World journal of stem cells最新文献

{"title":"GATA2 deficiency exacerbates chronic liver injury <i>via</i> disrupting hepatocyte death-regeneration balance: Clinical, histopathological, and molecular evidence.","authors":"Yun-Fen Chen, Su-Qun Li, Jing Zhang, Wen-Ting Ma, Ying Zhou, Jian-Xu Rao, Yu Yi, Qi-Jiao Cheng, Wei-Wei Zhong, Huan Chen, Ying-Hua Chen, Ya-Wen Luo, Yi-Huai He","doi":"10.4252/wjsc.v18.i2.112940","DOIUrl":"10.4252/wjsc.v18.i2.112940","url":null,"abstract":"<p><strong>Background: </strong>GATA-binding protein 2 (GATA2) is a critical transcription factor that plays an essential role in maintaining the stemness of hematopoietic stem cells. Mutations in GATA2 are recognized as disease-causing mutations for aplastic anemia (AA) and myelodysplastic syndromes; however, the mechanisms linking these mutations to chronic liver injury (CLI) (<i>e.g.</i>, cirrhosis) remain elusive.</p><p><strong>Aim: </strong>To investigate the molecular mechanisms through which GATA2 deficiency promotes CLI.</p><p><strong>Methods: </strong>Whole genome sequencing was performed to identify loss-of-function mutations in <i>GATA2</i> in a 55-year-old female patient who was suspected of and later diagnosed with AA and developed cirrhosis one year post-diagnosis. After establishing the genetic association between <i>GATA2</i> mutations and cirrhosis through clinical case analysis, liver injury murine and hepatocyte models were developed to characterize GATA2 expression in response to liver injury. rAAV8-TBG-<i>Gata2-</i>shRNA-mediated liver-specific <i>Gata2</i> knockdown was employed to elucidate the role of GATA2 in exacerbating liver injury.</p><p><strong>Results: </strong>The patient presented with a three-year medical history of dizziness, fatigue, and thrombocytopenia. Following conventional treatment, she developed severe fatigue, abdominal distension, and jaundice, indicative of liver disease. Multimodal evaluations, including bone marrow biopsy, flow cytometry, liver biopsy, and genetic testing, confirmed <i>GATA2</i> mutation-associated AA complicated by cirrhosis. Experimental studies in cellular and animal models demonstrated compensatory upregulation of hepatocyte GATA2 in response to endoplasmic reticulum stress and oxidative stress. Mechanistically, liver-specific <i>Gata2</i> knockdown exacerbated hepatocyte apoptosis, necroptosis, ferroptosis, and impaired regeneration. Furthermore, <i>Gata2</i> knockdown suppressed the adaptive unfolded protein response, attenuated the antioxidant response, and inhibited fatty acid β-oxidation.</p><p><strong>Conclusion: </strong>GATA2 deficiency drives the CLI by disrupting the hepatocyte death-regeneration balance.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"112940"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic potential of combined neural stem cells and mesenchymal stem cells therapy in acute cerebral infarction: A perspective.","authors":"Jing-Yu Li, Shu-Zhen Liu, Xin-Yi Xu, Lan Zhao","doi":"10.4252/wjsc.v18.i2.114433","DOIUrl":"10.4252/wjsc.v18.i2.114433","url":null,"abstract":"<p><p>Acute cerebral infarction (ACI) is one of the leading causes of mortality and long-term disability in adults, often resulting in neuronal loss and necrosis, accompanied by severe neurological deficits. Neural stem cells and mesenchymal stem cells play crucial roles in neural repair and protection, primarily through promoting angiogenesis, reconstructing neural networks, and inhibiting neuronal apoptosis. A recent randomized controlled trial demonstrated that combined neural stem cell and mesenchymal stem cell therapy significantly enhances neurological recovery in ACI patients by upregulating the expression of vascular endothelial growth factor and basic fibroblast growth factor. This study provides a theoretical foundation and clinical support for the application of stem cell-based precision medicine in ACI. This letter shares our perspectives on the combined stem cell therapy for ACI.