Virchows Archiv最新文献

{"title":"In this issue.","authors":"","doi":"10.1007/s00428-026-04748-z","DOIUrl":"https://doi.org/10.1007/s00428-026-04748-z","url":null,"abstract":"","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A locally advanced PML::JAK1 myofibroblastic sarcoma arising in the neck.","authors":"Saeko Soejima, Jotaro Nakashima, Naoki Kojima, Miyako Kitazono, Dai Inoue, Shunji Takahashi, Haruka Okada","doi":"10.1007/s00428-026-04744-3","DOIUrl":"https://doi.org/10.1007/s00428-026-04744-3","url":null,"abstract":"<p><p>A 54-year-old male patient presented with a painful right cervical mass encasing the common carotid artery. Histologically, the tumor consisted of polygonal to spindle-shaped cells with mild nuclear atypia and low mitotic activity (0-1/10 high-power fields). No myxoid stroma or necrosis was identified, and desmin expression was patchy. GenMineTOP, a dual DNA-RNA comprehensive genomic profiling system, revealed a PML exon 7-JAK1 exon 5 fusion. The tumor was surgically unresectable because of circumferential encasement of the right common carotid artery. After radiotherapy followed by doxorubicin chemotherapy, no distant metastases developed during 17 months of follow-up. PML::JAK1 myofibroblastic sarcomas have previously been reported in four abdominal cases, most of which showed aggressive behavior. This cervical case broadens the anatomic spectrum of PML::JAK1 myofibroblastic sarcomas to include the head and neck region and further expands their morphologic spectrum.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of fibroelastosis reveals distinct elastic and collagen fiber patterns in idiopathic and secondary pleuroparenchymal fibroelastosis.","authors":"Hiroyuki Katsuragawa, Hiroaki Ito, Tomohiro Handa, Masatsugu Hamaji, Toshi Menju, Ryo Sakamoto, Ryoma Bise, Hiroshi Date, Hironori Haga, Akihiko Yoshizawa","doi":"10.1007/s00428-026-04728-3","DOIUrl":"https://doi.org/10.1007/s00428-026-04728-3","url":null,"abstract":"<p><p>Pleuroparenchymal fibroelastosis (PPFE) is a rare idiopathic interstitial lung disease; however, similar histopathological features are also observed in secondary PPFE (SPPFE) and in non-PPFE entities. This study aimed to distinguish idiopathic PPFE (IPPFE), SPPFE, and non-PPFE by quantitatively assessing elastic and collagen fibers using a deep learning-based approach. We analyzed 1728 Elastica van Gieson-stained slides obtained from 174 explanted lungs, including IPPFE (n = 14), SPPFE (n = 34), and non-PPFE (n = 126). Elastic and collagen fiber areas were quantified using DenseNet. Elastic fibers were classified into dense and faint types and assessed in upper and lower lobes. In the upper lobes, IPPFE showed a lower median collagen fiber area/fibrosis area ratio (0.480) than SPPFE (0.555, P = 0.0197) and non-PPFE (0.611, P < 0.0001), while SPPFE also showed a lower ratio than non-PPFE (P = 0.0063). IPPFE and SPPFE showed higher median dense elastic fiber area/fibrosis area ratios (0.117 and 0.097, respectively) than non-PPFE (0.041; P < 0.0001 for both). Likewise, IPPFE and SPPFE showed higher median faint elastic fiber area/fibrosis area ratios (0.385 and 0.342, respectively) than non-PPFE (0.295; P = 0.0001 and P < 0.0001, respectively). Similar trends were observed in the lower lobes, although differences in collagen fiber area/fibrosis area ratios were less pronounced. In conclusion, fibroelastosis in IPPFE is characterized by a uniform, dense elastic fiber framework with faint elastic fibers, whereas SPPFE shows heterogeneous fibroelastosis with mixed collagen fibers. These findings confirm that IPPFE is a distinct condition from SPPFE and non-PPFE.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear grading of myxoid liposarcoma robustly predicts patient outcome: a study of 280 patients.","authors":"Lukas Marcelis, Astrid Vernemmen, Snježana Dotlić, Lea Jukic, Gregory W Charville, Phoebe L Li, Paari Murugan, M Zaki Karzoun, Ala Abu-Dayeh, Luna De Sutter, Annouschka Laenen, Matthew T Houdek, Friedl Sinnaeve, Hazem Wafa, Daphne Hompes, Patrick Schöffski, Andrew L Folpe","doi":"10.1007/s00428-026-04737-2","DOIUrl":"https://doi.org/10.1007/s00428-026-04737-2","url":null,"abstract":"<p><p>Myxoid liposarcoma (MLPS) exhibits variable morphology and clinical behavior. Current grading systems, which rely on the proportion of round cell areas, were developed for resections, rather than core biopsies. Additionally, criteria for round cell and \"transitional\" areas are subjective/poorly reproducible. It has recently been suggested that nuclear grading may be superior to traditional grading in predicting the behavior of MLPS. We compared nuclear and cellularity-based grading in a large, multinational MLPS cohort. 