Virchows Archiv最新文献

{"title":"Correction to: Xanthogranulomatous ureteritis can be associated with a ureter duplex and a complete duplex kidney.","authors":"Ondrej Ondič, Alexandra Corominas, Josef Skopal, Jan Pernický, Olga Dolejšová, Milan Hora","doi":"10.1007/s00428-026-04574-3","DOIUrl":"https://doi.org/10.1007/s00428-026-04574-3","url":null,"abstract":"","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The critical role of accurate neoplastic cell percentage (NCP) assessment: investigating targeted training strategies for pulmonary biopsy and cytology specimens.","authors":"Thi Mai Phuong Pham, Dieter Peeters, Jan von der Thüsen, Myriam Remmelink, Birgit Weynand, Elisabeth Dequeker","doi":"10.1007/s00428-026-04505-2","DOIUrl":"https://doi.org/10.1007/s00428-026-04505-2","url":null,"abstract":"<p><p>Cancer diagnostics and therapeutics have widely changed, and in advanced non-small cell lung cancer (aNSCLC), molecular analysis is crucial to identify actionable biomarkers. Targeted therapies specifically interfere with molecular mechanisms involved in tumor growth and proliferation to improve clinical outcomes and quality of life compared to conventional chemotherapy. However, suboptimal testing practices, including errors in neoplastic cell percentage (NCP) assessment, limit reliable downstream analyses, and therefore, hinder accurate targeted therapy decisions for NSCLC patients. This study conducted two assessment rounds in which participants evaluated cytology or biopsy cases to examine NCP assessment accuracy and molecular testing decisions among pathologists and non-pathologists. No evidence was found for changes in NCP assessment performance across rounds (OR = 1.996, 95% CI = [0.600;6.644], p = 0.260) and they were also not influenced by professional background (OR = 0.932, 95% CI = [0.611;1.421], p = 0.743). However, prior training in NCP assessment showed potential benefit for accurate NCP estimation. Additionally, incorrect NCP assessments were significantly linked to subsequent molecular testing decision errors (OR = 2.327, 95% CI = [1.286;4.212], p = 0.005), and the inter-observer agreement for cytology cases was poor with higher error rates for cytology cases compared to biopsy cases (OR = 2.389, 95% CI = [0.967;5.906], p = 0.059). In conclusion, a continuing need for training focusing on harmonization of NCP assessment and molecular testing decision-making remains. Ultimately, such assessment improvements will enhance accuracy of downstream precision medicine for NSCLC patients.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal cell carcinoma with a novel RAB1A::ALK fusion: expanding the molecular spectrum of ALK-rearranged RCC.","authors":"Claudia Andrea Gómez-González, Banu Sarsik-Kumbaraci, Fuat Kizilay, Serdar Kalemci, Sercan On, Sait Sen","doi":"10.1007/s00428-026-04565-4","DOIUrl":"https://doi.org/10.1007/s00428-026-04565-4","url":null,"abstract":"<p><p>Renal cell carcinoma associated with anaplastic lymphoma kinase rearrangement (ALK-RCC) is a rare subtype within the category of molecularly defined renal cell carcinomas. Due to its low incidence and highly heterogeneous clinicopathological features, ALK-RCC poses a significant diagnostic challenge. The implementation of advanced molecular techniques has facilitated the identification of various fusion partners, which may influence clinical behavior and guide targeted therapies. We report a case of ALK-RCC harboring a novel fusion partner, RAB1A::ALK. This report describes the clinicopathological and molecular features of the tumor, with a particular focus on the characterization of the RAB1A gene and its documented impact on carcinogenesis and prognosis across several solid malignancies. Our findings expand the molecular spectrum of ALK-RCC and emphasize the role of comprehensive molecular profiling in uropathology.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ER, PR, and HER2 triple positivity and triple negativity are associated with adverse prognostic significance in endometrial serous carcinoma.","authors":"Zhenwei Zhang, Tahreem A Karim, Liang Cheng, Kamaljeet Singh, M Ruhul Quddus","doi":"10.1007/s00428-026-04553-8","DOIUrl":"https://doi.org/10.1007/s00428-026-04553-8","url":null,"abstract":"<p><p>Endometrial serous carcinoma (ESC) is an aggressive tumor of the mullerian system. The prognostic significance of the combined status of HER2, estrogen receptor (ER), and progesterone receptor (PR) on ESC's survival and clinicopathologic outcome remains inadequately reported and understood. In this study, we retrospectively analyzed sixty-one ESC cases diagnosed at our institution between January 2017 and April 2024 for overall survival outcomes and pathologic presentation. Most ESC cases were ER-positive (n = 53, 87%) and