Sriwijaya Journal of Otorhinolaryngology最新文献

Molecular Biomarkers as Predictors of Treatment Response and Survival Outcomes in Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study at a Singapore Tertiary Hospital 预测头颈部鳞状细胞癌治疗反应和生存结果的分子生物标记物：新加坡一家三级医院的回顾性队列研究

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2024-08-09 DOI: 10.59345/sjorl.v2i1.151

Martin Curtis Lee, Nazilah Amir

{"title":"Molecular Biomarkers as Predictors of Treatment Response and Survival Outcomes in Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study at a Singapore Tertiary Hospital","authors":"Martin Curtis Lee, Nazilah Amir","doi":"10.59345/sjorl.v2i1.151","DOIUrl":"https://doi.org/10.59345/sjorl.v2i1.151","url":null,"abstract":"Introduction: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with variable treatment responses. Identification of molecular biomarkers could personalize treatment and improve outcomes. \u0000Methods: A retrospective cohort study was conducted at a tertiary hospital in Singapore. Patients with HNSCC treated between 2018-2023 were included. Pretreatment tumor biopsies were analyzed for biomarker expression (PD-L1, EGFR, TP53, HPV status) using immunohistochemistry and PCR. Clinical data were collected from medical records. Treatment response, survival, and associations with biomarkers were analyzed. \u0000Results: 250 patients were included. PD-L1 expression was associated with improved response to immunotherapy (p = 0.02). EGFR overexpression correlated with worse overall survival (p = 0.01). TP53 mutations were linked to increased locoregional recurrence (p = 0.03). HPV-positive tumors had a better prognosis (p < 0.001). \u0000Conclusion: Molecular biomarkers show promise in predicting treatment response and survival in HNSCC. Integration of these markers into clinical practice could facilitate personalized treatment strategies.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"77 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141922126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-related Hearing Loss and Its Correlation with Depression 老年性听力损失及其与抑郁症的相关性

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-12-22 DOI: 10.59345/sjorl.v1i2.80

Rohayu Rohayu

引用次数: 0

Chronic Suppurative Otitis Media Accompanied by Facial Nerve Paresis: A Case Report 伴有面神经麻痹的慢性化脓性中耳炎：病例报告

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-12-22 DOI: 10.59345/sjorl.v1i2.79

Alia Oktarisa, Danisa Siregar

{"title":"Chronic Suppurative Otitis Media Accompanied by Facial Nerve Paresis: A Case Report","authors":"Alia Oktarisa, Danisa Siregar","doi":"10.59345/sjorl.v1i2.79","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.79","url":null,"abstract":"Introduction: Chronic suppurative otitis media (CSOM) is marked by ear discharge (otorrhea) that lasts for more than six to eight weeks, middle ear inflammation that doesn't go away, and a ruptured eardrum. The purpose of this study is to describe examples of CSOM with facial nerve paresis and how such cases are managed. \u0000Case presentation: A thirty-year-old man complained to the Mataram Community Health Center two days before admission that his mouth was turning to the left, despite the fact that he was still able to speak well. Additionally, for four months, the patient complained of a constant discharge from the right ear. The fluid that emerges from the ear is sticky, yellow, and odorous; blood is not mixed with it. Upon inspection, a cholesteatoma and a flat-edge attic perforation on the tympanic membrane were discovered, together with a purulent and odorous discharge in the ear canal of the right ear. After a facial nerve examination, it was discovered that the forehead wrinkles were uneven and that the face was asymmetrical, with the right eyebrow unable to be raised. The patient was identified as having peripheral facial nerve paresis and persistent suppurative malignant otitis media of the auricula dextra. The patient is being treated with irrigation of the ear canal with 0.9% NaCl, cleaning of the cholesteatoma, and antibiotic administration: two drops of ofloxacin ear drops given twice a day, three times a day ciprofloxacin tablets 500 mg, three times a day methylprednisolone 16 mg, and advice to undergo a mastoidectomy. \u0000Conclusion: Complications including hearing loss, facial nerve palsy, subperiosteal abscess, petrositis, meningitis, cerebral abscess, and labyrinthine fistula are indicated for mastectomy surgical therapy.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138944281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Anatomy and Physiology of Gustatory and Olfactory System 味觉和嗅觉系统解剖学与生理学概述