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"114433"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic mesenchymal and neural stem cell therapy: Advancing neurorestoration in cerebral infarction.","authors":"Noura A A Ebrahim, Moamen O Othman, Neveen S Tahoun, Thoraya A Farghaly, Soliman M A Soliman","doi":"10.4252/wjsc.v18.i2.114372","DOIUrl":"10.4252/wjsc.v18.i2.114372","url":null,"abstract":"<p><p>Recent clinical and translational studies have increasingly highlighted the promise of combined stem cell strategies for neurorestoration following ischemic stroke. In this correspondence, we reflect on the recent trial by Yang <i>et al</i>, which reported that co-transplantation of mesenchymal stem cells (MSCs) and neural stem cells (NSCs) yielded significantly greater functional recovery in patients with acute cerebral infarction, as evidenced by improvements in both Barthel Index and National Institutes of Health Stroke Scale scores. Notably, this dual-cell intervention was accompanied by robust elevation of angiogenic and neurotrophic mediators, particularly vascular endothelial growth factor and basic fibroblast growth factor, suggesting a biologically plausible mechanism for the observed clinical benefit. MSCs contribute through trophic support, immunomodulatory effects, and promotion of vascular regeneration, whereas NSCs primarily facilitate neuronal replacement and reorganization of neural circuits. Together, these mechanisms offer a comprehensive, multitargeted approach to address the multifactorial nature of stroke pathology. Building on this pivotal work, we call for mechanistic studies and multicenter randomized clinical trials to refine cell dosing, timing, and bioengineering strategies, paving the way for the clinical integration of MSC/NSC co-therapy as a next-generation regenerative treatment for stroke.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"114372"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergetic pathways for Parkinson's disease therapy: The intersection of exercise and stem cell science.","authors":"An-Lin Zhang, Luan Wen","doi":"10.4252/wjsc.v18.i2.113930","DOIUrl":"10.4252/wjsc.v18.i2.113930","url":null,"abstract":"<p><p>Jiang <i>et al</i> reports a combined approach of exercise and induced pluripotent stem cell therapy in a Parkinson's disease mouse model<i>.</i> The authors show that exercise can improve motor function by raising epinephrine levels and activating the Wnt1-Lmx1a pathway, thereby supporting dopaminergic differentiation. When paired with induced pluripotent stem cells, these effects are further enhanced, leading to greater behavioral improvements and molecular evidence of neuronal repair compared with either intervention alone. While the translational path from animal models to clinical application is far from straightforward - given variability in disease progression, the durability of grafted neurons, and safety concerns - the study highlights an important point: Progress may rely less on single \"breakthroughs\" and more on the thoughtful combination of diverse strategies. This integrative perspective could help shape future directions in Parkinson's disease therapy.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"113930"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics.","authors":"Daniyaer Dilimulati, Diyaer Dilimulati, Lei Cui","doi":"10.4252/wjsc.v18.i2.113694","DOIUrl":"10.4252/wjsc.v18.i2.113694","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Adipose-derived stem cells (ADSCs) hold significant therapeutic potential for regenerative medicine, particularly in wound healing, owing to their multipotency, paracrine activity, and relative abundance. However, the clinical application of ADSC-based therapies is substantially limited by the harsh microenvironment of acute wounds, characterized by hypoxia, nutrient deprivation, and oxidative stress, which leads to massive apoptotic cell death post-transplantation. Preconditioning strategies to enhance cellular resilience have thus gained considerable interest. Recent insights from cancer biology highlight the crucial role of metabolic reprogramming, orchestrated by hypoxia-inducible factor-1α (HIF-1α), in promoting survival under stress. Our previous work demonstrated that preconditioning with α-ketoglutarate (α-KG) enhances ADSC survival and accelerates wound healing, purportedly through HIF-1α upregulation. Nevertheless, the precise metabolic mechanisms by which α-KG preconditioning confers cytoprotection remain incompletely elucidated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the mechanistic role of HIF-1α in mediating the enhanced survival and regenerative capacity of α-KG-preconditioned ADSCs in an acid burn wound model. Specifically, we sought to determine whether HIF-1α activation drives complementary adaptations in glutamine and glycogen metabolism to maintain redox and energy homeostasis, respectively, under the multifactorial stress conditions of a wound.