2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)最新文献_第4页

Chitosan microbeads with MNP on printed electrodes for electric stimulus responsive drug delivery 带有MNP的壳聚糖微珠在印刷电极上用于电刺激反应性药物递送

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985921

Ankita Mohapatra, M. Harris, M. Ghimire, B. Morshed, J. Jennings, W. Haggard, J. Bumgardner, S. Mishra, Tomoko Fujiwara

{"title":"Chitosan microbeads with MNP on printed electrodes for electric stimulus responsive drug delivery","authors":"Ankita Mohapatra, M. Harris, M. Ghimire, B. Morshed, J. Jennings, W. Haggard, J. Bumgardner, S. Mishra, Tomoko Fujiwara","doi":"10.1109/MeMeA.2017.7985921","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985921","url":null,"abstract":"Over the last few decades, various drug delivery systems (DDS) have been fabricated to overcome limitations of direct drug administration like solubility, short circulation lifetime, low tissue specificity, etc. Several of these DDS are also capable of controlling the passive drug release profile in response to a stimulus. This work describes a novel stimuli responsive DDS that alters its normal elution profile to release a higher drug amount when electric pulses are provided as excitation. The DDS is in form of microbeads made from chitosan cross linked with polyethylene glycol dimethacrylate, containing magnetite nanoparticles and vancomycin as the drug of interest. Silver (Ag) Inter-Digitated Electrodes (IDE) on Polyimide films were printed using a material printer and placed on the DDS. Two separate stimuli, each of 30 s duration were applied to the DDS via the IDE. The stimulated groups showed vancomycin release increased by 75% and 51% after the first and second stimuli respectively, in comparison to samples that were not stimulated. This preliminary work shows promising mechanism of a multiple- stimuli responsive DDS.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127118278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

High altitude study on finger reflectance SpO2 手指反射率SpO2的高空研究

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985875

Preejith Sreeletha Premkumar, Rohan Hajare, J. Joseph, M. Sivaprakasam

{"title":"High altitude study on finger reflectance SpO2","authors":"Preejith Sreeletha Premkumar, Rohan Hajare, J. Joseph, M. Sivaprakasam","doi":"10.1109/MeMeA.2017.7985875","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985875","url":null,"abstract":"Regular monitoring of blood oxygen saturation (SpO2) level and heart rate is critical not only during surgeries and in ICUs but also at home, especially for patients suffering from Chronic Obstructive Pulmonary Diseases. Reflectance pulse oximetry removes the hassles of probe based transmittance techniques and has the potential to emerge as the primary method for SpO2 measurement, especially for wearable and minimally intrusive physiological monitoring. Reflectance pulse oximetry at the finger can be used for intermittent monitoring applications by integrating the modality to life style devices like wrist watches. A wrist-worn finger based reflectance pulse oximeter which works in conjunction with a smart phone/tablet for cloud connectivity is presented. This paper describes the proposed system architecture and the data collection exercise carried out at high altitudes to obtain the calibration coefficients for device operation. The data collected during the high-altitude exercise was analyzed to verify the correlation between R values obtained from the device and the reference SpO2 measurements made using a standard equipment. The performance of the device was tested on 3 volunteers at heights of 5,360 m and 4,259 m from the sea level.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120810628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An accelerometer probe for local pulse wave velocity measurement 用于局部脉冲波速度测量的加速度计探头

