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The Birth of Bariatric Endocrinology and the Coming of Age of Obesity Medicine 肥胖内分泌学的诞生与肥胖医学时代的到来
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.01.10
J. M. González-Campoy
{"title":"The Birth of Bariatric Endocrinology and the Coming of Age of Obesity Medicine","authors":"J. M. González-Campoy","doi":"10.17925/USE.2016.12.01.10","DOIUrl":"https://doi.org/10.17925/USE.2016.12.01.10","url":null,"abstract":"A search of PubMed shows that in 1960, the year I was born, there were 110 publications on obesity. In 1991, the year I graduated from Mayo Medical School, the number had risen to 406 publications. By contrast, in 2015 there were 5470 publications on obesity. The last quarter of a century has led to the recognition of a world-wide epidemic of overweight and obesity, with a rise in all their complications.1–3 And with this recognition came the need to understand the underlying physiology and pathophysiology, and the eventual development of therapeutic interventions.4–6","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Advancements in Clinical Thyroidology in 2016 2016年临床甲状腺学进展
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.02.83
M. Brito, T. Davies
{"title":"Advancements in Clinical Thyroidology in 2016","authors":"M. Brito, T. Davies","doi":"10.17925/USE.2016.12.02.83","DOIUrl":"https://doi.org/10.17925/USE.2016.12.02.83","url":null,"abstract":"","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid Disease in Alopecia Areata, Lichen Planopilaris, and Frontal Fibrosing Alopecia—A Case Control Study of 144 Patients 斑秃、扁平秃苔、额部纤维化性脱发伴甲状腺疾病144例病例对照研究
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.02.85
T. Nguyen, Monica S Tsai, T. Grogan, C. Goh
{"title":"Thyroid Disease in Alopecia Areata, Lichen Planopilaris, and Frontal Fibrosing Alopecia—A Case Control Study of 144 Patients","authors":"T. Nguyen, Monica S Tsai, T. Grogan, C. Goh","doi":"10.17925/USE.2016.12.02.85","DOIUrl":"https://doi.org/10.17925/USE.2016.12.02.85","url":null,"abstract":"Background: Hair loss can be a troublesome aspect of thyroid disease for some patients. In addition to diffuse hair thinning, thyroid disease has been associated with clinically significant forms of alopecia, including alopecia areata (AA) and telogen effluvium. The role of thyroid disease in other causes of alopecia, such as lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), remains unclear. This study retrospectively assessed the role of thyroid dysfunction in AA, LPP and FFA. Methods: A systematic chart review of 144 patients was performed from September 2010 to July 2013. Data were analyzed using multivariate logistic regression to test for a relationship between thyroid disease and type of alopecia. Results: A total of 113 alopecia patients were analyzed. A positive history of thyroid disease was found in 16.0% of AA, 25.0% of FFA, 17.1% of LPP, and 15.1% of control patients. After controlling for age and sex, alopecia was not found to be a statistically significant predictor of thyroid disease. Conclusions: Although alopecia patients in this study had rates of thyroid dysfunction higher than the U.S. population, there were no significant differences in rates of thyroid dysfunction compared to the control group.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Prediabetes and Adolescence—Trends, Causes, Effects, and Screening 前驱糖尿病和青春期——趋势、原因、影响和筛查
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.02.94
Charikleia Stefanaki
{"title":"Prediabetes and Adolescence—Trends, Causes, Effects, and Screening","authors":"Charikleia Stefanaki","doi":"10.17925/USE.2016.12.02.94","DOIUrl":"https://doi.org/10.17925/USE.2016.12.02.94","url":null,"abstract":"1. Center for Adolescent Medicine and UNESCO Chair on Adolescent Health Care, Choremeio Research Laboratory, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, Greece; 2. Endocrine Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The Double Burden of Infectious Diseases and Diabetes—A Bidirectional Relationship 传染病与糖尿病的双重负担——一种双向关系
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/EE.2015.11.02.112
E. Sobngwi, J. Mbanya
{"title":"The Double Burden of Infectious Diseases and Diabetes—A Bidirectional Relationship","authors":"E. Sobngwi, J. Mbanya","doi":"10.17925/EE.2015.11.02.112","DOIUrl":"https://doi.org/10.17925/EE.2015.11.02.112","url":null,"abstract":"There is growing evidence for an etiological interaction between infectious diseases and diabetes, as well as for bidirectional influence of clinical presentation, spread, and outcomes. Some HIV treatments increase diabetes risk, and some infectious diseases may determine unique phenotypes of diabetes. Individuals who have type 2 diabetes have increased risk for tuberculosis and viral hepatitis and have poorer treatment outcomes. Joint noncommunicable diseases (NCDs) and infectious diseases clinics are the ideal method of tackling the double burden of these diseases in developing countries.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"112"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67586416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Novel Small Molecule Drug Derived from Methimazole (Phenylmethimazole) that Targets Aberrant Toll-like Receptor Expression and Signaling for the Potential Prevention or Treatment of Diabetes Mellitus and Non-alcoholic Fatty Liver Disease 一种从甲巯咪唑(苯基甲巯咪唑)衍生的新型小分子药物，靶向异常toll样受体表达和信号传导，可能预防或治疗糖尿病和非酒精性脂肪性肝病
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/USE.2015.11.1.17
Kelly D. Mccall, F. Schwartz