PR-positive (n = 42, 69%), while HER2 was positive in 43% of cases (n = 26). Subclassification based on the combined status of ER, PR and HER2 revealed significant heterogeneity of overall survival within both HER2-positive and negative groups. Notably, the triple-positive subgroup had the shortest median survival and poorer prognosis than the other subgroups (p = 0.04; median survival: 394 vs. 676.5 days). The triple-negative subgroup demonstrated significantly worse overall survival as well. The unfavorable clinical outcome in these subgroups was associated with a higher frequency of lower uterine segment, cervical, and lymph node involvement. This study demonstrates that combined HER2, ER, and PR status provides valuable prognostic information in ESC, enabling the identification of subgroups with distinct clinical behaviors. Stratification based on combined receptor status may facilitate more personalized treatment approaches and improve clinical outcomes in this aggressive malignancy. Further large-scale studies are needed to validate these findings and explore targeted therapeutic strategies for high-risk subgroups.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MLH1 promoter methylation, mismatch repair and intestinal differentiation markers in papillary thyroid carcinoma: real-world evidence from Galicia (Northwest Spain).","authors":"Fábio França Vieira E Silva, Guillermo Prada-Ramallal, Marina Di Domenico, María Elena Padín-Iruegas, Laura Isabel Rojo-Álvarez, Susana Belén Bravo-López, Paola Della Monica, Federica Colapietra, Andrea Ballini, José Manuel Cameselle-Teijeiro","doi":"10.1007/s00428-026-04557-4","DOIUrl":"https://doi.org/10.1007/s00428-026-04557-4","url":null,"abstract":"<p><p>Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy and is generally associated with a favorable prognosis. However, a subset of these tumors exhibits more aggressive behavior, underscoring the need for refined molecular and immunohistochemical characterization to improve diagnostic precision and prognostic stratification. Given the shared embryologic origin of the thyroid gland and gastrointestinal tract from the endoderm, intestinal differentiation markers (CDX2 and SATB2) and alterations in DNA mismatch repair (MMR) pathways, including MLH1 promoter methylation, may represent biologically relevant features in thyroid tumors. This study performed MLH1 promoter methylation analysis by pyrosequencing and protein expression of MLH1, PMS2, MSH2, MSH6, SATB2 and CDX2 by immunohistochemistry in 63 PTCs. Clinicopathological and molecular data were also collected for comparative analyses and correlation with progression-free survival (PFS). All PTCs retained expression of MMR proteins (MLH1, PMS2, MSH2, and MSH6), including the three tumors with MLH1 promoter hypermethylation. CDX2 positivity was detected in only two (3.2%) PTCs (classic and follicular subtypes), and SATB2 expression was absent in all cases. No significant association was identified between MLH1 promoter methylation, MMR protein expression, CDX2 or SATB2 expression, and PFS. In contrast, venous invasion was confirmed as a significant predictor of worse PFS (HR = 3.34; 95% CI 1.27-8.76; p = 0.014) in univariate analysis. MLH1 promoter methylation, MMR deficiency, and CDX2 are rare events in PTC and do not appear to influence PFS. Although infrequent, the expression of CDX2 is not exclusive to any PTC subtype.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoid adenocarcinoma of the lung: clinicopathologic and molecular analysis of 17 cases.","authors":"Behtash G Nezami, Stanislav Fridland, Lucas Santana Dos Santos, Lawrence Jennings, Madina Sukhanova, Xinyan Lu, Ankit Bharat, Samuel S Kim, David Dittman, Vikas Mehta, Anjana Yeldandi, Borislav A Alexiev","doi":"10.1007/s00428-026-04558-3","DOIUrl":"https://doi.org/10.1007/s00428-026-04558-3","url":null,"abstract":"<p><p>Hepatoid adenocarcinoma of the lung (HAL) is a rare subtype of non-small cell lung carcinoma characterized by morphologic and immunophenotypic overlap with hepatocellular carcinoma (HCC), creating diagnostic challenges for practicing pathologists. Because of its rarity, only limited information exists regarding its molecular profile and biologic behavior. We retrospectively analyzed 17 HAL cases diagnosed at Northwestern Memorial Hospital and describe their clinical presentation, morphologic features, immunohistochemical and molecular profiles, and clinical outcomes. Histologically, HAL is composed of polygonal to columnar epithelioid cells with abundant lightly eosinophilic, finely granular cytoplasm and predominantly solid and/or complex glandular growth patterns. Foci of mucinous differentiation may be present. Cytologic atypia, brisk mitotic activity, and tumor necrosis are common