, but an increase in PMD and LOS (p less than 0.001) compared to the age group less than 60 years. With corresponding individual intensive-therapeutic measures, however, both complications can be controlled in the majority of patients. Despite the demonstrated higher perioperative risk, the urgent ACVB operation proved to be strategically right (considering the results of EFg) for increasing the quality of life and improving the expectation of life also for patientes greater than 60 years, in particular with the operation indications of inApS and LAD.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":23809,"journal":{"name":"Zeitschrift fur Alternsforschung","volume":"44 5","pages":"273-9"},"PeriodicalIF":0.0,"publicationDate":"1989-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13954815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic indices and advanced age in acute myocardial infarct]. [急性心肌梗死的预后指标与高龄]。

Zeitschrift fur Alternsforschung Pub Date : 1989-09-01

V H Fiegler, K Kothe, G Dahn

引用次数: 0

[Orienting study of the modification of age-related changes by procaine in the pig]. [普鲁卡因改变猪年龄相关变化的定向研究]。

Zeitschrift fur Alternsforschung Pub Date : 1989-07-01

M Kietzmann, K Kaemmerer, H A Schoon

{"title":"[Orienting study of the modification of age-related changes by procaine in the pig].","authors":"M Kietzmann, K Kaemmerer, H A Schoon","doi":"","DOIUrl":"","url":null,"abstract":"In 3 and 14 years old mini pigs age dependent changes as well as the opportunity to modify them with a combination of procaine and haemotoporphyrine, administered daily over 6 weeks in doses of 150 mg procaine hydrochloride per animal (3-5 mg/kg b.w.), were tested. In serum a small age dependent increase in catecholamine concentration was recognized, while the concentration of cortisol was distinctly increased in the older pigs. The monoamine oxidase activity was increased in the liver of the 14 years old pigs while no differences were found in cerebral cortex. Under procaine the old animals showed a clear decrease in monoamine oxidase activity as well as in cholinesterase activity. Furthermore an age dependent decrease of the thymidine triphosphate incorporation rate as well as the amino acid incorporation rate was found in liver, cerebral cortex, small intestine and spleen. Jejunal enzyme activities also were decreased age dependently. Otherwise procaine hydrochloride induced an increase in intestinal enzyme activities of both animal groups. These findings demonstrate that different intermediary processes change age dependently. Also it is shown, that procaine hydrochloride develops intermediary effects.","PeriodicalId":23809,"journal":{"name":"Zeitschrift fur Alternsforschung","volume":"44 4","pages":"201-9"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13939270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Effect of procaine and procaine metabolites on coenzyme A and acetyl coenzyme A concentration in various tissues of the rat]. [普鲁卡因及其代谢物对大鼠各组织中辅酶A和乙酰辅酶A浓度的影响]。

Zeitschrift fur Alternsforschung Pub Date : 1989-07-01

M Kietzmann, K Kaemmerer

引用次数: 0

[Intermediary effectiveness of procaine and procaine metabolites following oral administration]. [口服普鲁卡因和普鲁卡因代谢物的中间有效性]。

Zeitschrift fur Alternsforschung Pub Date : 1989-07-01

K Kaemmerer, M Kietzmann

{"title":"[Intermediary effectiveness of procaine and procaine metabolites following oral administration].","authors":"K Kaemmerer, M Kietzmann","doi":"","DOIUrl":"","url":null,"abstract":"The influence of orally administrated procaine hydrochloride and of its metabolites diethylaminoethanol, monoethylaminoethanol and ethanolamine on specific intermediary processes in rats was tested. While the animals got procaine hydrochloride in a single dose or via food the incorporation rate of amino acids in protein was measured in homogenisates of liver tissue by the incorporation of a mixture of 14C-amino acids. Procaine hydrochloride, the commercial product K. H. 3, as well as diethylaminoethanol, monoethylaminoethanol and ethanolamine increased the amino acid incorporation rate in a dose and time dependent mode, while p-aminobenzoic acid remained without any effect. The dose of procaine hydrochloride inducing a maximal reaction was in the range of 50 to 100 mg/kg b. w. (250 to 500 mg/kg food). The minimal active dose was nearly at 10 mg/kg b. w. Paying regard to a metabolic factor of 10 the effective dose-range is nearly the dose used in experience with human beings to influence geriatric complaints. In the study described here haematoporphyrine (a component of the commercial product K. H. 3, not absorbed) shows no specific intermediary effect. May be it promotes the intestinal absorption of procaine hydrochloride by protection against intestinal hydrolysis. The intermediary effect of procaine hydrochloride is to measure on cellular or subcellular level without compatibility to the activity as a local anaesthetic. With regard to other intermediary effects mentioned in the literature like growth promotion or inhibition of monoamine oxidase activity, it is discussed whether the increase of the hepatic amino acid incorporation rate is corresponding to geriatric experiences made with procaine hydrochloride.","PeriodicalId":23809,"journal":{"name":"Zeitschrift fur Alternsforschung","volume":"44 4","pages":"189-99"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13937874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0