J. Mondal, Ashutosh Dutta, K. Das, D. Das, P. Karmakar, S. Sengupta, A. Bhattacharya, R. Das, M. Roy
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Probing Subsistence of Host Guest Inclusion Complexes of Oligosaccharides with Allopurinol for Regulatory Release with the Manifestation of Solvation Consequences
Article history: Received 09 February 2019 Accepted 01 March 2019 Available online 05 May 2019 The inspection of molecular interaction widespread in allopurinol and in aqueous solutions of α-, and HP-β-cyclodextrin have been probed by thermophysical properties. The established complexes obtained with 1:1 stoichiometry. Role of solvent (aqueous solution of α-CD, -CD, HP-β-CD) and contribution of solute–solute and solute–solvent interactions to solution complexes, have also been analyzed via stability constant-NMR, UV, steady state fluorescence, FTIR, HRMS, SEM, PXRD, cytotoxicity, hydrophobic effect, hydrogen-bonding, structural effects in creation of inclusion complexes.
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