Virchows Archiv最新文献_第10页

Correction to: Unveiling the risks of ChatGPT in diagnostic surgical pathology. 更正：揭示 ChatGPT 在外科病理诊断中的风险。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-04-01 DOI: 10.1007/s00428-024-03932-3

Vincenzo Guastaferro, Devin N Corbitt, Alessandra Bressan, Bethania Fernandes, Ömer Mintemur, Francesca Magnoli, Susanna Ronchi, Stefano La Rosa, Silvia Uccella, Salvatore Lorenzo Renne

引用次数: 0

Loss of insulin-expressing extra-islet cells in type 1 diabetes is accompanied with increased number of glucagon-expressing extra-islet cells. 1 型糖尿病患者体内表达胰岛素的胰岛外细胞丧失，同时表达胰高血糖素的胰岛外细胞数量增加。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-04-01 Epub Date: 2024-06-26 DOI: 10.1007/s00428-024-03842-4

Louise Granlund, Marcus Lundberg

{"title":"Loss of insulin-expressing extra-islet cells in type 1 diabetes is accompanied with increased number of glucagon-expressing extra-islet cells.","authors":"Louise Granlund, Marcus Lundberg","doi":"10.1007/s00428-024-03842-4","DOIUrl":"10.1007/s00428-024-03842-4","url":null,"abstract":"The presence of remaining insulin-positive cells in type 1 diabetes (T1D) is well-known. These cells are part of islets or appear as extra-islet insulin-positive cells scattered in the exocrine parenchyma. The latter are poorly described, and the presence of scattered endocrine cells expressing other islet hormones than insulin has not been explored. This study aimed to compare the extra-islet insulin- or glucagon-positive cells concerning their frequency, transcription-factor expression, and mitotic activity in subjects with and without T1D. Multispectral imaging was used to examine extra-islet cells by staining for insulin, glucagon, ARX, PDX1, and Ki67. This was done in well-preserved pancreatic tissue obtained from heart-beating organ donors with or without T1D. In three T1D donors, lobes with insulin-containing islets (ICI) were found. Within these, a higher frequency of extra-islet insulin-positive cells was observed compared to lobes with insulin-deficient islets (IDI). Increased frequency of glucagon-positive extra-islet cells was observed in donors with T1D (median 53 cells/mm2) when compared with non-diabetic donors (11 cells/mm2, p = 0.004). Proliferating endocrine cells were present in donors with, and without T1D, as demonstrated by Ki67-positive staining (0-3% of the cells expressing insulin or glucagon). The reduced frequency of extra-islet insulin-positive cells in lobes with IDI in donors with T1D suggests that the pathological mechanism causing beta cell demise in T1D affects entire lobes. The presence of an increased frequency of glucagon-positive extra-islet cells supports the notion of a preserved capacity to regenerate the endocrine pancreas in donors with T1D.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":"687-695"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141451637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EWSR1::BEND2 fusion sarcoma in bone: a report of two rare cases. 骨内EWSR1::BEND2融合肉瘤2例报告

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1007/s00428-025-04063-z

Sırma Çetin, Gökçen Ünverengil, İsmail Yılmaz, Nilsen Erdoğan, Ayça Erşen Danyeli, Ahmet Salduz, Bilge Bilgiç

引用次数: 0

Digital transformation of pathology - the European Society of Pathology expert opinion paper. 病理学的数字化转型-欧洲病理学会专家意见文件。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-31 DOI: 10.1007/s00428-025-04090-w

Catarina Eloy, Filippo Fraggetta, Paul J van Diest, António Polónia, Mónica Curado, Jordi Temprana-Salvador, Inti Zlobec, Elvira Purqueras, Cleo-Aron Weis, Xavier Matias-Guiu, Peter Schirmacher, Aleš Ryška

{"title":"Digital transformation of pathology - the European Society of Pathology expert opinion paper.","authors":"Catarina Eloy, Filippo Fraggetta, Paul J van Diest, António Polónia, Mónica Curado, Jordi Temprana-Salvador, Inti Zlobec, Elvira Purqueras, Cleo-Aron Weis, Xavier Matias-Guiu, Peter Schirmacher, Aleš Ryška","doi":"10.1007/s00428-025-04090-w","DOIUrl":"https://doi.org/10.1007/s00428-025-04090-w","url":null,"abstract":"An expert group mandated by the European Society of Pathology (ESP) outlines its recommendations on the digital transformation of pathology departments, aiming to facilitate the acquisition of resources for better patient care. This statement is directed at pathology professionals, offering guidance for the safe implementation of digital pathology while emphasizing the necessity of standardization, quality control, and sustainability. Digital pathology involves automating and standardizing laboratory workflows to produce high-quality whole slide images (WSIs), which are crucial for diagnosis, research, and education. A successful digital transformation requires a multidisciplinary approach, significant investment in human, structural, and informatic resources, and progressive adaptation of laboratory workflows. Key components include robust infrastructure; continuous training; and clear policies for hardware renewal, data storage, and interoperability. The transition demands attention to quality and production control, ensuring efficient WSI generation and timely diagnostic reporting. ESP strongly recommends that pathology departments, supported by funding organizations, start to prioritize digital transformation as a step toward improved patient care and in alignment with global healthcare initiatives. Collaboration, investment, and adherence to quality standards are critical to benefiting the most the full potential of digital pathology.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations. 混合型颗粒细胞瘤/会阴瘤：罕见的PIK3CA突变2例报告。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-30 DOI: 10.1007/s00428-025-04089-3

