World Journal of Plastic Surgery最新文献

A Giant Osteochondroma of Mandibular Coronoid that Mimicking Coronoid Hyperplasia: A Rare Clinical Case Report. 下颌冠状巨骨软骨瘤表现为冠状增生1例罕见临床报告。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.105

Moosa Mahmoudi, Kianoosh Mobasseri, Sara Samiei, Ali Labafchi

{"title":"A Giant Osteochondroma of Mandibular Coronoid that Mimicking Coronoid Hyperplasia: A Rare Clinical Case Report.","authors":"Moosa Mahmoudi, Kianoosh Mobasseri, Sara Samiei, Ali Labafchi","doi":"10.61186/wjps.14.1.105","DOIUrl":"10.61186/wjps.14.1.105","url":null,"abstract":"Osteochondroma, the most common benign tumor in the axial and appendicular skeleton, presents a unique challenge when encountered in the craniofacial region. We report a rare case of a 35-year-old female with a massive osteochondroma located on the mandibular coronoid process, resulting in a 20-year history of progressive mouth opening limitation, facial asymmetry, and zygomatic deformity. Comprehensive diagnostic procedures, including panoramic radiography and computed tomography (CT) imaging, were employed to accurately assess the extent of the lesion. This case highlights the importance of CT scans and three-dimensional reconstructions in confirming the diagnosis, particularly when panoramic radiographs exhibit limitations. The patient underwent a successful extraoral approach for coronoidectomy and excision of the osteochondroma, addressing both the functional and cosmetic aspects of the condition. Postoperative evaluations revealed significant improvement in mouth opening capacity, with no signs of recurrence during a 12-month follow-up period.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"105-111"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden Risks Unearthed: A Case of von Willebrand Disease Overlooked by Automated Preoperative Screening. 发现的隐患：1例血管性血友病被自动术前筛查忽视。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.85

Ana Cristina Seabra Robalo Gomes Jorge, Adelana Santos Stahl, Adrien Daigeler, Stéphane Stahl

引用次数: 0

The Effect of Zataria multiflora Nanoemulsion Gel on Rat Surgical Wound Healing. 何首乌纳米乳凝胶对大鼠手术伤口愈合的影响。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.33

Alireza Ganjipour, Ebrahim Nasiri-Formi, Soheil Azizi, Jafar Akbari, Hooshang Akbari, Seyyed Mohammad Hassan Hashemi

{"title":"The Effect of Zataria multiflora Nanoemulsion Gel on Rat Surgical Wound Healing.","authors":"Alireza Ganjipour, Ebrahim Nasiri-Formi, Soheil Azizi, Jafar Akbari, Hooshang Akbari, Seyyed Mohammad Hassan Hashemi","doi":"10.61186/wjps.14.1.33","DOIUrl":"10.61186/wjps.14.1.33","url":null,"abstract":"Background: We aimed to determine the effect of Zataria multiflora Nanoemulsion gel on surgical wound healing.Methods: This experimental study was conducted in the years 2021-2022 at the Animal Research Center of Mazandaran University of Medical Sciences, northern Iran. Forty two male Westar rats were randomly divided into six groups (n=7). After a surgical incision of full thickness with a 3 cm diameter, they were treated for 21 days with diltiazem 2% (positive control), placebo, and Z. multiflora emulsions and nanoemulsions at 2% and 4%, respectively. Macroscopic parameters of wound area and contraction, as well as pathological factors such as granulation, angiogenesis, epithelialization, collagen organization, bacterial colony, inflammation, creatine and epidermal thickness, hair follicles, and lymphatic ducts, were examined.Results: The mean wound size and contraction of the placebo group differed significantly from the other groups on all days, and on some days, the results indicated more favorable effects of nanoemulsions than Diltiazem. Based on the microscopic findings, the average scores on the seventh day were nearly different (P= 0.051); however, all groups scored higher than the placebo group. On the 21st day, the best results were related to the 4% Nanoemulsion (242.5), 2% Nanoemulsion (159.4), and 4% emulsion (159.3), followed by diltiazem (154.60), 2% emulsion (146.5), and placebo (70.7).Conclusion: Z. multiflora emulsions and nanoemulsions at 2% and 4% could be effective in healing surgical wounds, and the use of 4% Nanoemulsion yields the best results. This is recommended for use in clinical trial studies.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"33-42"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the Effect of 0.75% Ropivacaine and 2% Lidocaine on Intraoperative Bleeding and Postoperative Pain of Third Molar Surgery: A Double Blinded, Split Mouth Study. 比较0.75%罗哌卡因和2%利多卡因对第三磨牙手术术中出血和术后疼痛的影响：双盲、裂口研究。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.10