280 MLPS (1990-2025) were reviewed; nuclear grade was assigned using a slight modification of the Kawaguchi et al. system. Disease‑specific survival (DSS), metastasis‑free survival (MFS), and disease‑free survival (DFS) were estimated and the performance of both grading systems was compared. Tumors occurred in 152 males/128 females (median 45 years of age; range 15-91 years) and predominantly involved proximal deep soft tissues. Initial diagnoses were made with needle core (149 cases) and open biopsies (131 cases). DDIT3 rearrangement was documented in 195 tumors. Nuclear grades were 1 (71 cases), 2 (121 cases) and 3 (88 cases); grades 1 and 2 were considered \"low-grade\" and grade 3 \"high-grade\". Both systems assessed 192 (69%) and 88 (31%) tumors to be low and high-grade, respectively, although there was not perfect overlap. Clinical follow-up (280 patients; median 68 months, range: 3-355 months) showed 33 local recurrences, 96 distant metastases and 63 cancer-specific deaths. Tumors with low nuclear grade demonstrated significantly better DSS, MFS and DFS; those with low conventional grade did not. Identical results were seen with tumors diagnosed by needle biopsy (149 cases). The Harrell's C-index demonstrated nuclear grading to be superior in the prediction of DSS, MFS and DFS. We conclude that nuclear grading demonstrates superior prognostic performance over conventional grading, including in tumors diagnosed by needle biopsy. These results argue for more widespread adoption of nuclear grading in MLPS prognostication.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the genetic landscape of seromucinous hamartoma: novel HMGA2::PHF14 gene fusion - a case report.","authors":"Petr Slavík, Tomáš Vaněček, Petr Šteiner, Michal Michal, Martina Bradová","doi":"10.1007/s00428-026-04743-4","DOIUrl":"https://doi.org/10.1007/s00428-026-04743-4","url":null,"abstract":"<p><p>Seromucinous hamartomas (SH) are benign polypoid proliferations of small eosinophilic glands arising in the sinonasal tract. Together with respiratory epithelial adenomatoid hamartoma (REAH), they form a morphological continuum, and their hamartomatous designation has been increasingly questioned. Some authors now consider them stationary precancers potentially linked to tumor development through atypical sinonasal glands arising via the SH pathway. The molecular genetic background of SH remains poorly characterized, with no recurrent genetic alterations identified and no unequivocal molecular signature established to date. Here, we present a case of a 68-year-old woman with SH exhibiting a distinctive immunohistochemical staining pattern and a novel HMGA2::PHF14 fusion. This finding raises further questions about the true nature of a subset of SHs and underscores the need for thorough molecular characterization of these rare lesions.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous basaloid neoplasms with epithelial differentiation and EWSR1-fusions: a series of four cases.","authors":"Pierre Sohier, Melissa Gill, Daniel Pissaloux, Franck Tirode, Nicolas Macagno, Elisabeth G Demicco, Andreas Von Deimling, Faizan Malik, Shruti Agarwal, Carina A Dehner, Dmitry V Kazakov, Thibault Kervarrec","doi":"10.1007/s00428-026-04741-6","DOIUrl":"https://doi.org/10.1007/s00428-026-04741-6","url":null,"abstract":"<p><p>EWSR1::FLI1 is an established oncogenic driver of Ewing sarcoma, a malignant round cell sarcoma, while EWSR1::PBX3 fusions have been associated with myoepithelioma, in particular the syncytial type, which is characterized by cutaneous predilection, syncytial growth and co-expression of S100 and EMA in the absence of cytokeratin expression. We recently reported two cases of basaloid neoplasms with adnexal differentiation harboring EWSR1::FLI1 and EWSR1::PBX3 fusions. Herein, we report four additional basaloid epithelial tumors with similar morphologic features and EWSR1 fusions. We discuss the potential overlap between these cases with syncytial myoepitheliomas, and superficial adamantinoma-like Ewing sarcoma (ALES). The cases arose on the leg (n = 2), buttock, and back in 1 female and 3 males with a median age of 30 (range: 16-84). Microscopically all tumors were dermal based neoplasm with subcutaneous involvement in two. These neoplasms consist in basaloid tumor cells with trabecular growth patterns and prominent follicular differentiation in 3. A second solid or syncytial component was observed in two cases. Immunohistochemistry revealed BerEP4 positivity as well as cytokeratin expression in all cases. RNA sequencing revealed EWSR1::PBX3 in three cases and EWSR1::FLI1 in one. Transcriptomic and methylation comparison of the cases with a control group of skin tumors revealed the EWSR1::PBX3 basaloid tumors to form a cluster distinct from syncytial myoepitheliomas with EWSR1::PBX3 fusion while the EWSR1::FLI1-rearranged case co-clustered with the Ewing sarcoma group. Our findings confirm the existence of adnexal tumors with EWSR1-fusion and further highlight the diagnostic dilemmas between these tumors and other entities with EWSR1- fusions such as syncytial myoepithelioma and ALES.