Molecular Biomarkers as Predictors of Treatment Response and Survival Outcomes in Head and Neck Squamous Cell Carcinoma: A Retrospective Cohort Study at a Singapore Tertiary Hospital

Sriwijaya Journal of Otorhinolaryngology Pub Date : 2024-08-09 DOI:10.59345/sjorl.v2i1.151

Martin Curtis Lee, Nazilah Amir

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Abstract

Introduction: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with variable treatment responses. Identification of molecular biomarkers could personalize treatment and improve outcomes. Methods: A retrospective cohort study was conducted at a tertiary hospital in Singapore. Patients with HNSCC treated between 2018-2023 were included. Pretreatment tumor biopsies were analyzed for biomarker expression (PD-L1, EGFR, TP53, HPV status) using immunohistochemistry and PCR. Clinical data were collected from medical records. Treatment response, survival, and associations with biomarkers were analyzed. Results: 250 patients were included. PD-L1 expression was associated with improved response to immunotherapy (p = 0.02). EGFR overexpression correlated with worse overall survival (p = 0.01). TP53 mutations were linked to increased locoregional recurrence (p = 0.03). HPV-positive tumors had a better prognosis (p < 0.001). Conclusion: Molecular biomarkers show promise in predicting treatment response and survival in HNSCC. Integration of these markers into clinical practice could facilitate personalized treatment strategies.

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预测头颈部鳞状细胞癌治疗反应和生存结果的分子生物标记物：新加坡一家三级医院的回顾性队列研究

简介：头颈部鳞状细胞癌（HNSCC头颈部鳞状细胞癌（HNSCC）是一种异质性疾病，对治疗的反应各不相同。鉴定分子生物标志物可实现个性化治疗并改善疗效。研究方法新加坡一家三级医院开展了一项回顾性队列研究。纳入了2018-2023年间接受治疗的HNSCC患者。使用免疫组化和 PCR 分析治疗前肿瘤活检的生物标记物表达（PD-L1、EGFR、TP53、HPV 状态）。临床数据来自医疗记录。分析治疗反应、存活率以及与生物标记物的关联。结果：共纳入 250 例患者。PD-L1 表达与免疫疗法反应的改善有关（p = 0.02）。表皮生长因子受体（EGFR）过表达与总生存率降低相关（p = 0.01）。TP53突变与局部复发增加有关（p = 0.03）。HPV阳性肿瘤的预后较好（p < 0.001）。结论分子生物标志物有望预测 HNSCC 的治疗反应和生存率。将这些标志物纳入临床实践可促进个性化治疗策略的制定。

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Sriwijaya Journal of Otorhinolaryngology

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