Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献_第5页

Use of niosomes for the treatment of intracellular pathogens infecting the lungs. 利用纳米体治疗感染肺部的细胞内病原体。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 DOI: 10.1002/wnan.1891

Horacio Bach, Ana C Lorenzo-Leal

{"title":"Use of niosomes for the treatment of intracellular pathogens infecting the lungs.","authors":"Horacio Bach, Ana C Lorenzo-Leal","doi":"10.1002/wnan.1891","DOIUrl":"https://doi.org/10.1002/wnan.1891","url":null,"abstract":"The delivery of drugs in an encapsulated environment is designed to precisely target specific tissues, avoiding a systemic circulation of the drug. Lungs are organs exposed to the environment with multiple defense barriers. However, many pathogens can still colonize and infect the airways bypassing the hostile environment of the lungs. In more complicated situations, some pathogens have developed strategies to multiply and survive within macrophages, one of the first immune cell responses to clearing infections in mammals. Niosomes are artificial vesicles that can be loaded with drugs, offering an alternative strategy to treat intracellular pathogens as nanocarriers. Members of the mycobacteria genus are intracellular pathogens that have evolved to escape the immunological response, specifically in macrophages, the white cells responsible for the clearance of pathogens. This review analyzed the state-of-the-art niosome synthesis aimed at tackling the problem of intracellular pathogen therapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1891"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9787592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging nanoparticle designs against bacterial infections. 新兴的纳米颗粒设计对抗细菌感染。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 DOI: 10.1002/wnan.1881

Zhidong Zhou, Mingxuan Kai, Shuyan Wang, Dan Wang, Yifei Peng, Yiyan Yu, Weiwei Gao, Liangfang Zhang

{"title":"Emerging nanoparticle designs against bacterial infections.","authors":"Zhidong Zhou, Mingxuan Kai, Shuyan Wang, Dan Wang, Yifei Peng, Yiyan Yu, Weiwei Gao, Liangfang Zhang","doi":"10.1002/wnan.1881","DOIUrl":"https://doi.org/10.1002/wnan.1881","url":null,"abstract":"The rise of antibiotic resistance has caused the prevention and treatment of bacterial infections to be less effective. Therefore, researchers turn to nanomedicine for novel and effective antibacterial therapeutics. The effort resulted in the first-generation antibacterial nanoparticles featuring the ability to improve drug tolerability, circulation half-life, and efficacy. Toward developing the next-generation antibacterial nanoparticles, researchers have integrated design elements that emphasize physical, broad-spectrum, biomimetic, and antivirulence mechanisms. This review highlights four emerging antibacterial nanoparticle designs: inorganic antibacterial nanoparticles, responsive antibacterial nanocarriers, virulence nanoscavengers, and antivirulence nanovaccines. Examples in each design category are selected and reviewed, and their structure-function relationships are discussed. These emerging designs open the door to nontraditional antibacterial nanomedicines that rely on mechano-bactericidal, function-driven, nature-inspired, or virulence-targeting mechanisms to overcome antibiotic resistance for more effective antibacterial therapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1881"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9778814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects. 微针辅助的纳米颗粒透皮递送:最近的见解和前景。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 DOI: 10.1002/wnan.1884

Antonio José Guillot, Miquel Martínez-Navarrete, Valeria Zinchuk-Mironova, Ana Melero

{"title":"Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects.","authors":"Antonio José Guillot, Miquel Martínez-Navarrete, Valeria Zinchuk-Mironova, Ana Melero","doi":"10.1002/wnan.1884","DOIUrl":"https://doi.org/10.1002/wnan.1884","url":null,"abstract":"Transdermal delivery of drugs offers an interesting alternative for the administration of molecules that present certain troubles when delivered by the oral route. It can produce systemic effects or perform a local action when the formulation exerts an optimal controlled drug release or a targeted delivery to the specific cell type or site. It also avoids several inconveniences of the oral administration such as the hepatic first pass effect, gastric pH-induced hydrolysis, drug malabsorption because of certain diseases or surgeries, and unpleasant organoleptic properties. Nanomedicine and microneedle array patches (MAPs) are two of the trendiest delivery systems applied to transdermal research nowadays. However, the skin is a protective barrier and nanoparticles (NPs) cannot pass through the intact stratum corneum. The association of NPs and MAPs (NPs@MAPs) work synergistically, since MAPs assist NPs to bypass the outer skin layers, and NPs contribute to the system providing controlled drug release and targeted delivery. Vaccination and tailored therapies have been proposed as fields where both NPs and MAPs have great potential due to inherent characteristics. MAPs conception and easy use could allow self-administration and therefore facilitate mass vaccination campaigns in undeveloped areas with weak healthcare services. Additionally, nanomedicine is being explored as a platform to personalize therapies in such an important field as oncology. In this work we show recent insights that prove the benefits of NPs@MAPs association and analyze the prospects and the discrete interest of the industry in NPs@MAPs, evaluating different limiting steps that restricts NPs@MAPs translation to the clinical practice. This article is categorized under: Nanotechnology Approaches to Biology > NA Therapeutic Approaches and Drug Discovery > NA.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1884"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9792875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Metal-organic coordination polymers for delivery of immunomodulatory agents, and infectious disease and cancer vaccines. 用于输送免疫调节药剂以及传染病和癌症疫苗的金属有机配位聚合物。