Ani Toklu, Gauri Panse, George Jour, Konstantinos Linos, Jeffrey M Cloutier, Carina A Dehner

{"title":"Hybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations.","authors":"Ani Toklu, Gauri Panse, George Jour, Konstantinos Linos, Jeffrey M Cloutier, Carina A Dehner","doi":"10.1007/s00428-025-04089-3","DOIUrl":"https://doi.org/10.1007/s00428-025-04089-3","url":null,"abstract":"Hybrid peripheral nerve sheath tumors (PNSTs) are rare mesenchymal neoplasms with dual differentiation, most often combining two of the three main PNST types: schwannoma, neurofibroma, and perineurioma. Recognized by the WHO since 2013, these tumors can also exhibit fewer common combinations, such as hybrid granular cell tumor/perineurioma. We herein report two rare cases of hybrid granular cell tumor perineurioma with molecular analysis. Both tumors presented as dermal to subcutaneous, well-circumscribed lesions composed of a combination of spindled and granular cell components. By immunohistochemistry, the granular cells were positive for S100, SOX10, and CD68, while the perineurial cells were highlighted by EMA and GLUT1 stains. Subsequent molecular testing revealed pathogenic mutations involving PIK3CA in both cases. Our study expands on the clinical and pathologic spectrum and provides the first molecular data on these unusual neoplasms. Further, we provide a comprehensive review of the literature of all previously reported cases and briefly discuss relevant differential diagnoses and their molecular features.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic correlation and interdependence of basic patterns of placental injury. 胎盘损伤基本模式的临床病理相关性和相互依赖性。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-29 DOI: 10.1007/s00428-025-04073-x

Jerzy Stanek, Dustin Funk

{"title":"Clinicopathologic correlation and interdependence of basic patterns of placental injury.","authors":"Jerzy Stanek, Dustin Funk","doi":"10.1007/s00428-025-04073-x","DOIUrl":"https://doi.org/10.1007/s00428-025-04073-x","url":null,"abstract":"Placental lesions rarely occur in isolation and placental lesion multiplicity is associated with poorer pregnancy outcome than that of isolated lesions. As little is known about mutual relations of various patterns of placental injury simultaneously occurring in the same placentas, particularly in relation to gestational age, this retrospective observational analysis was undertaken to study those in a population of 2486 cases of the second half high-risk pregnancy dominated by fetal congenital anomalies. To this end, 23 independent clinical and 48 placental phenotypes were statistically compared among 6 basic patterns of placental injury: Group 1: acute inflammation, Group 2: chronic inflammation, Group 3: maternal vascular malperfusion, Group 4: fetal vascular malperfusion, large vessel, Group 5: fetal vascular malperfusion, distal villous, and Group 6: shallow placental implantation. All cases had E cadherin/CD34 immunostaining performed for the diagnosis of recent fetal vascular malperfusion. There was a significant overlap among the studied patterns and lesions of placental injury. Placental distal villous fetal vascular malperfusion and acute inflammation was most frequently statistically significantly associated with abnormal clinical conditions, while lesions of distal villous fetal vascular malperfusion and maternal vascular malperfusion with other placental lesions/patterns of injury. The double immunostaining was responsible for the fetal vascular malperfusion being the most common type of placental injury in this population of placentas. The acute inflammation best correlated with clinical condition in preterm pregnancy and distal villous fetal vascular malperfusion at term. Maternal vascular malperfusion plus the above two patterns of placental injury correlated best with other placental phenotypes in mid third trimester.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma. claudin-18.2在肝内胆管癌中的预后作用。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-28 DOI: 10.1007/s00428-025-04081-x

Yu-Hsuan Kuo, Khaa Hoo Ong, Ding-Ping Sun, Yu-Feng Tian, Chia-Ling Chou, Ti-Chun Chan, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Yow-Ling Shiue

