UltrasonicsPub Date : 2025-06-24DOI: 10.1016/j.ultras.2025.107741
Zhiheng Chen , Hongyuan Zhao , Yueying Hou , Enrui Zhang , Sicheng Yan , Junheng Yao , Xiaodong Xu , Xue-Jun Yan , Ming-Hui Lu , Yan-Feng Chen
{"title":"Characterization of multilayer films using ultrafast photoacoustic technology and artificial intelligence","authors":"Zhiheng Chen , Hongyuan Zhao , Yueying Hou , Enrui Zhang , Sicheng Yan , Junheng Yao , Xiaodong Xu , Xue-Jun Yan , Ming-Hui Lu , Yan-Feng Chen","doi":"10.1016/j.ultras.2025.107741","DOIUrl":"10.1016/j.ultras.2025.107741","url":null,"abstract":"<div><div>A high-precision nanoscale characterization technology for multilayer films is critical in microelectronics, optoelectronics and bio-medicine. Ultrafast photoacoustic technology provides non-contact structural profiling with sub-nanometer resolution. In this study, an advanced scheme combining ultrafast photoacoustic method and Artificial Intelligence (AI) is applied to automatically measure the thicknesses and crystal orientations of multilayer thin films and superlattices. We developed a dataset using a multilayer photoacoustic theoretical model consistent with experimental results. To mitigate experimental noise, we applied a variational mode decomposition (VMD)-backpropagation neural network (BPNN) algorithm and an AlexNet framework for samples properties prediction. Characterization results in SiO<sub>2</sub>, LiNbO<sub>3</sub> multilayers and GaAs/AlAs superlattices verify that this AI-based scheme can automatically get the knowledge of multiple properties with a higher precision in principle. This method enables tomographic detection of complex nanostructures and offers a novel approach for real-time monitoring of integrated devices and biomedical imaging.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107741"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144516969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-24DOI: 10.1016/j.ultras.2025.107726
Connor Challinor, Frederic Cegla
{"title":"On the robustness of coded excitation in ultrasonic acquisition systems","authors":"Connor Challinor, Frederic Cegla","doi":"10.1016/j.ultras.2025.107726","DOIUrl":"10.1016/j.ultras.2025.107726","url":null,"abstract":"<div><div>Coded excitation has been shown to be a simple yet effective technique for improving signal quality in ultrasonic active ranging applications. Despite many reported benefits, uptake of coded excitation in industrial applications to date has been minimal. The authors speculate that this can be in part attributed to a lack of understanding of the robustness of the technique in practical use. To combat this, this paper reports on research into the main mechanisms that can introduce performance degradation and describes the effect of the two most important mechanisms, referred to as symbol asymmetry and symbol misalignment. These mechanisms lower output signal quality through the introduction of unexpected signal artifacts, as well as by reducing useful signal amplitude. We show how symbol asymmetry can be introduced through hardware imperfections and the relative degradation severity associated with different imperfection types. We similarly show how symbol misalignment can be introduced when using coded excitation in non-stationary situations. As a result, we formulate the minimum hardware requirements and inspection conditions required to correctly utilise coded excitation such that users can be confident of achieving high quality outcomes. We quantitatively simulate and experimentally verify the output signal degradation across many scenarios to identify the operating conditions that need to be satisfied to ensure that degradation does not exceed an arbitrarily chosen threshold of 40 dB (the noise floor from random noise in our experimental setup).</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107726"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-24DOI: 10.1016/j.ultras.2025.107718
Dongdong Liang , Jiabin Zhang , Di Wang , Xiaoyu Qian , Feihong Dong , Jinyu Yang , Yunlong Bao , Jue Zhang
