Vestnik dermatologii i venerologii最新文献

{"title":"Deficient skin proteins rescue of expression in patients with epidermolysis bullosa: efficacy of gentamicin","authors":"O. G. Artamonova, A. Karamova, A. Kubanov, V. Chikin, E. Monchakovskaya","doi":"10.25208/vdv16737","DOIUrl":"https://doi.org/10.25208/vdv16737","url":null,"abstract":"Epidermolysis bullosa is a group of rare hereditary skin diseases based on mutations in the genes of structural proteins of the epidermis and the dermal-epidermal junction. Clinically, epidermolysis bullosa is characterized by the appearance of erosions and blisters on the skin and mucous membranes in response to any minor impact. Currently, the treatment of epidermolysis bullosa is only symptomatic. Pathogenetic methods of the epidermolysis bullosa therapy are under development. One of the new possible pathogenetic directions in the treatment of epidermolysis bullosa is aminoglycoside antibiotics (gentamicin, geneticin, paromomycin). A number of studies have shown the ability of gentamicin to promote readthrough terminating codon and resume the synthesis of type VII collagen in keratinocytes and fibroblasts in patients with epidermolysis bullosa with nonsense mutations in the COL7A1. The review presented the possibilities of gentamicin therapy for patients with epidermolysis bullosa, describes the mechanism of its action, summarizes data from clinical trials.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"265 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult path to the diagnosis of chromomycosis","authors":"T. Melnikova, Nataliya Burtseva, Tatiana Alekseevna Cheboksarova, Evgeniy Vladislavovich Sokolovskiy","doi":"10.25208/vdv13276","DOIUrl":"https://doi.org/10.25208/vdv13276","url":null,"abstract":"Chromomycosis is a slowly occurring mycosis of subcutaneous adipose tissue and skin. Most often, cases of the disease are recorded in countries with a tropical and subtropical climate. In the Russian Federation, the disease occurs sporadically. Very rarely (2 cases out of 100) malignant transformation into squamous cell carcinoma occurs. The article presents a clinical case of chromomycosis. A description is given of a patient in whom squamous cell carcinoma was detected at the onset of the disease, which was the reason for treatment by oncologists. Six months later, the patient had a relapse in the area of the postoperative scar and a focus in the area of the right hand. Repeated biopsy with histological examination made it possible to establish the correct diagnosis. Interest in the above clinical case was caused by the detection of chromomycosis in a resident of the city of St. Petersburg, who was not in endemic areas, was not engaged in agricultural work, and denied the primary injury. Our patient experienced a rapid malignancy of the focus, after surgical treatment, a recurrence of deep mycosis occurred. A good effect was obtained from systemic antimycotic therapy.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult path to the diagnosis of chromomycosis","authors":"T. Melnikova, Nataliya Burtseva, Tatiana Alekseevna Cheboksarova, Evgeniy Vladislavovich Sokolovskiy","doi":"10.25208/vdv13276","DOIUrl":"https://doi.org/10.25208/vdv13276","url":null,"abstract":"Chromomycosis is a slowly occurring mycosis of subcutaneous adipose tissue and skin. Most often, cases of the disease are recorded in countries with a tropical and subtropical climate. In the Russian Federation, the disease occurs sporadically. Very rarely (2 cases out of 100) malignant transformation into squamous cell carcinoma occurs. The article presents a clinical case of chromomycosis. A description is given of a patient in whom squamous cell carcinoma was detected at the onset of the disease, which was the reason for treatment by oncologists. Six months later, the patient had a relapse in the area of the postoperative scar and a focus in the area of the right hand. Repeated biopsy with histological examination made it possible to establish the correct diagnosis. Interest in the above clinical case was caused by the detection of chromomycosis in a resident of the city of St. Petersburg, who was not in endemic areas, was not engaged in agricultural work, and denied the primary injury. Our patient experienced a rapid malignancy of the focus, after surgical treatment, a recurrence of deep mycosis occurred. A good effect was obtained from systemic antimycotic therapy.