VirusDisease最新文献_第5页

Optimizing surveillance: feasibility of pooled sample testing for bovine alphaherpesvirus 1 detection by real-time PCR. 优化监测：实时聚合酶链反应检测牛甲疱疹病毒1型的合并样本检测的可行性。

IF 1.3

VirusDisease Pub Date : 2025-09-01 Epub Date: 2025-08-06 DOI: 10.1007/s13337-025-00934-w

Mallarap Sandhyarani, Rachamreddy Venkata Chandrasekhar Reddy, Nadikerianda Muthappa Ponnanna, Laxmi Narayan Sarangi

{"title":"Optimizing surveillance: feasibility of pooled sample testing for bovine alphaherpesvirus 1 detection by real-time PCR.","authors":"Mallarap Sandhyarani, Rachamreddy Venkata Chandrasekhar Reddy, Nadikerianda Muthappa Ponnanna, Laxmi Narayan Sarangi","doi":"10.1007/s13337-025-00934-w","DOIUrl":"10.1007/s13337-025-00934-w","url":null,"abstract":"The present study aimed to evaluate the feasibility and cost-effectiveness of pooled sample testing (PST) for the detection of bovine alphaherpesvirus 1 (BoAHV-1) in swab samples collected from animals. A pool of five samples were used and two modifications in the procedure were introduced to increase the sensitivity of the approach. The initial volume of the sample used for DNA extraction was increased from 200 µL to 500 µL and 10 µL of extracted DNA instead of 5 µL in the real-time PCR reaction set-up. In an initial spiking experiment with the BoAHV-1 virus, the modified PST approach resulted in a 1.1 Ct value lower than the conventional individual sample approach, supporting the efficacy of the pool size chosen. Subsequently, screening of 215 pools created from 1073 swab samples, revealed 29 pools (13.5%) positive for BoAHV-1. Further examination of the 145 individual samples contributing to these 29 positive pools revealed at least one positive sample in 22 pools, while 7 pools did not contain any positive samples. The overall percentage positivity of BoAHV-1 shedding detected through pooled sample testing was 2.86% (95% CI: 1.92%-4.08%), closely resembling the result from individual sample testing at 2.80% (95% CI: 1.97-3.96%). This similarity supports the potential use of the pooled sample testing (PST) approach in surveillance studies. In conclusion, the findings of this study demonstrate the feasibility of adopting PST for the detection and confirmation of BoHV-1 infection in animals using a real-time PCR assay.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 3","pages":"518-523"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12634961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological profile and factors associated with the delay in initiation of post exposure prophylaxis of animal bite cases at the tertiary care hospital, New Delhi: a hospital based study. 流行病学概况和与新德里三级保健医院动物咬伤病例接触后预防延迟启动相关的因素：一项基于医院的研究。

IF 1.3

VirusDisease Pub Date : 2025-09-01 Epub Date: 2025-07-09 DOI: 10.1007/s13337-025-00928-8

Ishant Kumar, Debashish Parmar, Sanjeet Panesar, Deepak Dhamnetiya

{"title":"Epidemiological profile and factors associated with the delay in initiation of post exposure prophylaxis of animal bite cases at the tertiary care hospital, New Delhi: a hospital based study.","authors":"Ishant Kumar, Debashish Parmar, Sanjeet Panesar, Deepak Dhamnetiya","doi":"10.1007/s13337-025-00928-8","DOIUrl":"10.1007/s13337-025-00928-8","url":null,"abstract":"Rabies remains a significant public health challenge in India, contributing to 35-40% of global rabies-related deaths, primarily due to delayed Post-Exposure Prophylaxis (PEP) initiation. This hospital-based cross-sectional study at a tertiary care facility in New Delhi aimed to assess the epidemiological profile of animal bite cases and identify determinants of PEP delays. Data were collected from 1,044 participants using a pretested questionnaire, with delays defined as PEP initiation ≥ 24 h post-bite. Results revealed that 69.5% of participants were aged 20-60 years, 78.3% were male, and 88.6% sustained dog bites. Most cases (83.7%) were Category 3 exposures, and 84.3% received PEP within 24 h. Delays occurred in 15.7% of cases, significantly associated with female gender (20.4% vs. 14.2% males, p = 0.022), rural residence (31.6% vs. 12.4% urban, p < 0.001), and semi-skilled occupations (18.5%). Key barriers included lack of awareness (15.5%), distance to healthcare (23.7%), and work constraints (23.9%). Urban residents and homeowners demonstrated faster PEP access (p = 0.002). The study underscores socioeconomic and systemic challenges, such as limited healthcare access and gender disparities, contributing to delays. Findings align with global patterns but highlight India's unique urban-rural divide and occupational influences. Targeted interventions, including community education, improved rural healthcare infrastructure, and subsidized PEP, are critical to reducing delays. Limitations include single-center design and cross-sectional constraints, limiting generalizability. Strengthening policy implementation and awareness campaigns, aligned with WHO's \"Zero by 30\" goals, is essential for rabies elimination.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 3","pages":"377-383"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12635000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive review and early detection strategies for severe fever with thrombocytopenia: insights from epidemiology, diagnostics, and evolving research with machine learning. 重症发热伴血小板减少症的综合审查和早期发现策略：来自流行病学、诊断和机器学习研究的见解