{"title":"Sparse aperture ultrasound-guided acoustic vortex tweezers for real-time microbubble aggregation in peripheral vasculature","authors":"Dongdong Liang , Jiabin Zhang , Di Wang , Xiaoyu Qian , Feihong Dong , Jinyu Yang , Yunlong Bao , Jue Zhang","doi":"10.1016/j.ultras.2025.107718","DOIUrl":"10.1016/j.ultras.2025.107718","url":null,"abstract":"<div><h3>Objective:</h3><div>Acoustic vortex tweezers (AVT) have potential to enhance the targeting efficiency of drug-loaded microbubbles (MBs). However, three major challenges remain: poor real-time imaging quality with single matrix probe, difficulty in switching between imaging and AVT emission, and difficulty in using real-time imaging to guide AVT focusing. In this study, we propose a novel approach to address these challenges through the application of a sparse-aperture emission strategy integrating ultrasound flow-imaging and AVT techniques.</div></div><div><h3>Methods:</h3><div>We present a real-time blood flow imaging (BFI) navigated AVT technique. Acoustic field characterization was conducted to compare sparse and full-aperture configurations using hydrophone measurements. Pulse parameter optimization for MBs aggregation efficiency was systematically analyzed using in vitro flow phantom models. Technical feasibility was ultimately evaluated through experiments in rabbit hindlimb venous vasculature.</div></div><div><h3>Results:</h3><div>The acoustic field of AVT at sparse aperture was consistent with that of full-aperture AVT. In the in vitro phantom, the acoustic pressure ranged from 0.35 to 0.65 MPa, with a pulse repetition frequency (PRF) greater than 1.5 kHz. This configuration effectively aggregated MBs at flow rates between 20 and 110 mL/h. We observed real-time venous blood flow in the lower limbs of rabbits and successfully guided AVT to aggregate MBs.</div></div><div><h3>Conclusion:</h3><div>This exploratory study combining BFI and AVT provides a novel approach for the controllable accumulation and quantitative release of drug-loaded MBs in future applications.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107718"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Singular value decomposition based motion magnification for B-mode visualization of magnetomotive ultrasound imaging","authors":"Wei-Hsiang Shen , Tzu-Min Yeh , Chih-Chia Huang , Zung-Hang Wei , Meng-Lin Li","doi":"10.1016/j.ultras.2025.107722","DOIUrl":"10.1016/j.ultras.2025.107722","url":null,"abstract":"<div><div>Magnetomotive ultrasound (MMUS) is a new modality for ultrasound imaging that detects magnetic nanoparticles within tissues. To localize these nanoparticles, an external oscillating magnetic field is used to induce magnetomotion of the nanoparticles, and motion tracking algorithms are used to track the motion sources, allowing the mapping of the nanoparticle distribution. The induced magnetomotion is generally at sub-wavelength and thus not visualizable to the naked eye in conventional B-mode imaging. In this work, we introduce a singular value decomposition (SVD)-based motion magnification technique for MMUS, enabling B-mode visualization of magnetomotion in B-mode imaging. An singular value filter (SVF) is designed adaptively to extract and amplify the induced magnetomotion of the nanoparticles in MMUS imaging, offering a visually clear representation of their dynamics and the associated shear wave propagation. We evaluated the technique using simulations, phantom experiments, and <em>in vivo</em> data. Our motion-magnified results reveal previously unseen motions of the nanoparticles, even in the presence of undesired motion noises. This research offers a new visualization mode for MMUS imaging.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"156 ","pages":"Article 107722"},"PeriodicalIF":3.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-23DOI: 10.1016/j.ultras.2025.107742
Yongqi Cui , Liang Zeng , Zhi Luo , Jiawei Ding
