World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering最新文献_第3页

Discovery of Human HMG-Coa Reductase Inhibitors Using Structure-Based Pharmacophore Modeling Combined with Molecular Dynamics Simulation Methodologies 利用基于结构的药效团模型结合分子动力学模拟方法发现人类HMG-Coa还原酶抑制剂

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2013-01-29 DOI: 10.5281/zenodo.1333334

Minky Son, Chanin Park, Ayoung Baek, Shalini John, Keun Woo Lee

{"title":"Discovery of Human HMG-Coa Reductase Inhibitors Using Structure-Based Pharmacophore Modeling Combined with Molecular Dynamics Simulation Methodologies","authors":"Minky Son, Chanin Park, Ayoung Baek, Shalini John, Keun Woo Lee","doi":"10.5281/zenodo.1333334","DOIUrl":"https://doi.org/10.5281/zenodo.1333334","url":null,"abstract":"3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor. Keywords—Anti-hypercholesterolemia drug, HMGR inhibitor, Molecular dynamics simulation, Structure-based pharmacophore modeling.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"31 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2013-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75657667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Assessment of Measuring/Rehabilitation Device for Myelopathy Patients with Lower Extremity Function 脊髓病患者下肢功能测量/康复装置的研制与评估

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2013-01-25 DOI: 10.5281/ZENODO.1333394

Hironobu Murayama, Shohei Shimizu, Masakazu Ohnuki, H. Mihara, T. Kanada

{"title":"Development and Assessment of Measuring/Rehabilitation Device for Myelopathy Patients with Lower Extremity Function","authors":"Hironobu Murayama, Shohei Shimizu, Masakazu Ohnuki, H. Mihara, T. Kanada","doi":"10.5281/ZENODO.1333394","DOIUrl":"https://doi.org/10.5281/ZENODO.1333394","url":null,"abstract":"Disordered function of maniphalanx and difficulty with ambulation will occur insofar as a human has a failure in the spinal marrow. Cervical spondylotic myelopathy as one of the myelopathy emanates from not only external factors but also increased age. In addition, the diacrisis is difficult since cervical spondylotic myelopathy is evaluated by a doctor’s neurological remark and imaging findings. As a quantitative method for measuring the degree of disability, hand-operated triangle step test (for short, TST) has formulated. In this research, a full automatic triangle step counter apparatus is designed and developed to measure the degree of disability in an accurate fashion according to the principle of TST. The step counter apparatus whose shape is a low triangle pole displays the number of stepping upon each corner. Furthermore, the apparatus has two modes of operation. Namely, one is for measuring the degree of disability and the other for rehabilitation exercise. In terms of usefulness, clinical practice should be executed before too long.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"17 1","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2013-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85314078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variant Polymorphisms Of Gst And Xrcc Genes And The Early Risk Of Age Associated Disease In Kazakhstan 哈萨克斯坦Gst和Xrcc基因的变异多态性与年龄相关疾病的早期风险

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2012-11-22 DOI: 10.5281/ZENODO.1057846

Z. Berkimbayeva, A. Mansharipova, E. Khussainova, L. Djansugurova

引用次数: 0

An Automatic Sleep Spindle Detector based on WT, STFT and WMSD 基于小波变换、STFT和WMSD的睡眠纺锤波自动检测器

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2012-08-24 DOI: 10.5281/ZENODO.1056589

José Esteves da Costa, M. Ortigueira, A. Batista, T. Paiva

引用次数: 13

The Cytotoxic Effect of PM 701 and its Fractions on Cell Proliferation of Breast Cancer Cells, McF7 pm701及其组分对乳腺癌细胞McF7增殖的细胞毒作用

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2011-01-21 DOI: 10.3923/AJDD.2011.200.208

