Yonago acta medica最新文献

{"title":"Factors Associated with Patient Satisfaction in Older Adults Undergoing Outpatient Musculoskeletal Rehabilitation.","authors":"Jun Tamura, Chika Tanimura, Takashi Wada, Yuki Kitsuda, Daiki Takemori, Yumi Saeki, Shinpei Enokida, Shinji Tanishima, Hideki Nagashima","doi":"10.33160/yam.2026.08.007","DOIUrl":"10.33160/yam.2026.08.007","url":null,"abstract":"<p><strong>Background: </strong>Musculoskeletal disorders (MSDs) are a leading cause of long-term care needs in Japan; therefore, rehabilitation is essential. Although patient satisfaction is an important indicator of care quality, factors associated with satisfaction among older adults receiving outpatient musculoskeletal rehabilitation remain unclear. Therefore, the present study aimed to examine patient satisfaction and its associated factors in this population.</p><p><strong>Methods: </strong>This observational study included 100 outpatients with MSDs at a community hospital in western Japan (mean age, 77.2 ± 6.1 years). Satisfaction was assessed using the Customer Satisfaction Scale based on Need Satisfaction in health care services (CSSNS), which covers competence, autonomy, relatedness to other participants, relatedness to service providers, and physiological needs. Physical function, psychological factors, personality traits, and environmental factors were also evaluated.</p><p><strong>Results: </strong>The mean total CSSNS score was 54.3 ± 7.5 points. Autonomy exhibited the lowest score, whereas relatedness to service providers demonstrated the highest. Greater satisfaction was significantly associated with longer rehabilitation duration, faster gait speed, older age, higher conscientiousness, and lower pain catastrophizing. Openness and agreeableness were associated with satisfaction in relatedness to service providers.</p><p><strong>Conclusion: </strong>Patient satisfaction was associated with physical factors, psychological factors, personality traits, and environmental factors, supporting individualized and psychologically supportive rehabilitation.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"271-279"},"PeriodicalIF":1.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultural Prescribing: Concepts, Evidence, Implementation, and the Contribution of Socially Engaged Art.","authors":"Daisuke Son","doi":"10.33160/yam.2026.08.006","DOIUrl":"10.33160/yam.2026.08.006","url":null,"abstract":"<p><p>Cultural prescribing is an emerging approach that connects people with arts, cultural activities, heritage, and culturally meaningful places to support health and well-being. It is usually situated within social prescribing and overlaps with Arts on Prescription, museum-based programmes, creative health, community arts, and participatory arts. However, inconsistent terminology and intervention models make its scope difficult to define. This critical narrative review clarifies the concept of cultural prescribing, summarizes its proposed mechanisms and current evidence, examines implementation and ethical challenges, and considers the contribution of socially engaged art. Existing reviews indicate that referral-based arts programmes can improve psychosocial well-being and may reduce anxiety, depression, loneliness, and social isolation, but the evidence remains limited by observational designs, heterogeneous interventions, selective participation, and insufficient long-term and economic evaluation. Cultural engagement may operate through emotional regulation, aesthetic absorption, meaning-making, identity development, learning, embodiment, social connection, place attachment, and collective agency. Implementation depends on trusted relationships, accessible and sustainable cultural infrastructure, adequate support for artists and community organizations, and attention to inequalities in participation. Socially engaged art is not synonymous with cultural prescribing, because it does not necessarily begin with a clinical referral or seek health outcomes. Nevertheless, its emphasis on dialogue, collaboration, shared authorship, and social transformation can extend cultural prescribing beyond the referral of individuals to pre-existing activities. Cultural prescribing can therefore be understood as a continuum from referral to participation, co-creation, and collective transformation. A relational and community-oriented model may be particularly relevant in Japan, where libraries, local festivals, traditional practices, and informal community spaces can function as cultural health assets. Future research should evaluate not only individual symptoms but also relationships, cultural inclusion, community capacity, and structural conditions.