Virchows Archiv最新文献_第2页

Clinicopathologic correlation and interdependence of basic patterns of placental injury.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-29 DOI: 10.1007/s00428-025-04073-x

Jerzy Stanek, Dustin Funk

{"title":"Clinicopathologic correlation and interdependence of basic patterns of placental injury.","authors":"Jerzy Stanek, Dustin Funk","doi":"10.1007/s00428-025-04073-x","DOIUrl":"https://doi.org/10.1007/s00428-025-04073-x","url":null,"abstract":"Placental lesions rarely occur in isolation and placental lesion multiplicity is associated with poorer pregnancy outcome than that of isolated lesions. As little is known about mutual relations of various patterns of placental injury simultaneously occurring in the same placentas, particularly in relation to gestational age, this retrospective observational analysis was undertaken to study those in a population of 2486 cases of the second half high-risk pregnancy dominated by fetal congenital anomalies. To this end, 23 independent clinical and 48 placental phenotypes were statistically compared among 6 basic patterns of placental injury: Group 1: acute inflammation, Group 2: chronic inflammation, Group 3: maternal vascular malperfusion, Group 4: fetal vascular malperfusion, large vessel, Group 5: fetal vascular malperfusion, distal villous, and Group 6: shallow placental implantation. All cases had E cadherin/CD34 immunostaining performed for the diagnosis of recent fetal vascular malperfusion. There was a significant overlap among the studied patterns and lesions of placental injury. Placental distal villous fetal vascular malperfusion and acute inflammation was most frequently statistically significantly associated with abnormal clinical conditions, while lesions of distal villous fetal vascular malperfusion and maternal vascular malperfusion with other placental lesions/patterns of injury. The double immunostaining was responsible for the fetal vascular malperfusion being the most common type of placental injury in this population of placentas. The acute inflammation best correlated with clinical condition in preterm pregnancy and distal villous fetal vascular malperfusion at term. Maternal vascular malperfusion plus the above two patterns of placental injury correlated best with other placental phenotypes in mid third trimester.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-28 DOI: 10.1007/s00428-025-04081-x

Yu-Hsuan Kuo, Khaa Hoo Ong, Ding-Ping Sun, Yu-Feng Tian, Chia-Ling Chou, Ti-Chun Chan, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Yow-Ling Shiue

{"title":"Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma.","authors":"Yu-Hsuan Kuo, Khaa Hoo Ong, Ding-Ping Sun, Yu-Feng Tian, Chia-Ling Chou, Ti-Chun Chan, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Yow-Ling Shiue","doi":"10.1007/s00428-025-04081-x","DOIUrl":"https://doi.org/10.1007/s00428-025-04081-x","url":null,"abstract":"Claudins are key components of tight junctions, essential for maintaining cellular adhesion, regulating intercellular molecule transport, and preserving cell polarity. Altered claudin expression can lead to tight junction dysfunction, potentially disrupting signaling pathways and contributing to the development of epithelial cancers. This study aims to explore the understudied role of CLDN18.2 in intrahepatic cholangiocarcinoma and its relationship with clinical outcomes. We analyzed tissue samples from 182 patients who underwent curative surgery for intrahepatic cholangiocarcinoma. Our research examined the relationship between CLDN18.2 expression and various clinical factors, including patient characteristics, pathological findings, and survival metrics such as overall survival (OS), disease-free survival (DFS), metastasis-free survival (MeFS), and local recurrence-free survival (LRFS). Overexpression of CLDN18.2 showed significant associations with R1 resection (p = 0.032) and advanced T stage (p = 0.043). Univariate analysis revealed that high CLDN18.2 expression was correlated with poorer OS (p = 0.0002), DFS (p < 0.0001), LRFS (p < 0.0001), and MeFS (p < 0.0001). Multivariate analysis further confirmed that high CLDN18.2 expression was independently associated with worse OS (p = 0.015), DFS (p < 0.001), LRFS (p < 0.001), and MeFS (p < 0.001). Overexpression of CLDN18.2 was associated with unfavorable clinical prognosis and adverse pathological features in intrahepatic cholangiocarcinoma. These findings suggest that CLDN18.2 could serve as a potential prognostic biomarker for intrahepatic cholangiocarcinoma.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-27 DOI: 10.1007/s00428-025-04082-w

