Thr92AlaD2多态性可能在甲状腺功能减退中起新作用

Q4 Medicine

US endocrinology Pub Date : 2015-01-01 DOI:10.17925/USE.2015.11.02.92

Elizabeth A. McAninch, A. Bianco

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引用次数: 1

摘要

2型去碘酶(D2)在甲状腺功能减退中起重要作用，其激活甲状腺激素的能力为左旋甲状腺素“单一治疗”提供了理由。D2 Thr92AlaD2普遍多态性与T4+T3“联合治疗”改善幸福感有关;潜在的机制尚不清楚，因为t4到t3的转化是正常的。新的研究表明，这可能是神经退行性疾病的一个危险因素。如果thr92alad2表达与治疗偏好之间的关系得到证实，个体化用药可能在甲状腺功能减退中发挥作用。

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The Thr92AlaD2 Polymorphism May Play a Novel Role in Hypothyroidism

The type 2 deiodinase (D2) has an important role in hypothyroidism, where its ability to activate thyroid hormone provides justification for levothyroxine “monotherapy.” A prevalent polymorphism in D2, Thr92AlaD2, has been associated with improved well-being on “combination therapy” with T4+T3; the underlying mechanism is unclear as T4-to-T3 conversion appears normal. Novel studies indicate this might be a risk factor for neurodegenerative disease. If the relationship between Thr92AlaD2-expression and treatment preference is confirmed, personalized medicine may play a role in hypothyroidism.

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来源期刊

US endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

1.90

自引率

0.00%

发文量