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"248-260"},"PeriodicalIF":1.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Diagnostics of Infectious Diseases.","authors":"Miyako Takata, Hiroki Chikumi, Ayumi Yoshifuji","doi":"10.33160/yam.2026.08.005","DOIUrl":"10.33160/yam.2026.08.005","url":null,"abstract":"<p><p>With the advances in molecular biology, molecular testing has been incorporated into pathogen testing for infectious diseases. There are two main objectives for the molecular diagnosis of infectious diseases- first, to detect pathogen genes by using highly sensitive nucleic acid amplification tests, such as polymerase chain reaction and isothermal amplification, and second, to characterize the properties of the pathogen using next-generation sequencing. Polymerase chain reaction plays a key role in molecular testing. The extensive development of polymerase chain reaction methods is underway, focusing on the acceleration of reaction time (microfluidic polymerase chain reaction), quantification (real-time polymerase chain reaction, digital polymerase chain reaction), full automation, and point-of-care testing. Isothermal amplification is a method for amplifying nucleic acids at a constant temperature. Loop-mediated isothermal amplification, recombinase polymerase amplification, and nucleic acid sequence-based amplification have been developed for isothermal amplification. Isothermal amplification does not require a thermal cycler or simplified temperature control; therefore, it is suitable for point of care testing. CRISPR-based diagnostics are a new method for detecting amplified nucleic acids. CRISPR-Cas reaction proceeds at a constant temperature, it is often combined with isothermal amplification. Next-generation sequencing has a high sequence throughput to rapidly obtain large amounts of genomic information and can be used to detect novel pathogens and diagnose complex infectious diseases. It can also be used to track the sources and transmission routes of outbreaks and monitor pathogen evolution. Furthermore, next generation sequencing has enabled the analysis of microbiomes that can serve as biomarkers for diseases or disease susceptibility. In the future, the molecular diagnosis of infectious diseases will advance by overcoming these shortcomings and integrating various technologies as hybrid platforms. This review describes the developments in molecular diagnostics for the treatment of infectious diseases.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"228-247"},"PeriodicalIF":1.0,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Simultaneous Drainage of Sinonasal and Intracranial Infections for Pediatric Rhinogenic Subdural Abscess.","authors":"Motoki Nakamori, Yosuke Nakamura, Hiromi Takeuchi, Hiroki Yoshioka, Masamichi Kurosaki, Kazunori Fujiwara","doi":"10.33160/yam.2026.08.004","DOIUrl":"10.33160/yam.2026.08.004","url":null,"abstract":"<p><p>Intracranial complications of acute rhinosinusitis have become rare in the antibiotic era, but delayed diagnosis and treatment can lead to severe or even fatal outcomes. Therefore, clinicians should always be aware of the potential for intracranial involvement when treating patients with paranasal sinus infections. We experience a case of an 11-year-old boy who developed a subdural abscess secondary to acute rhinosinusitis. The patient initially presented with frontal headache and vomiting on day 0, and computed tomography (CT) revealed left frontal, ethmoidal, and maxillary sinusitis. Despite intravenous antibiotic therapy with ceftriaxone, right lower limb paresis developed on day 5, and magnetic resonance imaging (MRI) demonstrated a left subdural abscess. Endoscopic sinus surgery (ESS) was performed at another hospital, but the abscess enlarged, leading to transfer to our institution. On admission, he exhibited impaired consciousness, right leg paresis, and diplopia. Emergency simultaneous ESS and burr-hole drainage were performed in collaboration between otorhinolaryngology and neurosurgery teams. Pus was drained from both the frontal sinus and subdural space, and a subdural drain was placed. Cultures of the pus were negative, and broad-spectrum antibiotics were continued. The patient's neurological symptoms gradually improved, and follow-up MRI on day 54 showed complete resolution of the abscess. He was discharged on day 55 without neurological sequelae. This case emphasizes the importance of accurate diagnosis and the rapid, simultaneous performance of paranasal sinus drainage and intracranial abscess drainage through multidisciplinary collaboration. We report such a pediatric case of acute rhinosinusitis complicated by a subdural abscess, together with a brief review of the relevant literature.