Nina Zidar, Lester D R Thompson, Abbas Agaimy, Göran Stenman, Henrik Hellquist, Alfons Nadal, Antti A Mäkitie, López Fernando, Primož Strojan, Alfio Ferlito

{"title":"The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?","authors":"Nina Zidar, Lester D R Thompson, Abbas Agaimy, Göran Stenman, Henrik Hellquist, Alfons Nadal, Antti A Mäkitie, López Fernando, Primož Strojan, Alfio Ferlito","doi":"10.1007/s00428-025-04082-w","DOIUrl":"https://doi.org/10.1007/s00428-025-04082-w","url":null,"abstract":"Despite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using international guidelines. These include extra- vs intratumoural vascular and perineural invasion, tumour budding, depth of invasion, and tumour-infiltrating lymphocytes. We also address the problem of specimen quality and type (open approach vs endoscopic surgery) and the related limitations. High-risk human papillomavirus infection is another controversial issue to be discussed, being rare in laryngeal SCC, with an indeterminate prognostic significance and less reliable p16 overexpression as a surrogate marker of HPV infection. Further studies are warranted to address the applicability and to see which of the described parameters may help to better stratify patients with laryngeal SCC and should therefore be included in the pathology report.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-26 DOI: 10.1007/s00428-025-04069-7

Pooja Navale, Ofer Zimmerman, James Wedner, Anupam Pande, Samuel Ballentine

{"title":"Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation.","authors":"Pooja Navale, Ofer Zimmerman, James Wedner, Anupam Pande, Samuel Ballentine","doi":"10.1007/s00428-025-04069-7","DOIUrl":"https://doi.org/10.1007/s00428-025-04069-7","url":null,"abstract":"Good's syndrome (GS) is a rare immunodeficiency associated with thymoma, characterized by increased susceptibility to bacterial, viral, and fungal infections, along with autoimmune manifestations. Gastrointestinal symptoms are common in GS, yet its clinical and histopathological features remain underrecognized. Due to significant overlap in clinical presentation and immunological profiles, GS is frequently misdiagnosed as common variable immunodeficiency (CVID). While gastrointestinal pathology in CVID has been well-documented, data on gastrointestinal manifestations in GS are limited. In this study, we analyzed two cases of GS, both demonstrating marked reduction of plasma cells across multiple gastrointestinal sites, with variable intraepithelial lymphocytosis and mild to moderate villous blunting in the duodenum and features secondary to chronic norovirus infection in one case, and an invasive adenocarcinoma with notable depletion of lamina propria plasma cells in the other. Accurate recognition of GS is essential for pathologists and clinicians, given its poorer prognosis compared to CVID.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Debating the pros and cons of computational pathology at the European Congress of Pathology (ECP) 2024.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-25 DOI: 10.1007/s00428-025-04084-8

Balazs Acs, Falko Fend, Catherine Guettier, Vincenzo L'Imperio, Diana Montezuma, Norman Zerbe, Inti Zlobec

引用次数: 0

DEK::AFF2 rearranged neoplasm with undifferentiated morphology and neuroendocrine phenotype in a pediatric patient.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-22 DOI: 10.1007/s00428-025-04071-z

Emma Rullo, Sabina Barresi, Evelina Miele, Alessandra Stracuzzi, Debora De Pasquale, Sara Patrizi, Francesca Gianno, Antonio d'Amati, Cira Di Gioia, Valentino Valentini, Rita Alaggio

引用次数: 0

Adenomyoma/adenomyomatosis-associated mural intracholecystic neoplasms: analysis of clinico-pathologic, imaging, and molecular features of a consecutive case series.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-21 DOI: 10.1007/s00428-025-04077-7

Alessandro Vanoli, Erica Travaglino, Marco Minetto, Anna Gallotti, Federica Grillo, Salvatore Corallo, Marcello Maestri, Andrea Peri, Paola Fugazzola, Francesca Antoci, Roberta Riboni, Antonio Di Sabatino, Luca Ansaloni, Andrea Pietrabissa, Gioacchino D'Ambrosio, Marco Paulli

