2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献

{"title":"Wireless intraoperative real-time monitoring of neurotransmitters in humans","authors":"E. Bah, Jan T. Hachmann, Seungeul B. Paek, Aiyana Batton, Paul K. Min, K. Bennet, Kendall H. Lee","doi":"10.1109/MeMeA.2017.7985861","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985861","url":null,"abstract":"For decades, Fast Scan Cyclic Voltammetry (FSCV) has been an established method for investigating neurochemical changes in animal models. Various neurotransmitters have been monitored successfully in vivo with high spatial and temporal resolution including dopamine, norepinephrine, adenosine, and serotonin. While FSCV has already provided myriad insights into physiological and pathophysiological neurochemical signaling in the brain, this technique has traditionally been restricted to small animal models. After initial implementations in large animal models, our group and others have recently translated FSCV successfully into humans, showing intraoperative neurochemical monitoring of dopamine and adenosine release in the human brain of patients undergoing deep brain stimulation (DBS) surgery for Parkinson's disease or essential tremor. In this review, we provide an overview of the recent advances in human electrochemistry and current state-of-the-art approach for performing neurochemical recordings in the intraoperative setting in humans. Furthermore, we describe pertinent technological developments such as the WINCS (Wireless Instantaneous Neurotransmitter Concentration Sensing) system and its successor WINCS-Harmoni, a next generation device capable of combining brain stimulation with real-time neurochemical recording in vivo. Finally, we discuss the future potentials of human electrochemistry to advance the understanding of the neurophysiology of the central nervous system, pathological neurochemical changes, and mechanisms of DBS. It is important to note that human neurochemistry is still in its infancy and numerous critical challenges will have to be addressed over the next decades. However, these preliminary studies have shown that DBS surgery offers a unique window of opportunity for performing neurochemical recordings that would be beyond the scope of preclinical research. This technique may thereby provide unprecedented insights into human brain chemistry and myriad neurological and psychiatric conditions.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128731841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacemaker: Narrow pulses generation for design and sensitivity test","authors":"Kah-Meng Chew, Doris Lau","doi":"10.1109/MeMeA.2017.7985840","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985840","url":null,"abstract":"A pacemaker is a small device that helps the heart to beat more regularly and properly. It does this with a small electric stimulation that controls the heartbeat. This paper outlines pulse generation and sensitivity test of a pacemaker. Designers require a generated signal to simulate the real pacemaker pulse signal to use for sensitivity testing of the pacemaker. Next generation of function generators offer the best signal generators that can simulated a pulse signal as narrow as 1usec pulse width and arbitrary cardiac signal. The new digital or mixed signal oscilloscope, with its high resolutions acquisition, allows designers to analyze both low amplitude (0.5 mV and 1 mV) ECG signal and pulse signal stimulus simultaneously allowing designers to make real-time adjustments to their pacemaker designs.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116097728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the best stimulation parameters to measure in situ the comunication between muscle and nerve in mouse Tibialis muscle","authors":"S. Pisu, E. Rizzuto, A. Musarò, Z. Prete","doi":"10.1109/MeMeA.2017.7985865","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985865","url":null,"abstract":"Investigating the path functionality of the nerve stimulation signal and the muscle contraction is of primary importance in the study of a wide variety of pathologic conditions: neuromuscular diseases like Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy, as well as acute denervation and aging. Alterations of coupling between motor neuron conduction and muscle contraction can be studied in mice, comparing the muscle contraction elicited by two alternating stimulation paradigms: direct stimulation on the membrane and indirect stimulation through the nerve. The fundamental assumption behind this approach is that in a healthy model the two stimulations should lead to the same contractile response of the muscle. In this work we have searched for the pulse stimulation parameters that better resemble the physiological action potential. Applying these optimized stimulations it is then possible to design new final protocols to evaluate all the contractile parameters of muscle tissue in a wide variety of pathological models.