Tubercle最新文献_第3页

Diagnostic dilemma and therapeutic non-compliance in a case of intracranial tuberculoma 颅内结核瘤1例诊断困境及治疗不依从性分析

Tubercle Pub Date : 1991-12-01 DOI: 10.1016/0041-3879(91)90058-Z

M.E. Ellis , M.A. Halim , R.K. Coates , A.A. Al-Hokail , S.M. Hussain Qadri , A. El-Yazigi

引用次数: 6

Processing and presentation of mycobacterial antigens: implications for the development of a new improved vaccine for tuberculosis control 分枝杆菌抗原的处理和呈递:对结核控制新改良疫苗开发的意义

Tubercle Pub Date : 1991-12-01 DOI: 10.1016/0041-3879(91)90048-W

I. Orme

引用次数: 8

Koch's phenomenon: can it be corrected? 科赫现象:它能被纠正吗?

Tubercle Pub Date : 1991-12-01 DOI: 10.1016/0041-3879(91)90047-V

J.L. Stanford

引用次数: 14

Differentiation between Mycobacterium avium and M. intracellulare by phenetic characteristics 鸟分枝杆菌与胞内分枝杆菌的表型分化

Tubercle Pub Date : 1991-12-01 DOI: 10.1016/0041-3879(91)90065-Z

M. Tsukamura, S. Yamori

引用次数: 2

The changing tubercle 变化的结节

Tubercle Pub Date : 1991-12-01 DOI: 10.1016/0041-3879(91)90046-U

John M. Grange

引用次数: 3

Differentiation between mycobacteria of the Mycobacterium tuberculosis complex by pyrolysis mass spectrometry 热裂解质谱法鉴别结核分枝杆菌复合体分枝杆菌

Tubercle Pub Date : 1991-09-01 DOI: 10.1016/0041-3879(91)90009-H

P.R. Sisson , R. Freeman , J.G. Magee , N.F. Lightfoot

引用次数: 19

Diagnostic value of ascites gamma interferon levels in tuberculous peritonitis. Comparison with adenosine deaminase activity 腹水γ干扰素水平对结核性腹膜炎的诊断价值。腺苷脱氨酶活性比较

Tubercle Pub Date : 1991-09-01 DOI: 10.1016/0041-3879(91)90007-F

E. Ribera , J.M. Martinez Vasquez , I. Ocaña , I. Ruiz , J.G. Jiminez , G. Encabo , R.M. Segura , C. Pascual

{"title":"Diagnostic value of ascites gamma interferon levels in tuberculous peritonitis. Comparison with adenosine deaminase activity","authors":"E. Ribera , J.M. Martinez Vasquez , I. Ocaña , I. Ruiz , J.G. Jiminez , G. Encabo , R.M. Segura , C. Pascual","doi":"10.1016/0041-3879(91)90007-F","DOIUrl":"10.1016/0041-3879(91)90007-F","url":null,"abstract":"<div><p>The value of ascites gamma interferon concentration and ascites adenosine deaminase activity in distinguishing tuberculosis from other causes of ascites was examined in a prospective study of 86 patients with ascites, including 16 with tuberculous peritonitis. Gamma interferon concentration was higher in tuberculous peritonitis than in the other causes of ascites (p < 0.0001), and a cut-off between 3 and 9 u/ml reached a sensitivity and a specificity of 100%. The mean (± SD) gamma interferon level in tuberculous ascites was 39.3 ± 18.3 u/ml in patients seronegative for HIV and 14.2 ± 4.7 μ/ml in patients with AIDS (p = 0.01). Adenosine deaminase activity in tuberculous ascites was also higher than in the other causes of ascites (p < 0.0001), and a cut-off of 40 u/l reached a sensitivity of 100% and a specificity of 97%. The two false positives for adenosine deaminase test were true negatives for the gamma interferon test. There was no significant correlation between gamma interferon concentration and adenosine deaminase activity either in tuberculous ascitis or in any other group. This study suggests that ascites gamma interferon determination may be very useful in the screening of tuberculous peritonitis, but Its cost makes it advisable to use adenosine deaminase activity as a routine test, at least in areas where tuberculosis is endemic.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"72 3","pages":"Pages 193-197"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(91)90007-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Comparison of three methods for decontamination of faeces for isolation of Mycobacterium tuberculosis 三种粪便净化方法分离结核分枝杆菌的比较