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985914

R. Arathy, J. Joseph, P. Nabeel, M. Sivaprakasam, Vartika Awasthi

{"title":"An accelerometer probe for local pulse wave velocity measurement","authors":"R. Arathy, J. Joseph, P. Nabeel, M. Sivaprakasam, Vartika Awasthi","doi":"10.1109/MeMeA.2017.7985914","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985914","url":null,"abstract":"The velocity of propagation of arterial blood pulse signals obtained from a smaller arterial section referred as local pulse wave velocity (PWV) is an index of cardiovascular events of a particular artery. In this work, we introduce a novel design of accelerometer probe for local PWV measurement from the carotid artery. The proposed probe was developed using highly sensitive dual MEMS accelerometers. The probe design with tiny dual element sensors was capable of simultaneously acquiring acceleration signals generated due to arterial wall displacement towards the skin surface. Measurements were performed from carotid artery over a smaller arterial section of length 24 mm. The ability of the probe to acquire continuous arterial waveforms and cycle-to-cycle local PWV measurement was verified by conducting an in-vivo test in multiple subjects (11 volunteers aged between 20 – 60 years) under controlled settings. Reliable as well as repeatable signals (maximum beat-to-beat variation was less than 13%) and carotid PWV measurement with high reproducibility was obtained. A correlation examination of the local PWV with heartrate and BP was conducted during the same study. A statistically significant correlation was observed with the correlation coefficient greater than 0.78 for BP parameters and 0.66 for heartrate. In-vivo validation study promising the potential use of the developed accelerometer probe for cuffless evaluation of BP parameters and heartrate as a confounder of local PWV assessment was obtained.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121016562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Ex-vivo measurement of the biaxial properties of rat vagina: Some preliminary results 大鼠阴道双轴特性的离体测量:一些初步结果

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985864

E. Rizzuto, Z. Prete, Alyssa Huntington, Roshelle Wijeratne, R. Vita

{"title":"Ex-vivo measurement of the biaxial properties of rat vagina: Some preliminary results","authors":"E. Rizzuto, Z. Prete, Alyssa Huntington, Roshelle Wijeratne, R. Vita","doi":"10.1109/MeMeA.2017.7985864","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985864","url":null,"abstract":"Pelvic floor disorders (PFDs) concern a wide range of disorders that occur when one of the organs of the reproductive system loses its functionality. To date, PFDs affect nearly 30 million women in the U.S. and the symptoms usually associated with these disorders include urinary and fecal incontinence, pain, psychological and emotional distress. While the exact etiology of PFDs is unknown, mechanical alterations to pelvic organs, supportive ligaments, fasciae, and muscles due to pregnancy, age, and weight gain contribute to the development of these disorders. There is an unmet clinical need to characterize the mechanical properties of the female reproductive organs and supporting tissues. One PFD is related to the decrease in the mechanical integrity of the vagina, which can cause the pelvic organs to descend into the vagina, a condition known as pelvic organ prolapse. Within this context, the aim of this work was to devise a biaxial testing system for assessing passive properties of rat vagina. While many studies characterized the uniaxial mechanical properties of vaginal tissues, biaxial mechanical properties are almost unexplored. Nonetheless, the nonlinear and anisotropic nature of vaginal tissue has already been shown in a few preliminary studies. In this study, the development of a testing system is presented. The system is tested using rubber specimens since the mechanical properties of rubber are well known. Finally, some preliminary data were collected using specimens from rat vagina. The results showed that the “toe region” of the tissue computed along the longitudinal axis is more extended than the counterpart measured along the circumferential axis, confirming the capability of the proposed system to properly measure the mechanical properties of vagina along the two main axes simultaneously.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116653713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gait partitioning methods in Parkinson's disease patients with motor fluctuations: A comparative analysis 帕金森病患者运动波动的步态划分方法:比较分析

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MEMEA.2017.7985910

Ilaria Mileti, M. Germanotta, S. Alcaro, Alessandra Pacilli, Isabella Imbimbo, M. Petracca, C. Erra, E. D. Sipio, I. Aprile, S. Rossi, A. Bentivoglio, L. Padua, E. Palermo

