Volume 5,Issue 1,2019最新文献

{"title":"Effect of Costus igneus Leaf Juice on Antidiabetic Activity of Glimepiride in Rats – A Suggestive Study","authors":"K. Akhil, B. .","doi":"10.30799/JNPR.075.19050103","DOIUrl":"https://doi.org/10.30799/JNPR.075.19050103","url":null,"abstract":"Article history: Received 30 March 2019 Accepted 20 April 2019 Available online 06 May 2019 Due to therapeutic efficacy, Costus igneus Nak. (CI), (popularly known as insulin plant) is one medicinal plant in the limelight of having cure for diabetes. An oral diabetic agent Glimepiride was selected to evaluate the activity in per se and in combination with Costus igneus. The study drugs (glimepiride or Costus igneus leaf juice) were administered orally and blood glucose levels were determined using Glucometer at stipulated time intervals. It perhaps works in pathophysiologic/metabolic deranged conditions as observed by its per se effect in streptozotocin-induced diabetic rats’ contrast to its effect in normal rats. The results of our study confirm that, the combined action of glimepiride and Costus igneus leaf juice has greater antidiabetic effects than their individual effects (per se).","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87301257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antimicrobial and Antifungal Activity of Chemical Constituents Isolated from Vernonia guineensis Roots (Asteraceae)","authors":".. Y.O.NgansoDitchou, A. K. Doutsing, .. M.T.G.MalaOpono, .. B.Nyasse","doi":"10.30799/JNPR.076.19050102","DOIUrl":"https://doi.org/10.30799/JNPR.076.19050102","url":null,"abstract":"","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78527223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing Subsistence of Host Guest Inclusion Complexes of Oligosaccharides with Allopurinol for Regulatory Release with the Manifestation of Solvation Consequences","authors":"J. Mondal, Ashutosh Dutta, K. Das, D. Das, P. Karmakar, S. Sengupta, A. Bhattacharya, R. Das, M. Roy","doi":"10.30799/jacs.205.19050105","DOIUrl":"https://doi.org/10.30799/jacs.205.19050105","url":null,"abstract":"Article history: Received 09 February 2019 Accepted 01 March 2019 Available online 05 May 2019 The inspection of molecular interaction widespread in allopurinol and in aqueous solutions of α-, and HP-β-cyclodextrin have been probed by thermophysical properties. The established complexes obtained with 1:1 stoichiometry. Role of solvent (aqueous solution of α-CD, -CD, HP-β-CD) and contribution of solute–solute and solute–solvent interactions to solution complexes, have also been analyzed via stability constant-NMR, UV, steady state fluorescence, FTIR, HRMS, SEM, PXRD, cytotoxicity, hydrophobic effect, hydrogen-bonding, structural effects in creation of inclusion complexes.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76353477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects on the Phagocytosis Modulation of Stems Extract and Triterpenes from Gouania longipetala (Hemsl.), A Plant of The Cameroonian Pharmacopeia","authors":"S. B. Tamo, S. R. Essama, O. N. Eteme, T.J.L. Mundene, J. Ze, E. T. Ngalani, D. K. Setchaba, B. Nyassé, F. Etoa","doi":"10.30799/JNPR.073.19050101","DOIUrl":"https://doi.org/10.30799/JNPR.073.19050101","url":null,"abstract":"Article history: Received 23 December 2018 Accepted 07 March 2019 Available online 17 April 2019 Immunomodulatory therapy is now being recognized as an alternative to conventional chemotherapy for a variety of disease conditions, involving the impaired immune response of the host. The goal of this study is to valorize Gouania longipetala (Hemsl.) like potential source of drugs against immune system dysfunction. This medicinal plant is commonly used in the Cameroonian pharmacopeia to cure a lot of diseases including inflammatory diseases. In this work, we evaluated the immunomodulation properties of infused stems extract (GLE) and triterpenes from G. longipetala (Hemsl.), with respect to the phagocytosis. GLE was obtained by infusion of dry bark powder in water and the triterpenes were isolated after fractionation of GLE in solvent systems following by column chromatography. The structure elucidation of isolated compounds was based on analysis of spectroscopic data including 1Dand 2D-NMR. The immunomodulation activity was evaluated by two methods. Firstly, the capacity of GLE and triterpenes to modulate phagocytic activity of polymorphonuclear (PMNs) cells was assessed in vitro against Candida albicans. Secondly, the ability of GLE to modulate reticuloendothelial system was investigated in vivo on wistar rats by carbon clearance test. Two triterpenes were isolated, alphitolic and epigouanic acids. The stimulation percentage of PMNs by plant extracts was ranged between 4.25 and 42.55% with GLE and between 14.89 and 46.80% with alphitolic acid. Epigouanic acid show biphasic activity profile, with stimulation of phagocytic activity of PMNs cells at lower concentrations and suppression effects at higher concentrations. In vivo test showed that GLE liberates the glutathione particles from animal’s liver and enhance the phagocytic activity by stimulating the reticuloendothelial system. The phagocytic index obtained was ranged between 0.020 ± 0.004 and 0.074 ± 0.006. The results obtained from this study show that extract from G. longipetala (Hemsl.) modulate phagocytic activity and would be therefore the potential sources of drugs against immunological disorders.