findings. Immunohistochemically, HAL is characterized by strong and diffuse HepPar1 expression, positivity for adenocarcinoma markers such as MOC31, and cytoplasmic immunoreactivity for TTF-1. Across the 17 cases, STK11 alterations were most frequent (52.9%), followed by TP53 (41.2%) and KRAS (35.3%). Concurrent KRAS + STK11 alterations were identified in 23.5% of cases, compared with The Cancer Genome Atlas (TCGA) cohorts of other lung adenocarcinomas (11/566, 2.0%) and HCC (0/372, 0%). HAL demonstrates highly aggressive behavior, with metastatic presentation even in low-stage tumors (T1: 33.3%; T2: 71.4%), frequent hematogenous spread, and death of disease in 41.2% of patients at a median follow-up of 5 months. In summary, HAL is a distinct subtype with characteristic morphologic and immunohistochemical features. Given its aggressive clinical course, accurate diagnosis is essential for patient management.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct molecular pathogenesis in the two most common subtypes of cutaneous squamous cell carcinoma.","authors":"Alexander J Neil, Dale Davis, Sean Singer, John Hanna","doi":"10.1007/s00428-026-04564-5","DOIUrl":"https://doi.org/10.1007/s00428-026-04564-5","url":null,"abstract":"<p><p>The Bowenoid subtype of cutaneous squamous cell carcinoma (SCC) has been distinguished from conventional SCC for over a century based on its different histopathologic appearance, clinical features, and biologic potential. While there has been extensive molecular analysis of conventional SCC, there has been comparatively little investigation of Bowenoid SCC. Here we show that loss of RB1 protein expression is a defining feature of Bowenoid SCC and reflects biallelic genetic inactivation which most commonly proceeds through mutation of one RB1 allele and copy number loss of the other allele. Neither RB1 protein loss nor RB1 mutations were seen in conventional SCC. A third, but much less common, form of cutaneous SCC is caused by human papillomavirus (HPV). This subtype showed similar morphologic features to Bowenoid SCC and also showed loss of RB1 protein expression. However, these tumors lacked RB1 mutation and likely inactivate RB1 through HPV's known capacity to promote post-translational degradation of RB1 protein. These data suggest that the two most common subtypes of cutaneous SCC proceed through distinct pathways of molecular pathogenesis and highlight an unexpected relationship between Bowenoid and HPV-associated cutaneous SCC.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated biomarker mapping reveals differential expression of senescence profiles in IDH-wild-type glioblastoma recurrent versus primary tumors.","authors":"Sofian Al Shboul, Moath Alrjoub, Ola Abu Al Karsaneh, Mirvat Surakhy, Ahmad Alhesa, Mohammad El-Sadoni, Maram Al-Sheyab, Anoud Alsoud, Kholoud Friehat, Ashraf I Khasawneh, Nidaa A Ababneh, Moureq R Alotaibi, Ted Hupp, Tareq Saleh","doi":"10.1007/s00428-026-04541-y","DOIUrl":"https://doi.org/10.1007/s00428-026-04541-y","url":null,"abstract":"<p><p>Glioblastoma (GBM) remains a lethal malignancy characterized by therapeutic resistance and recurrence. Emerging evidence suggests that senescent niches may shape tumor progression, support tumor stemness, and modulate immune engagement. We integrated transcriptomic data from the Glioma Longitudinal Analysis Consortium (GLASS; 118 primary and 113 recurrent IDH-wildtype GBM samples) with protein-level analysis from an independent cohort of 37 GBM patients (25 primary, 12 recurrent), including 6 matched primary-recurrent pairs. Senescence-, stemness-, and immune-related pathways were assessed using single-sample gene set enrichment analysis (ssGSEA), while immunohistochemistry quantified the expression of Lamin B1, Ki67, p53, SOX2, HLA-DRA, B2M, and CD56. Transcript-level validation was performed using matched-pair Wilcoxon testing in 101 GLASS pairs. Recurrent tumors demonstrated increased enrichment of senescence-associated transcriptional programs, including upregulated KAMMINGA_SENESCENCE and reduced TANG_SENESCENCE_TP53_TARGETS_DN scores. Lamin B1 and Ki67 protein levels were significantly lower in recurrent tumors (p = 0.004 and p = 0.016), while p53 expression increased overall (p = 0.001), suggestive of a senescence enrichment upon recurrence. In the matched analysis (6 pairs; 12 samples total), Lamin B1 and Ki67 generally trended lower at recurrence, although paired differences were not statistically significant. SOX2 expression remained broadly stable at the protein level but showed a modest decrease in RNA expression. Immune markers (HLA-DRA, B2M, CD56) exhibited minimal differences, although HLA-DRA increased significantly overall at recurrence (p = 0.025). Matched transcriptomic analysis in GLASS pairs supported recurrent-specific reductions in LMNB1, MKI67, and SOX2, with no consistent changes in TP53, HLA-DRA, B2M, or NCAM1. Recurrent IDH-wildtype GBM exhibits a transcriptional and protein expression shift towards a senescence-associated state with no concomitant changes in SOX2 and select immune markers.