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123687451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring cognitive ability in patients with moderate dementia using a modified “whack-a-mole”","authors":"Bruce Wallace, F. Knoefel, R. Goubran, Philippe Masson, Amanda Baker, Brianna Allard, Eleni Stroulia, Victor Guana","doi":"10.1109/MeMeA.2017.7985891","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985891","url":null,"abstract":"This paper presents results from the first 2 months of a 1-year study of 12 moderate dementia patients that participate in a weekly adult day program within a local community-care access center. The 12 patients are using a tablet-based whack-a-mole game, instrumented to record the user's behavior; this record is analyzed to extract indicators, as potential proxies of cognitive ability. Our partnership with the adult day program greatly eased recruitment: all but 1 eligible participant joined our study. The measurements recorded by the game include the detailed user progression through the game levels. There are two unique aspects to the design of our game: first, it includes two distinct targets requiring different actions, which increases the cognitive processing in the tap task for the users; second, each level is systematically more difficult than the last. The results show that the patients' performance within the game improves over the first few weeks; this indicates that they are learning the game and retaining ability gains from week to week, which is unexpected in dementia patients. Subsequently they appear to reach a performance plateau, with consistent performance from one week to the next. The performance levels are compared to their MMSE Total score and MMSE Orientation for Time sub-score and they are shown to have a maximum correlation of 0.465 and 0.654 respectively. These results demonstrate the potential for the whack-a-mole game to provide an ongoing measurement alternative for the MMSE and specifically the Orientation for Time sub-score that is a predictor of future decline.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"1968 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129927525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Savitzky-Golay digital differentiator for QRS complex detection in an electrocardiographic monitoring system","authors":"Erica N. Nishida, Odilon O. Dutra, Luís H. C. Ferreira, G. D. Colletta","doi":"10.1109/MeMeA.2017.7985881","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985881","url":null,"abstract":"This paper proposes using of a Savitzky-Golay digital differentiator (SGDD) in difference operation method (DOM) algorithm to detect QRS complex in an electrocardiographic monitoring system. Such modification enables using the SGDD low-pass feature to eliminate hardware filtering stages. Moreover, the SGDD also eliminates 60-Hz noise by choosing the proper window size and polynomial order. A Savitzky-Golay digital differentiator with thirteen samples window and third order polynomial, running at 360-Hz, increases the signal-to-noise ratio in 25 times. Performance has been evaluated by comparing the figures of merit for false positives, false negatives and true positives between both original DOM algorithm and the proposed modified one, showing notorious improvements.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"596 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116561222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posture sensing using a low-cost temperature sensor array","authors":"L. Russell, R. Goubran, F. Kwamena","doi":"10.1109/MeMeA.2017.7985917","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985917","url":null,"abstract":"Posture identification is an example of one of many physiological characteristics that can be used to determine a variety of health parameters. Pressure mats and camera analysis are common methodologies to determine posture of a subject in a chair. In this paper, we show results of a laboratory study of how we can determine posture of a subject using various arrays of multiple low-cost temperature sensors per section or characteristic to be determined. This can be a standalone occupancy and posture system, or can be fused with data from other technologies to validate data from pressure or visual-based systems. The system was tested with different types of furniture such as various styles of chairs, armrests, cushions, and beds.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126196619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tunable-resonance faraday device for dual cardiac sensing and energy harvesting","authors":"T. Secord, Andrew J. Johnson","doi":"10.1109/MeMeA.2017.7985885","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985885","url":null,"abstract":"Efficient energy harvesting from the mechanical energy of cardiac motion is an attractive means to avoid the use of batteries in implantable sensors for non-life sustaining applications. Ideally, a single device would integrate both sensing and energy harvesting functionality. This work describes a novel electromagnetic system that achieves high sensitivity sensing of cardiac signals while simultaneously providing adaptive and efficient energy harvesting capability utilizing tunable resonance. The harvested mechanical energy can then be deployed for myriad purposes including self-sustaining sensor operation, trickle charging of other nearby battery-powered devices (e.g. pacemakers), data logging, or periodic telemetry. Although some harvested energy is required adaptively tune a mechanical resonant frequency, this energy expenditure occurs at a relatively low frequency and is minimized with the chosen design concept. A prototype design is constructed and tested to demonstrate the viability of the approach.