World journal of pharmaceutical research最新文献

{"title":"DEVELOPMENT AND ASSESSMENT OF AN ANTIBIOTIC INTRAPOCKET DEVICE FOR PERIODONTAL DISEASE","authors":"N. Joy","doi":"10.20959/wjpr201711-9656","DOIUrl":"https://doi.org/10.20959/wjpr201711-9656","url":null,"abstract":"Periodontal disease causes destruction of adjuvant structures of the teeth predominate in all groups, ethnicities, races and both genders. It is generally agreed that gram negative anaerobic germs residing in periodontal vacuities are responsible for periodontitis. Systemic antibiotic therapy is employed in treating this diseased condition, but it has limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Different modes of local delivery devices are developed to deliver the drug locally into periodontal pits. These controlled intra-pocket devices also help in the maintenance of therapeutic drug concentration for the desired period of time. The goal of this research was to fabricate controlled release dental films, loaded with satranidazole as an antimicrobial agent which consists of a common biodegradable polymer and a co-polymer in different proportions for targeted delivery of drug. About 6 formulations of satranidazole dental inserts were prepared with gelatin as the principle biodegradable polymer and sodium alginate as a co-polymer in different ratios. Formulated periodontal films were then crosslinked with 2% v/v glutaraldehyde for 2 and 4 hours respectively inorder to upgrade the formulations for extended release. The dental inserts produced in such a manner were evaluated for their thickness uniformity, folding endurance, weight uniformity, % drug content, surface pH, swelling index, in-vitro drug release, in-vitro permeation, in-vitro antibacterial activity and stability studies. Based on these findings best film was selected as the one which is fabricated with gelatin and sodium alginate (1:1 ratio) i.e. F2 (2 hour crosslinked strip), since it can deliver the drug over MIC in each day of therapy and it is having an adequate drug content and other necessitate film characteristics. The kinetic models of the formulation F2 (2 hour crosslinked film) was then found and it denoted that the formulation undergoes zero order release kinetics and model fits to Higuchi which is reflective of the diffusion mechanism of World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1010-1033. Research Article ISSN 2277– 7105 *Corresponding Author Nigil Sebastian Joy Nirmala College of Pharmacy, Muvattupuzha, Kerala, India. Pin686661. Article Received on 02 August 2017, Revised on 22 August 2017, Accepted on 13 Sept. 2017 DOI: 10.20959/wjpr201711-9656","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"159 1","pages":"1010-1033"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75167580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF INJ. KENACORT IN THE MANAGEMENT OF FROZEN SHOULDER","authors":"A. Maan","doi":"10.20959/WJPR201711-9585","DOIUrl":"https://doi.org/10.20959/WJPR201711-9585","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"75 5","pages":"853-858"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91421594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY OF THE METHANOL LEAF EXTRACT OF LUFFA CYLINDRICA ON CERTAIN PATHOGENIC MICROBES.","authors":"Eze Charity Chinasa","doi":"10.20959/WJPR201711-9575","DOIUrl":"https://doi.org/10.20959/WJPR201711-9575","url":null,"abstract":"The attention of the pharmaceutical scientists has been drawn to studies on the potential antimicrobial activities of plant derived substances, an untapped source of antimicrobials which are used in traditional medicine in different settings. This led to the study of the phytochemical analysis and antimicrobial activity of the methanol leaf extract of Luffa cylindrica on certain pathogenic microbes: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Candida albicans, Aspergillus niger, which were isolated from the laboratory benches and toilet handles of the Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka. The percentage Ash value was determined to be 2.3%. Microscopic evaluation of the plant showed specific cellular structures like the parenchyma, oxalate crystals, epidermal hairs and stomata. S. aureus, S. typhi, P. aeruginosa and C. albicans were susceptible to the methanol leaf extract of L. cylindrica, with the exception of E. coli and A. niger which were resistant to the methanol extract. The phytochemical compounds present are Flavonoids, Alkaloids, Saponins, World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 17-41. Review Article ISSN 2277– 7105 *Corresponding Author Dr. Ezea Charity Chinasa Department of","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"12 1","pages":"17-41"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91546032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF VASTUKA (CHENOPODIUM ALBUM LINN.) ON BLOOD HEMOGLOBIN LEVEL: A RESEARCH STUDY","authors":"R. Kumawat","doi":"10.20959/WJPR201711-9543","DOIUrl":"https://doi.org/10.20959/WJPR201711-9543","url":null,"abstract":"Hemoglobin deficiency is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. On an average, globally 50% of the anemia is assumed to be attributed to iron deficiency. It is very common in rural population due to poverty and inadequate diet. Iron deficiency is primarily caused due to dietary insufficiency; therefore, this study aims to explore locally available dietary iron sources. The central hypothesis of the study being a low cost, locally available and culturally acceptable dietary substance supplementing adequate iron requirement will have a better chance of compliance in the population. A single blind Study was carried out in OPD patients of DG department of NIA, Jaipur for 30 days. Total 20 apparently healthy volunteers were registered for the trial and treated with Vastuka dry powder. The overall clinical improvement was highly significant.