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPERIENCE WITH THE FIXED COMBINATION OF BENZOYL PEROXIDE AND CLINDAMYCIN IN ACNE THERAPY","authors":"Anna Andreevna Verchoumova, Vladislav Rinatovich Khairutdinov, Igor N. Telichko","doi":"10.25208/vdv16050","DOIUrl":"https://doi.org/10.25208/vdv16050","url":null,"abstract":"Background: acne is one of the most common dermatoses, affecting more than 9% of the world's population. Acne negatively affects the patients quality of life and self-esteem, often leading to the development of anxiety and depression. The combination of pharmacological drugs with different mechanisms of action in one external dosage form can provide higher therapeutic efficacy.Objectives: to evaluate the effectiveness and tolerability of a combination drug with a fixed dose of clindamycin 1% and benzoyl peroxide 5% in the treatment of patients with mild to moderate papulopustular acne.Methods: a single-center, open-label, observational, prospective study lasting 6 weeks was performed, which included 40 patients with mild to moderate papulopustular acne who received a gel with a fixed dose of clindamycin 1% and benzoyl peroxide 5% once a day. A clinical assessment of the effectiveness of therapy was carried out, ph, greasiness and moisture of the facial skin were measured, and the dynamics of the dermatological quality of life index was studied.Results: the proportion of patients who showed significant improvement at the end of 6 weeks of treatment was 32/40 (80%). The total proportion of patients who showed significant and moderate improvement at the end of therapy reached 36/40 (90%). \u0000Conclusion: the results obtained showed the high therapeutic effectiveness of the gel with a fixed dose of clindamycin 1% and benzoyl peroxide 5% in the treatment of mild to moderate papulopustular acne.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"145 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the epidemiological situation and dynamics of the incidence of sexually transmitted infections in the Russian Federation over a ten-year period (2012-2022)","authors":"M. Rakhmatulina, E. Novoselova, L. Melekhina","doi":"10.25208/vdv16741","DOIUrl":"https://doi.org/10.25208/vdv16741","url":null,"abstract":"Sexually transmitted infections (STIs) are socially significant diseases and require close attention due to the multifactorial causes that influence their spread. In 2012-2022, the Russian Federation maintained a downward trend in the incidence of STIs (from 267.6 to 91.3 cases per 100 thousand population), established since 1998 in all age groups. In 2022, compared to 2012, the incidence rates decreased: syphilis - by 42.7%, gonococcal infection - by 77.7%, trichomoniasis - by 75.8%, chlamydial infections - by 72.1%, anogenital herpetic infection - by 51.2%, anogenital (venereal) warts – by 36.5%. \u0000But at the same time, in 2021 and 2022, there was an increase in the incidence of syphilis and gonococcal infection: compared to 2019, the increase in the incidence of syphilis was 25.9%, and that of gonococcal infection - 5.2%. The increase in the incidence of syphilis was largely due to an increase in this indicator in the Central (from 18.1 to 37.3 cases per 100 thousand population) and Northwestern (from 14.5 to 16.2 cases per 100 thousand population) federal districts ( FO). An increase in the incidence of gonococcal infection in 2022 compared to 2019 was observed in the Central (+26.3%), Northwestern (+31.2%) and Ural (+27.6%) Federal Districts.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"103 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the epidemiological situation and dynamics of the incidence of sexually transmitted infections in the Russian Federation over a ten-year period (2012-2022)","authors":"M. Rakhmatulina, E. Novoselova, L. Melekhina","doi":"10.25208/vdv16741","DOIUrl":"https://doi.org/10.25208/vdv16741","url":null,"abstract":"Sexually transmitted infections (STIs) are socially significant diseases and require close attention due to the multifactorial causes that influence their spread. In 2012-2022, the Russian Federation maintained a downward trend in the incidence of STIs (from 267.6 to 91.3 cases per 100 thousand population), established since 1998 in all age groups. In 2022, compared to 2012, the incidence rates decreased: syphilis - by 42.7%, gonococcal infection - by 77.7%, trichomoniasis - by 75.8%, chlamydial infections - by 72.1%, anogenital herpetic infection - by 51.2%, anogenital (venereal) warts – by 36.5%. \u0000But at the same time, in 2021 and 2022, there was an increase in the incidence of syphilis and gonococcal infection: compared to 2019, the increase in the incidence of syphilis was 25.9%, and that of gonococcal infection - 5.2%. The increase in the incidence of syphilis was largely due to an increase in this indicator in the Central (from 18.1 to 37.3 cases per 100 thousand population) and Northwestern (from 14.5 to 16.2 cases per 100 thousand population) federal districts ( FO). An increase in the incidence of gonococcal infection in 2022 compared to 2019 was observed in the Central (+26.3%), Northwestern (+31.2%) and Ural (+27.6%) Federal Districts.