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEF1 expression in melanocytic tumors cannot accurately predict CTNNB1 mutational status acting as a potential pitfall in bi-phenotypic lesions.","authors":"Dimitrios Goutas, Nikolaos Katsoulas, Maria Michelli, Martha Nifora, Pavlos Papadakis, Anastasios Stofas, Nektarios I Koufopoulos, Eleftheria Lakiotaki, Irini Theochari, Angelica Α Saetta, Ioannis G Panayiotides, Periklis G Foukas, Penelope Korkolopoulou, Vasileia Damaskou, Vasiliki Siozopoulou, Arnaud de la Fouchardiere","doi":"10.1007/s00428-026-04736-3","DOIUrl":"https://doi.org/10.1007/s00428-026-04736-3","url":null,"abstract":"<p><strong>Background: </strong>Most melanocytic lesions develop along a genetic continuum progressing from a nevus to melanoma. Melanocytomas represent an intermediate category of tumors that lie within that spectrum harboring additional genetic alterations that may affect their phenotype. WHO currently recognizes three melanocytoma categories: Pigmented Epithelioid Melanocytomas (PEMs), BAP1-inactivated Melanocytomas (BIMs) and WNT-activated deep penetrating/plexiform melanocytomas (naevus) (WNT-activated DPMNs). Among them, WNT-activated DPMNs represent an underrecognized entity often misinterpreted as other biphenotypic pigmented lesions or melanomas. Therefore, LEF1 has been proposed as a marker of increased utility in the diagnosis of WNT-activated DPMNs.</p><p><strong>Materials and methods: </strong>We assessed LEF1 expression in a series of 61 melanocytic tumors including 10 Spitz nevi, 16 blue nevi, 9 common nevi, 1 combined nevus, 9 melanomas (various subtypes), 12 WNT-activated DPMNs, 2 WNT-activated melanomas and 2 PEMs. Beta-catenin was evaluated in all combined lesions and in one atypical cellular blue nevus (n = 23). Furthermore, CTNNB1 mutational analysis was performed in 49 cases.</p><p><strong>Results: </strong>LEF1 nuclear positivity was detected in 43/61 cases, i.e. 6/10 (60%) Spitz nevi, 5/16 (31%) BN (4/5) bi-phasic BN, 0/5 dendritic BN and 1/6 cellular BN), 9/9 (100%) common nevi, 0/1 combined nevus, 9/9 (100%) melanomas, 12/12 (100%) WNT-activated DPMNs, 2/2 WNT-activated melanomas and 0/2 PEMs. Subsequent examination for CTNNB1 molecular status displayed mutations only in WNT-activated lesions. Nuclear beta-catenin was detected in 11/12 WNT-activated DPMNs and in both WNT-activated melanomas; the remaining 10 lesions assessed, including the atypical cellular blue nevus, demonstrated physiological membranous expression only.</p><p><strong>Conclusion: </strong>LEF1 expression should be interpreted cautiously in pigmented or combined melanocytic lesions. Its diagnostic value is enhanced when assessed alongside beta-catenin or supported by CTNNB1 mutation analysis.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of diagnostic artificial intelligence models for prostate pathology in a Middle Eastern cohort.","authors":"Peshawa J Muhammad Ali, Navin Vincent, Saman S Abdulla, Han N Mohammed Fadhl, Anders Blilie, Kelvin Szolnoky, Julia Anna Mielcarz, Xiaoyi Ji, Nita Mulliqi, Abdulbasit K Al-Talabani, Kimmo Kartasalo","doi":"10.1007/s00428-026-04742-5","DOIUrl":"https://doi.org/10.1007/s00428-026-04742-5","url":null,"abstract":"<p><p>Artificial intelligence (AI) for pathology is accelerating cancer diagnostics. For global adoption, studies in currently under-represented populations - where the potential gains from AI may also be greatest - are needed. We present the first external validation study in a Middle Eastern setting, focusing on diagnosis and Gleason grading of prostate cancer. We digitised 339 prostate glass slides from Kurdistan, Iraq, representing a consecutive series of 185 patients from 2013 to 2024. Each slide was scanned on three digital pathology scanners, generating 1,017 whole-slide images. Task-specific and foundation AI models demonstrated AI-pathologist grading concordance similar to pathologist-pathologist concordance (Cohen's quadratically weighted kappa 0.801 vs. 0.799). Cross-scanner concordance was high (kappa > 0.90) for all AI models across three scanners. The demonstrated robust performance on a low-cost compact scanner could enable validation studies in non-digitalised settings and cost-effective AI adoption in laboratories with limited sample volumes. The publicly shared dataset supports further research to facilitate broader adoption of AI pathology.