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI: 10.1007/s13337-025-00920-2

Abhishek S Rao, B H Karthik Pai, K Adithi, Rathika Shenoy, Sneha Nayak

{"title":"Comprehensive review and early detection strategies for severe fever with thrombocytopenia: insights from epidemiology, diagnostics, and evolving research with machine learning.","authors":"Abhishek S Rao, B H Karthik Pai, K Adithi, Rathika Shenoy, Sneha Nayak","doi":"10.1007/s13337-025-00920-2","DOIUrl":"10.1007/s13337-025-00920-2","url":null,"abstract":"Severe Fever with Thrombocytopenia Syndrome (SFTS) is a neglected tick-borne viral infection caused by Bandavirus dabieense (formerly known as Huaiyangshan banyangvirus and Dabie bandavirus), with the potential for endemic and pandemic transmission through ticks to humans, animals to humans, and human-to-human routes. Low platelet counts in patients (< 150,000 platelets/mm3) lead to severe complications, with a global case fatality ratio of 20-30%. This review aims to summarize Bandavirus dabieense, focusing on its epidemiology, global prevalence, and the impact of geographical and demographic factors on transmission. We conducted a systematic review and bibliometric analysis using the PRISMA framework and Scopus database. The study explores transmission routes of Bandavirus dabieense, diagnostic methods, treatments, and challenges, with an emphasis on machine learning (ML) for diagnosis and awareness initiatives. The results reveal global Bandavirus dabieense prevalence, transmission modes, diagnostic advancements, vector controls, and early detection hurdles. Bibliometric analysis identifies knowledge gaps and emphasizes the study's relevance. The review underscores the importance of understanding and addressing Bandavirus dabieense, advocating for proactive measures such as ML for diagnosis, recommendations for future work, and effective elimination strategies. Heightened awareness and comprehensive research are vital to mitigate the public health impact and reduce mortality associated with Bandavirus dabieense.Graphical abstract: ","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"241-262"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of in-vitro antiviral potential of Psidium guajava L. Extract against influenza A/(H1N1)pdm09 virus. 番石榴提取物对甲型H1N1流感病毒pdm09的体外抗病毒潜力评价。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1007/s13337-025-00922-0

Sanjit Boora, Sapna Wadhwa, Amit Lath, Anish Khan, Parveen Kumar, Paramjeet Gill, Devender Kumar, Samander Kaushik