{"title":"Pipeline corrosion detection via group delay accumulation effect of multi-path circumferential guided wave packets","authors":"Yongqi Cui , Liang Zeng , Zhi Luo , Jiawei Ding","doi":"10.1016/j.ultras.2025.107742","DOIUrl":"10.1016/j.ultras.2025.107742","url":null,"abstract":"<div><div>Circumferential Guided Waves (CGW) inspection offers a prospective approach for detecting corrosion damage in metallic pipeline structures. It could be used to identify the circumferential location of defects and provide quantitative assessments of defects. Typically, the group delay of the first wave packet passing through the corroded region is utilized to evaluate the variation in group velocity due to corrosion. However, the initial corrosion may induce group delay variations that fall below the sampling interval, thereby existing below the detection limit of conventional Time-Of-Flight (TOF) approaches. In this circumstance, a pipeline corrosion detection method based on the group delay accumulation effect of CGW multi-path wave packets is presented in this paper. In particular, it estimates the group delay of multi-path wave packets of normal and corroded CGW responses using the discrete analytic cross-correlation method. The experimental results indicate that due to the accumulation effect of multi-path wave packets, the group delay of the wave packets passing through the corroded region exceeds the sampling frequency limitation and becomes detectable. The multi-path wave packets pass through the corroded region multiple times, and with each pass, the group delay is accumulated. Thus, the accumulated group delay of the wave packets could increase detection sensitivity. Additionally, the stability of variations in group delay and phase shift is also considered. The experimental results show that with the corrosion area increasing, the group delay could consistently maintain the accumulation effect, while the variation in phase shift is irregular.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107742"},"PeriodicalIF":3.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-20DOI: 10.1016/j.ultras.2025.107740
Weigang Zhao , Shunli Jiang , Haoran Li , Xiangtian Gong , Yaodong Qi , Jiaqi Liang , Yechu Tian
{"title":"Low signal-to-noise ratio acoustic emission signal arrival time identification method based on fractal dimension ratio and AR-AIC combined algorithm","authors":"Weigang Zhao , Shunli Jiang , Haoran Li , Xiangtian Gong , Yaodong Qi , Jiaqi Liang , Yechu Tian","doi":"10.1016/j.ultras.2025.107740","DOIUrl":"10.1016/j.ultras.2025.107740","url":null,"abstract":"<div><div>To enhance the accuracy of acoustic emission (AE) signal arrival time identification in low signal-to-noise ratio environments, this study introduces a method integrating the fractal dimension ratio and AR-AIC algorithm. The fractal dimension ratio is employed to estimate the potential arrival time range, while AR-AIC further refines the estimation to determine the precise arrival time. Pencil lead break (PLB) experiments were conducted on concrete specimens to evaluate the proposed method under various conditions, including high and low signal-to-noise ratios, indistinct arrivals, and low-amplitude signals. A comprehensive comparison with traditional threshold, STA/LTA, and AR-AIC algorithms was performed, along with an assessment of localization accuracy. Experimental results indicate that the proposed approach effectively mitigates the influence of signal-to-noise ratio and amplitude on arrival time identification. Compared to conventional methods, the localization error was reduced by 47%, 23%, and 17%, respectively. These findings demonstrate the effectiveness of the proposed method in enhancing AE signal arrival time identification and source localization in complex environments.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107740"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimating the properties of bone phantom cylinders through the inversion of axially transmitted low-frequency ultrasonic guided waves","authors":"Aubin Chaboty , Vu-Hieu Nguyen , Guillaume Haiat , Pierre Bélanger","doi":"10.1016/j.ultras.2025.107694","DOIUrl":"10.1016/j.ultras.2025.107694","url":null,"abstract":"<div><div>Early detection of osteoporosis has increasingly focused on ultrasonic methods, particularly guided waves in axial transmission to assess cortical bone properties. This study demonstrates the potential of low-frequency measurements (<span><math><mo><</mo></math></span>500 kHz) for accurately inferring cortical mechanical and geometrical properties. A custom ultrasonic transducer centered at 350 kHz was used to acquire data, processed via a 2D fast Fourier transform to obtain dispersion curves. These were compared with simulations generated using the semi-analytical iso-geometric analysis (SAIGA) method, modeling a quasi-cylindrical bone geometry in void or immersed in olive oil. By incorporating an excitability parameter into the inversion algorithm, the proposed method achieved a less than 5% discrepancy between bone phantom properties determined via SAIGA inversion and bulk wave pulse-echo measurements, demonstrating its accuracy and potential for in vivo applications. Results also showed that high-wavenumber modes predominantly reflect material properties, whereas low-wavenumber modes below 100 kHz are sensitive to the overall bone geometry, highlighting the importance of low frequencies for a global bone characterization.