World Journal of Nuclear Medicine最新文献

{"title":"Submandibular Ectopic Thymic Mass in a 6-Month-Old Infant","authors":"Jordan Fenner, Israel Saramago, Jorge Oldan, M. Muhleman","doi":"10.1055/s-0042-1751055","DOIUrl":"https://doi.org/10.1055/s-0042-1751055","url":null,"abstract":"Infant ectopic cervical thymus is a relatively uncommon diagnosis and, in many cases, subclinical. If not subclinical, it may present as a palpable swelling or with compressive symptoms (i.e., stridor or dysphagia). Standard radiologic workup includes an ultrasound followed by magnetic resonance imaging (MRI) with tissue sampling if the ultrasound is indeterminate. In this case, an incidental submandibular mass was noted on a noncontrast MRI for seizures in a 6-month-old male infant. A radiologic and pathologic workup was performed for evaluation. However, this case is unique as fluorodeoxyglucose positron emission tomography/computed tomography was also utilized to potentially aid in the establishment of a diagnosis.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":"75 11","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sixteen-Frame Gated Myocardial Perfusion SPECT as a Surrogate for Equilibrium Radionuclide Angiography in Measurement of Systolic and Diastolic Indices: A Cross-Sectional Study","authors":"Toktam Hosseinnezhad Ariani, M. Ghodsirad, Faezeh Hosseinnejad Ariani, H. Poorzand, Ramin Sadeghi, V. D. Dabbagh Kakhki","doi":"10.1055/s-0044-1788334","DOIUrl":"https://doi.org/10.1055/s-0044-1788334","url":null,"abstract":"\u0000 Introduction Equilibrium radionuclide angiography (ERNA) has long been assumed as the preferred method to assess cardiac volumes as well as left ventricular systolic and diastolic indices. ERNA was used to diagnose subtle changes in cardiac function during chemotherapy or early stages of heart failure. Gated myocardial perfusion SPECT (GMPS) was introduced as a more feasible and versatile alternative to ERNA, but the precision of GMPS to assess systolic and diastolic indices has not yet been fully reviewed.\u0000 Method We studied the left ventricular systolic and diastolic functional indices measured by a 16-frame GMPS and compared the results with those of ERNA in 25 patients. All the images were analyzed visually, semi-quantitatively, and quantitatively using quantitative gated SPECT (QGS), quantitative blood pool SPECT (QBS), and planar gated blood pool (PGBP) software. The left ventricular functional indices calculated using QGS compared with those obtained using QBS and PGBP\u0000 Result Our study found a significant correlation between the left ventricular ejection fraction (LVEF) calculated using the PGBP, QGS, and QBS methods. There was a significant correlation between the LV peak ejection rate (LVPER) calculated by the PGBP and QGS analyses, and there was no significant difference in the LVPER calculated with the QGS and QBS methods. This study also revealed a significant correlation between the LV peak filling rate (LVPFR) calculated by QBS and QGS, with no significant difference between them. We also found a significant correlation between LV end systolic volume (LVESV) calculated using QGS and QBS and between LV end diastolic volume (LVEDV) calculated using QGS and QBS software. This study also revealed a significant correlation between the LV mean filling rate over the first third of diastole (LVMFR/3) calculated using the QGS and QBS software.\u0000 Conclusion Considering the significant correlation between LVEF, LVPER, LVPFR, LVESV, LVMFR/3, and LVEDV calculated using the QGS and QBS methods in our study, the 16-frame GMPS could be regarded as an acceptable substitute for ERNA in the investigation of systolic and diastolic indices.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":"36 2","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Visualization of Gallbladder on Post-therapy [ 177 Lu]Lu-DOTATATE Scintigraphy Mimicking a Liver Metastasis in a Duodenal Neuroendocrine Tumor","authors":"Parth Baberwal, R. Parghane, Sandip Basu","doi":"10.1055/s-0044-1788073","DOIUrl":"https://doi.org/10.1055/s-0044-1788073","url":null,"abstract":"Abstract We present a rare case of physiological uptake of [ 177 Lu]Lu-DOTATATE in the gallbladder, observed post-therapy, in a 47-year-old man with grade I duodenal neuroendocrine tumor (NET), despite no uptake being observed pre-therapy in the somatostatin receptor-positron emission tomography. On planar scintigraphy, the gallbladder uptake could have been misidentified as liver metastasis. By utilizing single photon emission computed tomography/computed tomography imaging, we were able to precisely localize the tracer and obtain anatomical morphological characteristics, thereby averting the potential for misinterpretation of liver metastasis resulting from the gallbladder's physiological uptake of [ 177 Lu]Lu-DOTATATE in NET patients.