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Molecular characterization of recombinant citrus yellow mosaic badnavirus infecting Coorg mandarin exhibiting yellow mosaic disease symptoms in high humid tropic region of Western Ghats. 西高止山高湿热带地区感染库尔格柑橘黄镶嵌病症状的重组柑橘黄镶嵌坏疽病毒的分子特征。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-05-30 DOI: 10.1007/s13337-024-00864-z

V Venkataravanappa, G S Madhu, B M Muralidhara, Shridhar Hiremath, M Krishna Reddy

{"title":"Molecular characterization of recombinant citrus yellow mosaic badnavirus infecting Coorg mandarin exhibiting yellow mosaic disease symptoms in high humid tropic region of Western Ghats.","authors":"V Venkataravanappa, G S Madhu, B M Muralidhara, Shridhar Hiremath, M Krishna Reddy","doi":"10.1007/s13337-024-00864-z","DOIUrl":"10.1007/s13337-024-00864-z","url":null,"abstract":"The citrus yellow mosaic badnavirus (CMBV) is one of the most important viruses causing yellowing and declining in different Citrus species. The Coorg mandarin, pomelo and grapefruit showing the yellow mosaic disease symptoms were collected from different famers field during the survey. Further viral pathogenicity was confirmed through grafting on Rangpur lime as root stock. To confirm the identity of the pathogen, total genomic DNA was extracted from Coorg mandarin, Pomelo and grapefruit were subjected to PCR amplification using ORF III specific primers. Further the complete genome of CMBV amplified using different sets of specific primers were cloned and sequenced. The sequence analysis showed that CMBV from the Coorg mandarin showed maximum nt identity of 94.5% with CMBV-AL infecting acid lime. Recombination and GC plot analysis showed that the recombination occurred at in low GC content regions of genome of the CMBV and are derived from the previously reported Badnaviruses infecting different Citrus species.Supplementary information: The online version contains supplementary material available at 10.1007/s13337-024-00864-z.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 2","pages":"310-320"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics of dengue viremia and its association with disease severity: an ambispective study. 登革热病毒血症的动力学及其与疾病严重程度的关系：一项前瞻性研究。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-06-29 DOI: 10.1007/s13337-024-00872-z

Puneet Bhatt, Anup Jayaram, Muralidhar Varma, Chiranjay Mukhopadhyay

{"title":"Kinetics of dengue viremia and its association with disease severity: an ambispective study.","authors":"Puneet Bhatt, Anup Jayaram, Muralidhar Varma, Chiranjay Mukhopadhyay","doi":"10.1007/s13337-024-00872-z","DOIUrl":"10.1007/s13337-024-00872-z","url":null,"abstract":"Background: Dengue virus (DENV) infection is an important public health problem and causes significant morbidity and mortality. DENV typically causes a febrile illness that ranges from mild asymptomatic infection to fatal dengue hemorrhagic fever (DHF) and/or dengue shock syndrome (DSS). Early prediction of severe dengue disease is of utmost importance for providing prompt monitoring and treatment. The search for an ideal biomarker (host or viral factors) for early prediction of severe dengue remains elusive.Aim: To standardize a real time qRT-PCR for quantifying dengue viremia in serum samples and evaluate the kinetics of dengue viremia and its significance in disease severity.Results: In this ambispective study of 126 laboratory confirmed dengue patients, 72 were primary infections and 54 were secondary infections. The most common serotype was serotype 1 (n = 37) followed by serotype 2 (n = 34). According to WHO 1997 dengue case classification, 111 patients were cases of dengue fever (DF), 13 from DHF and 02 from DSS. Day 3 viremia levels were significantly elevated in severe dengue patients (DHF/DSS) as compared to that of DF (p < 0.05). However, no such association was found between viremia levels and serotype or immune status.Conclusion: Dengue viremia has a significant association with disease severity and day 3 viremia levels may be used as a predictor for dengue disease severity.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 2","pages":"250-259"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccine approaches and treatment aspects against Crimean Congo hemorrhagic fever. 预防克里米亚刚果出血热的疫苗方法和治疗方法。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-05-28 DOI: 10.1007/s13337-024-00868-9

Soroush Sarmadi, Arash Ghalyanchilangeroudi, Hamideh Najafi

引用次数: 0

Molecular detection of human papillomavirus prevalence in clinically normal females and identification of high-risk HPV 16 and 18 under low resources setting: a cohort study from Sri Lanka. 低资源环境下临床正常女性人乳头瘤病毒流行率的分子检测及高危 HPV 16 和 18 的识别：斯里兰卡的一项队列研究。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-06-18 DOI: 10.1007/s13337-024-00875-w