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83865314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Physicochemical Properties and Toxic Heavy Metals Levels in Honey Samples from West of Libya","authors":"A. Salama, A. Etorki, M. Awad","doi":"10.30799/JACS.207.19050104","DOIUrl":"https://doi.org/10.30799/JACS.207.19050104","url":null,"abstract":"Article history: Received 23 February 2019 Accepted 21 March 2019 Available online 16 April 2019 This study was done to investigate the physicochemical properties of bee honey samples collected from different locations in west of Libya. The concentration of essential elements (Na, K, and Ca), and toxic heavy metals (Pb, Cd, Hg, and As) in honey samples were determined by flame photometer, and atomic absorption spectrometer. The results showed significant variation among the honey samples may be attributed to the plants floral types, which indicate that the mean values of moisture ranged from 20.6 to 25.1% was a slight higher than the Codex limit 20%, pH mean values 4.12 to 4.74, free acid equivalent 20 to 27 m eq./kg, total dissolved substance 646 to 994 ppm, and specific conductivity 638.5 to 1004 μS/cm. The mean values of minerals concentration in (mg/kg) such as potassium were ranged from 1120.1 to 1980.6, sodium 506.8 to 804.6, calcium 923.92 to 1117.5, lead 2.42 to 10.98, cadmium 0.125 to 0.150, mercury 0.021 to 0.10, and arsenic 0.006 to 0.018. The results revealed that the concentration of Hg and As in honey samples confine with the Codex range, on the other hand the study indicated that the concentration of Pb and Cd in honey confine with some international specifications and different with some others. The honey study may be useful for assessing the presence of environmental contaminants.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89823467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave Assisted Synthesis of Zinc Oxide Nanoparticles and Its Antimicrobial Efficiency","authors":". R.Deepa, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran","doi":"10.30799/JNST.215.19050116","DOIUrl":"https://doi.org/10.30799/JNST.215.19050116","url":null,"abstract":"Article history: Received 05 March 2019 Accepted 27 March 2019 Available online 31 March 2019 Zinc oxide (ZnO) nanoparticles have been synthesized via microwave-assisted method. The structural analysis was carried out using X-ray diffractometer. It showed that the ZnO nanoparticle exhibited hexagonal structure. Further the ZnO product was investigated by FT-IR and SEM analysis. Also antimicrobial efficiency in different concentrations have been studied and found good activity against Escherichia coli.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76017490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Investigation of Antimicrobial Activity of Tin Oxide Nanoparticles by Microwave Assisted Solution Method","authors":". S.Rajeswari, . J.UmaMaheswari, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran","doi":"10.30799/JNST.214.19050115","DOIUrl":"https://doi.org/10.30799/JNST.214.19050115","url":null,"abstract":"Article history: Received 05 March 2019 Accepted 27 March 2019 Available online 31 March 2019 Tin oxide (SnO2) nanoparticles have been synthesized via microwave-assisted solution method. The structural analysis was carried out using X-ray diffraction. It showed that the SnO2 nanoparticle exhibited primitive tetragonal structure. The SnO2 product was investigated by FT-IR, UV, SEM and antimicrobial activity studies of SnO2 have confirmed that they have biomedical applications.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91383312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of ZrO2 Nanoparticles using Microwave Assisted Method and Its Antimicrobial Activity","authors":". S.BabyAsha, . D.Muthuraj, . E.Kumar, . V.Veeraputhiran","doi":"10.30799/JNST.216.19050117","DOIUrl":"https://doi.org/10.30799/JNST.216.19050117","url":null,"abstract":"","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88449606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Structural Characteristics of Fe Doped ZnO Nanoparticles at Different Molarities and Temperatures","authors":"Anup Kr Kalita, S. Karmakar","doi":"10.30799/JNST.213.19050118","DOIUrl":"https://doi.org/10.30799/JNST.213.19050118","url":null,"abstract":"Article history: Received 04 March 2019 Accepted 30 March 2019 Available online 30 April 2019 Iron doped zinc oxide (Fe:ZnO) nanoparticles are prepared by wet chemical method at different molarities (0.025 M, 0.05 M and 0.1 M) and different temperatures (RT and 473 K). The nanoparticles are studied by X-ray diffraction (XRD), transmission electron microscopy (TEM) techniques. Crystallite sizes and lattice strain of nanoparticles are calculated by Williamson Hall (W-H) method. The average particle size of the nanoparticle is also calculated by Scherrer formula. Uniform deformation model (UDM), unifrom stress deformation model (USDM) and uniform deformation energy density model (UDEDM) are used to calculate stress, strain, and energy density involved in the sample. We get different particle sizes of nano particle perpendicular to different (hkl) planes. This shows that particles are not spherical in nature, particles are like rectangular block. It has been also observed from transmission electron micrograph that particles are of rectangular block types. The annealed sample shows larger particle size compared to the sample prepared at room temperature, which is an input for band gap engineering studies.","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"38 11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72688617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Characterization of Copper and Boron Codoped TiO2 Nanomaterials for the Photocatalytic Degradation of Methyl Orange Dye","authors":"S. A. Alim, T. Rao, M. R. Kumar","doi":"10.30799/JNST.209.19050113","DOIUrl":"https://doi.org/10.30799/JNST.209.19050113","url":null,"abstract":"","PeriodicalId":23586,"journal":{"name":"Volume 5,Issue 1,2019","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80053139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}