{"title":"Gait partitioning methods in Parkinson's disease patients with motor fluctuations: A comparative analysis","authors":"Ilaria Mileti, M. Germanotta, S. Alcaro, Alessandra Pacilli, Isabella Imbimbo, M. Petracca, C. Erra, E. D. Sipio, I. Aprile, S. Rossi, A. Bentivoglio, L. Padua, E. Palermo","doi":"10.1109/MEMEA.2017.7985910","DOIUrl":"https://doi.org/10.1109/MEMEA.2017.7985910","url":null,"abstract":"Measuring gait quality of patients through wearable sensors has become an useful tool to assist in drug administration. Several methods, based on inertial sensors placed on lower limbs, have been proposed over the last decade to estimate clinical meaningful parameters such as gait phase distribution. Application of those algorithms for monitoring gait abnormalities would have a tremendous potential in patients with Parkinson's disease. However, their applicability to patients with severe gait impairment has not been fully tested and compared. In the present study, we conducted a comparative analysis of gait phase detection methods applied to patients with Parkinson's disease both in OFF and ON levodopa conditions. We compared gait partitioning performance of three already proposed algorithms based on a threshold method and a novel Hidden Markov Model approach. Fourteen subjects with idiopathic PD have been enrolled in this study, and evaluated twice during the same day: both in OFF and in ON conditions. All patients have performed three walking tasks along a 20 m walkway in with four Inertial Measured Units placed on shanks and feet. The sagittal angular velocity of all segments and the linear acceleration of feet have been gathered to evaluate stance and swing phases. Force resistive sensors used as foot-switches have been placed under the feet to estimate the reference gait phase sequence. The goodness (G) of methods was evaluated through the Receiver Operating Characteristic. The results provided an optimum goodness for all examined methods (0 < G < 0.25). The best performance has been achieved with the Hidden Model Markov both in OFF (G=0.01) and ON (G=0.01) levodopa conditions. Our results encourage the applicability of HMM in developments of wearable systems for daily monitoring in patients with motor fluctuations.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"52 3-4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132874347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Wireless instrumented cane for walking monitoring in Parkinson patients 用于帕金森患者行走监测的无线手杖

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985912

Feriel Mekki, Michela Borghetti, E. Sardini, M. Serpelloni

{"title":"Wireless instrumented cane for walking monitoring in Parkinson patients","authors":"Feriel Mekki, Michela Borghetti, E. Sardini, M. Serpelloni","doi":"10.1109/MeMeA.2017.7985912","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985912","url":null,"abstract":"Instrumentation of conventional aids (walking stick, ortho-cane, crutch, walker, etc.) can generate numerous benefits for both the clinician and the patient, aiming at the improvement of walking activity. In this paper, a designed, fabricated and tested instrumented cane is presented. Its versatile characteristics permit an adoption for different applications. In this paper, the instrumented cane is personalized and tested in order to monitor the ambulation of Parkinson patients. The cane permits to monitor axial forces by means of a strain-bridge and movements by means of an Inertial Measurement Unit (IMU). It is also composed of a conditioning and transmission circuit, and a power management circuit. All the circuits are integrated on a circuit board. The designed device has been made in order to miniaturize the circuit board and improve the output signal during gait. A Bluetooth module transmits the data wirelessly to a remote computer. The acquisition data can be saved and viewed by a developed user interface realized with LabVIEW. The tilt and force sensing of the cane have been tested, and characterized in the laboratory. The mean experimental standard deviation was about 20 N for axial forces. Hysteresis, linearity, and drift were calculated, and the obtained accuracy was about 0.8°. The instrumented cane prototype is under trials to be adopted for the Parkinsonian community, in order to monitor their ambulation during rehabilitation sessions and as a proposal to detect the “mysterious clinical phenomenon” that is the Freezing of Gait (FoG).","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"2012 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128160048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Classification of the quality of wristband-based photoplethysmography signals 基于腕带的光容积脉搏波信号质量分类