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"294-298"},"PeriodicalIF":1.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of TcPO₂ in Assessing Microcirculatory Improvement and Minimizing Amputation Levels for Hemodialysis Access-Induced Distal Ischemia: A Case Report.","authors":"Kento Ikuta, Yoshiko Suyama, Ryunosuke Umeda, Makoto Ohga, Keiichi Fumita, Machiko Kuroda, Masayuki Endo, Yuichiro Kishimoto, Shunjiro Yagi","doi":"10.33160/yam.2026.08.003","DOIUrl":"10.33160/yam.2026.08.003","url":null,"abstract":"<p><p>Conventional pressure-based assessments (e.g., skin perfusion pressure) of Hemodialysis Access-Induced Distal Ischemia (HAIDI) are often limited by pain or ulcer location. We report the utility of transcutaneous oxygen pressure (TcPO₂) for objective clinical decision-making in this setting. An 84-year-old man developed ischemic necrosis of the left index, middle, and ring fingers secondary to HAIDI after arteriovenous graft creation. Angiography confirmed hemodynamic steal, which was treated with collateral vein coil embolization to restore perfusion while preserving access. TcPO₂ improved markedly from 29 to 73 mmHg (palm) and 6 to 64 mmHg (dorsum) post-intervention. These values exceeded the 40-mmHg healing threshold typically used for lower-extremity ischemia. Supported by these objective findings and favorable clinical progression, limited amputation was successfully performed instead of major amputation, resulting in complete healing. TcPO₂ provides a practical, noninvasive complementary means to confirm microcirculatory recovery, supporting decisions on the timing and feasibility of limited amputation in HAIDI when conventional methods are impractical.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"288-293"},"PeriodicalIF":1.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Function-Based Intervention, Acceptance and Commitment Therapy, and ICT-Enabled Collaboration for Chronic Self-Injurious Behavior in an Adult with Severe Intellectual Disability: A Case Report.","authors":"Masahiko Inoue, Tomohisa Yamanaka, Taro Okano, Ryuki Kadekaru, Teppei Imakita","doi":"10.33160/yam.2026.08.002","DOIUrl":"10.33160/yam.2026.08.002","url":null,"abstract":"<p><p>This case report describes an integrated intervention for chronic self-injurious behavior (SIB) in an adult woman with severe intellectual disability and autism spectrum disorder features. The intervention was delivered primarily through monthly consultations with her mother, with periodic involvement of community-based service providers. A functional assessment interview identified routine-specific antecedents and maintaining contingencies in bedtime, living room, undressing, hair-drying, and transportation settings. Based on these findings, context-specific environmental modifications and alternative responses were introduced. In parallel, Acceptance and Commitment Therapy-based psychological support was provided to the mother to reduce caregiving distress and promote more flexible, values-consistent responding. In addition, information and communication technology-enabled collaboration through a secure group chat-connecting the specialist, the mother, and community service providers-served three documented functions: real-time procedural alignment across care settings, rapid multi-agency behavioral assessment, and caregiver psychological support. Following implementation of the function-based strategies, SIB markedly decreased in the targeted settings. The mother's depressive symptoms also decreased, and interagency support became more consistent and sustainable. This case suggests that combining a function-based behavioral approach with caregiver-focused psychological support and ICT-enabled collaboration may be clinically useful for managing chronic SIB in adults with severe intellectual disability.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"280-287"},"PeriodicalIF":1.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes and Enabling Factors of Integrated Care in a Rural Aging Community in Japan: A Qualitative Study.","authors":"Shohei Taniguchi, Daisuke Son, Toshihiro Hamada, Minako Kamimoto, Shintaro Imaoka, Yuma Otsuka, Tsubasa Nakai, Shin-Ichi Taniguchi","doi":"10.33160/yam.2026.08.001","DOIUrl":"10.33160/yam.2026.08.001","url":null,"abstract":"<p><strong>Background: </strong>Japan faces one of the world's most rapidly aging populations, particularly in rural and mountainous regions. Since 2003, Japan has promoted the Community-based Integrated Care System, yet implementation and outcomes vary by region. This study aimed to explore the long-term outcomes and enabling factors of integrated care in a highly aged, depopulated rural town.