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histology-defined activated cancer-associated fibroblasts are associated with poor survival in diffuse-type gastric adenocarcinoma.","authors":"Joon Young Hur, Yung-Kyun Noh, Young-Woong Won, Byoung Kwan Son, Sung Hak Lee, Young Chan Wi, Mi Jung Kwon, Kyueng-Whan Min, Hyung Suk Kim, Dong-Hoon Kim","doi":"10.1007/s00428-026-04546-7","DOIUrl":"https://doi.org/10.1007/s00428-026-04546-7","url":null,"abstract":"<p><p>Activated cancer-associated fibroblasts (aCAFs), characterized by distinct histological features including fibroblast proliferation and extensive desmoplasia, play a key role in tumor progression induced by cancer cell infiltration and may serve as important predictive and prognostic factors in gastric cancer (GC). This study investigated the relationship between aCAFs and clinicopathologic factors and their impact on survival outcomes in 691 GC patients across two independent cohorts. aCAFs were identified based on histological features on H&E-stained slides, and clinicopathological parameters, survival outcomes, immune cell composition, and transcriptomic features were comprehensively evaluated. Publicly available transcriptomic datasets were also analyzed for translational insights. aCAFs were significantly associated with advanced T and N stages, vascular/lymphatic/perineural invasion, and necrosis. Higher histological grade tended to correlate with increased aCAF frequency (P = 0.061). Notably, aCAFs were less frequently observed in diffuse-type GC according to Lauren classification and in poorly cohesive carcinoma according to WHO classification compared to other subtypes (all P < 0.05). The presence of aCAFs was significantly associated with poor survival in diffuse-subtype GC and WHO-defined poorly cohesive carcinoma on univariate and multivariate analyses (all P < 0.05). aCAFs correlated with immune dysfunction but were not related to CD4 + and CD8 + T cell counts. Incorporating aCAF status modestly but consistently improved survival prediction in machine learning-based prognostic models. Histologically identifiable aCAFs on routine H&E slides represent a clinically accessible prognostic biomarker in diffuse-subtype GC, highlighting the importance of stromal morphology in risk stratification and providing a translational framework for future therapeutic studies targeting the tumor microenvironment.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRN::NTRK3-fused neoplasm with \"monster cells\" in the pelvis of a young adult female: expanding the clinicopathologic spectrum of NTRK-rearranged neoplasms.","authors":"Eva Manuela Pena-Burgos, Julia Suárez-González, Lourdes Hernández Muñoz, Marta Arregui Valles, Jose Manuel Asencio, Rodrigo Mora-Díaz, Jose Juan Pozo-Kreilinger","doi":"10.1007/s00428-026-04551-w","DOIUrl":"https://doi.org/10.1007/s00428-026-04551-w","url":null,"abstract":"<p><p>Gene fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes represent uncommon genetic alterations that may occur across a wide spectrum of tumor types. NTRK-rearranged sarcomas are most frequently identified in pediatric mesenchymal neoplasms, although they have also been described, less commonly, in adult mesenchymal tumors. We present the case of a 28-year-old woman with a large pelvic mass arising in relation to the psoas muscle. It was histologically composed of a dual cell population consisting of small hyperchromatic irregular cells intermixed with markedly pleomorphic \"monster cells\". Immunohistochemistry showed diffuse p16, Factor XIIIa, and CD163 positivity, while S100 protein, CD34, CD68 and other lineage-specific markers were negative. Pan-TRK immunostaining was negative. Targeted next-generation sequencing (NGS) was performed due to the non-specific findings of the tumor in a young adult patient, and a STRN::NTRK3 gene fusion involving exon 3 and exon 14, respectively, was identified, establishing this tumor as part of the emerging group of NTRK-rearranged neoplasms. Entrectinib was administered, and an excellent response was observed. This case emphasizes the relevance of performing NGS in cases with unusual clinicopathological findings to identify potential treatment options. Importantly, the morphology deviated from the classic fibrosarcoma-like appearance described in most adult NTRK3-fused neoplasms and broadens the morphological spectrum in which these neoplasms should be considered.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}