{"title":"Adenomyoma/adenomyomatosis-associated mural intracholecystic neoplasms: analysis of clinico-pathologic, imaging, and molecular features of a consecutive case series.","authors":"Alessandro Vanoli, Erica Travaglino, Marco Minetto, Anna Gallotti, Federica Grillo, Salvatore Corallo, Marcello Maestri, Andrea Peri, Paola Fugazzola, Francesca Antoci, Roberta Riboni, Antonio Di Sabatino, Luca Ansaloni, Andrea Pietrabissa, Gioacchino D'Ambrosio, Marco Paulli","doi":"10.1007/s00428-025-04077-7","DOIUrl":"https://doi.org/10.1007/s00428-025-04077-7","url":null,"abstract":"Adenomyoma/adenomyomatosis (AM) of the gallbladder is generally considered an incidental and innocuous finding; however, neoplastic lesions, including intracholecystic neoplasms (ICNs), flat-type dysplasia, and carcinomas, may arise within AM. AM-associated ICNs, composed of mural cystically dilated glands containing florid papillary proliferations lined by mucinous and/or overtly dysplastic epithelium, are very rare and poorly characterized. This study aimed at investigating the clinico-radiologic, phenotypic/immunophenotypic, and molecular features of a mono-institutional case series of four AM-ICNs (0.2% of cholecystectomies). Immunohistochemistry for CDX2, MUC2, MUC5AC, MUC6, MUC1, HER2, ß-catenin, and p53, as well as next-generation sequencing of 110 tumor-related genes (AmoyDx® Comprehensive Panel), were performed. Our study confirms the AM-ICN-associated clinico-demographic characteristics previously described, including the relatively low frequency of associated invasive carcinoma (one case, 25%), although high-grade dysplasia (HGD) was observed in three out of four cases. In two cases, imaging findings suspicious for neoplasm were seen. Segmental-type AM was seen in two cases. Predominantly cell phenotype was gastric foveolar in two AM-ICNs and pancreatobiliary in the other two cases (both with HGD), while the immunophenotype was hybrid/mixed in all cases. No case had nuclear ß-catenin expression nor Wnt pathway or KRAS gene alterations. One case showed both HER2 point mutation and HER2 amplification, while the AM-ICN associated with an invasive adenocarcinoma harbored TP53 mutation and p53 overexpression. In conclusion, our findings suggest the separation of AM-ICNs from other gallbladder dysplastic lesions.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of HTLV-1 infection on clinicopathological characteristics and tumour immune microenvironment in colorectal cancer.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-20 DOI: 10.1007/s00428-025-04074-w

Rin Yamada, Kota Arima, Hiromu Yano, Yukio Fujiwara, Kohei Yamashita, Kosuke Kanemitsu, Norihisa Hanada, Jun-Ichirou Yasunaga, Masaaki Iwatsuki, Yoshiki Mikami, Yoshihiro Komohara

{"title":"Impact of HTLV-1 infection on clinicopathological characteristics and tumour immune microenvironment in colorectal cancer.","authors":"Rin Yamada, Kota Arima, Hiromu Yano, Yukio Fujiwara, Kohei Yamashita, Kosuke Kanemitsu, Norihisa Hanada, Jun-Ichirou Yasunaga, Masaaki Iwatsuki, Yoshiki Mikami, Yoshihiro Komohara","doi":"10.1007/s00428-025-04074-w","DOIUrl":"https://doi.org/10.1007/s00428-025-04074-w","url":null,"abstract":"Recent advances in anti-cancer therapy have indicated the significance of the tumour immune microenvironment in tumour progression and resistance to anti-cancer therapy. This study investigated primary colorectal cancer (CRC) tissues resected from 180 cases in a single institute in a region highly endemic for human T-cell leukaemia virus type 1 (HTLV-1) carriers. Among those 180 cases, 35 HTLV-1 carriers were identified. CRC patients who were HTLV-1 carriers were significantly older (mean age: 76.9 vs. 72.7 years, P = 0.0341), with a lower incidence of lymph node metastases (pN0: 91% vs. 65%, P = 0.0085), and lower tumour stages (stage III or IV: 11% vs. 36%, P = 0.0117) compared to non-carriers. HTLV-1 carriers tended to show a lower incidence of relapse, although the difference was not significant (P = 0.2272). The density of forkhead box P3-positive regulatory T cells (Tregs) was significantly higher in HTLV-1 carriers (median density: 132 vs. 89 cells/mm2, P = 0.0051). In situ hybridisation showed cells positive for HTLV-1 basic leucine zipper factor, likely representing lymphocytes located in stroma around the cancer nest. Our findings indicate that lymph node metastasis was significantly suppressed in CRC patients infected with HTLV-1. Since HTLV-1 infection reportedly impairs the immunosuppressive functions of Tregs, anti-cancer immune responses are potentially enhanced in CRC patients who are HTLV-1 carriers.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pelvic spindle cell sarcomas harboring MEIS1::NCOA2 fusion and novel gene amplifications in 10q23-26 region: a potential predictor for tumor progression.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-20 DOI: 10.1007/s00428-025-04079-5