{"title":"Evaluation of in-vitro antiviral potential of Psidium guajava L. Extract against influenza A/(H1N1)pdm09 virus.","authors":"Sanjit Boora, Sapna Wadhwa, Amit Lath, Anish Khan, Parveen Kumar, Paramjeet Gill, Devender Kumar, Samander Kaushik","doi":"10.1007/s13337-025-00922-0","DOIUrl":"10.1007/s13337-025-00922-0","url":null,"abstract":"The rise of drug-resistant Influenza strains necessitates the development of new antiviral therapies. This study investigated the antiviral potential of aqueous extracts of Psidium guajava L. against the Influenza A/(H1N1)pdm09 virus. The extracts demonstrated significant antiviral activity and therapeutic efficacy in-vitro, achieving 99.98% virus suppression in co-treatment. FTIR analysis confirmed the presence of bioactive compounds such as phenolics, terpenoids, and alkaloids. Additionally, the extracts exhibited potent antioxidant activity, further enhancing their therapeutic potential. The efficacy of the extracts varied depending on the timing of treatment, with co-treatment yielding the best results, followed by some effectiveness in post-treatment scenario. Cytotoxicity assays confirmed the safety of Psidium guajava extracts on MDCK cells at therapeutic concentrations (CC50 > 100 µg/mL). These findings suggest that Psidium guajava extracts hold promise as potential candidates for the development of anti-influenza medications, particularly due to their multi-target efficacy.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"304-312"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marburg virus outbreak: a global health threat, zoonotic risks, and the urgent need for international action. 马尔堡病毒暴发：全球健康威胁、人畜共患风险以及采取国际行动的迫切需要。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-09-18 DOI: 10.1007/s13337-025-00940-y

Sayak Das, Nagendra Thakur, Arpita S Harnam, Janusz T Paweska, Ahmed S Abdel-Moneim, Shailendra K Saxena

{"title":"Marburg virus outbreak: a global health threat, zoonotic risks, and the urgent need for international action.","authors":"Sayak Das, Nagendra Thakur, Arpita S Harnam, Janusz T Paweska, Ahmed S Abdel-Moneim, Shailendra K Saxena","doi":"10.1007/s13337-025-00940-y","DOIUrl":"10.1007/s13337-025-00940-y","url":null,"abstract":"Bats, the archaic natural reservoir hosting a plethora of viruses, are rather a \"Pandora's Box\" and that has been opened. The recent SARS-CoV-2 pandemic has demonstrated the importance of global data sharing and international cooperation for health research. Recent Marburg virus (MARV) outbreaks have put West Africa on alert, and this calls for immediate attention from all travelers and globetrotters, as the situation is alarming. MARV is an enveloped virus with unsegmented negative-sense RNA as its genome, which belongs to the family of Filoviridae in the order Mononegavirales. MARV is a virus of zoonotic origin that can transmit from its natural reservoir in bats to primarily infect other hosts such as C. aethiops or humans. Marburg virus disease (Marburg/MVD) was first noted on the African continent in Uganda beginning in 1967, and subsequently, hemorrhagic fever outbreaks occurred in Belgrade, Yugoslavia, Marburg, and Frankfurt laboratories in 1968. Several preclinical evaluations for the Marburg virus vaccine, including vesicular stomatitis virus or adenoviral vectors, DNA, virus-like replicons, inactivated viruses, and combinatorial modalities, are under trial. However, due to the absence of a vaccine, it is imperative for policymakers and medical professionals to collaborate on developing effective safety and prevention protocols to curb the spread of the Marburg virus and control the ongoing outbreak. This situation underscores the need for proactive measures, timely responses, and international coordination to prevent further health crises linked to zoonotic viruses.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"233-240"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India. 印度一家三级医院造血干细胞移植（HSCT）后成人呼吸道病毒感染的发生率

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI: 10.1007/s13337-025-00925-x

Jyoti Jethani, Sameer Abdul Samad, Aashish Choudhary, Megha Brijwal, Bennet Angel, Vinod Joshi, Lalit Dar