Tubercle Pub Date : 1991-09-01 DOI: 10.1016/0041-3879(91)90011-G

B.W. Allen

引用次数: 14

A guinea pig model of experimental airborne tuberculosis for evaluation of the response to chemotherapy: the effect on bacilli in the initial phase of treatment 用于评价化疗反应的实验性空气传播结核豚鼠模型:治疗初期对杆菌的影响

Tubercle Pub Date : 1991-09-01 DOI: 10.1016/0041-3879(91)90013-I

D.W. Smith, V. Balasubramanian, E. Wiegeshaus

{"title":"A guinea pig model of experimental airborne tuberculosis for evaluation of the response to chemotherapy: the effect on bacilli in the initial phase of treatment","authors":"D.W. Smith, V. Balasubramanian, E. Wiegeshaus","doi":"10.1016/0041-3879(91)90013-I","DOIUrl":"10.1016/0041-3879(91)90013-I","url":null,"abstract":"<div><p>The purpose of this study was to develop and evaluate a guinea pig model of experimental airborne tuberculosis for its ability to assess chemotherapeutic regimens for their efficacy against virulent tubercle bacilli <em>in vivo</em> during the initial phase of treatment. The tissues examined included primary lung lesions and the metastatic foci in lung and spleen which result from the naturally occurring bacillaemia. The treatments examined, INH+RIF, INH+EMB, EMB+RIF, were initiated 4 weeks after infection and were continued for 8 weeks. Although minor differences were observed in the time of onset of a significant bactericidal effect or in the rate of decline in the microbial population, all three treatment combinations resulted in a significant reduction in the number of <em>M. tuberculosis</em> H37Rv recovered from primary lung lesions, primary lesion-free lung lobes and spleen. X-rays taken of excised inflated lung lobes showed a relationship between the degree of calcification of primary lung lesions and the number of surviving bacilli.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"72 3","pages":"Pages 223-231"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(91)90013-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

In vitro and in vivo activities of sparfloxacin (AT-4140) against Mycobacterium tuberculosis 司帕沙星(AT-4140)抗结核分枝杆菌的体内外活性研究

Tubercle Pub Date : 1991-09-01 DOI: 10.1016/0041-3879(91)90004-C

B. Ji, C. Truffot-Pernot, J. Grosset

{"title":"In vitro and in vivo activities of sparfloxacin (AT-4140) against Mycobacterium tuberculosis","authors":"B. Ji, C. Truffot-Pernot, J. Grosset","doi":"10.1016/0041-3879(91)90004-C","DOIUrl":"10.1016/0041-3879(91)90004-C","url":null,"abstract":"<div><p>The <em>in vitro</em> and <em>in vivo</em> activities of sparfloxacin (AT-4140) against <em>M. tubercubsis</em> are reported. The MICs of sparfloxacin for 50% and 90% of 18 clinical isolates were, respectively, 0.25 and 0.5 mg/l, one or two dilutions lower than that of ciprofklxacin and ofloxacin. In mice infected intravenously with 0.1 mg <em>M. tuberculosis</em> H37Rv strain, the minimal effective dosage of sparfloxacin, as assessed by survival rate, spleen enlargement and gross lung lesidns, was 12.5 mg/kg. The activities of various regimens were in the following rank order: INH 25 mg/kg = sparfloxacin 50–100 mg/kg > ofloxacin 300 mg/kg > (or =) sparfloxacin 25 mg/kg > spartloxacin 12.5 mg/kg > (or =) ofloxacin 200 mg/kg > ofloxacin 100 mg/kg > (or =) negative control. Therefore, on a weight to weight basis, sparfloxacin was six to eight-fold more active against <em>M. tuberculosis</em> infection in mice than ofloxacin. In addition, WIN 57273, a new broad-spectrum fluoroquinolone, at a dosage of 100 mg/kg daily, was inactive against <em>M. tuberculosis</em> infection.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"72 3","pages":"Pages 181-186"},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(91)90004-C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12828658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39