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":" 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewing the Diagnostic Performance of 99mTc-TRODAT-1 Imaging in Distinguishing Idiopathic Parkinson's Disease from Parkinson-Plus Syndromes","authors":"T. Singhal, M. Narayan, R. Manchanda, Parneet Singh, Minakshi Dhar, Ashutosh Tiwari, Niraj Kumar","doi":"10.1055/s-0044-1787995","DOIUrl":"https://doi.org/10.1055/s-0044-1787995","url":null,"abstract":"Abstract Aim  Diagnosing movement disorders can be challenging owing to their similar clinical presentations with other neurodegenerative and basal ganglia disorders, like idiopathic Parkinson's disease (IPD), essential tremors (ET), vascular parkinsonism, multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Technetium-99m labeled tropane derivative (99mTc-TRODAT-1) imaging can help in diagnosing Parkinson's disease at an early stage to help early initiation of the treatment. The current study aimed to evaluate the role of 99mTc-TRODAT-1 imaging in differentiating IPD and Parkinson-plus syndromes (PPS). Material and Methods  We have analyzed 38 patients, referred to our department for 99mTc-TRODAT imaging. These patients were thoroughly evaluated in the movement disorder clinic at our institute and had a possible/ probable diagnosis of IPD, Hoehn and Yahr (H&Y) stage I/II ( n  = 28) or PPS (PSP [ n  = 06] and MSA [ n  = 04]). Striatal uptake ratio (SUR) was calculated in all the patients and data was statistically analyzed. Results  The mean age of IPD, PSP, and MSA groups was 56.5 ± 12.15, 65.2 ± 11.1, and 51.2 ± 3.9 years, respectively. On qualitative evaluation, all patients had reduced striatal uptake on 99mTc-TRODAT imaging, with 31/38 patients showed a greater reduction in putaminal uptake compared with the caudate nucleus. On semiquantitative evaluation, mean total SUR was 0.58 ± 0.27, 0.53 ± 0.31, and 0.91 ± 0.20 in IPD, PSP, and MSA groups, respectively. The total SUR was lowest in the PSP group followed by IPD, but MSA had relatively higher SUR, although the difference was not statistically significant. Among the IPD patient group, 25/28 patients (89.3%) experienced a greater reduction in SUR values in the striatum contralateral to the side, where motor symptoms first manifested at disease onset. Conclusion  99mTc-TRODAT is a potential imaging biomarker for the evaluation of presynaptic dopaminergic dysfunction in patients with movement disorders. In our study cohort, mean SUR values were lowest for the PSP group followed by IPD and MSA group, which was in concordance with previous studies. However, the difference between SUR values in these two groups was not statistically significant. The present study emphasizes that the capacity of 99mTc-TRODAT-1 imaging alone for diagnosing IPD from PPS is constrained, although it offers a precise approach for distinguishing patients with IPD from those with essential tremors, drug-induced, or psychogenic parkinsonism. Consequently, more specific imaging biomarkers are needed to effectively differentiate between patients with IPD and those with PPS.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":" 1","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Use of Ambientally Stored Methylene Diphosphonate Radiopharmaceutical Aliquots in Solving Challenging Situations in Developing Countries","authors":"Jenipher None Zulu, Reuben None Katebe, Martalena None Ramli, Rita None Sakala, Elias None Mwape, Ernest None Chipasha, Bernard Mudenda Hang'ombe","doi":"10.1055/s-0044-1788278","DOIUrl":"https://doi.org/10.1055/s-0044-1788278","url":null,"abstract":"Abstract Objectives  The primary aim was to evaluate the prolonged quality characteristics of methyl diphosphonate (MDP) aliquots during ambient storage over a specified duration. This study further investigated potential additives that could enhance the stability of MDP aliquots stored under such conditions. Materials and Methods  This was a laboratory-based experimental study conducted at the University Teaching Adult Hospital in Lusaka, Zambia. A total of 36 MDP aliquots stored at ambient conditions and 4 MDP aliquots stored at conventional refrigerated frozen