{"title":"Incidence of respiratory viral infections in adults following hematopoietic stem cell transplant (HSCT) at a tertiary care hospital in India.","authors":"Jyoti Jethani, Sameer Abdul Samad, Aashish Choudhary, Megha Brijwal, Bennet Angel, Vinod Joshi, Lalit Dar","doi":"10.1007/s13337-025-00925-x","DOIUrl":"10.1007/s13337-025-00925-x","url":null,"abstract":"Respiratory viral infections carry a major risk of mortality and morbidity for HSCT recipients. It is important to analyze their seasonality, incidence, disease burden and associated risks. Hundred HSCT recipients were followed up prospectively for acute respiratory infection episodes for 18 months. qRT-PCR was performed for influenza virus (influenza A and B), human metapneumovirus (HMPV), respiratory syncytial virus (RSV), adenovirus, rhinovirus and parainfluenza virus (PIV 1-4). A total 318 respiratory episodes occurred, of which 252 episodes were seen in autologous (n = 78) and 66 episodes in allogeneic HSCT (n = 22). Of the total 158 episodes for which samples could be collected, 61(38.6%) tested positive. A higher infection rate (42.2%) was seen in autologous compared with allogeneic HSCT (25.7%). The most common viruses detected were rhinoviruses (31.1%), followed by PIV (19.6%), hMPV (16.3%), RSV (18%) and influenza viruses (14.7%). There were 5 episodes with the involvement of more than one virus and there were 94 episodes of lower respiratory tract infection (LRTI). The commonest viruses detected in LRTI were rhinovirus (18.6 per 100 patient years), followed by PIV (11), RSV (10), hMPV (8.9) and influenza virus (7.9). The in-hospital case fatality ratio was 30% for hMPV and 11.1% for influenza A/H3N2 virus. Respiratory viral infections are common in HSCT recipients. Higher mortality was seen in allogeneic recipients. Rhinoviruses are an important cause of infections in these groups. Immunizations for vaccine preventable viruses like influenza and RSV which shows high incidence needs to be considered.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"335-342"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of temperature on the replication of striped jack nervous necrosis virus in kidney cell line of rainbow trout (RTK). 温度对虹鳟肾细胞株（RTK）斑纹杰克神经坏死病毒复制的影响。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI: 10.1007/s13337-025-00914-0

Suryakodi Selvam, Nafeez Ahmed Abdul, Mithra Sivaraj, Kanimozhi Kumarasamy, Rajkumar Venkatesan, Taju Gani, Abdul Majeed Seepoo, Sahul Hameed Azeez Sait

{"title":"Effect of temperature on the replication of striped jack nervous necrosis virus in kidney cell line of rainbow trout (RTK).","authors":"Suryakodi Selvam, Nafeez Ahmed Abdul, Mithra Sivaraj, Kanimozhi Kumarasamy, Rajkumar Venkatesan, Taju Gani, Abdul Majeed Seepoo, Sahul Hameed Azeez Sait","doi":"10.1007/s13337-025-00914-0","DOIUrl":"10.1007/s13337-025-00914-0","url":null,"abstract":"In the present study, striped jack nervous necrosis virus (SJNNV) was replicated at different temperatures i.e. 10, 15, 20 and 25°C in kidney cell line of rainbow trout (Oncorhynchus mykiss) to study the virion stability. Cells infected at sub optimal temperature (10 and 15°C) did not cause any significant CPE, but caused typical CPE of multiple vacuoles in the cytoplasm in the cells infected with SJNNV at optimum temperature 20 and 25°C. An expected band in the RT-PCR analysis confirmed the infection, with high viral load of 2.17×108 and 3.08×108 copy number/mL of cDNA was quantified in RTK at 20 and 25°C for SJNNV by qPCR. The TCID50 value of SJNNV in infected RTK cell line gradually increased from low temperatures with maximum value at 25°C in course of infection. The capsid protein of SJNNV at different temperatures in RTK cell line was further confirmed by Western blot and quantified by iELISA. Results revealed that differences were found at different temperatures. The maximum OD value obtained with RTK cells infected was at 20 and 25°C. The results obtained from the present study revealed that the SJNNV possess the ability to cause infections to the fish species culturing in cold water attributes of the Indian aquaculture system, with proper screening and prophylactic measures this infection can be avoided.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"275-284"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variants underlying congenital Zika syndrome and severe microcephaly: a systematic review and meta-analysis. 先天性寨卡综合征和严重小头畸形的遗传变异：系统回顾和荟萃分析。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-06-05 DOI: 10.1007/s13337-025-00924-y

Ali A Rabaan, Abdulsalam Alawfi, Sarah Yahya Alsharif, Aref A Alamri, Mohammed Abdullah Haddad, Ali J Abushaheen, Mohammed Garout, Amer Alshengeti