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"702-708"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90625253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A REVIEW ON AROMA PROFILE OF CINNAMOMUM SPECIES IN NORTH AND NORTH EAST INDIA","authors":"G. Tewari","doi":"10.20959/WJPR201711-9501","DOIUrl":"https://doi.org/10.20959/WJPR201711-9501","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"79 1","pages":"200-221"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88252458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN OPEN LABELLED PILOT STUDY ON THE EFFICACY OF SIDDHA FORMULATION SADHAKUPPAI CHOORANAM FOR THE TREATMENT OF KUDAL KIRUMI (ASCARIASIS)","authors":"R. Savitha","doi":"10.20959/wjpr201711-9497","DOIUrl":"https://doi.org/10.20959/wjpr201711-9497","url":null,"abstract":"Intestinal worm infection is a common pediatric health problem causing morbidity and anguish. Sadhakuppai Chooranam is a traditional Siddha drug indicated for Kudal kirumi (Ascariasis) a common ailment among children. The current study was conducted among 40 pediatric patients (30 Out Patients and 10 In Patients) of the department of Kuzhanthai Maruthuvam at National institute of Siddha, Tambaram, Chennai. The trial drug Sadhakuppai Chooranam was given twice a day for 20 days and follow up was done once in 7 days. At each clinical visit clinical assessment was done and prognosis was noted. Laboratory investigations were done 0 day & 20th day of the trial, and the patients were followed up for another 2 months. The study data were circumspectly analyzed and are presented graphically in this work. The study results revealed that among the forty patients enrolled in the open labeled pilot study, 80% of them had very good prognosis with improvement in both clinical and laboratory parameters. Hence the trial drug Sadhakuppai Chooranam can be used clinically for the effective treatment of Kudal kirumi (Ascariasis).","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"25 1","pages":"546-552"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88379399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PURIFICATION AND CHARACTERIZATION OF L-ASPARGINASE ENZYME FROM SPINACEA OLERACEA","authors":"Sarina.P. Khabade","doi":"10.20959/WJPR201711-9544","DOIUrl":"https://doi.org/10.20959/WJPR201711-9544","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"17 1","pages":"709-717"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86420840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DENTAL EMERGENCY RESIDENCY PROGRAM","authors":"Talal H. Bokhamsin","doi":"10.20959/wjpr201710-9428","DOIUrl":"https://doi.org/10.20959/wjpr201710-9428","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"82 2","pages":"1364-1374"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72584992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF WOUND HEALING ACTIVITY OF POLYHERBAL GEL FORMULATION","authors":"Amrapali S. Kakade","doi":"10.20959/WJPR201710-8982","DOIUrl":"https://doi.org/10.20959/WJPR201710-8982","url":null,"abstract":"The aim of present study was Evaluation of Wound Healing activity of Polyherbal Gel Formulation. The different concentration of gel was prepared by using corbopol 940 as a gel base. Azadirachta Indica leaves extract, Tridax procumbens leaves extract, and honey by using partial thickness burn wound model in winster rats. All animals were divided into six groups. Group I was control, Group II was treated by 1% of Azadirachta Indica gel, Group III was treated by 1% of Tridax procumbens gel, Group IV were treated by 1% Honey gel . Group V were treated by polyherbal gel and Group IV were treated by Marketed Preparetion (Reference Standard). For 15 days all gel applied topically. The wound healing activity evaluated by physical parameters namely wound contraction and epithelialization. The polyherbal gel shows significant effect on wound healing activity.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"86 1","pages":"501-509"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78198469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF CLINICAL EFFICACY OF RAJATA YOGA IN PRAMEHA W.S.R. TO DIABETES MELLITUS","authors":"M. Bhavani","doi":"10.20959/WJPR201710-9441","DOIUrl":"https://doi.org/10.20959/WJPR201710-9441","url":null,"abstract":"Rasa Shastra has been serving humanity from centuries with its unique metallic and herbo-mineral formulations. Prameha is one among the 8 Mahagadas as numerated by our Acharyas. The syndrome Diabetes mellitus has been largely covered under the broad heading of Prameha. Diabetes mellitus is a metabolic disorder of carbohydrate, fat & protein characterized by hyperglycemia with or without glycosuria. According to the International Diabetic Federation (IDF), the disease affects 285 million people of the world‟s population in the 20 – 79 years age group and this number is expected to grow to 380 million by 2025. Rajata Yoga is mentioned in Rasa Tarangini and indicated in all types of Prameha. Rajata bhasma and Trijataka churna are the main ingredients of Rajata Yoga. Its clinical efficacy was evaluated in 30 patients of Prameha based on the signs and symptoms mentioned in classics. Rajata Yoga showed statistically extremely significant relief (p<0.0001) in Prabhuta mutrata, Avila mutrata, Karapada daha & suptata, Dourbalya, Kruchravyavayata, Pindikodveshtana, FBS, PPBS. It showed very significant relief (p< 0.001) in Sweda atipravrutti and significant relief in (p<0.05) in Pipasaadhikyata, Kshudaadhikyata.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"1079-1089"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78384186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}