IF 6.9 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 Epub Date: 2023-01-11 DOI: 10.1002/wnan.1877

Erik S Pena, Liubov M Lifshits, Meital Eckshtain-Levi, Eric M Bachelder, Kristy M Ainslie

{"title":"Metal-organic coordination polymers for delivery of immunomodulatory agents, and infectious disease and cancer vaccines.","authors":"Erik S Pena, Liubov M Lifshits, Meital Eckshtain-Levi, Eric M Bachelder, Kristy M Ainslie","doi":"10.1002/wnan.1877","DOIUrl":"10.1002/wnan.1877","url":null,"abstract":"Metal-organic coordination polymers (CPs) are a broad class of materials that include metal-organic frameworks (MOFs). CPs are highly ordered crystalline materials that are composed of metal ions (or metal ion clusters) and multidentate organic ligands that serve as linkers. One-, two-, and three-dimensional CPs can be formed, with 2D and 3D structures referred to as MOFs. CPs have gained a lot of attention due to attractive structural features like structure versatility and tunability, and well-defined pores that enable the encapsulation of cargo. Further, CPs show a lot of promise for drug delivery applications, but only a very limited number of CPs are currently being evaluated in clinical trials. In this review, we outlined features that are desired for CP-based drug delivery platform, and briefly described most relevant characterization techniques. We highlighted some of the recent efforts directed toward developing CP-based drug delivery platforms with the emphasis on vaccines against cancer, infectious diseases, and viruses. We hope this review will be a helpful guide for those interested in the design and evaluation of CP-based immunological drug delivery platforms. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1877"},"PeriodicalIF":6.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10405170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-encoded nanoparticle vaccine platforms for in vivo assembly of multimeric antigen to promote adaptive immunity. 基因编码的纳米颗粒疫苗平台，用于体内组装多聚抗原以促进适应性免疫。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 Epub Date: 2023-02-20 DOI: 10.1002/wnan.1880

Nicholas J Tursi, Ziyang Xu, Daniel W Kulp, David B Weiner

{"title":"Gene-encoded nanoparticle vaccine platforms for in vivo assembly of multimeric antigen to promote adaptive immunity.","authors":"Nicholas J Tursi, Ziyang Xu, Daniel W Kulp, David B Weiner","doi":"10.1002/wnan.1880","DOIUrl":"10.1002/wnan.1880","url":null,"abstract":"Nanoparticle vaccines are a diverse category of vaccines for the prophylaxis or treatment of various diseases. Several strategies have been employed for their optimization, especially to enhance vaccine immunogenicity and generate potent B-cell responses. Two major modalities utilized for particulate antigen vaccines include using nanoscale structures for antigen delivery and nanoparticles that are themselves vaccines due to antigen display or scaffolding-the latter of which we will define as \"nanovaccines.\" Multimeric antigen display has a variety of immunological benefits compared to monomeric vaccines mediated through potentiating antigen-presenting cell presentation and enhancing antigen-specific B-cell responses through B-cell activation. The majority of nanovaccine assembly is done in vitro using cell lines. However, in vivo assembly of scaffolded vaccines potentiated using nucleic acids or viral vectors is a burgeoning modality of nanovaccine delivery. Several advantages to in vivo assembly exist, including lower costs of production, fewer production barriers, as well as more rapid development of novel vaccine candidates for emerging diseases such as SARS-CoV-2. This review will characterize the methods for de novo assembly of nanovaccines in the host using methods of gene delivery including nucleic acid and viral vectored vaccines. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1880"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic nanomaterials-mediated neuromodulation. 磁性纳米材料介导的神经调节。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 DOI: 10.1002/wnan.1890