{"title":"Genetic variants underlying congenital Zika syndrome and severe microcephaly: a systematic review and meta-analysis.","authors":"Ali A Rabaan, Abdulsalam Alawfi, Sarah Yahya Alsharif, Aref A Alamri, Mohammed Abdullah Haddad, Ali J Abushaheen, Mohammed Garout, Amer Alshengeti","doi":"10.1007/s13337-025-00924-y","DOIUrl":"10.1007/s13337-025-00924-y","url":null,"abstract":"Congenital Zika syndrome (CZS) is a condition caused by the infection of the Zika virus (ZIKV) during pregnancy, with severe microcephaly as an additional condition commonly associated with CZS. Although not all embryos or fetuses exposed to ZIKV infection develop CZS, various genetic factors have been linked to the condition, which can cause other neurodevelopmental disorders. In this study, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol was employed to gather a total of 7191 studies from different sources, which were then filtered to 2794 unique studies after the removal of 4397 duplicates. From these studies, 107 met the inclusion criteria and were used to examine the relationship between genetic variants and CZS and severe microcephaly conditions. Subsequently, 32 studies were selected for meta-analysis to determine the statistical significance of the genes associated with microcephaly and CZS. The results of the meta-analysis revealed that microcephaly was significantly associated with genetic variation primarily found in ASPM, WDR62, STIL, and CEP135 genes, while the CDK5RAP2 gene did not demonstrate a statistically significant association with microcephaly. The study concluded that mutations in the assembly factor for the spindle microtubules (ASPM) gene frequently cause microcephaly across different geographical locations. The analysis also identified 39 genes reported in 580 cases, and the meta-analysis of the prime genes showed a direct association with microcephaly.Supplementary information: The online version contains supplementary material available at 10.1007/s13337-025-00924-y.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"313-325"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mumps genotypes circulating in Tamilnadu: A cross-sectional study. 流行性腮腺炎基因型在泰米尔纳德邦流行：一项横断面研究。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-05-21 DOI: 10.1007/s13337-025-00921-1

Jayalakshmi Raghavan, Merlin Sabastin, ArunKumar Manivel, Nivas Chakravarthy, V Krishnalakshmi, Mary Ajitha, Saravana Kumar, Kaveri Krishnasamy, Neetu Vijay, T S Selvavinayagam

{"title":"Mumps genotypes circulating in Tamilnadu: A cross-sectional study.","authors":"Jayalakshmi Raghavan, Merlin Sabastin, ArunKumar Manivel, Nivas Chakravarthy, V Krishnalakshmi, Mary Ajitha, Saravana Kumar, Kaveri Krishnasamy, Neetu Vijay, T S Selvavinayagam","doi":"10.1007/s13337-025-00921-1","DOIUrl":"10.1007/s13337-025-00921-1","url":null,"abstract":"Mumps is an acute viral infection marked by fever and swelling of the parotid glands. While effective live-attenuated vaccines have significantly reduced mumps cases in developed nations, outbreaks persist in developing regions with limited vaccination coverage. The mumps virus, a member of the Paramyxoviridae family, encodes eight proteins, including structural and non-structural ones. This study explores the epidemiology and genetic variation of the mumps virus in Tamil Nadu, India. Clinical specimens from suspected cases were analyzed using serological assays, real-time PCR, and Sanger sequencing, focusing on the SH gene, a critical genomic region for mumps virus genotype differentiation. The sequencing revealed amino acid substitutions in the clinical sample when compared with reference strains. Phylogenetic analysis highlighted the genetic diversity of the virus, indicating variations in the SH gene. These findings enhance understanding of MuV's epidemiology in India and highlight its relevance to global mumps epidemiology, especially in regions with suboptimal vaccine coverage. This research emphasizes the importance of continuous molecular surveillance and genetic analysis to monitor the evolution of MuV, improve vaccination strategies, and address challenges posed by outbreaks in resource-limited settings.","PeriodicalId":23708,"journal":{"name":"VirusDisease","volume":"36 2","pages":"295-303"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a novel Gammapartitivirus associated with endophytic Fusarium oxysporum through transcriptome dataset mining. 通过转录组数据挖掘鉴定与内生尖孢镰刀菌相关的新型γ - artitivirus。

IF 1.3

VirusDisease Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.1007/s13337-025-00918-w

Megha Das, A I Bhat

引用次数: 0