Sahand Samieirad, Elmira Pourafshar, Farid Shiezadeh, Majid Hosseini Abrishami

{"title":"Comparing the Effect of 0.75% Ropivacaine and 2% Lidocaine on Intraoperative Bleeding and Postoperative Pain of Third Molar Surgery: A Double Blinded, Split Mouth Study.","authors":"Sahand Samieirad, Elmira Pourafshar, Farid Shiezadeh, Majid Hosseini Abrishami","doi":"10.61186/wjps.14.1.10","DOIUrl":"10.61186/wjps.14.1.10","url":null,"abstract":"Background: We aimed to compare the effect of 0.75% ropivacaine and 2% lidocaine with 1:100,000 epinephrine on intraoperative bleeding and postoperative pain following mandibular third molar surgery.Methods: In this split-mouth clinical trial, 60 patients required bilateral impacted third molar of the mandible were prepared for operation in the Department of Maxillofacial Surgery of Mashhad Dental Faculty, Mashhad, Iran. Surgery was performed randomly on one side using ropivacaine and on the other side with lidocaine with epinephrine. The intraoperative bleeding, the postoperative pain (at 3, 6, 12, 18, and 24 hours after the operation), and the difficulty of the surgery were measured in each group and compared.Results: In all postoperative time intervals, the pain was lower in the ropivacaine group than in the lidocaine group. The rate of intraoperative bleeding in the ropivacaine group was lower than in the lidocaine group. In the lidocaine group, pain initially increased and reached its maximum value after three hours, but decreased after the sixth hour and reached its minimum value 24 hours after surgery. In the ropivacaine group, the pain increased initially and was at its peak at 3 and 6 hours, after which it decreased and reached its lowest value at 24 hours.Conclusion: Postoperative pain was less in the 0.75% ropivacaine group than in the 2% lidocaine with 1:100,000 epinephrine group during all postoperative periods. Also, the amount of bleeding during the operation was less in the ropivacaine group.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"10-16"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Feasibility of Clinical Studies on Cleft Lip and Palate Patients Based on the Hospital Records. 基于医院记录评价唇腭裂患者临床研究的可行性。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.28

Reza Vaghardoost, Noor Ahmad Latifi, Abolfazl Abbaszadeh, Shahram Roustaei, Mahdiye Tavakoli

{"title":"Evaluating the Feasibility of Clinical Studies on Cleft Lip and Palate Patients Based on the Hospital Records.","authors":"Reza Vaghardoost, Noor Ahmad Latifi, Abolfazl Abbaszadeh, Shahram Roustaei, Mahdiye Tavakoli","doi":"10.61186/wjps.14.1.28","DOIUrl":"10.61186/wjps.14.1.28","url":null,"abstract":"Background: Policy makers, researchers and health care professionals are faced daily with the challenge of how to prioritize their activities and actions in different areas of their responsibilities. In the field of health, their decisions are often influenced by the reality of population needs on the one hand and limited resources on the other. The correctness of decisions is completely dependent on the quality and accuracy of information from the target population. Patient registries, have for decades been an important source of data needed to evaluate clinical practice, evaluate health service delivery, and assess policy implications at the local, regional, national, and international levels.Method: Based on the research objectives, fourteen registration forms consisting of 790 variables were designed. The data of cleft lip and palate patients who underwent surgery in Hazrat Fatemeh Hospital during the year 2022, in Tehran, Iran, were collected and entered into the registration system, and then the amount of recorded data was assessed based on the research objectives.Results: Only 28% of the data of cleft lip and palate patients were recorded in the clinical files during their hospital stay, and 72% of the required data are not recorded. However, the accuracy of the recorded data and their validity has not been evaluated.Conclusion: In order to obtain the necessary data for the designed objectives, the data recorded in the hospital are not sufficient and accurate, and a registry is needed to record accurately the data of cleft lip and palate patients.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"28-32"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Challenges of Extensive Face and Neck Necrotising Fasciitis Reconstruction: A Case Report. 广泛面部及颈部坏死性筋膜炎重建的挑战：1例报告。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.93

Hui Yuan Lam, Hamidah Binti Mohd Zainal, Khai Luen Koh, Mohammad Ali Bin Mat Zain