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral desmoplastic stroma in carcinoma brain metastases harbors stromal cells with a cancer-associated fibroblast (CAF)-like immunophenotype.","authors":"Dave Bandke, Serge Weis, Andreas Gruber, Sabina Köfler, Rupert Langer","doi":"10.1007/s00428-026-04726-5","DOIUrl":"https://doi.org/10.1007/s00428-026-04726-5","url":null,"abstract":"<p><strong>Background: </strong>Research on the tumor microenvironment of brain metastases (BM) has largely focused on immune response, while the intratumoral stromal compartment remains poorly characterized. In primary carcinomas, cancer-associated fibroblast (CAF) are intratumoral stromal cells that enable tumor progression. A subset of carcinoma BM shows intratumoral desmoplastic stroma (IDS) including stromal cells. This raises the question of whether this represents a CAF population in an organ devoid of resident fibroblasts.</p><p><strong>Methods: </strong>Whole-slide immunohistochemistry using a CAF marker panel (ASMA, CD90, COL11A1, SPARC) was performed in 19 carcinoma BM with IDS and in 10 glioblastomas. Stroma staining was scored semi-quantitatively (0-3). An independent cohort of 20 primary carcinomas with desmoplastic stroma was analyzed descriptively using the same approach.</p><p><strong>Results: </strong>IDS stroma cells in BM exhibited consistent CAF-like immunophenotypes across the panel. Marker expression did not differ by primary tumor site (ASMA p = 0.439; CD90 p = 0.711; COL11A1 p = 0.328; SPARC p = 0.369). Compared with glioblastomas, carcinoma metastases showed markedly higher ASMA and COL11A1 scores ( p < 0.001 each). The summed CAF panel score was substantially higher in carcinoma metastases than in glioblastomas (p < 0.001). IDS cells lacked immunoreactivity supporting glial or endothelial origin (GFAP/S100/Olig2 negative; CD34 negative) and showed no evidence of entrapped axons.</p><p><strong>Conclusion: </strong>A subset of carcinoma BM contains an IDS compartment with a CAF-like immunophenotype that is distinct from glioblastoma and normal brain. These findings provide a histopathological framework supporting the presence of an intratumoral stromal compartment with a CAF-like immunophenotype in BM and motivate mechanistic studies to define cellular origin, subtype composition, and functional roles.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric dysplasia: an integrated classification of surface epithelium-derived precursor lesions.","authors":"Tetsuo Ushiku","doi":"10.1007/s00428-026-04739-0","DOIUrl":"https://doi.org/10.1007/s00428-026-04739-0","url":null,"abstract":"<p><p>Gastric dysplasia comprises a heterogeneous group of non-invasive epithelial neoplasms with distinct clinicopathological and biological characteristics. This review focuses on surface epithelium-derived lesions, including intestinal-type, foveolar-type, and serrated dysplasia/adenoma. Conventional low-grade intestinal-type dysplasias/adenomas arise mainly in atrophic and metaplastic mucosa associated with Helicobacter pylori infection or, much less frequently, autoimmune gastritis. Small, pale, flat-elevated lesions with orderly small-intestinal differentiation generally behave indolently, whereas large size, redness, depression, nodularity, high-grade histology, and abnormal p53 expression are associated with an increased risk of progression. Foveolar-type dysplasia/adenoma is particularly heterogeneous. Flat-elevated foveolar-type adenoma, raspberry-type adenoma, and dysplasia arising in fundic gland polyps represent distinct dysplasia subtypes with indolent behavior. In contrast, other foveolar-type lesions are biologically heterogeneous; some are associated with microsatellite instability-high or Epstein-Barr virus-associated gastric carcinoma, whereas others may represent the superficial component of poorly differentiated or deceptively well-differentiated adenocarcinoma. Gastric serrated dysplasia is rare but is frequently associated with invasive carcinoma and should be regarded as a high-risk lesion requiring complete resection. Accurate diagnosis therefore requires integration of histological findings with endoscopic appearance and the background gastric mucosa. The principal role of pathological diagnosis is to distinguish dysplastic lesions with indolent behavior from those carrying a non-negligible risk of progression to invasive carcinoma, thereby guiding optimal clinical management.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}