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985887

Nikhilesh Pradhan, S. Rajan, A. Adler, C. Redpath

{"title":"Classification of the quality of wristband-based photoplethysmography signals","authors":"Nikhilesh Pradhan, S. Rajan, A. Adler, C. Redpath","doi":"10.1109/MeMeA.2017.7985887","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985887","url":null,"abstract":"Wearable technologies have made ubiquitous, non-invasive continuous monitoring of vital signs outside of the clinical setting possible. Convenient and user friendly embedded sensors in wearable technologies such as wristbands or watch, unlike cumbersome electrocardiogram Holter monitors, have made long term monitoring possible in normal home/home-care setting. However, such vital sign monitors are highly susceptible to motion artifacts and hence the quality of signal suffers. In order to develop a reliable automated technique to estimate vital signs, it is necessary to understand and estimate the quality of the acquired signal. In this paper, we compare the characteristics of signal corrupted by motion artifact against the artifact-free photoplethysmographic (PPG) signal acquired from an Empatica E4 wristband over 24 hours from 15 participants as the first step toward understanding and quantifying the quality of PPG signals. Using four 10 second segments of artifact-free and clean PPG signal from each participant, features that describe the signal are extracted. Bhattacharyya distance measure is used to rank the features that represent quality of the PPG signal. Using set of highly ranked features, a Naïve Bayes classifier is designed to quantify the quality of the PPG signal.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132116868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Measuring performance of children with speech and language disorders using a serious game 用一个严肃的游戏来测量言语障碍儿童的表现

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985842

N. Nasiri, S. Shirmohammadi

{"title":"Measuring performance of children with speech and language disorders using a serious game","authors":"N. Nasiri, S. Shirmohammadi","doi":"10.1109/MeMeA.2017.7985842","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985842","url":null,"abstract":"Speech therapy via serious games gives an opportunity to children with speech disorders and hearing problems to overcome their problems by playing serious games. As far as children are more inclined to play games, so we intend to learn them by entertainments. In this paper, we have designed and implemented a serious game that can be used both as therapy and as a tool to measure the performance of children with speech impediments. The game consists of three steps. The first step provides information for parents or therapists to decide if their child needs speech therapy or not. In the second step, the child starts to learn specific words while playing the game. The third step aims to measure the performance of the child and evaluate how much the child has learned at the end of the game. The game has an avatar which can be controlled by the child through speech, with the objective of moving the avatar around the environment to earn coins. The avatar is controlled by both voice commands such as Jump, Ahead, Back, Left, Right, and arrow keys of the keyboard. The game allows the child to practice longer hours, compared to clinical approaches under the supervision of a therapist, which are time-limited. Our preliminary performance measurements indicate an improvement of 40% for children who play our game 5 times.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"429 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116001214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Breathing signal combining for respiration rate estimation in smart beds 智能床中呼吸频率估计的呼吸信号组合

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MEMEA.2017.7985893

H. Azimi, S. S. Gilakjani, M. Bouchard, Stephanie L. Bennett, R. Goubran, F. Knoefel

引用次数: 20

Detection of paroxysmal atrial fibrillation: A computationally efficient algorithm for use in a wearable telemedical system 阵发性心房颤动的检测:一种用于可穿戴远程医疗系统的计算效率算法

2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Pub Date : 2017-05-01 DOI: 10.1109/MeMeA.2017.7985896

J. Kirchner, Stefanie Schild, G. Fischer

{"title":"Detection of paroxysmal atrial fibrillation: A computationally efficient algorithm for use in a wearable telemedical system","authors":"J. Kirchner, Stefanie Schild, G. Fischer","doi":"10.1109/MeMeA.2017.7985896","DOIUrl":"https://doi.org/10.1109/MeMeA.2017.7985896","url":null,"abstract":"For early detection of the sporadic events of paroxysmal atrial fibrillation (AF), long-term ECG monitoring and data evaluation are required. To allow energy-efficient on-device preprocessing of the data, an as simple as possible algorithm is sought. The proposed approach is based on heart frequency data only and makes use of the increased heart rate variation with the occurrence of AF. Criteria for the choice of the free parameters of this method are derived, and it is shown that, under these conditions, results are insensitive against variations of these parameters. If a compromise between sensitivity and specificity is sought, i. e. equality of these values, 89, 4% are obtained in average. If instead sensitivity alone is optimized, i. e. for use with additional AF detection strategies, an average value of 99.6% is reached with specificity 38.4%. The algorithm forms the first step in the development of a computationally and thus energy efficient signal processing module for the purpose of reducing the amount of data that has to be stored or transmitted and then evaluated by the treating physician.","PeriodicalId":235051,"journal":{"name":"2017 IEEE International Symposium on Medical Measurements and Applications (MeMeA)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127894587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2