Xiaofeng Lu, Galong Li, Wangbo Jiao, Kuo Li, Tingbin Zhang, Xiaoli Liu, Haiming Fan

{"title":"Magnetic nanomaterials-mediated neuromodulation.","authors":"Xiaofeng Lu, Galong Li, Wangbo Jiao, Kuo Li, Tingbin Zhang, Xiaoli Liu, Haiming Fan","doi":"10.1002/wnan.1890","DOIUrl":"https://doi.org/10.1002/wnan.1890","url":null,"abstract":"Researchers have leveraged magnetic nanomaterials (MNMs) to explore neural circuits and treat neurological diseases via an approach known as MNMs-mediated neuromodulation. Here, the magneto-responsive effects of MNMs to an external magnetic field are manipulated to activate or inhibit neuronal cell activity. In this way, MNMs can serve as a nano-mediator, by converting electromagnetic energy into heat, mechanical force/torque, and an electrical field at nanoscale. These physicochemical effects can stimulate ion channels and activate precise signaling pathways involved in neuromodulation. In this review, we outline the various ion channels and MNMs that have been applied to MNMs-mediated neuromodulation. We highlight the recent advances made in this technique and its potential applications, and then discuss the current challenges and future directions of MNMs-mediated neuromodulation. Our aim is to reveal the potential of MNMs to treat neurological diseases in the clinical setting. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1890"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging. 纳米材料用于超极化核磁共振和磁共振成像。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-07-01 DOI: 10.1002/wnan.1879

Philip Saul, Leif Schröder, Andreas B Schmidt, Jan-Bernd Hövener

{"title":"Nanomaterials for hyperpolarized nuclear magnetic resonance and magnetic resonance imaging.","authors":"Philip Saul, Leif Schröder, Andreas B Schmidt, Jan-Bernd Hövener","doi":"10.1002/wnan.1879","DOIUrl":"https://doi.org/10.1002/wnan.1879","url":null,"abstract":"Nanomaterials play an important role in the development and application of hyperpolarized materials for magnetic resonance imaging (MRI). In this context they can not only act as hyperpolarized materials which are directly imaged but also play a role as carriers for hyperpolarized gases and catalysts for para-hydrogen induced polarization (PHIP) to generate hyperpolarized substrates for metabolic imaging. Those three application possibilities are discussed, focusing on carbon-based materials for the directly imaged particles. An overview over recent developments in all three fields is given, including the early developments in each field as well as important steps towards applications in MRI, such as making the initially developed methods more biocompatible and first imaging experiments with spatial resolution in either phantoms or in vivo studies. Focusing on the important features nanomaterials need to display to be applicable in the MRI context, a wide range of different approaches to that extent is covered, giving the reader a general idea of different possibilities as well as recent developments in those different fields of hyperpolarized magnetic resonance. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 4","pages":"e1879"},"PeriodicalIF":8.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10145894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protein cargo encapsulation by virus-like particles: Strategies and applications. 病毒样颗粒对蛋白质货物的封装:策略和应用。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-05-01 DOI: 10.1002/wnan.1869

Donna McNeale, Noor Dashti, Li Chen Cheah, Frank Sainsbury

{"title":"Protein cargo encapsulation by virus-like particles: Strategies and applications.","authors":"Donna McNeale, Noor Dashti, Li Chen Cheah, Frank Sainsbury","doi":"10.1002/wnan.1869","DOIUrl":"https://doi.org/10.1002/wnan.1869","url":null,"abstract":"Viruses and the recombinant protein cages assembled from their structural proteins, known as virus-like particles (VLPs), have gained wide interest as tools in biotechnology and nanotechnology. Detailed structural information and their amenability to genetic and chemical modification make them attractive systems for further engineering. This review describes the range of non-enveloped viruses that have been co-opted for heterologous protein cargo encapsulation and the strategies that have been developed to drive encapsulation. Spherical capsids of a range of sizes have been used as platforms for protein cargo encapsulation. Various approaches, based on native and non-native interactions between the cargo proteins and inner surface of VLP capsids, have been devised to drive encapsulation. Here, we outline the evolution of these approaches, discussing their benefits and limitations. Like the viruses from which they are derived, VLPs are of interest in both biomedical and materials applications. The encapsulation of protein cargo inside VLPs leads to numerous uses in both fundamental and applied biocatalysis and biomedicine, some of which are discussed herein. The applied science of protein-encapsulating VLPs is emerging as a research field with great potential. Developments in loading control, higher order assembly, and capsid optimization are poised to realize this potential in the near future. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 3","pages":"e1869"},"PeriodicalIF":8.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Instigation of the epoch of nanovaccines in cancer immunotherapy. 在癌症免疫疗法中开创纳米疫苗时代。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-05-01 Epub Date: 2022-11-21 DOI: 10.1002/wnan.1870