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107694"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144469954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-20DOI: 10.1016/j.ultras.2025.107734
Bertrand Mathon , Vincent Navarro , Thomas Pons , Sarah Lecas , Delphine Roussel , Stéphane Charpier , Alexandre Carpentier
{"title":"Ultrasound-induced blood–brain barrier opening and selenium-nanoparticle injection lower seizure activity: A mouse model of temporal lobe epilepsy","authors":"Bertrand Mathon , Vincent Navarro , Thomas Pons , Sarah Lecas , Delphine Roussel , Stéphane Charpier , Alexandre Carpentier","doi":"10.1016/j.ultras.2025.107734","DOIUrl":"10.1016/j.ultras.2025.107734","url":null,"abstract":"<div><h3>Background</h3><div>Given the limitations of current treatment options for drug-resistant mesial temporal lobe epilepsy (MTLE), the development of novel, nonablative and minimally invasive surgical techniques is essential.</div></div><div><h3>Objective and Methods</h3><div>In this study, low-intensity pulsed ultrasound (LIPU)- and microbubble-induced (henceforth LIPU) blood–brain barrier (BBB) opening combined with selenium-nanoparticle (SeNP) intravenous injection in a mouse model of mesial temporal lobe optimized the latter’s bioavailability in the brain epileptic tissue of the kainic acid (KA) mouse model of MTLE. We aimed to assess the safety and antiepileptic potential of LIPU-enhanced SeNP delivery against KA-induced seizures using long-term intracranial electroencephalogram video recordings and evaluating neuroinflammation, astrogliosis, neuronal apoptosis and neurogenesis in the hippocampal tissues of mice.</div></div><div><h3>Results</h3><div>First, we established that SeNP intravenous injection combined with LIPU-induced BBB disruption was the most effective method to achieve high and sustained selenium levels in the brain. The safety of this treatment was demonstrated after three treatment sessions, 1-week apart, with no adverse effects observed. Our results further showed a significantly lower frequency of epileptic seizures (–90 %, <em>P</em> = 0.001) in KA mice treated with LIPU + SeNPs compared to sham-treated controls. Short- and long-term histological changes were seen after that combined regimen, including less aberrant neurogenesis in the hippocampus hilum, less neuronal death throughout the hippocampus and less hippocampal microglial activation, which might collectively contribute to the observed antiseizure effect.</div></div><div><h3>Conclusion</h3><div>SeNP injection combined with LIPU-induced BBB disruption demonstrated potential as a promising approach to reduce seizure activity in MTLE; however, statistical comparison did not conclusively establish superiority over SeNPs alone. Further investigations are necessary to consider translational studies in humans.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107734"},"PeriodicalIF":3.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-19DOI: 10.1016/j.ultras.2025.107738
Tingzhen Feng , Tinghui Meng , Yuzhi Li , Gepu Guo , Juan Tu , Dong Zhang , Qingyu Ma
{"title":"Stable acoustic levitation based on coaxial confocal dual-frequency focused ultrasound and vortex beams","authors":"Tingzhen Feng , Tinghui Meng , Yuzhi Li , Gepu Guo , Juan Tu , Dong Zhang , Qingyu Ma","doi":"10.1016/j.ultras.2025.107738","DOIUrl":"10.1016/j.ultras.2025.107738","url":null,"abstract":"<div><div>Acoustic levitation enables the suspension of objects of different materials and scales through the acoustic radiation force (ARF), offering advantages of non-invasive, non-contact, deep penetration, label-free, and biocompatibility. However, achieving stable suspension using focused ultrasound (FU) or focused acoustic vortex (FAV) alone remains