2020 Advances in Science and Engineering Technology International Conferences (ASET)最新文献_第2页

Method Development and Force Degradation Study for Daclatasvir Using LC-MS/MS 采用LC-MS/MS对Daclatasvir进行药效降解研究

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118229

Hemlata M. Nimie, M. N. Deodhar

{"title":"Method Development and Force Degradation Study for Daclatasvir Using LC-MS/MS","authors":"Hemlata M. Nimie, M. N. Deodhar","doi":"10.1109/ASET48392.2020.9118229","DOIUrl":"https://doi.org/10.1109/ASET48392.2020.9118229","url":null,"abstract":"Daclatasvir (DCV) used for the treatment of chronic hepatitis C virus infection (HCV). The present piece of work contains development, validation and force degradation study for DCV has been carried out by using LC-MS/MS technique. The LC-MS system contains 4000 QTrap along with the Shimadzu LC 20AD LC System, controlled by Analyst 1.4.2 software for present study. For the preparation of standard drug DCV and its marketed formulations the diluent used was acetonitrile: water (50:50v/v). LC system runs with the conditions like use of C18 column (Thermo Scientific, 5µm, 4.6 X 250 mm size), column temperature 25°C (Ambient), Injection volume 2 µL, total run time 10 min, flow rate 0.5 mL/min and an isocratic mobile phase consist of 1mM Ammonium acetate Buffer pH=4 adjusted with 50% acetic acid in water as ‘A’ and acetonitrile as a solvent ‘B’ (20:80 v/v). Validation was carried out by testing parameters like LOD (limit of detection), LOQ (Limit of quantification) linearity, ruggedness, accuracy and precision in terms of reproducibility, repeatability according to ICH guidelines. The calibration range for DCV was 500 to 5000 ng/mL, where 800, 1600 & 3200 ng/mL concentrations of DCV set as an Internal QC with proper labeling. All Three QC samples applied n=6 times. For Mass spectrometry (MS) quantification of the DCV, the interest of mass m/z 740.50/514.10 was considered. The force degradation study has been carried out on LC-MS for DCV at different stress conditions. The drug was found to be stable in acidic, neutral, oxidative and photolytic but degrades in basic conditions. The proposed method is fast, economical, avoiding chemical steps and wet chemistry and thus provides a comparatively simpler, rapid green method for routine analysis in pharmaceutical industries.","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129649814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Journey of Education Technology towards Innovation 教育科技走向创新之旅

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118334

A. Ahmed, A. Moncey, Megha Mohan, Nikita Tresa Cyriac, Sahar Ali, S. Mariam, Mingxuan Lyu, Kamaladevi Baskaran

{"title":"Journey of Education Technology towards Innovation","authors":"A. Ahmed, A. Moncey, Megha Mohan, Nikita Tresa Cyriac, Sahar Ali, S. Mariam, Mingxuan Lyu, Kamaladevi Baskaran","doi":"10.1109/ASET48392.2020.9118334","DOIUrl":"https://doi.org/10.1109/ASET48392.2020.9118334","url":null,"abstract":"Technology has been growing constantly and has bought an impact on many different areas and fields most noticeably in the education sector. It has emerged as strong influencer in the teaching- learning process between tutors and students. Students are given an opportunity to learn and explore through technology. Education Technology facilitates learning and improving performance by creating, using and managing appropriate technological processes and resources. The purpose of this study is to understand the impact of Educational Technology journey towards innovation in UAE and to define the perception of three major players of the schooling sector - Teachers, Parents and Students. The questionnaire method of data collection was carried out in order to cover a greater number of respondents. The results indicate that while respondents are accommodating to the various benefits emerging from virtual classroom and increased employment of technology in the schooling system. They are also aware of the negative effects of technology and less appreciative of the continuous dependence of technology in the education system.","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129228850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nonlinear Optics of Photonic Crystals 光子晶体的非线性光学

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118251

Y. Benachour

引用次数: 0

Fabrication of acoustic microfluidic platforms for particle manipulation 粒子操纵声学微流控平台的研制

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118311

Abdullah Al-Ali, W. Waheed, E. Abu-Nada, A. Alazzam

引用次数: 3

FEA of RC Columns Reinforced with WWF Subjected to Concentric Loading 同心荷载作用下钢筋混凝土柱的有限元分析

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/aset48392.2020.9118337

Muhammad Kyaure, Mutaman Elyas

{"title":"FEA of RC Columns Reinforced with WWF Subjected to Concentric Loading","authors":"Muhammad Kyaure, Mutaman Elyas","doi":"10.1109/aset48392.2020.9118337","DOIUrl":"https://doi.org/10.1109/aset48392.2020.9118337","url":null,"abstract":"This paper investigates the potential of using Welded Wire Fabric (WWF) as longitudinal and transverse reinforcement in concrete columns as an alternative to conventionally tied columns. Commercial software package ABAQUS was used to develop a nonlinear finite element (FE) model capable of accurately simulating the axial behavior of concrete columns reinforced with WWF. A parametric study was conducted with the aim of evaluating the effect of replacing both longitudinal & transverse reinforcement with WWF in short concrete columns with concrete compressive strength of 50 MPa. Each WWF reinforced column is compared with its equivalent conventionally reinforced column in terms of dimensions, reinforcement ratio and material properties. Results from the FE analysis revealed that replacing conventional reinforcement with WWF resulted in a slight increase in strength and appreciable enhancement of ductility without compromising stiffness. In conclusion, WWF is a sufficient form of reinforcement for short concrete columns subjected to concentric loading. WWF could potentially yield more ductility in columns with optimal reinforcement ratio (3%).","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121979766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Density Functional Theory Studies of Vacancies in Penta-Graphene Nanoribbons 五石墨烯纳米带空位的密度泛函理论研究