Saurabh Shah, Paras Famta, Vinod Tiwari, Arun K Kotha, Rama Kashikar, Mahavir Bhupal Chougule, Young Hun Chung, Nicole F Steinmetz, Mohammad Uddin, Shashi Bala Singh, Saurabh Srivastava

{"title":"Instigation of the epoch of nanovaccines in cancer immunotherapy.","authors":"Saurabh Shah, Paras Famta, Vinod Tiwari, Arun K Kotha, Rama Kashikar, Mahavir Bhupal Chougule, Young Hun Chung, Nicole F Steinmetz, Mohammad Uddin, Shashi Bala Singh, Saurabh Srivastava","doi":"10.1002/wnan.1870","DOIUrl":"10.1002/wnan.1870","url":null,"abstract":"Cancer is an unprecedented proliferation of cells leading to abnormalities in differentiation and maturation. Treatment of primary and metastatic cancer is challenging. In addition to surgery, chemotherapy and radiation therapies have been conventionally used; however, they suffer from severe toxicity and non-specificity. Immunotherapy, the science of programming the body's own defense system against cancer has gained tremendous attention in the last few decades. However, partial immunogenic stimulation, premature degradation and inability to activate dendritic and helper T cells has resulted in limited clinical success. The era of nanomedicine has brought about several breakthroughs in various pharmaceutical and biomedical fields. Hereby, we review and discuss the interplay of tumor microenvironment (TME) and the immunological cascade and how they can be employed to develop nanoparticle-based cancer vaccines and immunotherapies. Nanoparticles composed of lipids, polymers and inorganic materials contain useful properties suitable for vaccine development. Proteinaceous vaccines derived from mammalian viruses, bacteriophages and plant viruses also have unique advantages due to their immunomodulation capabilities. This review accounts for all such considerations. Additionally, we explore how attributes of nanotechnology can be utilized to develop successful nanomedicine-based vaccines for cancer therapy. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 3","pages":"e1870"},"PeriodicalIF":8.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9677666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Titanium dioxide nanoparticles: Recent progress in antimicrobial applications. 二氧化钛纳米颗粒:抗菌应用的最新进展。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-05-01 DOI: 10.1002/wnan.1860

Almotasem Bellah Younis, Yazan Haddad, Ludmila Kosaristanova, Kristyna Smerkova

{"title":"Titanium dioxide nanoparticles: Recent progress in antimicrobial applications.","authors":"Almotasem Bellah Younis, Yazan Haddad, Ludmila Kosaristanova, Kristyna Smerkova","doi":"10.1002/wnan.1860","DOIUrl":"https://doi.org/10.1002/wnan.1860","url":null,"abstract":"For decades, the antimicrobial applications of nanoparticles (NPs) have attracted the attention of scientists as a strategy for controlling the ever-increasing threat of multidrug-resistant microorganisms. The photo-induced antimicrobial properties of titanium dioxide (TiO2 ) NPs by ultraviolet (UV) light are well known. This review elaborates on the modern methods and antimicrobial mechanisms of TiO2 NPs and their modifications to better understand and utilize their potential in various biomedical applications. Additional compounds can be grafted onto TiO2 nanomaterial, leading to hybrid metallic or non-metallic materials. To improve the antimicrobial properties, many approaches involving TiO2 have been tested. The results of selected studies from the past few years covering the most recent trends in this field are discussed in this review. There is extensive evidence to show that TiO2 NPs can exhibit certain antimicrobial features with disputable roles of UV light. Hence, they are effective in treating bacterial infections, although the majority of these conclusions came from in vitro studies and in the presence of some additional nanomaterials. The methods of evaluation varied depending on the nature of the research while researchers incorporated different techniques, including determining the minimum inhibitory concentration, cell count, and using disk and well diffusion methods, with a noticeable indication that cell count was the most and dominant criterion used to evaluate the antimicrobial activity. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 3","pages":"e1860"},"PeriodicalIF":8.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9