Variant Polymorphisms Of Gst And Xrcc Genes And The Early Risk Of Age Associated Disease In Kazakhstan

World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering Pub Date : 2012-11-22 DOI:10.5281/ZENODO.1057846

Z. Berkimbayeva, A. Mansharipova, E. Khussainova, L. Djansugurova

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Abstract

It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P 0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.

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哈萨克斯坦Gst和Xrcc基因的变异多态性与年龄相关疾病的早期风险

人们认为DNA破坏毒性代谢物有助于不同病理条件的发展。为了防止有毒物质的有害影响，细胞发展了许多保护机制，如酶促反应的解毒活性代谢物和修复DNA损伤。本研究的目的是研究GSTT1/GSTM1和XRCC1/3基因多态性与冠状动脉疾病(CAD)发病率之间的关系。为了检测这些基因在患者和对照组CAD易感性中的多态性，我们进行了基于PCR的基因分型分析。对于GST基因，CAD影响组GSTM1零基因型频率显著高于对照组(p0.1)。我们发现XRCC1 Arg399Gln和XRCC3 Thr241Met都与CAD风险无关。获得的数据表明，GSTM1零基因型携带者更容易患CAD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World Academy of Science, Engineering and Technology, International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering

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