Virchows Archiv最新文献_第2页

Apocrine variant of intraductal carcinoma of the parotid gland with sebaceous-like differentiation: expanding morphological and molecular spectrum of an enigmatic entity. 具有皮脂腺样分化的腮腺导管内癌的分泌变异型：一个神秘实体的形态学和分子谱扩展。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-24 DOI: 10.1007/s00428-024-03947-w

David João, Monica Feltri, Natalie Klubickova, Michal Michal, Denisa Kacerovská, Alena Skálová

引用次数: 0

Correction to: Abstracts 36th European Congress of Pathology - Abstracts. 更正：第 36 届欧洲病理学大会摘要 - 摘要。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-23 DOI: 10.1007/s00428-024-03950-1

Faris Kubba, N Pore, M Jagtiani

引用次数: 0

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know? 具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）：我们需要了解什么？

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-23 DOI: 10.1007/s00428-024-03953-y

Andrés Coca-Pelaz, Juan P Rodrigo, Abbas Agaimy, Dana M Hartl, Göran Stenman, Vincent Vander Poorten, Antti A Mäkitie, Mark Zafereo, Karthik N Rao, Gregory W Randolph, Alessandra Rinaldo, Alfio Ferlito

{"title":"Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?","authors":"Andrés Coca-Pelaz, Juan P Rodrigo, Abbas Agaimy, Dana M Hartl, Göran Stenman, Vincent Vander Poorten, Antti A Mäkitie, Mark Zafereo, Karthik N Rao, Gregory W Randolph, Alessandra Rinaldo, Alfio Ferlito","doi":"10.1007/s00428-024-03953-y","DOIUrl":"https://doi.org/10.1007/s00428-024-03953-y","url":null,"abstract":"Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule category characterized by follicular architecture with papillary nuclear features but lacking classical papillary carcinoma features like papillae or psammoma bodies. The diagnosis of NIFTP is based on histological examination and excludes cases with high-risk mutations like BRAFV600E. NIFTP carries a low risk of recurrence and distant metastasis, prompting a more conservative surgical approach compared to classical papillary thyroid carcinoma. The management of NIFTP typically involves lobectomy with postoperative monitoring of thyroglobulin levels and performing neck ultrasounds. While the identification of NIFTP represents a significant advancement in thyroid cancer diagnosis, challenges remain in refining preoperative diagnostic tools and establishing optimal long-term follow-up strategies. The objective of this review is to provide a comprehensive overview of NIFTP, including its histopathological characteristics, molecular profile, clinical presentation, diagnostic criteria, management strategies, and future research directions.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology. 在临床癌症治疗中报告体细胞变异：瑞士分子病理学学会的建议。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-23 DOI: 10.1007/s00428-024-03951-0

Yann Christinat, Baptiste Hamelin, Ilaria Alborelli, Paolo Angelino, Valérie Barbié, Bettina Bisig, Heather Dawson, Milo Frattini, Tobias Grob, Wolfram Jochum, Ronny Nienhold, Thomas McKee, Matthias Matter, Edoardo Missiaglia, Francesca Molinari, Sacha Rothschild, Anna Bettina Sobottka-Brillout, Erik Vassella, Martin Zoche, Kirsten D Mertz

{"title":"Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology.","authors":"Yann Christinat, Baptiste Hamelin, Ilaria Alborelli, Paolo Angelino, Valérie Barbié, Bettina Bisig, Heather Dawson, Milo Frattini, Tobias Grob, Wolfram Jochum, Ronny Nienhold, Thomas McKee, Matthias Matter, Edoardo Missiaglia, Francesca Molinari, Sacha Rothschild, Anna Bettina Sobottka-Brillout, Erik Vassella, Martin Zoche, Kirsten D Mertz","doi":"10.1007/s00428-024-03951-0","DOIUrl":"https://doi.org/10.1007/s00428-024-03951-0","url":null,"abstract":"Somatic variant testing through next-generation sequencing (NGS) is well integrated into Swiss molecular pathology laboratories and has become a standard diagnostic method for numerous indications in cancer patient care. Currently, there is a wide variation in reporting practices within our country, and as patients move between different hospitals, it is increasingly necessary to standardize NGS reports to ease their reinterpretation. Additionally, as many different stakeholders-oncologists, hematologists, geneticists, pathologists, and patients-have access to the NGS report, it needs to contain comprehensive and detailed information in order to answer the questions of experts and avoid misinterpretation by non-experts. In 2017, the Swiss Institute of Bioinformatics conducted a survey to assess the differences in NGS reporting practices across ten pathology institutes in Switzerland. The survey examined 68 reporting items and identified 48 discrepancies. Based on these findings, the Swiss Society of Molecular Pathology initiated a Delphi method to reach a consensus on a set of recommendations for NGS reporting. Reports should include clinical information about the patient and the diagnosis, technical details about the sample and the test performed, and a list of all clinically relevant variants and variants of uncertain significance. In the absence of a consensus on an actionability scheme, the five-class pathogenicity scheme proposed by the ACMG/AMP guideline must be included in the reports. The Swiss Society of Molecular Pathology recognizes the importance of including clinical actionability in the report and calls on the European community of molecular pathologists and oncologists to reach a consensus on this issue.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142508936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant epithelioid neoplasm with GLI1 gene rearrangement (PANX3::GLI1 transcript) and MDM2 gene amplification. 恶性上皮样肿瘤，伴有 GLI1 基因重排（PANX3::GLI1 转录本）和 MDM2 基因扩增。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-23 DOI: 10.1007/s00428-024-03949-8