Subhashini Muhandiram, Thusitha K Karunarathna, Eranga H Siriweera, Chathura J Ratnayake, Suranga P Kodithuwakku

{"title":"Molecular detection of human papillomavirus prevalence in clinically normal females and identification of high-risk HPV 16 and 18 under low resources setting: a cohort study from Sri Lanka.","authors":"Subhashini Muhandiram, Thusitha K Karunarathna, Eranga H Siriweera, Chathura J Ratnayake, Suranga P Kodithuwakku","doi":"10.1007/s13337-024-00875-w","DOIUrl":"10.1007/s13337-024-00875-w","url":null,"abstract":"High oncogenic risk types of human papillomaviruses are mainly transmitted via sexual contact and are the main cause of cervical cancer in females in developing countries. Molecular detection of HPV infection enables early cancer detection; however, it is not widely used in low-income countries due to resource constraints. The aim of this study was to assess economical yet sensitive HPV detection and genotyping assays for both physician and self-collected cervical samples in a resource limited diagnostic setting. A previously reported polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) based HPV detection and genotyping protocol was verified using direct DNA sequencing to accurately identify the HPV 16 and 18 genotypes in a routine-diagnostic set-up. Then the HPV prevalence in a cohort of 433 clinically normal females was performed using PCR-RFLP diagnostic tool. Finally, the performance of the PCR-RFLP HPV screening tool was further evaluated against self-collected samples. HPV 16 and 18 genotyping with the PCR-RFLP consistently agreed with the sequencing data. The HPV prevalence in the screening cohort was 5.8%. HPV 16 and 18 were the most common high-risk HPV genotypes detected in the study cohort. Self-sampling vs physician collected samples from the same subject resulted in an overall concordance of 93% for HPV detection. The PCR-RFLP protocol can be used effectively under low resource settings for HPV 16/18 diagnosis and genotyping. The self-sampling approach can be recommended to increase HPV screening among women in Sri Lanka.Supplementary information: The online version contains supplementary material available at 10.1007/s13337-024-00875-w.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 2","pages":"271-280"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the interaction between Influenza virus and the nuclear pore complex: insights into viral replication and host immune response. 揭示流感病毒与核孔复合体之间的相互作用：洞察病毒复制和宿主免疫反应。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-07-18 DOI: 10.1007/s13337-024-00879-6

Madhu Khanna, Kajal Sharma, Shailendra K Saxena, Jai Gopal Sharma, Roopali Rajput, Binod Kumar

{"title":"Unravelling the interaction between Influenza virus and the nuclear pore complex: insights into viral replication and host immune response.","authors":"Madhu Khanna, Kajal Sharma, Shailendra K Saxena, Jai Gopal Sharma, Roopali Rajput, Binod Kumar","doi":"10.1007/s13337-024-00879-6","DOIUrl":"10.1007/s13337-024-00879-6","url":null,"abstract":"Influenza viruses are known to cause severe respiratory infections in humans, often associated with significant morbidity and mortality rates. Virus replication relies on various host factors and pathways, which also determine the virus's infectious potential. Nonetheless, achieving a comprehensive understanding of how the virus interacts with host cellular components is essential for developing effective therapeutic strategies. One of the key components among host factors, the nuclear pore complex (NPC), profoundly affects both the Influenza virus life cycle and the host's antiviral defenses. Serving as the sole gateway connecting the cytoplasm and nucleoplasm, the NPC plays a vital role as a mediator in nucleocytoplasmic trafficking. Upon infection, the virus hijacks and alters the nuclear pore complex and the nuclear receptors. This enables the virus to infiltrate the nucleus and promotes the movement of viral components between the nucleus and cytoplasm. While the nucleus and cytoplasm play pivotal roles in cellular functions, the nuclear pore complex serves as a crucial component in the host's innate immune system, acting as a defense mechanism against virus infection. This review provides a comprehensive overview of the intricate relationship between the Influenza virus and the nuclear pore complex. Furthermore, we emphasize their mutual influence on viral replication and the host's immune responses.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 2","pages":"231-242"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection. 大麻素对病毒感染的免疫调节作用：综述其在 SARS-CoV2 感染中的潜在用途。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-05-27 DOI: 10.1007/s13337-024-00871-0