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128061305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining changes in image segmented arteries in response to blood occlusion","authors":"Stephanie L. Bennett, R. Goubran, F. Knoefel","doi":"10.1109/MeMeA.2017.7985909","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985909","url":null,"abstract":"The world's expanding and aging population has created a demand for unobtrusive, automated healthcare solutions. Thermal imaging aids in the development of these solutions by enabling the extraction of physiological signals in an unobtrusive manner. This paper aims to examine the potential for thermal video in conjunction with image segmentation methods to quantitatively describe the behavior of blood vessels as blood flow is occluded and relieved. Thermal video of a subject's arm wearing a wireless blood pressure cuff was captured as the cuff operated. Each frame of the thermal video was subjected to three methods of image segmentation (to identify the arteries); basic thresholding, watershed method and level set method. Results from each method were compared; all methods resulted in successful segmentation, but varied in region identification performance. The basic method resulted in the least accurate segmentations, the level set method resulted in the smoothest boundaries and most accurate shape, and the watershed method resulted in a crude shape but best identified the correct areas. When the segmentation results were quantified in terms of region area and examined over time, all methods indicated a smaller area when blood had been occluded, and a larger area both initially and during vascular recovery. The watershed method best characterized the vascular behaviour, while being computationally inexpensive. These results suggest that thermal video in conjunction with image segmentation methods, particularly watershed method, can be used to indicate blood flow through a segmented vessel.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133205934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG analysis of Evoked Potentials of the brain to develop a mathematical model for classifying Tinnitus datasets","authors":"Yasaman Emami, Coskun Bayrak","doi":"10.1109/MeMeA.2017.7985906","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985906","url":null,"abstract":"Tinnitus is hearing a sound of buzzing, ringing, whooshing, etc. when there are no actual sounds existing specially when the background is quiet. Per statistics from the American Tinnitus Association, these symptoms affect twenty percent of population's life. In this study, we investigate 12 individuals distributed between 6 normal subjects and 6 subjects suffering from Tinnitus to develop a mathematical model for identifying Tinnitus patients in compare with normal subjects using a 14-channel low cost commodity neuroheadset (Emotiv). Our pipeline involves collecting Electroencephalography (EEG) data from the 12 subjects. We then perform noise reduction, after that we split the data into training and testing datasets, followed by labeling, fusion and randomization using Independent Component Analysis approach to then be passed to several classification algorithms to be compared and chosen from the best candidate models based on the best calculated accuracy. We compare Support Vector Machine approach versus K Nearest Neighbor as final models. We then validate the selected model using the test data resulting in a model capable of classifying EEG data as Tinnitus or not. Our method demonstrates that commodity EEG neuroheadsets can be used to identify Tinnitus patients using our proposed model.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124453075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Android framework for automatic diagnosis of heart diseases","authors":"Hicaro S. Santos, Odilon O. Dutra, E. M. Moreira, Luís H. C. Ferreira","doi":"10.1109/MeMeA.2017.7985878","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985878","url":null,"abstract":"This paper proposes the model of an Android based framework. It gives functionality to identify QRS complex, cardiac rhythm rate and filters. Moreover, with its software engineered structure, it can be expanded with children classes specialized on other functions, as well as automated heart decease diagnosis. As it is compatible with the standard Health Level 7 (HL7) format, more specifically, the Annotated ECG (aECG) HL7 version 3, a system developed with the proposed framework can interoperate with any other HL7 compatible ECG system. It has been tested with the OpenEinthoven platform together with the BlueHeart Android application. It intends to be a benchmark for the development of heart diseases diagnosis algorithms.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115944895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}