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Human ADSCs were isolated from lipoaspirates and preconditioned with dimethyl-α-KG. &lt;i&gt;In vitro&lt;/i&gt;, cells were subjected to single or combined stressors (hypoxia, glucose deprivation, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;-induced oxidative stress). Genetic modulation was performed using lentiviral shRNAs targeting HIF-1α, GLS1, and PYGL, or an overexpression vector for GLS1. Metabolic profiling included assessments of glycolytic flux, glucose oxidation, fatty acid β-oxidation, oxygen consumption, and glycogen content. Redox status was evaluated &lt;i&gt;via&lt;/i&gt; glutathione (GSH) (GSH/GSH disulfide) ratios and reactive oxygen species (ROS) levels. &lt;i&gt;In vivo&lt;/i&gt;, a murine acid burn wound model was established, and pre-labeled ADSCs were implanted. Cell survival was tracked &lt;i&gt;via&lt;/i&gt; flow cytometry (Annexin V-PI) and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. Wound healing was assessed histologically.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;α-KG preconditioning significantly enhanced the survival of ADSCs both &lt;i&gt;in vitro&lt;/i&gt; under stress and &lt;i&gt;in vivo&lt;/i&gt; in burn wounds. This was concomitant with HIF-1α stabilization. Mechanistically, HIF-1α orchestrated a dual metabolic adaptation: (1) It promoted glutaminolysis &lt;i&gt;via&lt;/i&gt; GLS1, increasing glutamate and GSH synthesis, which enhanced antioxidant capacity and reduced ROS levels; and (2) It simultaneously stimulated glycogen storage (Gys1 upregulation) and mobilizat","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"113694"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles.","authors":"Zhuo-Jin Shi, Xiao-Mei Ying, Wei Liu","doi":"10.4252/wjsc.v18.i2.114303","DOIUrl":"10.4252/wjsc.v18.i2.114303","url":null,"abstract":"<p><p>Recent studies have demonstrated that synovial mesenchymal stem cell-derived small extracellular vesicles (EVs) engineered to deliver GrpE-like 1 activated PTEN-induced kinase 1-dependent mitophagy and restored chondrocyte homeostasis. This study revealed that interleukin-1β-challenged chondrocytes exhibited efficient cargo transfer, increased mitophagy signaling with reduced p62 levels, lower oxidative stress, and a shift toward matrix preservation, characterized by higher collagen II and aggrecan levels, and lower matrix metallopeptidase 13 and ADAM metallopeptidase with thrombospondin type 1 motif 5 levels. In a rat knee osteoarthritis model, intra-articular dosing preserved cartilage architecture and improved histological scores. Collectively, these findings suggest that EV-based delivery of mitochondrial regulators is a plausible disease-modifying strategy, rather than purely symptomatic care. Building on this evidence, this editorial distills key advances and outlines near-term research and translational priorities, including standardized EV characterization, pharmacokinetics, dosing, safety, and manufacturability. The suitability of GrpE-like 1-loaded small EVs for early-stage osteoarthritis was also evaluated.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"114303"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Synergism of calycosin and bone marrow-derived mesenchymal stem cells to combat podocyte apoptosis to alleviate adriamycin-induced focal segmental glomerulosclerosis\".","authors":"Qiong-Dan Hu, Rui-Zhi Tan, Yuan-Xia Zou, Jian-Chun Li, Jun-Ming Fan, Fahsai Kantawong, Li Wang","doi":"10.4252/wjsc.v18.i2.116824","DOIUrl":"10.4252/wjsc.v18.i2.116824","url":null,"abstract":"<p><p>[This corrects the article on p. 617 in vol. 15, PMID: 37424951.].</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"116824"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerostin silencing in human umbilical cord mesenchymal stem cells enhances bone regeneration <i>via</i> Wnt pathway activation.","authors":"Prashasti Sharma, Dharmendra Kumar Maurya","doi":"10.4252/wjsc.v18.i2.114980","DOIUrl":"10.4252/wjsc.v18.i2.114980","url":null,"abstract":"<p><p>Steroid-induced avascular necrosis of the femoral head is a debilitating condition caused by prolonged glucocorticoid exposure, leading to bone death and disrupted metabolism. Current treatment options are limited, especially in late-stage disease, emphasizing the urgent need for novel regenerative therapies. This study by Lv <i>et al</i> explores the therapeutic potential of human umbilical cord mesenchymal stem cells (MSCs) genetically modified to silence sclerostin, a known inhibitor of bone formation <i>via</i> the Wnt/β-catenin pathway. The authors engineered sh-human umbilical cord MSCs and demonstrated their enhanced osteogenic differentiation and suppression of adipogenesis compared to unmodified MSCs in a steroid-induced rat model of femoral head necrosis. Significant improvements were observed in bone microarchitecture, biochemical markers of bone metabolism, and histological parameters. This investigation suggests that sclerostin silencing enhances MSC efficacy by activating Wnt signaling, thereby offering a promising regenerative strategy for steroid-induced avascular necrosis of the femoral head that targets the core imbalance in bone remodeling.