</p><p><strong>Methods: </strong>A qualitative study using semi-structured interviews was conducted with eight healthcare and welfare professionals involved in long-standing community care in Nichinan Town, Tottori Prefecture. Participants were selected via convenience and snowball sampling. Data were analyzed using the Steps for Coding and Theorization (SCAT) method.</p><p><strong>Results: </strong>Three main categories were identified: (1) effects of long-term integrated care, including the development of a culture of information sharing and improved interprofessional collaboration; (2) enabling factors, such as the central role of the Integrated Community Care Support Center, physician participation in case conferences, and the structured sharing of good practices; and (3) contextual challenges, such as workforce shortages, evolving care needs, and limited informal support.</p><p><strong>Conclusion: </strong>Sustained integrated care in aging rural communities can foster effective interprofessional collaboration and enhance care quality. A neutral coordinating entity such as the ICCS Center, along with regular sharing of practical case outcomes, may play a vital role in maintaining long-term integration. These findings offer insights for other aging, underserved regions aiming to implement or strengthen integrated care systems.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 3","pages":"261-270"},"PeriodicalIF":1.0,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13503118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topiramate-Responsive Myoclonic Status Epilepticus in a Child with Progressive Myoclonus Epilepsy Due to Neuronal Ceroid Lipofuscinosis Type 8: A Case Report.","authors":"Hirokazu Tsuchie, Yukino Kawanami, Go Yoshino, Tohru Okanishi, Yoshihiro Maegaki","doi":"10.33160/yam.2026.05.009","DOIUrl":"10.33160/yam.2026.05.009","url":null,"abstract":"<p><p>Progressive myoclonus epilepsy (PME) is a severe developmental and epileptic encephalopathy characterized by drug-resistant seizures and progressive neurological regression. In the late stage, patients often develop myoclonic status epilepticus (MSE), for which an optimal treatment has not been established. Neuronal ceroid lipofuscinosis type 8 (NCL8), caused by pathogenic variants in the <i>CLN8</i> gene, is a rare lysosomal disorder that can present with PME. However, published clinical experience is limited. We report the case of a boy with PME due to NCL8 who developed recurrent MSE with respiratory compromise and showed clinical improvement following the introduction of oral topiramate. He had developmental delays from late infancy, onset of epilepsy at three years of age, and multiple seizure types, including myoclonic seizures, generalized tonic-clonic seizures, and atypical absence seizures. Neurological regression progressed, and the patient became bedridden by 6 years of age. NCL8 was diagnosed based on the presence of a known pathogenic <i>CLN8</i> variant and autofluorescent storage material in lysosomes identified on skin biopsy. At nine years of age, frequent and prolonged myoclonic seizures, confirmed by long-term video electroencephalography (EEG), occurred repeatedly with oxygen desaturation, requiring intensive care with continuous midazolam infusion. Despite escalation of antiseizure medication therapy, MSE persisted. After the initiation and titration of oral topiramate, the duration and frequency of myoclonic events decreased, allowing successful withdrawal of the continuous midazolam infusion. No further MSE occurred during an 8-month follow-up period, although occasional isolated myoclonic events persisted. Therefore, topiramate may be a useful therapeutic option for MSE in children with PME due to NCL8.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 2","pages":"223-227"},"PeriodicalIF":1.0,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Factors Associated with Help-Seeking Intention Among Adults in Rural Japan.","authors":"Shinya Takeda, Maki Ota, Yuki Fujii, Jin Hiroe, Sumire Hiroe, Mitsue Kawakami, Ayaka Kishishita, Kazuyoshi Morimoto, Hiroaki Moriyasu, Jun-Ichi Nagaishi, Hideyuki Tazumi, Mari Yamamoto, Eiko Yamamoto","doi":"10.33160/yam.2026.05.010","DOIUrl":"10.33160/yam.2026.05.010","url":null,"abstract":"<p><strong>Background: </strong>Clarifying the psychosocial factors associated with help-seeking intention among residents in rural areas is essential for developing community-based support systems and preventing social isolation. This study examined psychosocial factors associated with help-seeking intention among adults in a rural region of Japan.