challenging due to the absence of both trapping and propulsive forces. This study proposes a stable acoustic levitation scheme that employs coaxial confocal dual-frequency FU and FAV beams, implemented by a focused sector array. Theoretical analyses of force balance for objects with the size much smaller than the wavelength are performed, and ARFs in both axial and radial directions are calculated based on the Gor’kov potential. It is demonstrated that the suspension capability primarily depends on the peak pressure of FU, with the minimum threshold determined by the object's gravity. A longer axial range of upward propulsion, characterized by a lower threshold height and a higher steady-state height, is created by a higher peak pressure of FU. The trapping force is governed by the peak-pressure ratio between FAV and FU, with a constant minimum ratio (0.69) being nearly independent of the density and size of objects. A high-precision dual-frequency holographic direct digital synthesis technology based on phase sampling is developed to design an 8-channel driving system capable of real-time adjustments to frequency, pressure, and phase. Focused fields composed of dual-frequency FU and FAV beams are constructed by an 8-element focused sector array. By independently regulating the peak pressures of FAV and FU, the upward and downward movements and stable suspension of polystyrene particles along the beam axis in water are successfully realized. The proposed scheme significantly enhances the stability and precision of on-axis acoustic levitation, validating its potential for contactless manipulation and container-free processing. Additionally, the dual-frequency holographic technology can improve the regulation flexibility of multiplexed fields, making it adaptable to diverse applications while reducing the driving complexity for source arrays.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107738"},"PeriodicalIF":3.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonicsPub Date : 2025-06-19DOI: 10.1016/j.ultras.2025.107739
Yuxin Yang , Zhongzhi Jin , Huijuan Zhou , Yirui Li , Wanjia Zhang , Yang Xiang , Dawei Wu , Chenghai Li , Faqi Li
{"title":"Wearable ultrasound regulation of blood glucose levels in type 2 diabetic db/db mice","authors":"Yuxin Yang , Zhongzhi Jin , Huijuan Zhou , Yirui Li , Wanjia Zhang , Yang Xiang , Dawei Wu , Chenghai Li , Faqi Li","doi":"10.1016/j.ultras.2025.107739","DOIUrl":"10.1016/j.ultras.2025.107739","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, imposes a notable burden on human health. Current treatments that require long-term medication and dietary control often face challenges with patient compliance. Although low-intensity pulsed ultrasound (LIPUS) shows promise in regulating blood glucose, the clinical application of traditional ultrasound devices remains challenging due to their large size and high cost. Through theoretical simulation, we designed and fabricated a wearable ultrasound patch with a frequency of 986 kHz and its wearable driving device for use in blood glucose regulation in db/db mice. The liver–pancreas region of the db/db mice was exposed to the wearable ultrasound device with the following parameters: frequency at 986 kHz, duty cycle at 30 %, pulse repetition frequency of 2 kHz, I<sub>SATA</sub> of 86.81 mW/cm<sup>2</sup>, and 10-min duration. Results showed that LIPUS-treated db/db mice exhibited a prolonged time for blood glucose to return to baseline levels after 8-week LIPUS exposure. Improved glucose tolerance, reduced insulin resistance, and decreased body weight were also observed. Liver morphology was well maintained, demonstrating LIPUS effectiveness in regulating blood glucose in db/db mice. Biological safety tests indicated no adverse effects on the tissues. This study demonstrates that the use of a wearable ultrasound device, through low-intensity pulsed ultrasound (LIPUS), can effectively regulate blood glucose levels in db/db mice. Our approach offers a noninvasive solution for regulating blood glucose levels in patients with T2DM and holds promise for ultrasound application in metabolic disease treatment.</div></div>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"155 ","pages":"Article 107739"},"PeriodicalIF":3.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}