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"114980"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic applications of mesenchymal stem cell-derived extracellular vesicles in pain management: A narrative review of emerging evidence and future directions.","authors":"Sara Akhtar Khan, Prakash Gangadaran, Prachi Tiwari, Ramya Lakshmi Rajendran, Azfar Jamal, Shaheenkousar H Hattiwale, Kushi Anand, Saurabh Kumar Jha, Chae Moon Hong, Byeong-Cheol Ahn, Suhel Parvez","doi":"10.4252/wjsc.v18.i2.116184","DOIUrl":"10.4252/wjsc.v18.i2.116184","url":null,"abstract":"<p><p>Pain remains a major clinical challenge because current therapies often have limited efficacy and substantial adverse effects. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are emerging as promising candidates with anti-inflammatory, immunomodulatory, and neuroprotective actions. Preclinical studies show that MSC-EVs alleviate inflammatory, neuropathic, and cancer-related pain by modulating immune responses and promoting neural repair, thereby reducing nociceptor sensitization. MSC-EVs also hold potential as drug-delivery vehicles and as biomarkers for pain diagnosis due to their stability and bioactive cargo (<i>e.g.</i>, microRNAs and proteins). This narrative review summarizes terminology, mechanisms, therapeutic applications, and translational challenges of MSC-EVs in pain management, emphasizing their capacity to reshape the treatment landscape. Despite hurdles in scalable manufacturing, dosing, and regulation, ongoing clinical investigations support their promise as a biologically driven strategy for pain therapy.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"116184"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cell functions under inflammatory niches.","authors":"Ying-Chu Zhao, Guo-Yue Li, Si Chen, Yi-Lin Wang, Jing-Yi Feng, Yu Cao","doi":"10.4252/wjsc.v18.i2.114032","DOIUrl":"10.4252/wjsc.v18.i2.114032","url":null,"abstract":"<p><strong>Background: </strong>Mesenchymal stem cells are promising regenerative therapies; however, inflammation often impairs their function. Epiregulin (EREG), a member of the epidermal growth factor family, regulates cell migration, differentiation, and tissue repair. However, its effects on periodontal tissue regeneration using mouse bone marrow stem cells (mBMSCs) under inflammatory conditions remain unclear. We hypothesized that EREG activates epidermal growth factor receptor (EGFR)-extracellular signal-regulated kinase 1/2 (ERK1/2) in inflammatory conditions to improve mBMSC function and periodontitis treatment results.</p><p><strong>Aim: </strong>To investigate EREG's role in periodontal tissue regeneration, aiming to identify therapeutic targets for periodontal treatment.</p><p><strong>Methods: </strong>Tumor necrosis factor alpha stimulates inflammation. Lentiviral short hairpin RNA inhibited EGFR expression. Scratch wounds, Transwell assays, Alizarin Red staining, and Western blotting were used to assess the effects and mechanisms of EREG on the migration, chemotaxis, and osteogenic differentiation capacity of mBMSCs. Micro-computed tomography and histological staining evaluated periodontal tissue regeneration.</p><p><strong>Results: </strong>EREG enhances the migration, chemotaxis, and osteogenic differentiation of mBMSCs under inflammatory conditions. Mechanistically, EREG binds to EGFR and activates the ERK1/2 signaling pathway to stimulate these functions. Local administration of EREG facilitated periodontal tissue regeneration in a rat model of periodontitis.</p><p><strong>Conclusion: </strong>EREG promotes mBMSC function <i>via</i> the EREG-EGFR-ERK1/2 pathway under inflammatory conditions and facilitates periodontal tissue regeneration.</p>","PeriodicalId":23775,"journal":{"name":"World journal of stem cells","volume":"18 2","pages":"114032"},"PeriodicalIF":4.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12968805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}