F. Khorshid

{"title":"The Cytotoxic Effect of PM 701 and its Fractions on Cell Proliferation of Breast Cancer Cells, McF7","authors":"F. Khorshid","doi":"10.3923/AJDD.2011.200.208","DOIUrl":"https://doi.org/10.3923/AJDD.2011.200.208","url":null,"abstract":"Breast cancer is the most common malignancy in the world among women. Many therapies have been designed to treat this disease. Mamectomy, chemotherapy and radiotherapy are still the main therapies of breast cancer. However, the results were unsatisfactory and still far from the ideal treatment. PM 701is a natural product, has anticancer activity. The bioactive fraction PMF and subfraction PMFK had been isolated from PM701. PM 701 and its fractions were proved to have a cytotoxic properties against different cancer cell lines. This article is directed for the further examination of lyophilized PM701 and its active fractions on the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK were adding to the cultural medium, where MCF-7 is incubated. PM 701, PMF or PMFK were able to inhibit significantly the proliferation of MCF-7 cells, Moreover these new agents were proved to induce apoptosis of the breast cancer cells; through its direct effect on the nuclei. Keywords—Anticancer agent, breast carcinoma, MCF-7 cell line, PM 701","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"1 1","pages":"15-19"},"PeriodicalIF":0.0,"publicationDate":"2011-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86800773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A Tubular Electrode for Radiofrequency Ablation Therapy 一种用于射频消融治疗的管状电极

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2010-10-21 DOI: 10.1108/03321641211227320

C. Antunes, T. Almeida, N. Raposeiro, B. Gonçalves, Paulo Almeida, A. Antunes

引用次数: 5

A Novel Method Based on Monte Carlo for Simulation of Variable Resolution X-ray CT Scanner: Measurement of System Presampling MTF 一种基于蒙特卡罗的变分辨率x射线CT模拟新方法:系统预采样MTF的测量

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2010-08-26 DOI: 10.5281/ZENODO.1070916

Hossein ARABI, A. K. Asl

{"title":"A Novel Method Based on Monte Carlo for Simulation of Variable Resolution X-ray CT Scanner: Measurement of System Presampling MTF","authors":"Hossein ARABI, A. K. Asl","doi":"10.5281/ZENODO.1070916","DOIUrl":"https://doi.org/10.5281/ZENODO.1070916","url":null,"abstract":"The purpose of this work is measurement of the\u0000system presampling MTF of a variable resolution x-ray (VRX) CT\u0000scanner. In this paper, we used the parameters of an actual VRX CT\u0000scanner for simulation and study of effect of different focal spot sizes\u0000on system presampling MTF by Monte Carlo method (GATE\u0000simulation software). Focal spot size of 0.6 mm limited the spatial\u0000resolution of the system to 5.5 cy/mm at incident angles of below 17o\u0000for cell#1. By focal spot size of 0.3 mm the spatial resolution\u0000increased up to 11 cy/mm and the limiting effect of focal spot size\u0000appeared at incident angles of below 9o. The focal spot size of 0.3\u0000mm could improve the spatial resolution to some extent but because\u0000of magnification non-uniformity, there is a 10 cy/mm difference\u0000between spatial resolution of cell#1 and cell#256. The focal spot size\u0000of 0.1 mm acted as an ideal point source for this system. The spatial\u0000resolution increased to more than 35 cy/mm and at all incident angles\u0000the spatial resolution was a function of incident angle. By the way\u0000focal spot size of 0.1 mm minimized the effect of magnification nonuniformity.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"64 1","pages":"355-359"},"PeriodicalIF":0.0,"publicationDate":"2010-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80334228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preoperative to Intraoperative Space Registration for Management of Head Injuries 颅脑损伤的术前至术中空间登记

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2009-09-28 DOI: 10.5281/ZENODO.1082948