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-12-22 DOI: 10.59345/sjorl.v1i2.93

Tania Arifani

引用次数: 0

The Role of Stem Cells in Hearing Restorative Therapy 干细胞在听力恢复疗法中的作用

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-12-22 DOI: 10.59345/sjorl.v1i2.94

Rachmat Hidayat

{"title":"The Role of Stem Cells in Hearing Restorative Therapy","authors":"Rachmat Hidayat","doi":"10.59345/sjorl.v1i2.94","DOIUrl":"https://doi.org/10.59345/sjorl.v1i2.94","url":null,"abstract":"Stem cells play a crucial role in the advancement of restorative hearing therapy, marking the beginning of a new era in the treatment of hearing loss. Researchers are currently focusing on studying many types of stem cells, including mesenchymal stem cells (MSC), embryonic stem cells (ESC), induced pluripotent stem cells (iPSC), neural stem cells (NSC), and otic progenitor cells, in order to restore or enhance hearing function. Stem cells possess the capacity to undergo differentiation into auditory cells, namely hair cells within the cochlea, which serves as the foundation for the restoration of auditory functionality. Stem cells promote the regeneration of nearby tissue, facilitate the development of new auditory cells, and enhance the quality of the ear's mucous membrane, thus establishing a conducive environment for healing. It is the stem cells that make growth factors, which help repair, regeneration, and differentiation of new auditory cells. This creates an ideal environment for cells to multiply. By enabling the creation of customized therapies that can specifically match the unique characteristics of each patient, induced pluripotent stem cells (iPSC) introduce a personalized approach to treating hearing loss.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"10 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138943896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Immunobiological Aspects of Allergic Rhinitis 过敏性鼻炎的免疫生物学研究

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-12-19 DOI: 10.59345/sjorl.v1i2.92

Rachmat Hidayat

引用次数: 0

Overview Aspects of Anatomy and Histology of the Trachea, Pharynx, Larynx, and Esophagus: A Narrative Literature Review 气管、咽部、喉部和食道的解剖学和组织学综述:一篇叙述性文献综述

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-04-27 DOI: 10.59345/sjorl.v1i1.35

Mariance, Yoan Levia Magdi

引用次数: 0

The Relationship between Cholesteatoma Stage and Hearing Bone Erosion Degree in Chronic Suppurative Otitis Media Patients with Cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia 印度尼西亚巴东Dr. M. Djamil总医院胆脂瘤合并慢性化脓性中耳炎患者胆脂瘤分期与听力骨侵蚀程度的关系

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-04-27 DOI: 10.59345/sjorl.v1i1.31

Bima Riantardo Hafni, Nirza Warto

{"title":"The Relationship between Cholesteatoma Stage and Hearing Bone Erosion Degree in Chronic Suppurative Otitis Media Patients with Cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia","authors":"Bima Riantardo Hafni, Nirza Warto","doi":"10.59345/sjorl.v1i1.31","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.31","url":null,"abstract":"Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the middle ear mucosa and mastoid space. Cholesteatoma is an ectopic keratinized epithelial tissue that develops through the mucosa of the middle ear cavity and desquamates, resulting in the accumulation of keratin and epithelial debris. This study aimed to determine the relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia. \u0000Methods: This study was an observational case series study. A total of 70 research subjects were included in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients with a diagnosis of CSOM with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia and have complete medical record data. Data analysis was carried out using SPSS software version 25. Correlation analysis between cholesteatoma stage and degree of osseous erosion was performed using the Spearman correlation test, p<0.05. \u0000Results: The majority of research subjects were aged 21-30 years (28.6%) and were male (51.4%). Based on clinical symptoms, the majority of patients experience otorrhoea for 5 to 10 years (47.1%), perforated type membrane total tympani (54.3%), degree of erosion of the ossicles type D (48.6%), stage 4 cholesteatoma (61.4%) and granulation tissue (81.4%). \u0000Conclusion: There is a relationship between the stage of cholesteatoma and the degree of erosion of the ossicles in patients with CSOM (chronic suppurative otitis media) with cholesteatoma at Dr. M. Djamil General Hospital, Padang, Indonesia.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123509369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Sensorineural Deafness Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia 印度尼西亚巨港市Mohammad Hoesin总医院感音神经性耳聋患者概况