{"title":"A Novel Small Molecule Drug Derived from Methimazole (Phenylmethimazole) that Targets Aberrant Toll-like Receptor Expression and Signaling for the Potential Prevention or Treatment of Diabetes Mellitus and Non-alcoholic Fatty Liver Disease","authors":"Kelly D. Mccall, F. Schwartz","doi":"10.17925/USE.2015.11.1.17","DOIUrl":"https://doi.org/10.17925/USE.2015.11.1.17","url":null,"abstract":"Toll-like receptors (TLRs) are pattern-recognition receptors located on the surface or within (endosome) immune cells (dendritic), whose function is to recognize pathogens from the environment and mediate both the innate and acquired immune responses. Environmental activation of TLRs in nonimmune cells is now recognized as a significant pathway that mediates the loss of self-tolerance in autoimmune diseases, as well as inflammationinduced cell damage in many chronic diseases. We have developed a small molecule drug derived from methimazole, phenylmethimazole (C10), which interferes with the environmental induction of TLR signaling in nonimmune cells and is an active inhibitor of pathologic inflammation in many animal disease models. This article has been written to introduce clinicians to TLR function and the potential therapeutic role that their inhibition could play in many inflammatory/autoimmune diseases, including diabetes and nonalcoholic fatty liver disease (NAFLD).","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Functionally Refractory Patient in Diabetes—Prevalence and Predictors within Specialist Care Registries 糖尿病功能性难治性患者——专科护理登记的患病率和预测因素
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/USE.2015.11.1.30
R. Aronson
{"title":"The Functionally Refractory Patient in Diabetes—Prevalence and Predictors within Specialist Care Registries","authors":"R. Aronson","doi":"10.17925/USE.2015.11.1.30","DOIUrl":"https://doi.org/10.17925/USE.2015.11.1.30","url":null,"abstract":"A recent literature survey reviewed all published global registries, evaluating them for patient outcome data and characteristics. Using registry data to define the patient characteristics of refractory patients, the authors characterized the functionally refractory patient in diabetes and provided a predictive model to facilitate the recognition of such a patient in a specialist practice. At the specialist level, the authors have identified common predictive elements of a functional refractory status: insulin usage, greater number of microvascular complications, earlier age of onset and longer durations of diabetes, and greater complexity and number of therapies. This editorial provides a brief overview and commentary of the authors’ original descriptive literature review and findings.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Team Care—The Preferred Approach to Diabetes Treatment 团队护理——糖尿病治疗的首选方法
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/USE.2015.11.02.75
L. Siminerio
{"title":"Team Care—The Preferred Approach to Diabetes Treatment","authors":"L. Siminerio","doi":"10.17925/USE.2015.11.02.75","DOIUrl":"https://doi.org/10.17925/USE.2015.11.02.75","url":null,"abstract":"Diabetes is a lifestyle disease that requires the person living with the disease to make many daily decisions about diet, activity level, and medications, as well as adequate support to manage the disease successfully. Research has shown that a team-based approach to diabetes care is an effective way to help people with diabetes manage the disease, prevent and treat complications, provide behavior-change strategies, and cope with the emotional challenges this chronic disease brings [1]. Although the team may look different for each patient, it usually represents a variety of disciplines and may include a physician, registered dietitian, diabetes educator, nurse, pharmacist, psychologist, podiatrist, dentist, other professionals and resources within the community.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"75"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The Thr92AlaD2 Polymorphism May Play a Novel Role in Hypothyroidism Thr92AlaD2多态性可能在甲状腺功能减退中起新作用
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/USE.2015.11.02.92
Elizabeth A. McAninch, A. Bianco
{"title":"The Thr92AlaD2 Polymorphism May Play a Novel Role in Hypothyroidism","authors":"Elizabeth A. McAninch, A. Bianco","doi":"10.17925/USE.2015.11.02.92","DOIUrl":"https://doi.org/10.17925/USE.2015.11.02.92","url":null,"abstract":"The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine “monotherapy.” A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on “combination therapy” with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Refractory Patient—Managing Diabetes by the Ear 难治性糖尿病患者的耳部管理
US endocrinology Pub Date : 2015-01-01 DOI: 10.17925/USE.2015.11.1.32
S. Kalra, Y. Gupta
{"title":"The Refractory Patient—Managing Diabetes by the Ear","authors":"S. Kalra, Y. Gupta","doi":"10.17925/USE.2015.11.1.32","DOIUrl":"https://doi.org/10.17925/USE.2015.11.1.32","url":null,"abstract":"Refractory, or ‘difficult to control,’ diabetes is a commonly encountered condition in specialist practice. This editorial describes the characteristics of people with diabetes who are unable to achieve optimal glycemic control, despite aggressive drug therapy. It reflects upon the importance of bidirectional communication between patient and physician, and highlights the need for systematic history taking, empathic listening, and therapeutic patient education. The editors call for practicing ‘diabetes therapy by the ear,’ in conjunction with evidence-based pharmacological therapy, to help reduce the prevalence of refractory diabetes.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"11 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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