Dmitry Konovalov, Anastasia Sharlai, Agnesa Panferova, Daria Korobova, Dmitrii Rogozhin, Alexander Druy

引用次数: 0

Combined immunohistochemical profile CD10/LMO2/MYC is a useful tool to screen MYC rearrangements in aggressive large B-cell lymphomas. CD10/LMO2/MYC联合免疫组化图谱是筛查侵袭性大B细胞淋巴瘤中MYC重排的有效工具。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-22 DOI: 10.1007/s00428-024-03945-y

Natalia Papaleo, Andrea Molina-Alvarez, Gustavo Tapia, Ricard Onieva, Marta Salido, Carmen Lome-Maldonado, Xavier Ara-Mancebo, Anna Puiggros, Blanca Espinet, Carmen Blazquez, Diana Fuertes, Blanca Sanchez-Gonzalez, Jose Yelamos, Xavier Calvo, Luis Colomo

{"title":"Combined immunohistochemical profile CD10/LMO2/MYC is a useful tool to screen MYC rearrangements in aggressive large B-cell lymphomas.","authors":"Natalia Papaleo, Andrea Molina-Alvarez, Gustavo Tapia, Ricard Onieva, Marta Salido, Carmen Lome-Maldonado, Xavier Ara-Mancebo, Anna Puiggros, Blanca Espinet, Carmen Blazquez, Diana Fuertes, Blanca Sanchez-Gonzalez, Jose Yelamos, Xavier Calvo, Luis Colomo","doi":"10.1007/s00428-024-03945-y","DOIUrl":"https://doi.org/10.1007/s00428-024-03945-y","url":null,"abstract":"Aggressive large B-cell lymphomas (LBCL) are a heterogeneous group of lymphomas with variable biological characteristics, for which the identification of MYC rearrangements (MYCr) is a defining and prognostic feature. Both the International Consensus Classification and the 5th edition of the World Health Organization Classification of Hematolymphoid Tumors recommend performing cytogenetic studies in all aggressive LBCL to detect MYCr. Since MYCr incidence is low, cost-effective screening tools are necessary. We asked whether the immunohistochemical combined profile of CD10, LMO2, and MYC could be a useful tool to screen for MYCr. For this purpose, we used two strategies: first, a scoring system assigning 0 points each for CD10 - , LMO2 + , and MYC - and 1 point for CD10 + , LMO2 - , and MYC + , adding the results, and second, an algorithm that selected tumors with CD10 + /LMO2 - profile and/or MYC overexpression. All analyses were performed in a training series including 482 cases from a single center and a validation series of 124 patients from two centers. The resulting system classified cases in scores from 0 to 3. Scores 0 and 1 had low MYCr (0/92 and 7/224, 3%, respectively), being higher for scores 2 (40/98, 41%) and 3 (61/68, 90%) (P < 0.001) in the training cohort. The incidence of MYCr in the validation series was as follows: score 0, 0/29 cases; score 1, 3/64 (5%); score 2, 10/23 (43.5%); score 3, 8/8 (P < 0.001). Sensitivity and negative predictive values were respectively 93.5% and 97.8% for the training and 85.7% and 96.8% for the validation cohorts. The algorithm rescued 2 and 1 MYCr cases included in score 1 from both series. In conclusion, we suggest that both approaches combining the interpretation of CD10/LMO2/MYC by immunohistochemistry are useful to screen for MYCr.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion. 细胞周期蛋白-D1重排是TP53缺失的脾边缘区淋巴瘤大细胞转化的继发事件。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-21 DOI: 10.1007/s00428-024-03946-x

Giby V George, Diana G Adlowitz, K Riley Okeson, Fatima Zahra Jelloul, Hong Fang, Wei Wang, Dennis P O'Malley, L Jeffrey Medeiros, Siba El Hussein

引用次数: 0

Pseudomyogenic hemangioendothelioma presenting as a penile lesion. 假性肌源性血管内皮瘤表现为阴茎病变。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-21 DOI: 10.1007/s00428-024-03944-z