conditions were labeled with technitium-99m ( 99m Tc) and tested for radiochemical purity (RCP) and other quality characteristics. A comparative analysis of the stability and quality of MDP aliquots from the two cohorts was then conducted. Statistical Analysis  Stata 14 was used to analyze the data on the RCP of all MDP aliquots. Results  The RCP of ambient stored MDP aliquots was found to be ranging from 98 to 99%, while that for frozen and refrigerated ones ranged from 99 to 100%. There was also a 1% increase in RCP for both cohorts with argon gas purging (98 and 99%, respectively). Conclusion  The RCP of MDP aliquots from both cohorts was much higher than the required minimum of 90% implying that there was no significant association of their stability and quality with the mode of storage. However, purging with argon gas seemed to increase the stability further in both streams. The study findings show potential for application in resource-constrained environments and centers, especially in developing countries, where challenges to maintain the cold storage chain of these important radiopharmaceuticals are likely to be encountered due to power outages.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":" 3","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Dose Epidermal Radionuclide Therapy with 188 Re (Rhenium) Resin in a Patient with Multiple Actinic Keratoses","authors":"Siroos Mirzaei, R. Kunstfeld","doi":"10.1055/s-0044-1788075","DOIUrl":"https://doi.org/10.1055/s-0044-1788075","url":null,"abstract":"Abstract Aim  High-dose epidermal radionuclide therapy using a nonsealed 188 Re (Rhenium) resin is an alternative treatment option for nonmelanoma skin cancer. In this case study, we present the possible use of this therapy in a patient with multiple actinic keratosis (AK), which is a precancer of the skin. Methods  A 55-year-old male was presented in our department with multiple AK, located on the cheek, temporal, and frontal area, with 1, 1, 2.1, and 2.5 cm 2 surface. Applied activity was 80, 80, 167, and 168 MBq 188 Re with a target absorbed dose for each lesion 35 Gy at 1 mm. The treatment was well tolerated. Results  At 17 months’ follow-up, all treated area showed complete remission. There were no side effects, except mild focal hypopigmentation. Conclusion  This case demonstrates the high potential of epidermal radionuclide therapy with a nonsealed 188 Re as a noninvasive, effective, and well-tolerated therapy option for patients with multiple AK, when surgery is difficult to perform or not recommended of other reasons.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":" 8","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demonstration of Resolution of Community-Acquired Pneumonia Over a Short Course of Antibiotics on [ 18 F]FDG-PET/CT Undertaken for Suspected Perimyocarditis Evaluation","authors":"Parth Baberwal, S. Sonavane, Sandip Basu","doi":"10.1055/s-0044-1788074","DOIUrl":"https://doi.org/10.1055/s-0044-1788074","url":null,"abstract":"Abstract A 28-year-old male presenting with left-sided pleuritic chest pain, cough, palpitation, and fever with mild ST depression in II, III, and aVF, raised troponin I, troponin T, creatine phosphokinase-MB, and erythrocyte sedimentation rate was referred for F-18 2-fluoro 2-deoxyglucose positron emission tomography with noncontrast computed tomography ([ 18 F]FDG-PET/CT) to rule out perimyocarditis. The first scan revealed incidental finding of [ 18 F]FDG avid left lobar pneumonia and inadequate myocardial suppression, thus perimyocarditis could not be ruled out. The clinician was informed and after counseling, patient consented for a repeat study post-high fat-low carbohydrate diet. A regional [ 18 F]FDG-PET/CT on the 5th day revealed adequate myocardial suppression, ruling out perimyocarditis. However, the metabolic and anatomical resolution of previously noted left lobar pneumonia was also observed in such a span of time with the administered antibiotics.","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":" 11","pages":""},"PeriodicalIF":0.