Mohammad Hassan Kalantar Neyestanaki, Omid Gholizadeh, Fatemeh Hosseini Tabatabaie, Sama Akbarzadeh, Saman Yasamineh, Hamed Afkhami, Somayeh Sedighi

{"title":"Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection.","authors":"Mohammad Hassan Kalantar Neyestanaki, Omid Gholizadeh, Fatemeh Hosseini Tabatabaie, Sama Akbarzadeh, Saman Yasamineh, Hamed Afkhami, Somayeh Sedighi","doi":"10.1007/s13337-024-00871-0","DOIUrl":"10.1007/s13337-024-00871-0","url":null,"abstract":"The COVID-19 pandemic is a global health crisis affecting millions of people worldwide. Along with vaccine development, there is also a priority to discover new drugs and treatments. One approach involves modulating the immune system to manage inflammation and cytokine storms. Patients with a high severity of complications exhibit a high level of inflammatory cytokines, particularly IL-6, in the airways and other infected tissues. Several studies have reported the function of the endocannabinoid system in regulating inflammation and different immune responses. Cannabinoids are a class of natural chemicals found in the Cannabis plant. Recently, the anti-inflammatory properties of cannabinoids and their mediatory immunosuppression mechanisms through the endocannabinoid system have engrossed scientists in the health field for infectious conditions. Research suggests that the immune system can regulate cytokine activation through cannabinoid receptors, particularly with Cannabidiol (CBD), the second most prevalent compound in cannabis. While CBD has been deemed safe by the World Health Organization and shows no signs of abuse potential, excessive CBD use may lead to respiratory depression. CBD shows promise in reducing immune cell recruitment and cytokine storms in organs affected by SARS-CoV2. However, before clinical use, it's crucial to evaluate cannabinoid-based medications' active ingredient concentrations and potential interactions with other drugs, along with associated side effects. Indication-based dosing, consistent formulations, and ensuring purity and potency are essential. This review highlights cannabinoids' effects on COVID-19 management and prognosis, drawing from preclinical and clinical studies.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"35 2","pages":"342-356"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein. p38-MAPK 是合成 SARS-CoV-2 蛋白的先决条件。

VirusDisease Pub Date : 2024-06-01 Epub Date: 2024-05-27 DOI: 10.1007/s13337-024-00873-y

Priyasi Mittal, Nitin Khandelwal, Yogesh Chander, Assim Verma, Ram Kumar, Chayanika Putatunda, Sanjay Barua, Baldev Raj Gulati, Naveen Kumar

引用次数: 0

Abstracts of the papers presented in the international conference of Indian Virological Society, VIROCON 2023 on “Advancements in global virus research towards one health” held during 01–03 December, 2023 at ICAR-National Research Centre for Banana, Tiruchirappalli, Tamil Nadu, India 2023 年 12 月 1 日至 3 日在印度泰米尔纳德邦蒂鲁奇拉帕利 ICAR 国家香蕉研究中心举行的印度病毒学协会国际会议 VIROCON 2023 "全球病毒研究进展，实现共同健康 "论文摘要

VirusDisease Pub Date : 2024-05-20 DOI: 10.1007/s13337-024-00867-w

引用次数: 0

Prevalence and risk factor for H9N2 avian influenza virus in poultry retail shops of Madhya Pradesh 中央邦家禽零售店的 H9N2 禽流感病毒流行率和风险因素

VirusDisease Pub Date : 2024-05-16 DOI: 10.1007/s13337-024-00865-y

Baleshwari Dixit, H. Murugkar, S. Nagarajan, C. Tosh, Manoj Kumar, Anubha Pathak, Sivasankar Panickan, Neeraj Shrivastav, Anjani K. Mishra, Manu Dixit

引用次数: 0

Epidemiological and clinical profile of HTLV-1 patients: a closer look at a reference center in Bahia, Brazil HTLV-1 患者的流行病学和临床概况：巴西巴伊亚州参考中心的近距离观察

VirusDisease Pub Date : 2024-05-13 DOI: 10.1007/s13337-024-00862-1

J. Nascimento, Daniele Leite Alves, Ana Flávia Novaes, Qesya Rodrigues Ferreira, Felipe de Oliveira Andrade, Roberta Muniz Luz Silva, Saadia Oliveira Ribeiro, Riviane Santana Souza, Luciane Amorim Santos, T. Araújo, Guilherme Barreto Campos, Filipe Ferreira de Almeida Rego, Davi Tanajura Costa, F. K. Barreto

引用次数: 0