{"title":"The Challenges of Extensive Face and Neck Necrotising Fasciitis Reconstruction: A Case Report.","authors":"Hui Yuan Lam, Hamidah Binti Mohd Zainal, Khai Luen Koh, Mohammad Ali Bin Mat Zain","doi":"10.61186/wjps.14.1.93","DOIUrl":"10.61186/wjps.14.1.93","url":null,"abstract":"Necrotising fasciitis (NF) is a rare, severe, rapidly progressive, and life-threatening synergistic infection that primarily affects the superficial fascia. Although unusual in head and neck surgeries, necrotizing fasciitis may have drastic consequences. Dental problems, burns, trauma, and peritonsillar abscesses often cause the condition. We describe a rare case of extensive facial necrotising fasciitis secondary to carbimazole-induced agranulocytosis. A protective tracheostomy, prophylactic thyroidectomy, serial surgical debridement, and broad-spectrum antibiotics therapy were initiated. Our team referred the patient for subsequent soft tissue reconstruction. Reconstruction was challenging as it involved a full-thickness cheek defect extending to the oral commissure, lower lip, and anterior neck. In a single-stage procedure, we utilised a transverse upper gracilis free flap to reconstruct full-thickness tissue loss, provide tissue bulk, and seal the dead space. Reconstructing various parts of the face and lips while ensuring aesthetic and functional results can be difficult..","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"93-97"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Therapeutic Outcomes of Trapezius Muscle Transfer in Brachial Plexus Injury Patients: A Case Analysis at 15 Khordad Hospital, Tehran. 斜方肌转移治疗臂丛损伤的疗效：德黑兰15 Khordad医院一例分析。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.97

Soraya Shahrokh Shahraki, Farnood Gharghabi, Masoud Yavari

{"title":"The Therapeutic Outcomes of Trapezius Muscle Transfer in Brachial Plexus Injury Patients: A Case Analysis at 15 Khordad Hospital, Tehran.","authors":"Soraya Shahrokh Shahraki, Farnood Gharghabi, Masoud Yavari","doi":"10.61186/wjps.14.1.97","DOIUrl":"10.61186/wjps.14.1.97","url":null,"abstract":"Background: We investigated the therapeutic outcomes of trapezius muscle transfer in individuals diagnosed with brachial plexus damage.Methods: We examined patients diagnosed with brachial plexus palsy referred to 15 Khordad Hospital in Tehran, Iran during 2018-20. The patients considered for inclusion in the study were those who were eligible for trapezius muscle transfer surgery, either on the affected side or the unaffected side. The evaluation focused on various aspects, including shoulder range of motion, muscle strength, shoulder pain, age and gender distribution, as well as satisfaction and function levels of the shoulder.Results: The suitability of shoulder motions, shoulder abduction, and muscular strength in patients who underwent ipsilateral side trapezius muscle transfer surgery was greater compared to those who underwent contralateral side trapezius transfer. In the investigation of postoperative shoulder function among patients who underwent trapezius muscle transfer surgery on the ipsilateral side, it was shown that 3 patients (25%) exhibited favorable function, while 6 patients (50%) demonstrated acceptable function, and 3 patients (25%) displayed excellent function. Out of the total sample size of 9 patients who underwent surgery for trapezius muscle transfer on the contralateral side, 6 patients (66.7%) exhibited favorable function, while 3 patients (33.3%) demonstrated acceptable function.Conclusion: Employing the contralateral trapezius muscle as a substitute when utilizing the ipsilateral trapezius muscle is not feasible is a viable alternative with favorable function.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"97-104"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Lipoabdominoplasty with the Application of Intra-Abdominal Pressure and Respiratory Airway Pressure in Women: A Multicenter Prospective Study. 一项多中心前瞻性研究：应用腹内压力和呼吸气道压力对女性腹部脂肪成形术的影响。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.52

Khalil Rostami, Amirhossein Karimi, Soraya Shahrokh

{"title":"The Effects of Lipoabdominoplasty with the Application of Intra-Abdominal Pressure and Respiratory Airway Pressure in Women: A Multicenter Prospective Study.","authors":"Khalil Rostami, Amirhossein Karimi, Soraya Shahrokh","doi":"10.61186/wjps.14.1.52","DOIUrl":"10.61186/wjps.14.1.52","url":null,"abstract":"Background: Abdominoplasty surgery is associated with intra-abdominal pressure (IAP) and respiratory airway pressure (RAP) changes. We aimed to assess the impact of the lipoabdominoplasty on the simultaneous changes in the IAP and RAP and their predictive factors for the first time.Methods: This prospective study was conducted on 30 women who underwent lipoabdominoplasty between November 2021 and November 2022 in Modares and 15- Khordad hospitals affiliated with Shahid Beheshti University of Medical Sciences, Tehran, Iran. Patients underwent lipoabdominoplasty by a surgeon with more than ten years of experience. RAP was measured based on P platue and P Peak three times (after anesthesia, after plication, and after surgery).Results: The mean changes of IAP and RAP were significantly different based on the p peak and p plateau after anesthesia, plication, and surgery (P<0.001). Changes in IAP with BMI, degree of laxity, degree of plication, number of pregnancies, xiphoid to pubis distance, and 12th vertebra to ASIS distance were related. RAP (p peak and P platue) with a degree of laxity, degree of plication, number of pregnancies, IAP, xiphoid to pubis distance, and 12th vertebra to ASIS distance were related (P<0.05).Conclusion: lipoabdominoplasty significantly affects changes in IAP and RAP after anesthesia, plication, and surgery. During lipoabdominoplasty, surgeons should simultaneously pay attention to the changes in both IAP and RAP from the beginning to the end of the surgery, especially in obese women with a history of multiple pregnancies and patients with severe laxity.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"52-58"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tendon Wrapping with Amniotic Membrane on Zone 6 Extensor Tendon Repair Outcomes. 羊膜包裹肌腱对6区伸肌腱修复效果的影响。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.72