</p><p><strong>Methods: </strong>A total of 448 adults living in Tottori Prefecture, Japan, participated in an online survey. Measures included help-seeking intention, perceived social climate, intrapersonal factors, social and interpersonal resources, and attitudes and skills related to help-seeking. Hierarchical logistic regression was conducted, with age and gender in Step 1 and 23 psychosocial variables in Step 2 using forward likelihood-ratio selection. Multicollinearity was assessed, and sensitivity analyses examined robustness.</p><p><strong>Results: </strong>Individuals who believed that \"it is unavoidable to burden others as long as one is alive\" had higher help-seeking intention (OR = 2.69). Those endorsing that \"it is better to be useful to others\" also showed higher intention (OR = 4.94). Participants who had consulted someone during childhood worries were more likely to have help-seeking intention (OR = 6.48). Having a place to connect with others outside home, school, or work was associated with higher intention (OR = 1.90). Believing that \"being listened to is meaningful\" was associated with higher intention (OR = 2.59), and willingness to \"consult another person if the first consultation did not go well\" was also positive (OR = 3.88). In contrast, individuals who felt isolated (OR = 0.43) and those who did not know how to seek support (OR = 0.30) were less likely to have help-seeking intention.</p><p><strong>Conclusion: </strong>Help-seeking intention in rural adults was associated with diverse psychosocial factors, including tolerance toward burdening others, value of being useful, childhood help-seeking experience, third places, perceived value of being listened to, persistence in help-seeking, subjective isolation, and uncertainty about how to seek help.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 2","pages":"204-212"},"PeriodicalIF":1.0,"publicationDate":"2026-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Myelin Oligodendrocyte Glycoprotein Antibody-Positive Aseptic Meningitis at the Identical Site in a Child: Leptomeningeal Enhancement Detected by Contrast-Enhanced FLAIR Imaging.","authors":"Ayano Okuda, Tohru Okanishi, Kento Ohta, Go Yoshino, Masahiro Umeda, Ikko Ohshiro, Yuto Arai, Sotaro Kanai, Yoshihiro Maegaki","doi":"10.33160/yam.2026.05.008","DOIUrl":"10.33160/yam.2026.05.008","url":null,"abstract":"<p><p>Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is an acquired demyelinating syndrome of the central nervous system mediated by MOG antibodies. Clinical phenotypes include optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis. MOG antibody-associated meningitis (MOGAM) is a form of aseptic meningitis characterized by the presence of serum MOG antibodies. Parenchymal lesions are typically absent in MOGAM; however, some cases may progress to MOGAD. Leptomeningeal lesions are rarely detected on contrast-enhanced T1-weighted magnetic resonance imaging (MRI) but may be conspicuous on contrast-enhanced fluid-attenuated inversion recovery (FLAIR) imaging. We report a case of a 5-year-old boy who initially presented with a prolonged headache and fever. Contrast-enhanced FLAIR imaging revealed localized leptomeningeal enhancement (LME), and the patient was treated for suspected aseptic meningitis. Subsequently, additional parenchymal lesions developed, and serum MOG antibodies were detected, leading to a diagnosis of MOGAD. He achieved remission with corticosteroid therapy but experienced a relapse a year later, with LME localized to the same site on MRI. At recurrence, the contrast-enhanced T1-weighted image showed faint leptomeningeal enhancement, whereas contrast-enhanced FLAIR imaging clearly depicted LME. Intravenous methylprednisolone pulse therapy was promptly initiated, which resulted in resolution without progression to MOGAD. This is the first pediatric report of recurrent MOGAM with LME recurring at the identical site. Contrast-enhanced FLAIR imaging enabled early detection of LME at recurrence and facilitated timely corticosteroid therapy, which may have prevented progression to MOGAD.</p>","PeriodicalId":23795,"journal":{"name":"Yonago acta medica","volume":"69 2","pages":"218-222"},"PeriodicalIF":1.0,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13198970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148017665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}