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"58 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A patient with severe acne: therapy perspectives","authors":"Tatyana Trapeznikova, O. Letyaeva, Oleg . Ziganshin, Valeria Gubina","doi":"10.25208/vdv9838","DOIUrl":"https://doi.org/10.25208/vdv9838","url":null,"abstract":"Acne is a common dermatological disease that peaks between 12 and 25. The tendency of inflammatory elements to appear on the skin, especially the face, leads to psycho-emotional imbalance and significantly reduces the patient’s quality of life. In 95% of cases, the outcome of acne is the formation of cicatricial deformities, the treatment of which often takes years. If inflammatory elements are present, treatment should be aimed at ensuring a long-term remission of the disease, including preventing the formation of new scars. \u0000This work aims to determine the efficacy and safety of acne treatment using systemic isotretinoin. \u0000The article presents the results of systemic isotretinoin use in severe forms of acne and acne that is resistant to standard treatments based on clinical cases. It was proved that the benefits obtained from isotretinoin usage are much more significant than the possible risk of side effects, especially if the patient’s skin tends to scar. The latest data on the etiology and pathogenesis of cicatricial deformities is presented. A review of modern techniques for the correction of post-acne cicatricial deformities was carried out. \u0000Isotretinoin is clinically proven to be highly effective and safety safe for both severe acne. \u0000The use of isotretinoin to treat acne is effective and reduces the risk of scarring.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"82 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of using a combination of laser radiation with wavelengths of 585 and 1064 nm in the treatment of patients with basal cell skin cancer","authors":"Rifat R. Saytburkhanov, X. Plakhova, I. N. Kondrakhina, А. A. Kubanov","doi":"10.25208/vdv16047","DOIUrl":"https://doi.org/10.25208/vdv16047","url":null,"abstract":"Background. Basal cell skin cancer is the most common skin malignancy, and its incidence has been rapidly increasing throughout the world in recent decades. \u0000Aims. To study the effectiveness of using laser radiation with a wavelength of 585 nm and 1064 nm in a sequential (sequential) combined mode for the treatment of patients with superficial and nodular forms of basal cell skin cancer using dermoscopic and confocal microscopic in vivo examination. \u0000Materials and methods. The study included 30 patients with histologically confirmed basal cell skin cancer, who received treatment in the conditions of the Consultative and Diagnostic Center of the State Research Center of Dermatovenereology and Cosmetology of Russian Ministry of Health in the period from 2020 to 2021, using a pulsed dye laser (wavelength 585 nm) and long-pulse neodymium laser (wavelength 1064 nm). \u0000Results. In the subgroup of patients with the nodular form of basal cell carcinoma (n = 15): in 11 patients the duration of treatment was 1 procedure, in 3 patients – 2 procedures, in 1 patient — 3 procedures. In the subgroup of patients with superficial basal cell carcinoma (n = 15 ): in 2 patients the course of treatment was 2 procedures, in 13 patients — 1 procedure. Patients have now completed treatment and are being followed up with visits every 6 months for 3 years. According to dermoscopic and confocal microscopic studies, there is no evidence of continued growth and relapse in all patients. No side effects or adverse events were recorded. \u0000Conclusions. The combined sequential use of 585 nm and 1064 nm laser radiation may be an effective treatment for patients with low-risk basal cell skin cancer of recurrence. The results of our study indicate that clinical tumor removal without scarring can be achieved and may be an alternative treatment option for those who do not wish to use traditional surgical approaches.