Reem Youssef, Jessica L Davis, William J Anderson, Andres M Acosta

{"title":"Pseudomyogenic hemangioendothelioma presenting as a penile lesion.","authors":"Reem Youssef, Jessica L Davis, William J Anderson, Andres M Acosta","doi":"10.1007/s00428-024-03944-z","DOIUrl":"https://doi.org/10.1007/s00428-024-03944-z","url":null,"abstract":"Pseudomyogenic hemangioendothelioma (PHE) is a rare, usually multifocal neoplasm typically affecting individuals in the second-to-fourth decade of life, with a male predominance. It often arises in the distal extremities and characteristically involves multiple tissue planes. Presentation of this neoplasm as a primary penile lesion is exceedingly rare, with only five cases previously documented in the literature. We report the clinicopathologic features of five additional PHEs presenting as primary penile tumors and review previously published cases. Tumors affected young to middle-aged adult patients and had a relatively bland clinical appearance, mimicking indolent lesions such as epidermal inclusion cysts. Microscopically, they were ill-defined nodules composed of plump spindle cells and round neoplastic cells with abundant, densely eosinophilic cytoplasm and eccentric nuclei resembling rhabdomyoblasts. Neoplastic cells demonstrated infiltrative growth, including foci of perineural invasion. Immunohistochemistry demonstrated invariable co-expression of keratins, endothelial markers (CD31 and/or ERG), and FOSB. In conclusion, penile PHE is rare but should be considered in the differential diagnosis of penile lesions with spindle cell and/or rhabdomyoblast-like morphology affecting young to middle-aged adult patients.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary central nervous system diffuse large B-cell lymphoma with MYC and BCL2 rearrangements associated with deep brain stimulation device. 原发性中枢神经系统弥漫性大 B 细胞淋巴瘤，伴有 MYC 和 BCL2 重排，与脑深部刺激装置有关。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-18 DOI: 10.1007/s00428-024-03948-9

Kirill A Lyapichev, Sri Bharathi Kavuri, Patrick J Karas, Laura Wu, Nahyun Jo, John Heymann, Hadi Yaziji, Jianli Dong, Farkhod Tursunbaev, Rasha Alfattal, Michelle Madden Felicella

引用次数: 0

Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma. 肝细胞癌中肿瘤 CD147 表达、肿瘤浸润淋巴细胞和 oncostatin M 之间的关系

IF 3.4 3区医学

Virchows Archiv Pub Date : 2024-10-12 DOI: 10.1007/s00428-024-03939-w

Yasuyuki Shigematsu, Hiroaki Kanda, Yu Takahashi, Kengo Takeuchi, Kentaro Inamura

{"title":"Relationships between tumor CD147 expression, tumor-infiltrating lymphocytes, and oncostatin M in hepatocellular carcinoma.","authors":"Yasuyuki Shigematsu, Hiroaki Kanda, Yu Takahashi, Kengo Takeuchi, Kentaro Inamura","doi":"10.1007/s00428-024-03939-w","DOIUrl":"https://doi.org/10.1007/s00428-024-03939-w","url":null,"abstract":"In hepatocellular carcinoma (HCC), CD147 expression contributes to tumor malignancy; however, its relationship with the tumor-immune microenvironment (TIME) remains unclear. This study aimed to elucidate the clinicopathological characteristics associated with CD147 expression in HCC and investigate its association with the TIME, specifically its association with tumor-infiltrating lymphocytes (TILs) and oncostatin M (OSM). Using 397 HCC specimens from patients undergoing curative-intent resection, we assessed CD147 expression in tumor cells and quantified OSM-positive cells and various TILs (CD8+, CD4+, FOXP3+, and CD20+ cells) in the TIME. Using tissue microarrays, these assessments were performed through immunohistochemical analysis. We investigated the associations between CD147 expression status, the density of OSM-positive cells, and the densities of various TILs. High CD147 expression, found in 332 specimens (83.6%), was associated with advanced clinical stage (P = 0.029), fibrosis (P = 0.036), and higher densities of FOXP3+ cells (P = 0.0039), CD4+ cells (P = 0.0012), and OSM-positive cells (P = 0.0017). In CD147-high tumors, OSM-positive cell density was associated with all assessed TIL subsets (CD8+, CD4+, FOXP3+, and CD20+ cells; all Ps < 0.001), whereas in CD147-low tumors, OSM-positive cell density was associated only with FOXP3+ cells (P = 0.0004). In HCC, CD147 expression is associated with an immunosuppressive TIME, characterized by increased FOXP3+ regulatory T cells and a correlation with OSM-positive cells. These results elucidate the potential mechanisms through which CD147 facilitates tumor-immune evasion, suggesting the CD147 - OSM axis as a promising target for therapeutic intervention in HCC.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0