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of F18-FDG PET/CT in the Evaluation of Pituitary Uptake.","authors":"Adersh Stanly, Saumya Sara Sunny, Justin Benjamin, Hesarghatta Shyamasunde Asha, David Mathew, Junita Rachel John, Julie Hephzibah","doi":"10.1055/s-0044-1787967","DOIUrl":"10.1055/s-0044-1787967","url":null,"abstract":"<p><p><b>Introduction</b>  Pituitary adenoma is the most common disease that affects the gland and may be classified as functional/nonsecretory tumors. Inflammatory/infective causes may also affect the pituitary gland. The 18F-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) may have an incremental value in assessing these lesions and in determining their clinical significance. <b>Aim</b>  This article assesses the utility of F18-FDG PET/CT in detecting and determining clinical profile of pituitary lesions with abnormal uptake. <b>Methodology</b>  Retrospective analysis of all patients who underwent F18-FDG PET/CT from January 2015 to January 2023 was done. Those with abnormal pituitary uptake (standardized uptake value [SUV] > 2.5) were included in the study. SUV value along with relevant anatomical details, biochemical parameters, histopathological details, and follow-up imaging were analyzed. <b>Results</b>  Among 15,085 studies, a total of 36 patients (21 males/15 females, average age 47.36 years, range: 17-75 years) with pituitary uptake (0.23%) were included. Out of 36 patients, causes are primary pituitary tumor (21/36, 58%), tubercular hypophysitis (3/36, 8%), lymphocytic hypophysitis (2/36, 6%), lymphomatous involvement (2/36, 6%), autoimmune hypophysitis (1/36, 3%), questionable significance/incidental (4/36, 11%), and metastasis (3/36, 8%)-one each from neuroendocrine tumor ileum, chondrosarcoma, and adenocarcinoma lung. There was no difference in the SUV range between the different etiologies. Among 21 patients with pituitary tumor, biochemical evaluation was done in 19 patients. Two patients were lost to follow-up and did not have biochemical evaluation. Among them, 8 underwent endoscopic transsphenoidal radical excision and 1 patient had PET-CT-guided stereotactic radiosurgery alone. In another 8 patients who had prior endoscopic transsphenoidal radical excision, uptake was noted as residual lesion on PET-CT. Of them, 3 underwent subtotal excision and 5 had PET-CT-guided stereotactic radiosurgery. Biopsy was done in 14 patients, of which 11 were macroadenoma and 3 were microadenoma. Overall, magnetic resonance imaging (MRI) brain was performed in 22 of them and the findings were concordant with F18-FDG PET/CT. <b>Conclusion</b>  F18-FDG PET/CT is a useful modality in the evaluation of pituitary uptake. It has an incremental value along with MRI brain and biochemical parameters and is useful for follow-up. Due to its high diagnostic accuracy, it is particularly useful in those with suspected residual/recurrent adenomas.</p>","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":"23 4","pages":"234-241"},"PeriodicalIF":0.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Marrow: Unveiling Uncommon Sites of ALL Relapse with ¹⁸ F-FDG PET/CT.","authors":"Siven Kar, Harshita Gupta, Nusrat Shaikh, Vikram Lele","doi":"10.1055/s-0044-1787894","DOIUrl":"10.1055/s-0044-1787894","url":null,"abstract":"<p><p>Extramedullary infiltration of acute lymphoblastic leukemia/lymphoma (ALL) to genital organs is extremely rare. Here, we present a case report of an asymptomatic 49-year-old female, known case of precursor B-cell ALL, who was incidentally detected with thickened and heterogeneously hyperechoic endometrium on sonography. Contrast magnetic resonance imaging detected large polypoidal enhancing lesions showing intense diffusion restriction occupying the endometrial cavity and similar lesions in the left adnexa, left ovary, and fallopian tube which were suspicious for leukemic infiltration because of the clinical history and atypical appearance of the lesions. ¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography ( ¹⁸ F-FDG PET/CT) was done which revealed intensely metabolically active lesion in the endometrial cavity, left adnexa, omental nodules, retroperitoneal lymph node, pancreatic lesion, and few irregular nodules in the right lower lobe. Biopsy findings confirmed extramedullary relapse of ALL. Hence, ¹⁸ F-FDG PET/CT can act as a good whole body survey to look for extramedullary sites of relapse.</p>","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":"23 4","pages":"282-284"},"PeriodicalIF":0.6,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Activation Protein Inhibitor Theranostics: A Huge Opportunity with its Fair Share of Oncological Pitfalls.","authors":"Akram Al-Ibraheem","doi":"10.1055/s-0044-1787886","DOIUrl":"10.1055/s-0044-1787886","url":null,"abstract":"","PeriodicalId":23742,"journal":{"name":"World Journal of Nuclear Medicine","volume":"23 2","pages":"71-72"},"PeriodicalIF":0.6,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}