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"696 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic therapy of rosacea with systemic tetracyclines","authors":"Alexey Samtsov","doi":"10.25208/vdv14701","DOIUrl":"https://doi.org/10.25208/vdv14701","url":null,"abstract":"The article presents modern data on the pathophysiology of rosacea and diagnostic criteria for dermatosis. The historical aspects of the introduction of systemic tetracyclines into the therapy of rosacea are outlined. The effect of doxycycline and minocycline on the mechanisms of rosacea development is covered in detail, taking into account modern ideas about the pathogenesis of the disease. At the same time, the advantage of minocycline, compared with doxycycline, is noted, which is manifested by a more pronounced anti-inflammatory effect, as well as a higher antibacterial efficacy, which allows the use of low dosages of minocycline and thereby reduces the risk of adverse events, especially from the gastrointestinal tract. The data of various studies are presented, indicating the expediency of prescribing subantimicrobial doses, as well as the results of evaluating the effectiveness and safety of domestic minocycline minoleksin. It has been proven that the effectiveness of tetracyclines is associated with a pathogenetic effect on innate immunity reactions, with a pronounced anti-inflammatory effect, especially minocycline, suppression of a number of microorganisms, which, apparently, are not a key link in the pathogenesis of rosacea, but can be a trigger factor and initiate inflammation. In addition, minocycline most effectively inhibits the activity of metalloproteinases and increases epidermal hydration","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"451 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current communication and behavioral aspects of HIV and STIs: findings from a survey of Medical University students","authors":"A. A. Khryanin, T. А. Shpiks, M. V. Russkikh","doi":"10.25208/vdv14865","DOIUrl":"https://doi.org/10.25208/vdv14865","url":null,"abstract":"Aims: To assess the specifics of sexual behavior and awareness among young people regarding STIs and HIV infection, as well as to study the attitude and degree of readiness to help HIV-infected patients among medical university students. \u0000Materials and methods: To assess the level of awareness on STI and HIV prevention and risky sexual behavior, a sociological survey was conducted through an anonymous questionnaire with the signing of voluntary anonymous consent. To identify the psychological features of the students, which may influence the behavior, the propensity to risk, the attitude towards the disease, the method of assessing the level of communicative tolerance of V.V. Boyko was used. The distribution of responses was analyzed for the entire population of respondents, a representative appropriate volume for each questionnaire. Statistical analysis was performed using Microsoft Excel and SPSS. The 2 criterion and Student's independent t-criterion were assessed. Statistical significance was set as p0.05. \u0000Results: A total of 565 4th year NSMU students participated in the study which was conducted from 2022-2023. The results of the study demonstrated that the use of the Internet among young people as a source of information about STIs and HIV infection is becoming more popular year by year. The sexual behavior of the students participating in the study was characterized as risky. It was found that medical students (20.5%) experience fear of HIV infection when providing medical care to HIV-infected patients. The level of professional communicative tolerance of future physicians is assessed as high. \u0000Conclusions: The low level of awareness among young people with regard to sexual health requires strengthening the implementation of existing activities on primary prevention of STIs and HIV infection, as well as the introduction of new preventive measures for these infections, adapted to the needs of young people.The ignorance of the legal aspects of providing care to HIV-infected patients, which was revealed in the course of the survey among medical students, requires more detailed study of these issues during the preparation of future doctors for professional activities.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}