M. Gooroochurn, M. Ovinis, D. Kerr, K. Bouazza-Marouf, M. Vloeberghs

{"title":"Preoperative to Intraoperative Space Registration for Management of Head Injuries","authors":"M. Gooroochurn, M. Ovinis, D. Kerr, K. Bouazza-Marouf, M. Vloeberghs","doi":"10.5281/ZENODO.1082948","DOIUrl":"https://doi.org/10.5281/ZENODO.1082948","url":null,"abstract":"A registration framework for image-guided robotic surgery is proposed for three emergency neurosurgical procedures, namely Intracranial Pressure (ICP) Monitoring, External Ventricular Drainage (EVD) and evacuation of a Chronic Subdural Haematoma (CSDH). The registration paradigm uses CT and white light as modalities. This paper presents two simulation studies for a preliminary evaluation of the registration protocol: (1) The loci of the Target Registration Error (TRE) in the patient's axial, coronal and sagittal views were simulated based on a Fiducial Localisation Error (FLE) of 5 mm and (2) Simulation of the actual framework using projected views from a surface rendered CT model to represent white light images of the patient. Craniofacial features were employed as the registration basis to map the CT space onto the simulated intraoperative space. Photogrammetry experiments on an artificial skull were also performed to benchmark the results obtained from the second simulation. The results of both simulations show that the proposed protocol can provide a 5mm accuracy for these neurosurgical procedures. Keywords—Image-guided Surgery, Multimodality Registration, Photogrammetry, Preoperative to Intraoperative Registration. I. INTRODUCTION HIS paper presents a registration framework designed to support image-guided solutions for three neurosurgical procedures that are routinely employed in the management of head injuries. Registration is a general term used to describe the alignment of two datasets, with respect to a reference coordinate system, with the aim of reducing the disparity between them; alternatively recovering that disparity may be the goal. A registration basis consists of features chosen that relate both datasets in terms of the disparity involved. The","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"22 1","pages":"230-237"},"PeriodicalIF":0.0,"publicationDate":"2009-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77685998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

En-Face Optical Coherence Tomography Combined With Fluorescence In Material Defects Investigations For Ceramic Fixed Partial Dentures 面光学相干层析结合荧光技术在陶瓷固定局部义齿材料缺陷研究中的应用

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2009-08-29 DOI: 10.5281/ZENODO.1082301

C. Sinescu, M. Negruțiu, M. Rominu, C. Haiduc, E. Petrescu, Marius Leretter, A. Podoleanu

{"title":"En-Face Optical Coherence Tomography Combined With Fluorescence In Material Defects Investigations For Ceramic Fixed Partial Dentures","authors":"C. Sinescu, M. Negruțiu, M. Rominu, C. Haiduc, E. Petrescu, Marius Leretter, A. Podoleanu","doi":"10.5281/ZENODO.1082301","DOIUrl":"https://doi.org/10.5281/ZENODO.1082301","url":null,"abstract":"Optical Coherence Tomography (OCT) combined with the Confocal Microscopy, as a noninvasive method, permits the determinations of materials defects in the ceramic layers depth. For this study 256 anterior and posterior metal and integral ceramic fixed partial dentures were used, made with Empress (Ivoclar), Wollceram and CAD/CAM (Wieland) technology. For each investigate area 350 slices were obtain and a 3D reconstruction was perform from each stuck. The Optical Coherent Tomography, as a noninvasive method, can be used as a control technique in integral ceramic technology, before placing those fixed partial dentures in the oral cavity. The purpose of this study is to evaluate the capability of En face Optical Coherence Tomography (OCT) combined with a fluorescent method in detection and analysis of possible material defects in metalceramic and integral ceramic fixed partial dentures. As a conclusion, it is important to have a non invasive method to investigate fixed partial prostheses before their insertion in the oral cavity in order to satisfy the high stress requirements and the esthetic function.","PeriodicalId":23673,"journal":{"name":"World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering","volume":"11 1","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"2009-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77876545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forward Simulation of a Parallel Hybrid Vehicle and Fuzzy Controller Design for Driving/Regenerative Propose 并联混合动力汽车正演仿真及驱动/再生模糊控制器设计

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2008-08-22 DOI: 10.7726/jgei.2013.1003

P. Naderi, A. Farhadi, S. Bathaee

引用次数: 6