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Management Options for Infertile Women with Polycystic Ovary Syndrome 多囊卵巢综合征不孕妇女的治疗选择
US endocrinology Pub Date : 2018-01-01 DOI: 10.17925/USE.2018.14.2.67
G. Mariani, J. Bellver
{"title":"Management Options for Infertile Women with Polycystic Ovary Syndrome","authors":"G. Mariani, J. Bellver","doi":"10.17925/USE.2018.14.2.67","DOIUrl":"https://doi.org/10.17925/USE.2018.14.2.67","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a heterogenous condition affecting 5–10% of women at reproductive age. It is the most common cause of anovulatory infertility, characterized by hyperandrogenism and arrested follicle development, and is frequently associated with metabolic features such as insulin resistance and obesity. The diagnosis of PCOS, based on the Rotterdam criteria (2003), can be made when at least two of the following three main features are met: oligo-ovulation and/or anovulation, hyperandrogenism (clinical and/or biochemical), and polycystic ovarian morphology at ultrasound examination. Several approaches to ovulation induction have been proposed in women with PCOS. These approaches vary in efficacy, treatment duration, cost, and patient compliance. Management includes lifestyle changes, pharmacotherapy (metformin, clomiphene citrate, letrozole, gonadotropins, inositol), laparoscopic surgery (ovarian drilling), and assisted reproductive techniques, usually in vitro fertilization (see Figure 1). Clinical decisions in PCOS anovulatory patients are currently supported by a recently published international evidence-based guideline that provides 166 recommendations to help clinicians in the diagnosis and management of PCOS and to guide clinical practice.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"14 1","pages":"67"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Telemedicine Services for Emerging Adults with Type 1 Diabetes 新兴成人1型糖尿病患者的远程医疗服务
US endocrinology Pub Date : 2018-01-01 DOI: 10.17925/USE.2018.14.2.73
Neesha Ramchandani
{"title":"Telemedicine Services for Emerging Adults with Type 1 Diabetes","authors":"Neesha Ramchandani","doi":"10.17925/USE.2018.14.2.73","DOIUrl":"https://doi.org/10.17925/USE.2018.14.2.73","url":null,"abstract":"Emerging adults with type 1 diabetes (T1D) often find it challenging to manage their diabetes well due to the many competing priorities they are juggling during this time. The majority of emerging adults (72%) are already looking for health information online, so telemedicine may be an avenue to explore with them. Telemedicine services for individuals with T1D are becoming increasingly popular and have been found to be beneficial for those who use them. However, there are very few multi-component telemedicine services available for individuals with T1D, and none of them provide a comprehensive technology-based system. Additionally, while these multi-component T1D telemedicine systems often included emerging adults in the group under study, the average age of the study subjects was usually above the age range of emerging adulthood. This suggests that specific developmental needs of emerging adults are not being addressed by these telemedicine systems, nor are the issues faced by diverse populations. More research needs to be done to address which telemedicine services, if any, would be beneficial for this especially vulnerable population.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"14 1","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Letter from the Journal 《华尔街日报》的来信
US endocrinology Pub Date : 2018-01-01 DOI: 10.17925/USE.2018.14.1.11
M. Marcovecchio
{"title":"Letter from the Journal","authors":"M. Marcovecchio","doi":"10.17925/USE.2018.14.1.11","DOIUrl":"https://doi.org/10.17925/USE.2018.14.1.11","url":null,"abstract":"","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"42 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80643268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The New Psychosocial Position Statement from the American Diabetes Association 美国糖尿病协会的新社会心理立场声明
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.01.10
L. Siminerio
{"title":"The New Psychosocial Position Statement from the American Diabetes Association","authors":"L. Siminerio","doi":"10.17925/USE.2017.13.01.10","DOIUrl":"https://doi.org/10.17925/USE.2017.13.01.10","url":null,"abstract":"Received: March 20, 2017 Published Online: May 8, 2017 Citation: US Endocrinology, 2017;13(1):Epub ahead of print Corresponding Author: Linda Siminerio, Professor of Medicine and Nursing, University of Pittsburgh, Falk Medical Building, Room 570, 3601 Fifth Avenue, Pittsburgh PA 15213, US. E: simineriol@upmc.edu D iabetes self-management education and support provides the foundation for helping people with diabetes to be able to navigate decisions and activities related to managing their life-long disease. Here, Linda Siminerio of the School of Medicine and Nursing, University of Pittsburgh, Pennsylvania, US discusses psychological factors affecting people with diabetes, self-management and the multiple benefits of ongoing education and support.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 Diabetes in Athletes 运动员的1型糖尿病
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.51
J. Yardley
{"title":"Type 1 Diabetes in Athletes","authors":"J. Yardley","doi":"10.17925/USE.2017.13.02.51","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.51","url":null,"abstract":"Managing training and competition with type 1 diabetes is complicated, but not impossible. Athletes, and their diabetes care providers, should be aware of everything that might impact blood glucose responses to exercise. These factors include the type, timing, intensity and duration of exercise, as well as the timing and size of insulin dosage adjustments and carbohydrate intake. Due to differences in physiology (age, sex, fitness levels, etc.) there is no \"one size fits all\" solution, however, with careful planning and record-keeping, athletes with type 1 diabetes have the same opportunities for success in their sport as everyone else.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"51"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Magnetic Resonance Imaging-guided Focused Ultrasound in Movement Disorders—A Review 磁共振成像引导聚焦超声在运动障碍中的应用综述
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.74
L. Talman, Binit B. Shah