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-04-27 DOI: 10.59345/sjorl.v1i1.34

Ahmad Hifni, Abla Ghanie, Lisa Apriyanti

{"title":"Overview of Sensorineural Deafness Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia","authors":"Ahmad Hifni, Abla Ghanie, Lisa Apriyanti","doi":"10.59345/sjorl.v1i1.34","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.34","url":null,"abstract":"Introduction: Sensorineural deafness is deafness that occurs due to disturbances in the inner ear or in the nerve pathways from the inner ear to the brain. This study aimed to provide an overview of sensorineural deaf patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. \u0000Methods: This study was a descriptive observational study and used secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 50 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients aged > 18 years who were diagnosed with sensorineural hearing loss at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the January-December 2022 period and had complete medical record data. \u0000Results: The majority of research subjects have an age range of > 50 years. Subject the majority of studies have male gender. The majority of research subjects complained of deafness in both ears. The majority of research subjects have a profound hearing threshold. \u0000Conclusion: Characteristics of sensorineural deafness at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, generally occur at the age of > 50 years, male gender, occurs bilaterally, and has a very poor hearing threshold.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130681630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Acute Pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia 印度尼西亚巨港市Mohammad Hoesin总医院急性咽炎的特点

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2023-04-27 DOI: 10.59345/sjorl.v1i1.33

Puspa Zuleika, Adelien

{"title":"Characteristics of Acute Pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia","authors":"Puspa Zuleika, Adelien","doi":"10.59345/sjorl.v1i1.33","DOIUrl":"https://doi.org/10.59345/sjorl.v1i1.33","url":null,"abstract":"Introduction: Pharyngitis presents with a variety of symptoms, including sudden sore throat, fever, headache, lymphadenitis, and sometimes abdominal pain, nausea, fatigue, and/or rash. This study aimed to provide data on the basic characteristics of acute pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. \u0000Methods: This study was a descriptive observational study. This study uses secondary data obtained from medical record data at the medical records installation of Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. A total of 100 research subjects participated in this study, and the research subjects met the inclusion criteria. The inclusion criteria in this study were patients diagnosed with acute pharyngitis at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, for the period January – December 2022 and who have complete medical record data. Observations on sociodemographic data as well as observations on clinical data, were carried out in this study. Univariate data analysis was performed to present the distribution of frequencies and percentages of each variable. Data analysis was carried out using SPSS version 25. \u0000Results: The majority of research subjects are in the age range of 0-14 years. The majority of research subjects are female. The majority of research subjects had clinical symptoms of sore throat and difficulty swallowing. The symptoms that arise in acute pharyngitis depend on the microorganisms that accompany it. Acute pharyngitis caused by bacteria is characterized by severe headache, fever or chills, malaise, painful swallowing, vomiting, and possibly coughing but rarely. \u0000Conclusion: The characteristics of pharyngitis patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, are aged 0-14 years with prominent clinical symptoms of sore throat and difficulty swallowing.","PeriodicalId":236484,"journal":{"name":"Sriwijaya Journal of Otorhinolaryngology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124355502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0