{"title":"Prognostic role of claudin-18.2 in intrahepatic cholangiocarcinoma.","authors":"Yu-Hsuan Kuo, Khaa Hoo Ong, Ding-Ping Sun, Yu-Feng Tian, Chia-Ling Chou, Ti-Chun Chan, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Yow-Ling Shiue","doi":"10.1007/s00428-025-04081-x","DOIUrl":"https://doi.org/10.1007/s00428-025-04081-x","url":null,"abstract":"Claudins are key components of tight junctions, essential for maintaining cellular adhesion, regulating intercellular molecule transport, and preserving cell polarity. Altered claudin expression can lead to tight junction dysfunction, potentially disrupting signaling pathways and contributing to the development of epithelial cancers. This study aims to explore the understudied role of CLDN18.2 in intrahepatic cholangiocarcinoma and its relationship with clinical outcomes. We analyzed tissue samples from 182 patients who underwent curative surgery for intrahepatic cholangiocarcinoma. Our research examined the relationship between CLDN18.2 expression and various clinical factors, including patient characteristics, pathological findings, and survival metrics such as overall survival (OS), disease-free survival (DFS), metastasis-free survival (MeFS), and local recurrence-free survival (LRFS). Overexpression of CLDN18.2 showed significant associations with R1 resection (p = 0.032) and advanced T stage (p = 0.043). Univariate analysis revealed that high CLDN18.2 expression was correlated with poorer OS (p = 0.0002), DFS (p < 0.0001), LRFS (p < 0.0001), and MeFS (p < 0.0001). Multivariate analysis further confirmed that high CLDN18.2 expression was independently associated with worse OS (p = 0.015), DFS (p < 0.001), LRFS (p < 0.001), and MeFS (p < 0.001). Overexpression of CLDN18.2 was associated with unfavorable clinical prognosis and adverse pathological features in intrahepatic cholangiocarcinoma. These findings suggest that CLDN18.2 could serve as a potential prognostic biomarker for intrahepatic cholangiocarcinoma.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better? 组织病理学对喉部鳞状细胞癌预后的影响：我们能不能做得更好？

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-27 DOI: 10.1007/s00428-025-04082-w

Nina Zidar, Lester D R Thompson, Abbas Agaimy, Göran Stenman, Henrik Hellquist, Alfons Nadal, Antti A Mäkitie, López Fernando, Primož Strojan, Alfio Ferlito

{"title":"The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?","authors":"Nina Zidar, Lester D R Thompson, Abbas Agaimy, Göran Stenman, Henrik Hellquist, Alfons Nadal, Antti A Mäkitie, López Fernando, Primož Strojan, Alfio Ferlito","doi":"10.1007/s00428-025-04082-w","DOIUrl":"https://doi.org/10.1007/s00428-025-04082-w","url":null,"abstract":"Despite decades of progress, laryngeal squamous cell carcinoma (SCC) is still associated with significant morbidity and mortality worldwide. Additional biomarkers are needed to apply precision medicine and predict the clinical course. We reviewed and summarised routinely reported histopathologic features (e.g. subtypes of laryngeal SCC) along with promising potential biomarkers not yet routinely assessed using international guidelines. These include extra- vs intratumoural vascular and perineural invasion, tumour budding, depth of invasion, and tumour-infiltrating lymphocytes. We also address the problem of specimen quality and type (open approach vs endoscopic surgery) and the related limitations. High-risk human papillomavirus infection is another controversial issue to be discussed, being rare in laryngeal SCC, with an indeterminate prognostic significance and less reliable p16 overexpression as a surrogate marker of HPV infection. Further studies are warranted to address the applicability and to see which of the described parameters may help to better stratify patients with laryngeal SCC and should therefore be included in the pathology report.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation. Good's综合征的胃肠道病理，超越常见的可变免疫缺陷：临床病理观察。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-26 DOI: 10.1007/s00428-025-04069-7

Pooja Navale, Ofer Zimmerman, James Wedner, Anupam Pande, Samuel Ballentine

{"title":"Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation.","authors":"Pooja Navale, Ofer Zimmerman, James Wedner, Anupam Pande, Samuel Ballentine","doi":"10.1007/s00428-025-04069-7","DOIUrl":"https://doi.org/10.1007/s00428-025-04069-7","url":null,"abstract":"Good's syndrome (GS) is a rare immunodeficiency associated with thymoma, characterized by increased susceptibility to bacterial, viral, and fungal infections, along with autoimmune manifestations. Gastrointestinal symptoms are common in GS, yet its clinical and histopathological features remain underrecognized. Due to significant overlap in clinical presentation and immunological profiles, GS is frequently misdiagnosed as common variable immunodeficiency (CVID). While gastrointestinal pathology in CVID has been well-documented, data on gastrointestinal manifestations in GS are limited. In this study, we analyzed two cases of GS, both demonstrating marked reduction of plasma cells across multiple gastrointestinal sites, with variable intraepithelial lymphocytosis and mild to moderate villous blunting in the duodenum and features secondary to chronic norovirus infection in one case, and an invasive adenocarcinoma with notable depletion of lamina propria plasma cells in the other. Accurate recognition of GS is essential for pathologists and clinicians, given its poorer prognosis compared to CVID.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Debating the pros and cons of computational pathology at the European Congress of Pathology (ECP) 2024. 在2024年欧洲病理学大会（ECP）上辩论计算病理学的利弊。

IF 3.4 3区医学

Virchows Archiv Pub Date : 2025-03-25 DOI: 10.1007/s00428-025-04084-8

Balazs Acs, Falko Fend, Catherine Guettier, Vincenzo L'Imperio, Diana Montezuma, Norman Zerbe, Inti Zlobec

引用次数: 0