{"title":"The Use of Magnetic Resonance Imaging-guided Focused Ultrasound in Movement Disorders—A Review","authors":"L. Talman, Binit B. Shah","doi":"10.17925/USE.2017.13.02.74","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.74","url":null,"abstract":"T he use of surgical treatments for movement disorders has been well established for several decades, with a strong focus, in the past, on ablative lesioning procedures and, more recently, deep brain stimulation. Magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) is emerging as a newly recognized surgical technique for the treatment of various movement disorders. The most robust data, demonstrating safety and efficacy of MRgFUS, have been published in trials directed at treatment of essential tremor (ET); however, many trials are underway to define its role in other movement disorders, such as Parkinson’s disease with preliminary results echoing those from studies in ET. The full potential for use of MRgFUS, both in the field of movement disorders and beyond, is only beginning to be explored.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"74"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Headache in the Emergency Room 头痛在急诊室
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.94
Kourosh Kahkeshani, Huma U. Sheikh
{"title":"Headache in the Emergency Room","authors":"Kourosh Kahkeshani, Huma U. Sheikh","doi":"10.17925/USE.2017.13.02.94","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.94","url":null,"abstract":"","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MC4R Mutation in Early-onset Severe Childhood Obesity—Genotype–phenotype Correlation 早发性重度儿童肥胖的MC4R突变-基因型-表型相关性
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.69
D. Khandelwal, S. Birla, Arundhati Sharma, R. Khadgawat
{"title":"MC4R Mutation in Early-onset Severe Childhood Obesity—Genotype–phenotype Correlation","authors":"D. Khandelwal, S. Birla, Arundhati Sharma, R. Khadgawat","doi":"10.17925/USE.2017.13.02.69","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.69","url":null,"abstract":"M elanocortin-4 receptor (MC4R; OMIM#155541) encodes a 332-amino acids protein possessing typical G-protein-coupled receptors' (GPCRs) structural design having three intact and functional domains, mutations which lead to the most recurrent type of monogenic obesity. Methods: We report here a case of a 5-year-old boy from Iraq who presented to the clinic for evaluation of progressive weight gain since he was 6 months of age. There were no symptoms of hypothalamic dysfunction except increase in appetite. His height was 120 cm (97th centile of the Centers for Disease Control and Prevention [CDC] growth chart, mid parental height was 50th centile), weight was 57 kg (>97th centile on CDC chart) and body mass index was 39.6 kg/m2 (>97th centile on CDC chart). A monogenic cause of obesity was strongly suspected in view of early onset severe childhood obesity. Results: Mutation screening of MC4R revealed a homozygous isoleucine by arginie at codon 69 (I69R) mutation in the patient, while his father was heterozygous for this mutation. Conclusion: We describe a monogenic form of obesity with characteristic presentation due to I69R MC4R mutation inherited as an autosomal recessive condition. The finding is different from previous reports which have documented this mutation to be inherited in a dominant manner. The findings of the present study reiterate the complex nature of obesity with possible involvement of modifier genes and/or genetic heterogeneity in its causation.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"69"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of a Rare Association Between Right Thyroid Hemiagenesis, Lingual Thyroid, and Papillary Thyroid Cancer 右甲状腺功能不全、舌甲状腺与甲状腺乳头状癌罕见相关1例
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.01.01
Umal Azmat, J. Phay, T. Teknos, J. Bekeny, F. Nabhan
{"title":"A Case of a Rare Association Between Right Thyroid Hemiagenesis, Lingual Thyroid, and Papillary Thyroid Cancer","authors":"Umal Azmat, J. Phay, T. Teknos, J. Bekeny, F. Nabhan","doi":"10.17925/USE.2017.13.01.01","DOIUrl":"https://doi.org/10.17925/USE.2017.13.01.01","url":null,"abstract":"L ingual thyroid and thyroid hemiagenesis are rare thyroid developmental abnormalities. These conditions can be present with other thyroid diseases, whether functional ones involving abnormal thyroid hormone levels, or structural ones such as presence of thyroid nodules, however the association with thyroid cancer and lingual thyroid or thyroid hemiagenesis is rare. In addition to that, when thyroid hemiagenesis is present, it is usually in the left lobe. We describe here a pregnant patient who presented with metastatic cervical nodes from thyroid cancer who was found on imaging to have right thyroid hemiagenesis. After she underwent an initial surgery for thyroid cancer and metastatic nodal disease, she was then later discovered to have a lingual thyroid. In this case we report this extremely rare combination and also discuss the potential implications of this association on the diagnosis and management of these patients particularly initial surgery and imaging studies needed for the thyroid cancer.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"01"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hyperfiltration and Albuminuria—A Deadly Combination 高滤过和蛋白尿是一种致命的组合
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.01.12
C. Lardinois
{"title":"Hyperfiltration and Albuminuria—A Deadly Combination","authors":"C. Lardinois","doi":"10.17925/USE.2017.13.01.12","DOIUrl":"https://doi.org/10.17925/USE.2017.13.01.12","url":null,"abstract":"I ndividuals with chronic kidney disease (CKD) are at high risk of coronary heart disease (CHD), and roughly half die of CHD without developing end-stage renal disease. Two key kidney measurements: estimated glomerular filtration rate (eGFR) and albuminuria, are consistently associated with high CHD risk. An eGFR greater than 105 ml/min per 1.73m2 (hyperfiltration) and an albumin-to-creatinine ratio (ACR) greater than 5 mg/g are both independently associated with an increased risk of CHD. Therefore, eGFR and ACR should be taken into account for cardiovascular prediction.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"183 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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