Seyed Esmail Hassanpour, Masoud Yavari, Seyed Mehdi Moosavizadeh, Khalil Rostami, Hojjat Layegh

{"title":"Effect of Tendon Wrapping with Amniotic Membrane on Zone 6 Extensor Tendon Repair Outcomes.","authors":"Seyed Esmail Hassanpour, Masoud Yavari, Seyed Mehdi Moosavizadeh, Khalil Rostami, Hojjat Layegh","doi":"10.61186/wjps.14.1.72","DOIUrl":"10.61186/wjps.14.1.72","url":null,"abstract":"Background: Extensor tendon repair is prone to adhesion that affects the outcomes of tendon repair surgery and tendon function regain. Prevention of these complications should be considered in tendon rupture treatment. We aimed to evaluate the effect of tendon wrapping with amniotic membrane on the outcomes of extensor tendon repair in zone 6.Methods: This randomized controlled clinical trial was conducted on 30 patients with an extensor tendon injury in zone 6 following penetrating trauma to extensor digitorum communis of the third and fourth digits referred to 15 Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran . Patients were randomly assigned into two matched groups based on age and gender. Both groups underwent tendon repair using the modified Kessler method. In the intervention group (n=15), the repair site was wrapped with an amniotic membrane, while the control group underwent the traditional procedure without wrapping. Both groups underwent a similar rehabilitation process. Patients were followed up for 6 months. The QuickDash score, range of motion (ROM), complications, and recovery duration were recorded for patients in both groups.Results: The patients in the intervention group had a lower QuickDash score (P<0.001), ROM (P<0.001), and shorter recovery duration (P<0.001) compared to the control group. The only complication was a wound infection that was seen in one patient in the control group. There was no evidence of tendon re-rupture and amniotic membrane hypersensitivity among patients.Conclusion: Amniotic, wrapping is an effective method in extensor tendon repair and is associated with better outcomes and faster recovery, suggesting less peritendinous fibrosis.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"72-78"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Efficiency of Microneedling with PRP Versus Microneedling with Tranexamic Acid in the Treatment of Melisma. PRP微针与氨甲环酸微针治疗Melisma疗效比较。

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World Journal of Plastic Surgery Pub Date : 2025-01-01 DOI: 10.61186/wjps.14.1.79

Nader Pazyar, Havva Hajati, Reza Yaghoobi, Nima Bakhtiari

{"title":"Evaluation of the Efficiency of Microneedling with PRP Versus Microneedling with Tranexamic Acid in the Treatment of Melisma.","authors":"Nader Pazyar, Havva Hajati, Reza Yaghoobi, Nima Bakhtiari","doi":"10.61186/wjps.14.1.79","DOIUrl":"10.61186/wjps.14.1.79","url":null,"abstract":"Background: Melasma, characterized by irregular skin hyperpigmentation, presents a therapeutic challenge with limited universal solutions. Platelet-rich plasma (PRP) and Tranexamic Acid (TXA), coupled with microneedling, offer promising avenues for treatment. This clinical trial sought to compare the efficacy and adverse effects of microneedling with PRP versus TXA in managing melasma.Methods: The study was a single-blind, randomized controlled trial from May 2022 to Apr 2023 and enrolled 23 female melasma patients. Using the coin toss method, patients were randomly assigned to receive microneedling with PRP on one side and microneedling with TXA on the other. Evaluation parameters included Melasma Area and Severity Index (MASI) scores, melasma improvement grading, patient satisfaction, and treatment-related side effects, monitored over three sessions at 3-week intervals.Results: Both microneedling approaches demonstrated effectiveness, with the PRP group exhibiting significantly lower MASI scores at the 6th and 9th wk. However, no significant distinctions were observed in improvement grading or patient satisfaction between the PRP and TXA groups. Side effects were minimal, limited to transient burning and mild pain during the procedure.Conclusion: Microneedling with PRP and TXA emerged as a safe and effective treatment for melasma. While the PRP group showed potential superiority in MASI scores, comprehensive considerations, including patient preferences and long-term outcomes, are crucial. Larger, multi-center studies with extended follow-up periods are warranted for a more nuanced understanding of these treatments in melasma management.","PeriodicalId":23736,"journal":{"name":"World Journal of Plastic Surgery","volume":"14 1","pages":"79-84"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0