Yu Gao, Yang Lu, Jian Cui, Xin He, Hongying Zhang

{"title":"Pelvic spindle cell sarcomas harboring MEIS1::NCOA2 fusion and novel gene amplifications in 10q23-26 region: a potential predictor for tumor progression.","authors":"Yu Gao, Yang Lu, Jian Cui, Xin He, Hongying Zhang","doi":"10.1007/s00428-025-04079-5","DOIUrl":"https://doi.org/10.1007/s00428-025-04079-5","url":null,"abstract":"MEIS1::NCOA1/2 fusion undifferentiated spindle cell sarcomas generally arise from genitourinary and gynecologic tracts and mostly exhibit low-grade malignancies according to limited cases. Here, we report two cases from pelvic cavities. Case 1 showed low-grade morphology of monotonous spindle cells with moderate atypia in short fascicular or storiform patterns, while case 2 exhibited marked atypia, brisk mitosis, and significant necrosis. Notably, both cases identified intracytoplasmic eosinophilic globules. Next-generation sequencing analysis observed MEIS1::NCOA2 rearrangements in both cases, but only case 2 detected additional 10q23-26 amplifications and CTNNB1 mutation (c.94G > T/p.D32Y). Case 1 developed twice local recurrences in 3 years, while case 2 metastasized to the liver and gastroduodenal interstice and died 7 months after intraabdominal surgery. To the best of our knowledge, it is the first report about MEIS1::NCOA2 fusion sarcoma with distant metastasis to the abdomen. The extra 10q23-26 amplifications and CTNNB1 mutation may indicate potential predictors for malignancy in this study.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unique clinical, morphological, and molecular characteristics of tumors associated with PSC-IBD.

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-19 DOI: 10.1007/s00428-025-04072-y

Andrea Vajsova, Monika Cahova, Lukas Bajer, Eva Sticova, Ivana Juskova, Mojmir Hlavaty, Ondrej Fabian

{"title":"Unique clinical, morphological, and molecular characteristics of tumors associated with PSC-IBD.","authors":"Andrea Vajsova, Monika Cahova, Lukas Bajer, Eva Sticova, Ivana Juskova, Mojmir Hlavaty, Ondrej Fabian","doi":"10.1007/s00428-025-04072-y","DOIUrl":"https://doi.org/10.1007/s00428-025-04072-y","url":null,"abstract":"Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree, leading to significant liver function impairment over time. There is a strong association with inflammatory bowel diseases (IBD), together representing a distinct and complex medical condition. Patients with PSC-IBD face a heightened risk of various cancers, particularly colorectal carcinoma (CRC) and cholangiocarcinoma (CCA) as the most common types. In this review, we aim to characterize the distinctive features of PSC-IBD-associated carcinomas. Cancer pathogenesis in PSC-IBD is shaped by various factors including dysregulated bile acid metabolism, gut dysbiosis, and unique immune responses. PSC-IBD-associated CRC is often right-sided and warrants vigilant monitoring due to its higher incidence and unique morphological features compared to CRC arising in the terrain of IBD alone. CCA shares substantial genetic similarities with extrahepatic CCA and poses diagnostic challenges since it is frequently detected at advanced stages due to symptom overlap with PSC. Besides, reliable predictive biomarkers for targeted therapy remain largely unexplored. The distinct molecular, genetic, and histopathological profiles of CRC and CCA in PSC-IBD underscore the complexity of these malignancies and highlight the need for continued research to develop precise therapeutic strategies.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0