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118169

Khaldoun Tarawneh

引用次数: 1

Quality-dependent adaptation in a swarm of drones for environmental monitoring 一群用于环境监测的无人机的质量依赖适应

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118235

Giulia de Masi, E. Ferrante

引用次数: 13

FE modeling of concerte beams reinforced in flexure using BFRP bars BFRP筋受弯混凝土梁的有限元模拟

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118321

Haya H. Mhanna, Hakem Alkhraisha, F. Abed

{"title":"FE modeling of concerte beams reinforced in flexure using BFRP bars","authors":"Haya H. Mhanna, Hakem Alkhraisha, F. Abed","doi":"10.1109/ASET48392.2020.9118321","DOIUrl":"https://doi.org/10.1109/ASET48392.2020.9118321","url":null,"abstract":"This paper aim to investigate the flexural behavior of concrete beams reinforced longitudinally with Basalt Fiber Reinforced Polymer (BFRP) bars. Finite element (FE) modeling software, ABAQUS, is used to develop a nonlinear model capable of simulating the behavior of FRP reinforced beams in flexure. To validate the FE model, data extracted from ABAQUS were verified through a comparison with published experimental data. Through a parametric study, this paper aims to study the effect of varying the reinforcement ratio on the flexural behavior of BFRP reinforced beams. The reinforcement ratios studied are 0.003, 0.0047, 0.0068, and 0.0123. The paper also present comparative analysis among various FRP reinforcement bars. BFRP reinforced beam is compared with Glass Fiber Reinforced Polymer (GFRP) and Carbon Fiber Reinforced Polymer (CFRP) reinforced beams with similar reinforcement ratio. A third parametric study was conducted to evaluate the effect of varying the number of reinforcement bars while keeping the axial stiffness constant. The results showed an increasing trend of flexural capacity with the increase in reinforcement ratio. The results also indicated the much larger deflection resistance of the CFRP reinforced beams as compared to BFRP and GFRP beams. Lastly, varying the number of reinforcement bars had no effect on the strength of the beam but rather on the stiffness.","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115963774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of friction stir welding of high-density polyethylene 高密度聚乙烯搅拌摩擦焊接技术综述

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118183

S. Iftikhar, A. Mourad, J. Sheikh-Ahmad

{"title":"An overview of friction stir welding of high-density polyethylene","authors":"S. Iftikhar, A. Mourad, J. Sheikh-Ahmad","doi":"10.1109/ASET48392.2020.9118183","DOIUrl":"https://doi.org/10.1109/ASET48392.2020.9118183","url":null,"abstract":"Friction stir welding (FSW) and friction stir spot welding (FSSW) of thermoplastics is becoming popular because of its many industrial applications. This paper specifically reviews the experimental studies available on the FSW and FSSW of high density polyethylene (HDPE), as it is a high demand thermoplastic material used in many industrial applications. The effect of process parameters (tool rotational speed, traverse speed, plunge depth, etc.), tool material and geometry (profile and size), and medium conditions (open-air, submerged, heat-assisted, cooling-assisted, etc.) on the weld joint mechanical properties are discussed. These studies help with narrowing the ranges of all the parameters involved, to optimize welding conditions to achieve highest joint strength. ANOVA (analysis of variance)-based studies are also discussed which help in determining the relative significance of the parameters affecting the joint strength. The thermal behavior of the weld joints, through differential scanning calorimetry (DSC) studies, has also been discussed. Finally, a few recommendations for future studies are presented.","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131637708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Preparing for the smart cities: IoT enabled last-mile delivery 为智慧城市做准备:支持物联网的最后一英里交付

2020 Advances in Science and Engineering Technology International Conferences (ASET) Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118197

Leena Wanganoo, Abhinandan H. Patil

{"title":"Preparing for the smart cities: IoT enabled last-mile delivery","authors":"Leena Wanganoo, Abhinandan H. Patil","doi":"10.1109/ASET48392.2020.9118197","DOIUrl":"https://doi.org/10.1109/ASET48392.2020.9118197","url":null,"abstract":"UAE is among the fastest-growing e-commerce country in the Middle East, and this provides ample growth opportunity to the last mile parcel/courier delivery companies. Yet, the sector struggles to achieve its objective of providing exemplary customer satisfaction and minimizing the operating cost. This paper explores the challenges faced by the logistics companies engaged in the last mile delivery of e-commerce parcels. Firstly, in most countries of the Middle East including UAE there is” No descriptive delivery address “available, which means no postal codes or Zip codes of the final delivery point and secondly, most of the logistics provider still operate on legacy driven semi - digitized track & trace systems for the transportation and customer relation management. This leads to the poor last-mile delivery performance of the logistics provider ultimately impacting the e-commerce brand reputation. To increase efficiency, there is a need to embrace innovative technologies and integrate the supply chain key partners. Based on the exploratory study, we suggest a conceptual framework based on integrated technologies like GPS, IoT, and TMS which will provide the delivery operator with real-time visibility, reliability, and a smart last-mile solution. The unique three technology blend will provide full digitization of the core operations, seamless co-ordination with multiple sources, data-based decision making and real-time visibility.","PeriodicalId":237887,"journal":{"name":"2020 Advances in Science and Engineering Technology International Conferences (ASET)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131167132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9